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Results for “ANENCEPHALUS”

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At least 37 records · Page 2Linked to original sources
PubMed1979

Anencephalus, drinking water, geomagnetism and cosmic radiation.

The mortality rates from anencephalus from 1950-1969 in Canadian cities are shown to be strongly correlated with city growth rate and with horizontal geomagnetic flux, which is directly related to the intensity of cosmic radiation. They are also shown to have some association with the magnesium content of drinking water. Prior work with these data which showed associations with magnesium in drinking water, mean income, latitude and longitude was found to be inadequate because it dismissed the observed geographic associations as having little biological meaning, and because the important variables of geomagnetism and city growth rate were overlooked.

Anencephaly↗
PubMed1981

Intergenerational factors in the etiology of anencephalus and spina bifida.

To test the hypothesis that events and conditions early in women's lives influence their future risk of producing babies with anencephalus and spina bifida, a case-control study compared mothers of affected infants with mothers whose infants were normal. Occupational class scores of husbands and fathers of the case mothers and control mothers were also compared. While there was no difference between the scores of case and control husbands, the mean score of fathers of case mothers was significantly less than that of the fathers of control mothers. This can be an indication that case mothers grew up under less favorable conditions. These findings, in conjunction with the pattern evident from previous epidemiological studies, support the hypothesis that intergenerational factors play a rôle in the etiology of these defects.

Adult↗
PubMed1981

Influence of social class on the risk of recurrence of anencephalus and spina bifida.

This study suggests that social class has an effect on the incidence of anencephalus and spina bifida, the malformations being more frequent in the lower socio-economic groups. A family study of 226 patients with a CNS malformation suggests that social class also may be important in determining the recurrence risk of such malformations: there are higher risks in social classes III, IV and V than in social classes I and II.

Anencephaly↗
PubMed1976

Twinning and anencephalus occurrence in relation to fetus-fetus interaction.

The hypothesis proposed by Knox (1970) that an anencephalic fetus arises from a fetus-fetus interaction between two dizygous twins predicts that the twinning rate, the population incidence of anencephalus, and the female proportion of anencephalics in a population should be positively interrelated. These associations were tested using Canadian data during a long period of time and over a large geographical area. The results did not support the hypothesis.

Anencephaly↗
PubMed1976

Anencephalus in Scotland 1961-72.

Data relating to the incidence of anencephalus for the 12-year period 1961-72 were abstracted from the Statistical Reviews of the Registrar General for Scotland. It was shown that considerable geographical variation is still apparent with the highlands having, in general, the lower incidences. In comparison with the earlier study of Edwards (1958), there were some changes: the incidence in the areas to the west had increased and that in those to the east decreased. During the 12-year period there was an overall decline in the incidence of the lesion; this was most marked in births to women under 20 years, and to those of social classes III, IV, and V. The decline was least apparent for births to women of high social class and the unmarried. It was shown that there was little seasonal variation in the time of delivery, but that even when the trend had been taken into account the yearly fluctuation was significantly different from that expected, with an excess of cases in 1961 and 1971.

Adult↗
PubMed1986

Secular trends in anencephalus prevalence in New Zealand.

Although the aetiology of anencephalus is unknown, changes in prevalence over time are thought to provide strong evidence of the effect of environmental factors in causation. In a number of countries the rate of this neural tube defect is declining. The rate in New Zealand has also fallen significantly (p less than 0.001) from 1.17/1000 total births in 1968 to 0.39/1000 in 1983, with the greatest decrease occurring in the female rate (approximately 4.16% per year). The aetiological implications of these findings and their consequences for programmes of prenatal diagnostic testing and maternal screening are discussed.

Abortion, Therapeutic↗
PubMed1997

Quantitative evaluation of human placental aromatase in abnormal pregnancy--anencephalus and hydatidiform mole.

To determine why estriol (E3) levels in the urine and serum are extremely low in pregnancies with anencephalus or hydatidiform mole, both the aromatase activity and the tissue P450arom concentration in solubilized fractions of placental or mole microsomes was measured. The aromatase activity was measured by tritiated water assay and the tissue P450arom concentration was determined by sandwich enzyme-linked immunosorbent assay (ELISA). Consequently, any tissue P450arom concentration was at a lower level than the regression line for that in normal placenta. The aromatase activity also showed a tendency to be lower than that in normal placenta. These results therefore suggest that a decrease of E3 in these abnormal pregnancies would result mainly in a lower level of tissue P450arom concentration.

Anencephaly↗