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PubMed1998

Autonomic markers of arousal during sleep in patients undergoing investigation for obstructive sleep apnoea, their relationship to EEG arousals, respiratory events and subjective sleepiness.

Estimating the degree of sleep fragmentation is an important part of a respiratory sleep study and is conventionally measured using EEG micro arousals or is inferred indirectly from respiratory abnormalities such as apnoeas and desaturations. There is a need for less labour-intensive measures of sleep fragmentation, and transient rises in blood pressure and heart rate may fulfil this role. Forty unselected sleep clinic referrals undergoing investigation for possible obstructive sleep apnoea (OSA) were studied with one night of polysomnography. Three conventional indices of sleep fragmentation (EEG micro arousals, apnoea/hypopnoea index (AHI) and oxygen saturation dip rate (SaO2 dips)) and two autonomic indices (heart rate and blood pressure rises) have been compared. Correlations between these five indices ranged from r=0.38 to r=0.73. Of the two autonomic indices, the correlations for blood pressure rises with SaO2 dips and EEG micro arousals were stronger (r=0.71 and r=0.65, respectively) than those for heart rate rises (0.55 and 0.51). All indices of sleep fragmentation, apart from heart rate rises, were similar in their correlation with subjective sleepiness (r-values 0.21-0.36). Arousals implied from blood pressure rises (using pulse transit time) can be measured easily, are objective, and appear no worse at predicting subjective sleepiness than either EEG micro arousals or AHI. They may therefore provide a useful alternative to manual scoring of micro arousals from the EEG as an index of sleep fragmentation in sleep clinic patients undergoing investigation for possible OSA.

Adult↗
PubMed1993

Horizontal component of electro-oculogram as a parameter of arousal in dementia: relationship between intellectual improvement and increasing arousal under pharmacotherapy.

Although nootropics and metabolically active compounds sometimes attenuate intellectual deficits of dementia patients, this mechanism has not been discussed or investigated. The authors hypothesized that these compounds act to enhance attention and/or concentration by increasing the arousal level, and then improve intellectual functions. Based on this hypothesis, the authors investigated the arousal level and the improvement of intellectual functions in ten patients with Alzheimer type dementia and ten patients with multi-infarct dementia before and after 3 months pharmacotherapy using bifemelane hydrochloride. They then analyzed whether the increases in arousal level involves or relates to the improvement of intellectual functions. On the 20 patients, psychological tests were carried out, and the arousal level was evaluated using the frequency of rapid eye movements in the electro-oculogram (EOG) before and after 3 months administration of bifemelane hydrochloride. As a result, a significant positive correlation was observed between the improvement on the Hasegawa's dementia scale and the rate of increase in rapid eye movements in the EOG. The EOG monitoring can be a great help in establishing an objective evaluation method on drug efficacy.

Aged↗
PubMed1993

Effectiveness of arousal and arousal plus overcorrection to reduce nocturnal bruxism.

This study investigated the effectiveness of arousal and arousal + overcorrection to treat bruxism in a 28-year-old male with a 6-month history of bruxing and a 24-year-old female with a 3-month history of bruxing. An A-B-A-B-A-BC-A multiple baseline design across subjects with follow-ups was used to evaluate the effectiveness of the interventions. Results indicated that, although arousal reduced the frequency of bruxing in both subjects, it did not completely eliminate the behavior. The addition of overcorrection to arousal resulted in a complete cessation of bruxing. The discussion focuses on the possible mechanisms of action and directions for further evaluation of the combined procedure.

Adult↗
PubMed1983

Biochemical and morphometric studies of heart, liver and skeletal muscle from the hibernating, arousing and aroused big brown bat, Eptesicus fuscus.

Heart, liver, pectoralis major, and plasma of hibernating, arousing and aroused bats were studied. The activities of four mitochondrial enzymes and three morphometric parameters of mitochondria did not change in the heart. Mitochondrial enzyme activities in the liver and pectoralis major did not change. Lactate dehydrogenase activity and isoenzyme content in heart, liver and pectoralis major did not change. Heart lipid content determined morphometrically decreased transiently after 30 min arousal from hibernation. Plasma free fatty acid concentration increased significantly by 7.5 min and peaked at 15 min after arousal from hibernation. Concentrations of heart free fatty acids, triglycerides, glycerol, and cholesterol and liver triglycerides did not change.

Animals↗
PubMed1996

Wakefulness and arousal in neonates born to women with schizophrenia: diminished arousal and its association with neurological deviations.

Arousal at 3-4 days of age was blindly assessed during the course of a standardized neurological examination of offspring born to index women with schizophrenic (n = 20), schizo-affective (n = 12), affective (n = 19) and unspecified functional (n = 4) psychoses, as well as 70 offspring born to control women with no history of psychosis. The offspring of women with schizophrenia was the only index group to differ from controls in showing significantly reduced arousal. Among the offspring of schizophrenics, reduced arousal was associated with neurological abnormality and deviant sensitivity to stimulation but not with obstetric complications. Only a subgroup of schizophrenics' offspring showed these characteristics. Deviations in arousal, neurological status and sensitivity may be part of a more generalized pattern representing a possibly genetically based neurodevelopmental disorder evident within this particular group at heightened risk for schizophrenia.

Adult↗
PubMed2004

Low respiratory sinus arrhythmia and prolonged psychophysiological arousal in posttraumatic stress disorder: heart rate dynamics and individual differences in arousal regulation.

BACKGROUND: There is extensive evidence that the parasympathetic branch of the autonomic nervous system can modulate psychophysiological arousal. To date, no studies have investigated associations between cardiac vagal tone and the time course of arousal during exposure to trauma-related stimuli in posttraumatic stress disorder (PTSD). METHODS: Thirty-one subjects, 29 with PTSD and 2 with partial PTSD, had electrocardiograms recorded during baseline and 2-minute traumatic and neutral script-driven imagery periods. Heart rate, respiratory sinus arrhythmia (RSA), and heart rate half-recovery to the trauma script were quantified, and subjects were divided into low and high baseline RSA groups. RESULTS: Across all participants, heart rate significantly increased from the neutral to the trauma script and RSA significantly decreased from baseline to trauma script (p < .05). As predicted, low RSA subjects had more prolonged heart rate increases to the trauma script than high RSA subjects (p < .001), and heart rate half-recovery was negatively correlated to baseline RSA (r = -.50, p =.005). CONCLUSIONS: This study is the first to find decreased RSA in response to a traumatic reminder and an association between low baseline RSA and sustained conditioned arousal in PTSD. Low vagal tone may account for deficient arousal and emotion regulation capacities often observed in PTSD.

Adult↗
PubMed1980

Arousal and cognition: Picture Vocabulary performance and individual differences in physiological arousal.

The contribution of individual differences in physiological arousal to intellective assessment in learning disabled children was studied. Arousal was measured by salivary response and intellective function (receptive vocabulary) by the Peabody Picture Vocabulary Test. It was predicted that best performance would be found at intermediate levels of arousal. Peabody scores of learning disabled subjects of high, middle, and low arousal showed a non-significant trend in the predicted direction. Reasons for the lack of significance of this hypothesized trend were proposed and needed research outlined.

Arousal↗
PubMed1992

Arousability and stress-related physical symptoms: a validation study of Coren's arousal predisposition scale.

Coren's Arousal Predisposition Scale was validated against 249 college students' self-ratings of stress-related physical symptoms and an item that assessed general level of health. As we predicted, the 126 high-arousability subjects were substantially higher in mean stress-related symptoms score and lower in general health than the 123 peers low in arousability. These data suggest that the Arousal Predisposition Scale may be a useful instrument in the study of human stress.

Adult↗
PubMed2003

[Cortical arousal, autonomic arousal. Evaluation techniques and clinical importance].

The respiratory disorders expressed by obstructive hypopneas and apneas during sleep, as well as the sequences of crescendo in respiratory effort without hypopneas or apneas which define the upper airway resistance syndrome, terminate with (thanks to) an arousal, defined by EEG changes. In some cases, the activation of the central nervous system is restricted to a sympathetic activation, which has been mainly studied in the cardiovascular area, and is not always accompanied by a cortical arousal. Various approaches (heart rate, blood pressure, pulse transit time, peripheral arterial tonometry) make the identification of sympathetic activation possible. Sympathetic activation seems to be more sensitive than cortical arousal to the stimulations generated by the respiratory system via an activation of mechanoreceptors stimulated by the increased respiratory effort in response to total or partial occlusion of the upper airway. The mechanisms of the cortical or autonomic arousal are not fully understood, but their detection could be a diagnostic tool for the identification of such disorders. Such tools are currently under validation.

Airway Obstruction↗
PubMed2005

EEG synchronisation during sleep-related epileptic seizures as a new tool to discriminate confusional arousals from paroxysmal arousals: preliminary findings.

Confusional arousals, paroxysmal arousals (as part of the nocturnal frontal lobe epilepsy) and normal arousals and awakenings from NREM sleep are frequently a challenge for differential diagnosis. In this article we describe the course of synchronisation between different EEG channels during nocturnal seizures in 3 patients with sleep-related epileptic seizures and in 1 patient with sleep terrors. The functional interactions between the different EEG channels during the nocturnal seizures were analysed by means of the so-called synchronisation likelihood (SL). SL is a measure of the dynamical (linear and nonlinear) interdependencies between a time series (EEG channel) and one or more other time series. The main results of our study are the confirmation of a significant increase in EEG synchronisation during sleep-related seizures and the indication that clinically similar ictal motor patterns might be generated by different neurophysiological mechanisms, characterised by different patterns of synchronisation involving multiple or single frequency bands. This new approach might be useful to differentiate motor seizures, emerging from NREM sleep, from parasomnias (arousal disorders) when both ictal and interictal EEGs are uninformative.

Adult↗
PubMed1988

Understanding the effects of fear-arousing communications: the role of cognitive factors and amount of fear aroused.

This paper reports an experimental study investigating the role of cognitive factors and fear in mediating the effects of "fear-arousing" health threat communications. Seventy-seven cigarette smokers were shown either a videotape about smoking or a control videotape on a different health topic before completing a questionnaire assessing their intentions to try to quit, the level of fear aroused, and three cognitive factors: (a) probability difference (perceived reduction in risk of health damage that follows from successful cessation), (b) utility of health damage, and (c) confidence. The smoking videotape influenced probability difference, utility, intentions, and follow-up reports of attempts at cessation. As predicted, both probability difference and utility influenced intention, which in turn influenced behavior. Neither confidence nor the amount of fear aroused by the videotape had significant effects on intention.

Adult↗
PubMed1987

Sexual anxiety and female sexual arousal: a comparison of arousal during sexual anxiety stimuli and sexual pleasure stimuli.

Sexual arousal occurring during sexual anxiety stimuli was compared to sexual arousal occurring during sexual pleasure stimuli in 19 sexually functional women. Stimuli were individualized narratives based on descriptions given by each subject. Sexual arousal was measured by monitoring vaginal blood flow with a vaginal photoplethysmograph. Results showed significant increases in vaginal blood flow in response to both sexual anxiety and sexual pleasure. However, increases in the pleasure condition were significantly greater than those in the anxiety condition. Analysis of the blood flow across time showed a significant linear increasing trend in the pleasure condition and a lack of such a trend in the anxiety condition.

Adolescent↗
PubMed1986

Effects of medroxyprogesterone acetate on subjective arousal, arousal to erotic stimulation, and nocturnal penile tumescence in male sex offenders.

Three chronic pedophiliac sex offenders were treated individually with medroxyprogesterone acetate (MPA) over a minimum of 3 months. Genital and subjective response to erotic stimulation, nocturnal penile tumescence, self-reporting of sexual urges, and testosterone levels were recorded repeatedly throughout the study. A single-subject reversal design was used and medication was administered through a double-blind procedure. The results showed that self-report of arousal outside of a laboratory setting was unreliable as a measure of the drug effect. In a laboratory setting, however, there appeared to be a significant reduction in the report of arousal to erotic stimuli while genital arousal decreased only slightly. Reversal of these responses occurred in only one subject during a final placebo phase. Nocturnal penile tumescence was significantly decreased during MPA administration and appeared to be related to decreases in total testosterone.

Adult↗
PubMed1987

Hard-driving and speed-impatience components of the type A behavior pattern as predictors of physiological arousal, subjective arousal and challenge seeking.

Male and female subjects first worked on a cognitive task under conditions of either low or high challenge followed by a physical exercise task. Heart rate, systolic blood pressure, diastolic blood pressure, subjective arousal, subjective fatigue, and preferred levels of challenge for subsequent tasks were assessed. The results indicated that subjects with high Hard-Driving scores reported lower subjective arousal while working on the cognitive tasks and preferred to work on more challenging cognitive and physical exercise tasks in a subsequent phase of the experiment. In contrast, subjects with high Hard-Driving scores, high Speed-Impatience scores, or high overall Type A scores did not evidence higher physiological arousal in response to either the cognitive or the physical exercise tasks. Utilization of the components of the Type A pattern yielded greater specificity of results and suggests that Type A's are at greater risk from coronary disease for reasons other than those that have been traditionally hypothesized.

Adult↗
PubMed1985

The experience of arousal: a new basis for studying arousal effects in sport.

Sports psychologists have for some time put forward the inverted-U-hypothesis as a useful working model of the relationship between arousal and performance. Although some emphasis in the sports psychology literature has been placed on the limitations of the hypothesis, generally the notion of an optimal level of arousal has been well received. A few authors have been less tolerant of the arguments put forward in the inverted-U-hypothesis and the restrictions of its theoretical stance. Sports psychologists have been slow to suggest or adopt diverse theoretical perspectives and consequently little real progress has been made. The danger is that this approach has become widely accepted almost without question. This review paper attempts to sum up the current position and, based on recent work, recommend alternative interpretations of arousal effects in sport.

Arousal↗
PubMed1994

Re-examination of arousing and de-arousing effects of cigarette smoking.

An attempt was made to replicate arousing and de-arousing effects of cigarette smoking originally reported by Golding and Mangan. Changes in electrodermal activity, heart rate, and magnitude in the EEG alpha (7.5-11.5 Hz) and beta (13.5-20 Hz) bands were measured under conditions of both mild sensory isolation as well as stress induced by loud white-noise. Under both conditions, real smoking as well as sham smoking an unlit cigarette increased beta activity and the skin potential response. In contrast, only real smoking produced a significant increase in heart rate, decrease in alpha activity, and increase in skin potential. De-arousing effects reported by Golding and Mangan for white-noise stress were not replicated.

Adult↗
PubMed1989

The Stress-Arousal Checklist as a measure of situational stress versus simple arousal.

The Stress-Arousal Checklist was developed as a self-report measure both of arousal and of the favorable or unfavorable appraisal of that arousal. Previous studies with the checklist showed differential sensitivity of the two subscales to experimental manipulations. In the present study, the convergent and discriminant validity were further explored by comparing scores with those on the State-Trait Anxiety Inventory-State. The results supported the validity of the two-factor structure.

Adult↗
PubMed2002

The relationship between mismatch negativity and arousal level. Can mismatch negativity be an index for evaluating the arousal level in infants?

BACKGROUND: Electrophysiological and behavioral studies have shown that stimulus relevance contributes to auditory processing in sleep and auditory stimuli changes the sleep stages. So we observed changes in auditory processing due to sleep stages by recording infant mismatch negativity (MMN) during different states and investigated the arousal mechanisms. METHODS: Auditory event-related potentials (ERPs) of 26 neonates were recorded using high-density EGI EEG system. Stimuli consisted of 1000 Hz tones with 90% probability as standard and 1200 Hz with 10% probability as deviant. Study 1 was designed for the confirmation of the recording of MMN from neonates and Study 2 for investigating whether an appropriate stimulus onset asynchrony (SOA) of the stimulus would induce a clear difference in the latency or amplitude. RESULTS: (Study 1) MMN were obtained from all subjects. No differences of the latencies, amplitudes and distribution due to arousal or sleep stage were observed. After the MMN response occurred, a prominent negativity like Nc was seen in response to deviant stimuli in active sleep and waking state. (Study 2) No distinct differences between the difference states were seen in any SOA. CONCLUSIONS: Only MMN did not characterize the arousal or sleep stage. But the modality of the auditory evoked potentials (AEPs) may differ according to the state, so further detailed investigation could enable the detection of the infants' state using the AEP.

Journal Article↗