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Hakim Ali Gilani was a native of Gilan. He was a distinguished physician and medical writer. He wrote commentary on canon of Avicenna. He came to India during Akbar's time and served two Mughal rulers, Akbar and Jahangir. He was praised very much by the medical historians for his vast knowledge, curiosity and intelligence. A brief account of his achievements has been given in this article.
A recent screening performed at the CHU Cocody in Abidjan (Ivory Coast) revealed six cases of hemoglobin "D". The use of a rapid strategy based on isoelectric focusing studies, finger-printing, reverse phase high performance liquid chromatography and solid phase microsequence technique led to the characterization of three abdominal hemoglobins. The first variant corresponded to the Hb Korle Bu (beta 73 (E17) Asp leads to Asn) (pI = 7.210) which is common in this country. The second, Hb Avicenna (beta 47 (CD6) Asp leads to Ala) (pI = 7.225) has not yet been reported in Africa. The last one was a new variant, Hb Cocody (beta 21 (B3) Asp leads to Asn) (pI = 7.205). A large number of hemoglobin "D" have been detected in European, American negroes, Amerindian or Asiatic populations, but only few observations were reported in Africa. Large screenings and discriminative methodologists must provide information on the polymorphism of hemoglobin D in the African population.
A great scientist encyclopaedist of the Middle ages Abu Ali Ibn Sina (Avicenna) in his brillant work "Cannon of medical science" systematized and interpreted the achievments of medical sciences, made his contribution into medical theory and practice. If we take together all the data on bones and muscles presented by him in his "Cannon of medical science" and arrange them in the sequence they are given in the body, a graceful systematized table of scientific knowlege on bones and muscles--a prototype of future osteology and myology will be obtained. In the "Canon of medical science" sources of the functional trend in morphology are layed: structure of the osseous and muscular systems is closely connected with the practical medicine. In his work Ibn Sina gives a correct and precise description of anatomical structure of the osseous system and bone functions, and the muscular system, in particular. A thorough study of the "Canon of medical science" clearly demonstrates that Ibn Sina made a great contribution, for his time, into the development of anatomy, not only successfully followed his predecessors, but greatly extended their scientific researches and corrected their errors.
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In a survey for abnormal haemoglobin variants in voluntary blood donors in Iran, a new variant was found in a young male who presented no clinical symptoms. It had the same electrophoretic mobility as haemoglobin D in alkaline buffers. Separation of the constituent polypeptide chains in acid urea buffer revealed it to be different from haemoglobin D previously found among Iranians. Analysis of its structure demonstrated a substitution to alanine (beta 47 Asp replaced by Ala) in the same residue as involved in haemoglobin G-Copenhagen (beta 47 Asp replaced by Asn).