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At least 37 records · Page 2Linked to original sources
PubMed1976

Comparative, immunological studies on lymphangiectasia of the small intestine revealed in protein losing gastroenteropathy and Behçet's disease.

Lymphangiectasia of the small intestine was demonstrated in 9 to 18 cases with protein losing gastroenteropathy and in 10 of 26 cases with Behçhet's disease. Protein losing gastroenteropathy was compared to Behçet's disease in view of immunological aspects. Immunoglobulin containing cells in the jejunal mucosa of protein losing gastroenteropathy were decreased, whereas Behçet's disease had normal or increased distribution. This suggested that suggested that immunoglobulin may be lost into the intestinal lumen or that production of those cells may be inhibited in protein losing gastroenteropathy. Decreased DNCB skin reaction and impaired blastoid transformation of peripheral lymphocytes in both of two diseases suggested that there should be immunological defect in those diseases. However, in Behçet's disease, investigation of the thymus disclosed hyperplasia and the presence of lymphoid follicle which does not appear in normal state. In conclusion, protein losing gastroenteropathy is in immunological deficiency state due to the congenital or acquired disorders of lymphatics which implies abnormal protein loss, decreased immunoglobulin containing cells in the jejunal mucosa and decreased sensitivity. On the contrary, in Behçet's disease hyperimmune state is present based on thymic hyperplasia.

Adult↗
PubMed1989

[Comparative immunologic characteristics of patients with acute and chronic bronchitis].

Twenty patients with acute, 24 with chronic nonobstructive and 16 with chronic obstructive bronchitis were examined over time. The activity of the inflammatory process was taken into account while analyzing the data obtained in the course of immunologic studies. The patients with chronic bronchitis demonstrated a noticeable decrease in the immune response as compared to those with acute bronchitis. Application of multidimensional statistic analysis made it possible to reveal the most informative characteristics of immune responsiveness in acute and chronic bronchitis depending on the intensity of obstruction and the phase of the inflammatory process.

Acute Disease↗
PubMed1982

Comparative immunological studies in rats following cryosurgery and surgical excision of 3-methylcholanthrene-induced primary autochthonous tumors.

Post-operative antitumor immunity was studied by comparing the results following cryosurgery and surgical excision of 3-methylcholanthrene-induced primary autochthonous tumors in WKA/Hok rats. Immunity was tested by challenge with the autochthonous tumors on the 4th and 21st days post-operatively. Antitumor resistance which developed following cryosurgery was found in 7 out of 14 rats (50%) challenged after 4 days and in 2 out of 13 rats (15%) challenged after 21 days. Following surgical excision, however, resistance was found in 13 out of 18 rats (72%) challenged after 4 days and in 10 out of 17 rats (58%) challenged after 21 days. Therefore, the development of antitumor immunity by surgical excision was more effective than by cryosurgery (P less than 0.02). In addition, the enhancement of autochthonous tumor growth as compared with that of the control rats was clearly demonstrated after cryosurgery in 4 out of 14 rats (29%) challenged 4 days afterwards and in 3 out of 13 rats (23%) challenged 21 days afterwards. After surgical excision, however, this was seen in only 3 out of 18 rats (17%) challenged 4 days afterwards, and in 0 out of 17 rats (0%) challenged 21 days afterwards. These results suggest not only that the development of antitumor immunity is delayed but also that the tumor growth is more likely to be enhanced by cryosurgery than by surgical excision.

Animals↗
PubMed1978

Comparative immunological studies on cryosurgery and surgical operation using Moloney murine sarcoma virus-induced primary tumors in BALB/c mice.

The effect of cryosurgery and surgical operation on Moloney murine sarcoma virus-induced primary tumors in the treated and untreated groups of BALB/c mice was compared in terms of tumor growth, cumulative mortality, lymphocyte-mediated cytotoxicity, proliferative response of lymphocytes, and humoral antibody formation. The results indicate that cryosurgical treatment showed both in vivo and in vitro effects; (i) tumor growth and cumulative mortality in mice treated by cryosurgery were significantly lower than those in untreated groups, and (ii) their cellular immune response was enhanced, as manifested by increase in a proliferative response and in lymphocyte-mediated cytotoxic activity against Moloney murine leukemia virus-induced lymphoma. The proliferative response of spleen cells and the cytotoxic activity of lymphocytes were not parallel; the proliferative response detected by 3H-thymidine incoroporation manifested peak activity 3 days after cryosurgery, but the cytotoxic activity detected by 125I-iododeoxyuridine-releasing tests was considerably decreased at this stage. Two weeks after cryosurgery and thereafter, however, the cytotoxic activity of this group increased to a level higher than that of untreated or surgically treated groups. On the contrary, surgical operation abrogated the proliferative response of spleen cells. Immunofluorescence tests revealed, however, that humoral antibody formation was higher in surgically operated groups than in other groups.

Animals↗
PubMed1975

Comparative immunology of Galapagos iguana hemoglobins.

The antigenic properties of the major hemoglobin component of the Galapgaos iguanas were studied using second-approximation qualitative and quantitative immunochemical techniques. Phylogenetic distances, relative to the Galapagos marine iguana. Amblyrhynchus cristatus, were established on the basis of immunological cross-reactions.

Animals↗
PubMed1992

A comparative immunological analysis of the oral mucosa in chronic graft-versus-host disease and oral lichen planus.

Oral mucosal biopsies of 12 allogeneic marrow transplant recipients with chronic graft-versus-host disease (GVHD) involving the mouth were compared with biopsies taken before transplantation. They were also compared with biopsies from otherwise healthy patients with oral lichen planus, and with those from a control group of normal individuals. Biopsies from chronic GVHD exhibited a low number of infiltrating T lymphocytes (CD3 cells) compared with those from oral lichen planus, which showed intense cell infiltration (p less than 0.005). The ratio of CD4 to CD8 cells in biopsies taken after the manifestation of chronic GVHD exhibited no consistent variation compared with those taken before transplantation or with biopsies of oral lichen planus. The CD4/CD8 ratio in all groups investigated varied between 4:1 and 6:1. The number of natural killer cells (CD57), was increased in biopsy specimens taken before transplantation compared with the other groups. The frequency of homing receptor, Leu-8 bearing T cells was low in the biopsy specimens of all groups, compared with the corresponding frequency in peripheral blood (10-45 and 60-90%, respectively; p less than 0.001). In the biopsies from chronic GVHD and oral lichen planus the number of lymphocytes with transferrin receptors was increased compared with the pretransplant and control groups. Virtually no infiltrating cells were carrying interleukin-2 receptors (CD25) in any of the groups studied. Langerhans cells (CD1) were more frequently found in the specimens from chronic GVHD and oral lichen planus than in the pretransplant specimens and the control group (p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1972

Comparative immunological and enzymatic study of the tryptophan synthetase beta 2 subunit in the Enterobacteriaceae.

The beta(2) subunits of tryptophan synthetase, formula alpha(2)beta(2), from Escherichia coli, Shigella dysenteriae, Enterobacter aerogenes, Salmonella typhimurium, and Serratia marcescens were compared by three criteria. (i) alphabeta association constants for the various beta(2) subunits and E. coli alpha subunit varied between 3.6 x 10(8)m(-1) for E. coli and 0.33 x 10(8)m(-1) for S. marcescens; values for the other organisms were intermediate. (ii) Antiserum neutralization of the beta(2) subunit enzyme activity using anti-E. coli beta(2) serum showed significant cross-reaction among the organisms (E. coli, 1.0; S. dysenteriae, 0.98; S. typhimurium, 0.67; E. aerogenes, 0.61; S. marcescens, 0.42). (iii) Quantitative microcomplement fixation showed E. coli beta(2) and S. marcescens beta(2) subunits to have an index of dissimilarity of 1.8 while the other organisms had intermediate indexes. Similar complement fixation data were obtained with antisera from separate rabbits and from first course and boost sera. These findings suggest that the general surface structure and the respective alpha subunit binding site of the beta(2) subunits from these Enterobacteriaceae have been strongly conserved.

Antigens, Bacterial↗
PubMed1982

Antigens from Histoplasma capsulatum and Blastomyces dermatitidis. I. Immunological comparative studies from polysaccharide-protein complexes of both fungi.

Certain groups of fungi share chemical structures which makes difficult isolation and differentiation of specific antigens by the usual methods of extraction and purification. Therefore, we have oriented our studies to the immunological and biochemical characterization of differences and similarities of molecular structures from fungi, etiologic agents of systemic mycoses, hoping to establish criteria for the utilization and handling of these antigens. A deproteinized polysaccharide-protein complex (D-PPC) was isolated from Histoplasma capsulatum and Blastomyces dermatitidis. The immunological studies with humoral tests indicate a variable cross reaction between antigens of both species. In immunodiffussion systems, the reaction was specific for each species using saline solution of phosphate butter solution, while using an agarose veronal system, the cross reactions were very evident. In addition, differences in cross reactions were obtained with immunoelectrophoresis, haemagglutination and complement fixation microtest. This variation to cross reaction responses suggest that these antigens (D-PPC) share common structures but at the same time must have some different component owned by each one of the fungi which makes them more specific than crude antigens.

Antigens, Fungal↗