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The advent of guilt feelings as a common depressive symptom: a historical comparison on two continents.

Historical shifts in the symptomatology of mental disease are surprisingly overlooked but common phenomena that should cast considerable light on the relation between social and intrapsychic processes. The enormous increase in chronicity and mortality in mental hospitals during the second half of the 19th century, and the shift from the shell-shock of the first World War to the battle fatigue of the second are examples which have been well documented but not well explained. The advent of guilt feelings in depression or melancholia is a lesser known instance but one with perhaps greater theoretical significance. Melancholia has been known almost throughout recorded history, but until the 16th century the number of recorded cases exhibiting exaggerated guilt feelings and self-accusations was very small, and the old physicians did not include them in their descriptions of the condition. In Asia and in Africa, moreover, it is claimed that these symptoms are rare even today, except among the Westernized. If we fully understood the other features of the disease or if the symptoms had no relevance to course and treatment, these facts might be treated simply as curiosities; but neither is the case. Depression is still not adequately understood, and some theories on it derive largely from the exaggerated guilt feelings and the psychic structure which is supposed to produce the latter. Hence it could be instructive to examine under what conditions these symptoms first became common in different societies.

Africa↗

HIV-associated cognitive impairment before and after the advent of combination therapy.

The objective of this study was to describe the occurrence of HIV dementia and neuropsychological testing abnormalities in a new cohort of HIV-seropositive individuals at high risk for HIV dementia and to compare these results to a cohort before the advent of highly active antiretroviral therapy (HAART). HAART has been associated with improvements in cognitive performance in some HIV-infected patients. However, it is uncertain whether HAART has changed the frequency of specific neurocognitive abnormalities. Baseline data from 272 HIV-seropositive subjects in the Dana cohort recruited from January, 1994, to December, 1995, and 251 HIV-seropositive subjects in the Northeastern AIDS Dementia Consortium (NEAD) cohort recruited from April, 1998, to August, 1999, were compared. Participants in both cohorts received nearly identical assessments. After adjusting for differences in age, education, gender, race, and CD4 count between the two cohorts, there were no differences in the occurrence of HIV dementia or abnormalities either 1 SD or 2 SDs below established norms for any of the neuropsychological tests. Even though HAART has reduced the incidence of HIV dementia, HIV-associated cognitive impairment continues to be a major clinical problem among individuals with advanced infection.

AIDS Dementia Complex↗

Utilization of health services by poor children since advent of medicaid.

Many sources of data confirm that utilization of health services by poor children has increased since the advent of Medicaid in 1966. Poor children make approximately the same number of visits to medical provides each year as do non-poor children. Considering the greater need for services among poor children, few suggest that their full need is met. Available data are not entirely adequate to document how or where the increased utilization has occurred. The Medicaid legislation appeared to presume that poor children would be "mainstreamed" into the same provider systems that are used by the non-poor. Data from national and local surveys are cited in support of the possibility that Medicaid has in fact had a paradoxical effect, proportionately increasing publicly sponsored provider systems, and proportionately decreasing poor children's utilization of private medical providers.

Adolescent↗

The introduction of dram shop legislation in the United States and the advent of server training.

This paper discusses the relationship of research to policy in the matter of dram shop liability and server training in the USA. The discussion is made difficult by the apparent lack of any such relationship. While research in the area has only just been published, dram shop liability in the USA actually dates to the nineteenth century, with its current form shaped by the repeal of prohibition in 1933. Because liability law and liability insurance vary from state to state, current movements for reform and server training arise somewhat spontaneously in different localities and with different emphases. Research constitutes only a minor influence among several others more salient to the political process of policy formation. The advent of mandatory server training in the state of Oregon is used to illustrate the somewhat capricious nature of progress in responsible beverage service.

Alcohol Drinking↗

Radical prostatectomy for clinically advanced (cT3) prostate cancer since the advent of prostate-specific antigen testing: 15-year outcome.

UNLABELLED: In the first paper in this section, authors from the Mayo Clinic describe their experience and 15-year outcomes in the controversial subject of radical prostatectomy in patients with clinical T3 prostate cancer. The findings were interesting in many respects, but the authors concluded that radical prostatectomy as part of multimodal treatment for patients with clinical T3 disease offers cancer control and good survival rates. There follows a series of papers on both prostate cancer and bladder cancer, but the final paper in this section from the UK attempts to define the accuracy of urologists and oncologists in assessing patient life-expectancy. Using various methods they found that, rather disappointingly, doctors were poor at predicting 10-year survival, leading to the possible outcome that some patients may be denied treatment after a pessimistic assessment of life-expectancy. OBJECTIVE: To report a long-term experience with extirpative surgery in patients presenting with locally advanced (cT3) prostate cancer, as the best management of such patients remains a problem. PATIENTS AND METHODS: In a single-institution retrospective study identifying 5652 men who had radical prostatectomy (RP) for histologically confirmed prostate cancer since the advent of prostate-specific antigen (PSA) testing (1987-97), 15% (842) had RP for cT3 disease. The median follow-up of these men was 10.3 years. Cancer-specific, overall and disease-free survival was plotted and compared with those of patients having RP for cT2 disease during the same period. Perioperative morbidity, continence and erectile function rates were examined, with a multivariate analysis for risk factors of disease recurrence. RESULTS: Freedom from local or systemic disease at 5, 10, and 15 years after RP for cT3 disease was 85%, 73% and 67%; the respective cancer-specific survival rates were 95%, 90% and 79%. Significantly many men who did not receive neoadjuvant therapy (27%) were clinically over-staged (pT2) and most men with pT3 disease (78%) received adjuvant therapy. The mean time to adjuvant therapy after RP was not significantly different between men with cT3 and cT2 disease (4.0 and 4.3 years). Pathological grade (> or =7), positive surgical margins, and nondiploid chromatin were all independently associated with a significant risk for clinical disease recurrence, while preoperative PSA level had little effect on outcome. Complications and continence rates after RP in patients with cT3 mirrored those in patients with cT2 disease. CONCLUSIONS: Significantly many patients with cT3 prostate cancer are overstaged (pT2) in the PSA era. RP as part of a multimodal treatment strategy for patients with cT3 disease offers cancer control and survival rates approaching those achieved for cT2 disease. Pathological grade, ploidy and margin status are all significant predictors of outcome after RP. Complications and incontinence rates in patients with cT3 disease mirror those after RP for cT2 disease.

Aged↗

Sexual behaviour of adolescents before and after the advent of AIDS.

OBJECTIVES: To asses changes in sexual behaviour and use of contraceptive methods in Danish adolescents from the period before the advent of AIDS up to the present. DESIGN: Comparative study comparing data obtained from two identical cross sectional surveys SETTING: Grenaa Gymnasium, Denmark. SUBJECTS: 626 high school students in 1982 and 499 high school students in 1996. METHODS: An anonymous standardised self administered questionnaire handed out to high school students at Grenaa Gymnasium in spring 1982. In spring 1996 an identical questionnaire was handed out to every high school student at the same gymnasium. MAIN OUTCOME MEASURES: Age at first sexual intercourse, contraceptive use, and reasons for choice of contraceptive strategy. RESULTS: Today more males had experienced the first sexual intercourse before their 16th birthday (p = 0.047) compared with 1982, the reverse held for females (p = 0.003). From 1982 to 1996 condom use increased in males with no regular partner (p = 0.009). In females with no regular partner, there was during the same period an increase in considering the condom a personal contraceptive method (p = 0.017). In 1982 and 1996 protection from sexually transmitted diseases was given as reason for the choice of contraceptive strategy by 21% and 72% of males with no regular partner (p < 0.001), and by 7% and 32% of males with a regular partner (p < 0.001). The corresponding figures for females in 1982 and 1996 were 10% and 71% (p < 0.001) for those with no regular partner and 4% and 21% (p < 0.001) for those with a regular partner. CONCLUSION: Condom use has increased among adolescents with no regular partner brought up under the widespread awareness of AIDS, and the reason for this is to be protected from sexually transmitted diseases. A future decline in the incidence of various sexually transmitted diseases may be expected, and information on safe sexual practices should be continued.

Acquired Immunodeficiency Syndrome↗

Developmental expression of the peripheral-type benzodiazepine receptor and the advent of steroidogenesis in rat adrenal glands.

Although the precise mechanism whereby cholesterol is transported across the outer mitochondrial membrane is uncertain, a multimeric receptor complex termed the peripheral-type benzodiazepine receptor (PBR) appears essential for this process. We therefore predicted that adrenal cells at different developmental stages would express PBR coincidentally with the advent of steroidogenesis. Adrenals of neonatal rats demonstrate greatly reduced sensitivity to ACTH that gradually increases after the first 2 weeks of life. Thus, neonates have lower circulating corticosterone levels following exposure to stress. We examined mitochondrial PBR ligand binding activity, immunoreactive (ir) PBR content, and adrenal sensitivity to ACTH in vivo and in vitro. Ontogeny of both mitochondrial PBR ligand binding capacity and irPBR directly paralleled that of ACTH-inducible steroidogenesis in isolated rat adrenal cells and in rats injected with ACTH. In addition, neonatal PBR had approximately 2-fold higher affinity for PK11195, a synthetic ligand that binds with high affinity to PBR. No correlation was observed during neonatal life between ir-steroidogenic acute regulatory (StAR) protein content and steroidogenesis. These results are consistent with the hypothesis that PBR is an absolute prerequisite for adrenocortical steroidogenesis, and suggest that the stress hyporesponsive period of neonatal rats may result from decreased PBR expression. In addition, the higher affinity of neonatal PBR and the relatively high basal expression of StAR protein in neonatal adrenals may partly explain the high constitutive steroidogenesis characteristic of neonatal rat adrenal cells.

Adrenal Glands↗

Serostatus disclosure to sexual partners by HIV-infected women before and after the advent of HAART.

HIV-positive individuals have been encouraged by public health officials to disclose their HIV status to sexual partners. In deciding what to do, however, they must weigh what they see as the potential costs and benefits of disclosing or not disclosing. In the present report we examine the reasons women offer for disclosing or not disclosing their serostatus and the reactions to that disclosure among two matched samples of HIV-infected women. The first sample was interviewed in 1994-1996, before the widespread availability of HAART; while the second sample was interviewed from 2000-2003 after these medications were widely in use. The findings reveal striking similarities between the two time periods in women's reasons for sharing or not sharing their status with partners, and the reactions to disclosure they experienced. The reconceptualization of AIDS as a chronic illness, rather than an acute fatal one, did not appear to have diminished women's felt responsibility to share their diagnosis with potential sexual partners nor their fear that disclosure would be met with rejection. The data revealed that disclosure remains a highly stressful event for HIV-infected women and that they experience considerable emotional suffering as a result of the diminished sense of self-worth and physical attractiveness brought about by their diagnosis. These findings suggest that intervention efforts toward reducing the stigmatization of HIV/AIDS and for assisting women to manage the stress of disclosure and non-disclosure and address women's feelings of self-worth continue to be needed despite the advent of HAART.

Adult↗

The advent of human diploid cell rabies vaccine: impact on vaccine utilization in New Mexico.

Three months' experience with the newly licensed human diploid cell rabies vaccine in the New Mexico comprehensive consultation-biologics system was reviewed. Comparison with the same period in 1978 and 1979 showed no increase in vaccine utilization despite the advent of this simpler-to-use, safer rabies vaccine. Anti-rabies treatments appear to be minimally influenced by new vaccine technology when a comprehensive consultation system is available to support and guide the private physician.

Diploidy↗

Psychosocial characteristics of New York City HIV-infected women before and after the advent of HAART.

OBJECTIVES: We compared level of psychosocial distress of HIV-infected women living in New York City before the advent of highly active antiretroviral therapy (HAART) with level of psychosocial distress reported by women living with the disease after the use of HAART became widespread. METHODS: Data were from HIV-positive New York City women aged 18 to 50 years, enrolled through outreach and self-referral. We compared scores on measures of psychological state and psychosocial adjustment to illness of 74 women interviewed in 1994-1996 with scores of a matched group of 74 women interviewed in 2000-2002. RESULTS: A significant difference between groups was found only with regard to adjustment to illness in their domestic environment, with poorer adjustment reported, on average, by women in the 2000-2002 sample. CONCLUSIONS: Although new treatments have significantly improved the physical health of those living with HIV/AIDS, no evidence was found that these treatments significantly improved psychological health for women, regardless of history of protease inhibitor use.

Adaptation, Psychological↗

Observations on 82 patients with extradural hematoma. Comparison of results before and after the advent of computerized tomography.

A consecutive, unselected series of 82 patients with epidural hematoma treated between 1973 and 1980 is presented. Forty-one patients were managed before the advent of computerized tomography (CT) and the other 41 after this neuroradiological method was available. Mortality and disability rates which were 29.2% and 31.7% during the pre-CT period decreased to 12.1% and 19.5%, respectively, with the aid of CT scanning. This technique allowed a more rapid and accurate diagnosis of the hematomas than angiography, and defined better the presence and the evolutional changes of the associated cerebral lesions. As a consequence, surgery has been more effectively planned and executed during the CT era.

Adolescent↗

Chronic acalculous cholecystitis: changes in patient demographics and evaluation since the advent of laparoscopy.

BACKGROUND AND OBJECTIVE: To analyze patients with chronic acalculous cholecystitis over ten years, during which laparotomy was replaced by laparoscopy as the dominant operation for cholecystectomy in regard to patient demographics, diagnostic evaluations, follow-up symptoms, and additional operations. METHODS: Of 7181 cholecystectomies from June 1985 to June 1995, 301 patients had chronic acalculous cholecystitis. All subsequent hospital admissions and emergency room visits were reviewed through May 1997. Office records were available for review in 158 cases. Two eras were defined, the open era from June 1985 through May 1990, and the laparoscopic era from June 1990 through June 1995. RESULTS: Twice as many patients with chronic acalculous disease underwent cholecystectomy after the advent of laparoscopy. Patients with chronic acalculous disease were significantly younger than patients with cholelithiasis in both open and laparoscopic cases. The percentage of white women increased from 64.7% in the open to 75.7% in the laparoscopic era (p<0.05). The numbers of preoperative diagnostic tests performed decreased from 4.7+/-2.4 in the open to 3.2+/-1.8 in the laparoscopic era (p<0.05). Twenty-two percent of patients had continued symptoms postoperatively, and 8 patients (2.7%) required other abdominal operations within one year of cholecystectomy. CONCLUSION: Chronic acalculous cholecystitis is a disease of white females, doubling in frequency over the decade of review. Of these, 78% of patients had resolution of their symptoms on long-term follow-up.

Adolescent↗

Review of myelograms in evaluation of spinal lesions prior to advent of computed tomography (CT) scan in Ghana.

We retrospectively reviewed myelographic appearances of 2005 patients in ten years prior to advent of computed tomography (CT) scan in three major hospitals in Ghana. 877 (43.75%) were normal and 1128 (56.25%) were pathological. The lesions detected were spondylosis 321 (28.22%), disc herniation 272 (24.37%) trauma 172 (15.25%), Pott's disease 133 (11.79%), spinal tumours 101 (8.96%); Arachnoiditis 74 (6.56%) and spinal stenosis 46 (4.07%). Myelography still remains the examination of choice in the investigation of spinal lesions in the sub-region.

Adolescent↗

External gastrointestinal fistula after the advent of total parental nutrition.

From 1984 to 1988, 173 patients with 190 external gastrointestinal fistulae and given total parenteral nutrition (TPN) were reviewed. The advent of TPN has enabled the patients to be operated in a better condition under a well-planned procedure, and has therefore modified the principle of surgical intervention. However, no significant improvement has been noted in the mortality rate and spontaneous closure rate as compared with the years without TPN. The diseases have changed in pattern to afflict older population and increase the incidence of complicated fistula because of the more sophisticated surgery. It may also have something to do with delayed intervention of the intraabdominal abscess and delayed surgical closure of the fistula due to TPN administration. Early and aggressive treatment against intraabdominal infection, and early closure of the fistulae which fail to close spontaneously with 6-week conservative treatment after subsidence of infection, are advocated.

Abscess↗

Does the advent of endoscopic ultrasound (EUS) sound the death knell for endoscopic retrograde cholangiopancreatography (ERCP)?

INTRODUCTION: Endoscopic retrograde cholangiopancreatography (ERCP) has been the premier diagnostic and therapeutic endoscopic procedure in the management of pancreatic and biliary diseases (PBD). The use of endoscopic ultrasound (EUS), including EUS-guided fine needle aspiration (FNA), of pancreatic and biliary tumours has become more widely available in the last decade and has gradually replaced diagnostic ERCP. Together with EUS, other imaging modalities like magnetic resonance cholangiopancreatography (MRCP) have resulted in a decrease in the number of ERCPs. With the advent of interventional EUS, ERCP is at risk of being completely eclipsed. METHODS: A search of all relevant articles on EUS and ERCP from Medline and peer-reviewed journals. RESULTS: This review article examines the exact place of ERCP and EUS and their relative contributions in the management algorithm of PBD. CONCLUSION: Although diagnostic EUS, including EUS-guided FNA, is well established in the evaluation of PBD, interventional EUS is still in its infancy and its true potential is unknown. Therefore, therapeutic ERCP still has a vital, albeit smaller role to play in the treatment of pancreatic and biliary diseases.

Biliary Tract Diseases↗

[Modern advent of imaging diagnostics].

Real-time ultrasound has so far revealed its out-standing usefulness in detecting sick fetuses of any kind, and leading them to an appropriate management. Fetal medicine thus established today is further emerging into new era by introducing so-called new technological advent, involving color flow mapping, which will surely enable to evaluate the fetus in utero more precisely, and to understand them even on the pathophysiological basis; that is to say a goal of fetal medicine. Such is the issue herein discussed.

Female↗

The advent of printing as an obstacle to the development of rational medicine.

At the time that printing came onto the scene in western Europe in the mid-1400s, the medical community was struggling in the depths of superstition, and little rational medicine was being practiced. With this new invention, a flood of ancient, outmoded texts was released upon the public, and eager readers frequently were unaware that books they were being sold as new works were actually in some cases a thousand years old. Added to this was the fact that the appearance in print of this irrational material lent credibility and authoritativeness to unscientific writings. Thus, in contrast to many other fields which were immeasurably helped by the advent of the printed book, rational medicine was in fact held back and prevented from developing for at least a full century. It was not until the Renaissance was well under way that important original contributions by such towering figures as Vesalius supplanted these worthless repetitions of ancient superstitions.

Europe↗

Occupational health nursing and the advent of managed care: meeting the challenges of the current health care environment.

1. The evolution of occupational health nursing and the advent of managed care enable today's practitioners to play strategic roles in planning, implementation, coordination, and evaluation of new health care delivery models. 2. Workers' compensation cost control strategies should include: 1) a focus on primary, secondary, and tertiary prevention and health promotion; 2) quality health care by trained and experienced occupational health professionals; 3) case management to ensure quality of care and to control unnecessary expenses; 4) effective communication between management and injured client to reduce litigation. 3. Many employers go beyond the traditional catastrophic cases and include chronic illnesses, such as diabetes and asthma, and high risk pregnancies for case management. 4. Worksite health and safety programs are a critical component of the nation's health care system.

Health Care Reform↗