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At least 37 records · Page 2Linked to original sources
PubMed1995

Adoligoses, oligosaccharides of rare sugars from Adonis aleppica.

Five novel tri-, tetra-, and penta-saccharides named adoligoses A-E [1-5], consisting of rare didesoxy sugars and their 3-O-Me ethers, have been isolated from Adonis aleppica. Their structures were determined by dcims and nmr measurements. Full establishment of the proton spin-systems was based on 2D nmr data, spectral simulation procedures, and force-field calculations. Sarmentose and cymarose moieties were found in both anomeric configurations and represent a major difference from alepposides A-D, biogenetically related cardenolide oligoglycosides isolated previously from the same plant source. This is the first report on complex, long-chained oligosaccharides of 2,6-didesoxy sugars found typically in cardenolide and pregnane glycosides.

Carbohydrate Sequence↗
PubMed2004

A genetic basis for the "Adonis" phenotype of low adiposity and strong bones.

Toll receptors in Drosophila contribute to host defense and establish the body plan. Mammalian homologues of Toll, the Toll-like receptors (TLRs), are thought to function only in host defense. Here, we report that mice harboring mutations in TLR4 or in CD14, a co-receptor for TLR4, have an "ideal" body plan consisting of increased bone mineral content, density, and size as well as decreased body fat. These mutant mice live long lives, have normal activity and fertility, and show no evidence of infection. Unlike many strains of caged wild-type mice, they do not become obese. Although all mice continue to gain body fat, bone content, and overall weight, the difference in bone content and body fat between mutant and wild-type mice increases with age. Thus, defects in TLR4/CD14 complex generate an "Adonis" phenotype, characterized by this ideal body type, and this function could potentially be exploited for the treatment of osteoporosis and obesity.

Adipose Tissue↗
PubMed1989

Adonis microcarpa (pheasant's eye) toxicity in pigs fed field pea screenings.

Seed of Adonis microcarpa (pheasant's eye) fed at 5.6 g/kg of the diet induced virtually total feed refusal within 3 d in growing and finishing pigs. It also caused vomiting, rapid and shallow breathing and death in a minority. These effects were probably caused by cardiac glycosides whose structure and effects closely resemble those of digoxin. Feed intake and growth recovered within 2 weeks of removal of the seed.

Animal Feed↗