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At least 37 records · Page 2Linked to original sources
PubMed1986

Histologic analysis of tissue response to bucrylate-pantopaque mixture.

A toxicologic-pathologic study of isobutyl-2-cyanoacrylate (Bucrylate) was carried out first in dogs and then in humans whose arteriovenous malformations were infused with this embolic agent. The canine specimens obtained at 7, 18, 28, and 147 days after embolization showed the development of a mild histiocytic giant cell reaction, which evolved to end-state sclerotic arteritis. The response was confined to the vessels and did not involve contiguous parenchymal tissues. Ten human specimens, obtained from 1 hr to 7 years after treatment, showed a similar bland reaction with no evidence of suppuration or premalignant changes.

Adolescent↗
PubMed1990

Embolization of cerebral arteriovenous malformations with bucrylate. Experience in a first series of 29 patients.

The experience with embolization of intracerebral arteriovenous malformations (AVMs) with bucrylate (isobutyl-2-cyanoacrylate) in 29 patients is reported. In 9 cases (31%) less than 1/3 of the AVM nidus was occluded, in 12 (41%) 1/3 to 2/3, in 4 (14%) more than 2/3, and total occlusion was only seen in 3 cases (10%). One patient was never embolized, owing to procedure complications. At follow-up angiography in 20 patients, partial revascularization was found in 11 AVMs and further occlusion in 2. Complications occurred in 11 cases (38%). Five patients (17%) suffered from hemorrhage: 2 died, one deteriorated severely and 2 recovered. Unintentional embolization or edema resulted in neurologic deficits in 6 patients (21%), permanent in 3 and reversible in 3. Symptomatic improvement was initially found in 13 patients (45%) but was stable only in 9. In 9 patients (38%) embolization was followed by elective surgery or irradiation. The best results were obtained in small and medium-sized AVMs (less than 6 cm) while there was a high risk of complications and an uncertain palliative effect in large AVMs.

Adolescent↗
PubMedDate not supplied

[Endoscopic obturation of esophagogastric varices with bucrylate. I. Clinical study of 49 patients].

The authors report the results of endoscopic obliteration of recently bleeding esophagogastric varices with Bucrylate (isobutyl-2-cyanoacrylate) in 49 patients. Forty-five patients had cirrhosis; in all patients, propranolol was contraindicated or had failed, hepatocellular function was poor, or early rebleeding had occurred. In 15 cases, injections were made during active bleeding of esophageal or gastric varices; in 14 cases, the hemorrhage stopped immediately. The cumulative percentages of patients free of variceal rebleeding 1.6 and 12 months after inclusion were 88.63 and 58 p. 100 respectively. The cumulative percentages of patients surviving 1, 12 and 18 months after inclusion were 70, 53 and 46 p. 100 respectively. The cumulative percentages of survival at 6 months after inclusion were 100.63 and 13 p. 100 in grade A, B and C patients respectively. The major causes of death were liver failure and sepsis; autopsy revealed mediastinitis in 3 patients. Long-lasting esophageal strictures developed in two patients. This procedure differs from endoscopic sclerotherapy in that gastric varices can be adequately obliterated and the risk of early rebleeding seems to be decreased.

Adult↗
PubMedDate not supplied

Histopathologic effects of transarterial bucrylate occlusion of intracerebral arteries in mongrel dogs.

Bucrylate was injected directly into the cerebral cortical arteries of mongrel dogs. Preparations for light and electron microscopy were obtained from 5 min to 5 months after the introduction of the polymer. A mixed pattern of damage to arterial endothelium was seen, including electron microscopic documentation of stripping away of the endothelium. Acute effects include a subocclusive thrombogenic matrix, which causes partial or complete thrombosis. The long-term reactions are those of a chronic inflammatory response to a foreign body.

Animals↗
PubMed1994

[Complications of varicocele embolization: adhesion of the intravascular catheter during infusion of bucrylate].

The introduction of percutaneous occlusion techniques to manage a varicocele has made possible the control of the process with success rates similar to those obtained with conventional surgery. Its efficacy and minimal invasive nature, although not entirely risk-free, are responsible for its expansion. Contribution of one case of adhesion of the intravascular catheter to the underlying spermatic vein wall during infusion with isobutyl cyanoacrylate (bucrylate) as embolization material, an event which forced immediate surgical removal.

Adult↗
PubMed1990

Revascularization of brain arteriovenous malformations after embolization with bucrylate.

Between 1984 and 1988, 52 brain arteriovenous malformations (AVMs) were embolized in the Radiology Department of the Toronto Western Hospital. 9 were localized in the occipital lobe. There was angiographic follow-up ranging from one to four years. Two embolized AVMs, both occipital, showed revascularisation at 6 months and two years respectively. In one case the embolization had resulted in a complete obliteration of the AVM. In the other, the nidus was reduced by 95%. It is suggested that the occipital lobe, because of its rich vascularity, is more prone than other parts of the brain to produce intense collateralization leading indirectly to resupply of embolized AVMs. Existence of these collaterals may also explain the rarity of visual defects in occipital AVMs. These cases confirm the need for post therapeutic angiographic controls to assess the stability of the results obtained.

Adult↗
PubMed1989

Inadvertent bucrylate pulmonary embolization: a case report.

Detection of small, dense, rectangular opacities that follow the course of pulmonary vessels on chest radiographs should raise the suspicion of a prior therapeutic occlusion of the blood supply of a mass or of an arteriovenous fistula elsewhere with embolization of the occlusive material to the lungs. This article demonstrates the radiographic findings of such an occurrence in an asymptomatic woman.

Adult↗
PubMed1986

Improved technique of bucrylate embolisation in brain arteriovenous malformation. The use of additional temporary balloon occlusion.

Problems currently limiting the success and safety of calibrated leak balloon embolisation include suboptimal occlusion of malformation bed due to multiple or inaccessible pedicles and neural deficits due to paradoxical embolisation of normal brain. Analysis of preliminary calibrated leak balloon angiograms supported by temporary balloon occlusion of other pedicles yields insights into the dynamics of blood flow to anterior malformations. Strategies have been devised using temporary balloon occlusion to improve filling of malformation bed and reduce paradoxical embolisation of eloquent brain.

Bucrylate↗