Human detectability of various modulation wave forms in frequency-modulated tones [proceedings].
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Humans↗
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A new approach to blood pressure and blood volume modulation during hemodialysis: an adaptive fuzzy control module.
The paper proposes a fuzzy logic based procedure able to control as far as possible the behaviour of the blood pressure of a patient during a dialysis session, allowing him to reach the foreseen dry weight. A PI discrete-time fuzzy control is used in order to compare the controlled variables concerning the (blood pressure and blood volume) to the reference values. Two different reference tables, concerning the pressure and volume errors and rates are introduced, then the proposed control actions are mixed in order to obtain the final value (net ultrafiltration rate). A smooth function of volemia acts on the second control variable, Na concentration in the dialysate. The adaptive control system was simulated on an IBM-PC, rules and terms were expressed by linguistic judgements like: IF "situation", THEN "action". A pre-processor converts the rules into the numerical values of the reference tables. The obtained simulation results are satisfactory, the introduction of the Na control allows reaching the target dry weight of the patient with a stable blood pressure.
Adult↗
To modulate or not to modulate; to infuse or to bolus; the enigma of 5-fluorouracil is still alive after all these years.
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Antimetabolites, Antineoplastic↗
[Let's modulate the AV modulation].
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Atrial Fibrillation↗
Galanin modulation of seizures and seizure modulation of hippocampal galanin in animal models of status epilepticus.
We examined the role of hippocampal galanin in an animal model of status epilepticus (SE). Control rats showed abundant galanin-immunoreactive (Gal-IR) fibers in the dentate hilus, whereas no Gal-IR neurons were observed. Three hours after the onset of self-sustaining SE (SSSE), induced either by intermittent stimulation of the perforant path for 30 min (PPS) or by injection of lithium and pilocarpine, Gal-IR fibers disappeared in the hilus and remained absent for up to 1 week afterward. Twelve hours after the induction of SE by PPS or 3 hr after pilocarpine administration, Gal-IR neurons appeared in the hilus; these neurons increased in number after 1 d and gradually declined 3 and 7 d later. Galanin concentration in the hippocampus, measured by ELISA, significantly decreased on the plateau of SSSE and increased 24 hr after PPS. Galanin (0.05 nmol) injected into the hilus prevented the induction of SSSE, and 0.5 nmol of galanin stopped established SSSE. These effects were attenuated by galanin receptor antagonists (M35 > M40 >/= M15). 2-Ala-galanin (5 nmol), a putative agonist of galanin type 2 receptors, prevented but was unable to stop SSSE. M35 facilitated the development of SSSE when given before PPS. We suggest that hippocampal galanin acts as an endogenous anticonvulsant via galanin receptors. SE-induced galanin depletion in the hippocampus may contribute to the maintenance of seizure activity, whereas the increase of galanin concentration and the appearance of galanin-immunoreactive neurons may favor the cessation of SSSE. The seizure-protecting action of galanin SSSE opens new perspectives in the treatment of SE.
Animals↗
Second-order temporal modulation transfer functions.
Detection thresholds were measured for a sinusoidal modulation applied to the modulation depth of a sinusoidally amplitude-modulated (SAM) white noise carrier as a function of the frequency of the modulation applied to the modulation depth (referred to as f'm). The SAM noise acted therefore as a "carrier" stimulus of frequency fm, and sinusoidal modulation of the SAM-noise modulation depth generated two additional components in the modulation spectrum: fm-f'm and fm+f'm. The tracking variable was the modulation depth of the sinusoidal variation applied to the "carrier" modulation depth. The resulting "second-order" temporal modulation transfer functions (TMTFs) measured on four listeners for "carrier" modulation frequencies fm of 16, 64, and 256 Hz display a low-pass segment followed by a plateau. This indicates that sensitivity to fluctuations in the strength of amplitude modulation is best for fluctuation rates f'm below about 2-4 Hz when using broadband noise carriers. Measurements of masked modulation detection thresholds for the lower and upper modulation sideband suggest that this capacity is possibly related to the detection of a beat in the sound's temporal envelope. The results appear qualitatively consistent with the predictions of an envelope detector model consisting of a low-pass filtering stage followed by a decision stage. Unlike listeners' performance, a modulation filterbank model using Q values > or = 2 should predict that second-order modulation detection thresholds should decrease at high values of f'm due to the spectral resolution of the modulation sidebands (in the modulation domain). This suggests that, if such modulation filters do exist, their selectivity is poor. In the latter case, the Q value of modulation filters would have to be less than 2. This estimate of modulation filter selectivity is consistent with the results of a previous study using a modulation-masking paradigm [S. D. Ewert and T. Dau, J. Acoust. Soc. Am. 108, 1181-1196 (2000)].
Adult↗
Interactions between immunoglobulin-like and catalytic modules in Clostridium thermocellum cellulosomal cellobiohydrolase CbhA.
Cellobiohydrolase CbhA from Clostridium thermocellum cellulosome is a multi-modular protein composed starting from the N-terminus of a carbohydrate-binding module (CBM) of family 4, an immunoglobulin(Ig)-like module, a catalytic module of family 9 glycoside hydrolases (GH9), X1(1) and X1(2) modules, a CBM of family 3 and a dockerin module. Deletion of the Ig-like module from the Ig-GH9 construct results in complete inactivation of the GH9 module. The crystal structure of the Ig-GH9 module pair reveals the existence of an extensive module interface composed of over 40 amino acid residues of both modules and maintained through a large number of hydrophilic and hydrophobic interactions. To investigate the importance of these interactions between the two modules, we compared the secondary and tertiary structures and thermostabilities of the individual Ig-like and GH9 modules and the Ig-GH9 module pair using both circular dichroism (CD) spectroscopy and differential scanning calorimetry (DSC). Thr230, Asp262 and Asp264 of the Ig-like module are located in the module interface of the Ig-GH9 module pair and are suggested to be important in 'communication' between the modules. These residues were mutated to alanyl residues. The structure, stability and catalytic properties of the native Ig-GH9 and its D264A and T230A/D262A mutants were compared. The results indicate that despite being able to fold relatively independently, the Ig-like and GH9 modules interact and these interactions affect the final fold and stability of each module. Mutations of one or two amino acid residues lead to destabilization and change of the mechanism of thermal unfolding of the polypeptides. The enzymatic properties of native Ig-GH9, D264A and T230A/D262A mutants are similar. The results indicate that inactivation of the GH9 module occurs as a result of multiple structural disturbances finally affecting the topology of the catalytic center.
Calorimetry, Differential Scanning↗
Detection of combined frequency and amplitude modulation.
This article is concerned with the detection of mixed modulation (MM), i.e., simultaneously occurring amplitude modulation (AM) and frequency modulation (FM). In experiment 1, an adaptive two-alternative forced-choice task was used to determine thresholds for detecting AM alone. Then, thresholds for detecting FM were determined for stimuli which had a fixed amount of AM in the signal interval only. The amount of AM was always less than the threshold for detecting AM alone. The FM thresholds depended significantly on the magnitude of the coexisting AM. For low modulation rates (4, 16, and 64 Hz), the FM thresholds did not depend significantly on the relative phase of modulation for the FM and AM. For a high modulation rate (256 Hz) strong effects of modulator phase were observed. These phase effects are as predicted by the model proposed by Hartmann and Hnath [Acustica 50, 297-312 (1982)], which assumes that detection of modulation at modulation frequencies higher than the critical modulation frequency is based on detection of the lower sideband in the modulated signal's spectrum. In the second experiment, psychometric functions were measured for the detection of AM alone and FM alone, using modulation rates of 4 and 16 Hz. Results showed that, for each type of modulation, d' is approximately a linear function of the square of the modulation index. Application of this finding to the results of experiment 1 suggested that, at low modulation rates, FM and AM are not detected by completely independent mechanisms. In the third experiment, psychometric functions were again measured for the detection of AM alone and FM alone, using a 10-Hz modulation rate. Detectability was then measured for combined AM and FM, with modulation depths selected so that each type of modulation would be equally detectable if presented alone. Significant effects of relative modulator phase were found when detectability was relatively high. These effects were not correctly predicted by either a single-band excitation-pattern model or a multiple-band excitation-pattern model. However, the detectability of the combined AM and FM was better than would be predicted if the two types of modulation were coded completely independently.
Adult↗
Measurement of first- and second-order modulation detection thresholds in listeners with cochlear hearing loss.
First- and second-order modulation detection thresholds were measured in normal hearing and hearing-impaired listeners. 'First-order' modulation detection thresholds correspond to the ability of listeners to detect sinusoidal amplitude modulation (SAM); they are measured as a function of the frequency of that modulation, f(m). 'Second-order' modulation detection thresholds correspond to the ability to detect sinusoidal modulation applied to the modulation depth of a SAM signal; they are measured as a function of the frequency of the modulation applied to the modulation depth (referred to as f(m)'). In this case, the SAM signal acts as a 'carrier' stimulus of frequency f(m) and sinusoidal modulation of the SAM-signal's modulation depth (at rate f(m)') generates two additional components in the modulation spectrum at f(m)-f(m)' and f(m)+f(m)'. In both groups of listeners, first-order modulation detection thresholds were measured for modulation frequencies f(m) ranging between 4 Hz and 32 Hz, and second-order modulation detection thresholds were measured for second-order modulation frequencies f(m)' ranging between 1 Hz and 11 Hz, using a fixed first-order modulation frequency f(m) of 16 Hz. The results showed that, in hearing-impaired listeners: first-order modulation detection thresholds were within the normal range up to f(m) = 16 Hz and poorer than normal at f(m) = 32 Hz; second-order modulation detection thresholds were within the normal range at f(m)' = 3, 5 and 11 Hz, and poorer than normal at f(m)' = 1 Hz and 7 Hz. These results suggest that cochlear damage has little effect on the detection of both sinusoidal and complex temporal envelopes.
Adult↗
Across-critical-band processing of amplitude-modulated tones.
Two experiments using two-tone sinusoidally amplitude-modulated stimuli were conducted to assess cross-channel effects in processing low-frequency amplitude modulation. In experiment I, listeners were asked to discriminate between two sets of two-tone amplitude-modulated complexes. In one set, the modulation phase of the lower frequency carrier tone was different from that of the upper frequency carrier tone. In the other stimulus set, both amplitude-modulated carriers had the same modulator phase. The amount of phase shift required to discriminate between the two stimulus sets was determined as a function of the separation between the two carriers, modulation depth, and modulation frequency. Listeners could discriminate a 50 degrees-60 degrees phase shift between the modulated envelopes for tones separated by more than a critical band. In experiment II, the modulation depth required to detect modulation of a probe carrier was measured in the presence of an amplitude-modulated masker. The threshold for detecting probe modulation was determined as a function of the separation between the masker and probe carriers, the phase difference between the masker and probe modulators, and masker modulation depth (in all conditions, the rate of probe and masker modulation was 10 Hz). The threshold for detecting probe modulation was raised substantially when the masker tone was also modulated. The results are consistent with theories suggesting that amplitude modulation helps form auditory objects from complex sound fields.
Auditory Perception↗
Calcium-dependent interaction between gamma-carboxyglutamic acid-containing and N-terminal epidermal growth factor-like modules in factor X.
The N-terminal epidermal growth factor (EGF)-like module in factor X binds a single Ca2+ with low affinity (Kd = 2.2 mM). When it is linked to the gamma-carboxyglutamic acid (Gla)-containing module, however, the affinity increases approximately 20-fold (Kd = 120 microM), indicating an interaction between the two modules and making the site in the N-terminal EGF-like module essentially saturated at physiological Ca2+ concentrations. We have now used the thioredoxin system to probe Ca(2+)-induced conformational changes and interaction between modules in the light chain of factor X. Thioredoxin, in conjunction with thioredoxin reductase and NADPH, allows direct measurements of the rate and extent of disulfide bond reduction. Most disulfide bonds accessible to the reducing agent were found to be located in the light chain of the protein. Moreover, those disulfide bonds that were resistant to reduction by thioredoxin in the presence of Ca2+, but were readily reduced in the absence of the metal ion, were located in the N-terminal EGF-like module and in the Gla module, whereas disulfide bonds in the C-terminal EGF-like module appeared to be equally accessible whether Ca2+ was present or not. Comparison of the rate of disulfide bond reduction in the isolated modules with that in mixtures of modules indicated that a Ca(2+)-dependent interaction occurred between the Gla and the N-terminal EGF-like module. This interaction was mediated by the C-terminal alpha-helical part of the Gla module. The affinity between the modules was low and could not be determined accurately owing to competing equilibria, presumably Ca(2+)-dependent aggregation of the isolated Gla module. By comparing the rates of disulfide bond reduction in Gla module-containing fragments before and after decarboxylation of Gla, we could demonstrate that Ca2+ binding to sites in the Gla module as well as to the single site in the EGF-like module contribute to the interaction between the two modules.
1-Carboxyglutamic Acid↗
Modulators of the glucocorticoid receptor also regulate mineralocorticoid receptor function.
Modulators are proposed to be novel ether aminophosphoglycerides that stabilize unoccupied and occupied glucocorticoid receptor steroid binding and inhibit glucocorticoid receptor complex activation. Two isoforms, modulator 1 and modulator 2, have been purified from rat liver cytosol [Bodine, P.V., & Litwack, G. (1990) J. Biol. Chem. 265, 9544-9554]. Since the mineralocorticoid receptor is relatively resistant to activation, modulator's effect on rat distal colon mineralocorticoid receptor function was examined. Warming of unoccupied receptor decreased residual specific [3H]aldosterone binding by 86 +/- 2%. Both modulator isoforms completely prevented this destabilization with Km's of 2 +/- 1 microM modulator 1 and 24 +/- 5 microM modulator 2. Warming of occupied mineralocorticoid receptors decreased [3H]aldosterone binding by 56 +/- 3%. Modulator only partially stabilized occupied receptor binding with Km's of 10 +/- 2 microM modulator 1 and 68 +/- 8 microM modulator 2. Modulator inhibited receptor activation with Km's of 3 +/- 1 microM modulator 1 and 33 +/- 10 microM modulator 2. Double-reciprocal analysis showed linear kinetics, and mixing modulator isoforms together had additive effects on unoccupied and occupied receptor steroid binding stabilization and activation inhibition. Colon cytosol contained a low molecular weight, heat-stable factor(s) which inhibited receptor activation and stabilized occupied receptor steroid binding. Molybdate completely stabilized unoccupied mineralocorticoid receptor steroid binding and inhibited activation with half-maximal effects at 3-4 mM but only stabilized occupied receptor binding by approximately 40%. These data indicate that (i) apparent physiologic concentrations of modulator stabilize mineralocorticoid receptor steroid binding and inhibit receptor activation, (ii) an aldosterone-responsive tissue contains a modulator-like activity, and (iii) molybdate mimics the effects of modulator.(ABSTRACT TRUNCATED AT 250 WORDS)
Aldosterone↗
Modulation by applied electric fields of Purkinje and stellate cell activity in the isolated turtle cerebellum.
Quasi steady-state electric fields were applied across the isolated turtle cerebellum to study the relationship between applied field, neuronal morphology and the modulation of the neuronal spike firing pattern. Spiking elements were identified electrophysiologically using extracellular recording methods and by subsequent horseradish peroxidase injection, which revealed their dendritic morphology and orientation. The electric field was precisely defined by measuring the voltage gradients induced in the cerebellum by 40 s constant-current pulses. The field was constant in the vertical (dorso-ventral) axis and zero in the horizontal plane, in agreement with theory. Neurones were modulated by applying a sinusoidal field at frequencies between 0.05 and 1.0 Hz. Modulated cells exhibited an increase in firing frequency and fell into one of four classes, depending on the direction of the field that produced the modulation. Thus neurones were excited by: ventricle-directed fields (V modulation), pia-directed fields (P modulation), both of the above (V/P modulation) or showed no consistent modulation (non-modulation). Most Purkinje somata and primary dendrites (nineteen out of twenty-eight) and most Purkinje dendrites (eighteen out of thirty), were V modulated with maximum rate proportional to the peak field intensity. The dendrites of these cells were consistently oriented toward the pia. Among the stellate cells, the lower molecular layer stellates, with dendrites extending predominantly towards the pia, were mostly (nineteen out of thirty-two) V modulated. The mid-molecular layer stellates, which showed much variability in dendritic orientation, were distributed among all four of the modulation classes. The upper molecular layer stellates, with a mostly horizontal dendritic alignment, were mainly (nine out of sixteen) non-modulated. All groups of spiking elements showed a correlation between patterns of modulation by applied fields and dendritic orientation, which suggests the degree of differential polarization of the extended cable elements of the neurone by the applied field as the basic mechanism for field-induced excitation or inhibition. The threshold for modulation among all neurones was 15-20 mV/mm, which is similar to the fields that modulate other nervous tissues. This suggests that many neurones can be modulated by fields of the order of 10-20 mV/mm.
Action Potentials↗
Mechanisms of modulation gap detection.
It has been postulated that the central auditory system contains an array of modulation filters, each responsive to a different range of modulation frequencies present at the outputs of the (peripheral) auditory filters. In the present experiments, we tested what we call the "dip hypothesis," that a gap in modulation is detected using the "dip" in the output of the modulation filter tuned to the modulator frequency. In experiment 1, the task was to detect a gap in the sinusoidal amplitude modulation imposed on a 4-kHz carrier. The modulator preceding the gap ended with a positive-going zero-crossing. There were three conditions, differing in the phase at which the modulator started at the end of the gap; zero-phase, at a positive-going zero-crossing; pi-phase, at a negative-going zero-crossing; and "preserved" phase, at the phase the modulator would have had if it had continued without interruption. Modulation frequencies were 5, 10, 20, and 40 Hz. Psychometric functions for detection of the gap were measured using a two-alternative forced-choice task. For the zero-phase and preserved-phase conditions, the detectability index, d', increased monotonically with increasing gap duration. For the pi-phase condition, performance was good (d' > 1) for small gap durations, and initially worsened with increasing gap duration, before improving again for longer gap durations. This is the pattern of results expected from the dip hypothesis, provided that the modulation filters have Q values of 2 or more. However, it is also possible that a rhythm cue was used to improve performance in the pi-phase condition for short gap durations; the introduction of the gap markedly disrupted the regular rhythm produced by the modulator peaks. In experiment 2, the rhythm cue was disrupted by varying the modulator period randomly around its nominal value, except for the modulator periods immediately before and after the gap. This markedly impaired performance, and resulted in psychometric functions that were very similar for the zero-phase and pi-phase conditions. This pattern of results is inconsistent with the dip hypothesis. For both experiments, modulation gap "thresholds" (d' approximately 1) were roughly constant when expressed as a proportion of the modulator period. Possible mechanisms of modulation gap detection are discussed and evaluated.
Attention↗
Solution structure and dynamics of the central CCP module pair of a poxvirus complement control protein.
The complement control protein (CCP) module (also known as SCR, CCP or sushi domain) is prevalent amongst proteins that regulate complement activation. Functional and mutagenesis studies have shown that in most cases two or more neighbouring CCP modules form specific binding sites for other molecules. Hence the orientation in space of a CCP module with respect to its neighbours and the flexibility of the intermodular junction are likely to be critical for function. Vaccinia virus complement control protein (VCP) is a complement regulatory protein composed of four tandemly arranged CCP modules. The solution structure of the carboxy-terminal half of this protein (CCP modules 3 and 4) has been solved previously. The structure of the central portion (modules 2 and 3, VCP approximately 2,3) has now also been solved using NMR spectroscopy at 37 degrees C. In addition, the backbone dynamics of VCP approximately 2,3 have been characterised by analysis of its (15)N relaxation parameters. Module 2 has a typical CCP module structure while module 3 in the context of VCP approximately 2,3 has some modest but significant differences in structure and dynamics to module 3 within the 3,4 pair. Modules 2 and 3 do not share an extensive interface, unlike modules 3 and 4. Only two possible NOEs were identified between the bodies of the modules, but a total of 40 NOEs between the short intermodular linker of VCP approximately 2,3 and the bodies of the two modules determines a preferred, elongated, orientation of the two modules in the calculated structures. The anisotropy of rotational diffusion has been characterised from (15)N relaxation data, and this indicates that the time-averaged structure is more compact than suggested by (1)H-(1)H NOEs. The data are consistent with the presence of many intermodular orientations, some of which are kinked, undergoing interconversion on a 10(-8)-10(-6) second time-scale. A reconstructed representation of modules 2-4 allows visualisation of the spatial arrangement of the 11 substitutions that occur in the more potent complement inhibitor from Variola (small pox) virus.
Amino Acid Sequence↗
Gamma-aminobutyric acidergic and glycinergic inputs shape coding of amplitude modulation in the chinchilla cochlear nucleus.
Amplitude modulation is a prominent acoustic feature of biologically relevant sounds, such as speech and animal vocalizations. Enhanced temporal coding of amplitude modulation signals is found in certain dorsal and posteroventral cochlear nucleus neurons when they are compared to auditory nerve. Although mechanisms underlying this improved temporal selectivity are not known, involvement of inhibition has been suggested. gamma-Aminobutyric acid- and glycine-mediated inhibition have been shown to shape the dorsal cochlear nucleus and posteroventral cochlear nucleus response properties to other acoustic stimuli. In the present study, responses to amplitude modulation tones were obtained from chinchilla dorsal cochlear nucleus and posteroventral cochlear nucleus neurons. The amplitude modulation carrier was set to the neuron's characteristic frequency and the modulating frequency varied from 10 Hz. Rate and temporal modulation transfer functions were compared across neurons. Bandpass temporal modulation transfer functions were observed in 74% of the neurons studied. Most cochlear nucleus neurons (90%) displayed flat or lowpass rate modulation transfer functions to amplitude modulation signals presented at 2540 dB (re: characteristic frequency threshold). The role of inhibition in shaping responses to amplitude modulation stimuli was examined using iontophoretic application of glycine or gamma-aminobutyric acidA receptor agonists and antagonists. Blockade of gamma-aminobutyric acidA or glycine receptors increased stimulus-evoked discharge rates for a majority of neurons tested. Synchronization to the envelope was reduced, particularly at low and middle modulating frequencies, with temporal modulation transfer functions becoming flattened and less bandpass in appearance. Application of glycine, gamma-aminobutyric acid or muscimol increased the modulation gain over the low- and mid-modulation frequencies and reduced the discharge rate across envelope frequencies for most neurons tested. These findings support the hypothesis that glycinergic and gamma-aminobutyric acidergic inputs onto certain dorsal cochlear nucleus and posteroventral cochlear nucleus neurons play a role in shaping responses to amplitude modulation stimuli and may be responsible for the reported preservation of amplitude modulation temporal coding in dorsal cochlear nucleus and posteroventral cochlear nucleus neurons at high stimulus intensities or in background noise.
Acoustic Stimulation↗
Effect of amplitude modulation on profile detection.
The effect of amplitude modulation on profile detection was examined in three experiments. The observer's task was to determine in which observation interval an increment was added to the 1000-Hz target component of a multitone complex in which the components were equally spaced on a logarithmic frequency scale from 200 to 5000 Hz. The target was unmodulated throughout the study. In some conditions, all nontarget components of the standard were modulated in phase; in other conditions, they were modulated with random phase. In experiment 1, the threshold was measured as a function of the modulation rate. The results show that, at low modulation rates, 5 Hz for example, modulation elevates threshold by about 13 dB. The threshold decreases as the modulation rate increases, with the threshold elevation being only 3 dB at 80 Hz. In experiment 2, threshold was measured as a function of modulation depth for both 21- and 5-component complexes. The results show that for a 5-Hz modulation rate the threshold decreases as the modulation depth decreases, and that the rate of decrease is greater for the 21-component complex than for the 5-component complex. In experiment 3, the effects of random-phase modulation were explored; the phase of the modulation waveform was randomly chosen for each component. The results show that there is no difference between in-phase and random-phase modulation when each component occupies a different critical band. If, however, two or more components occupy the same critical band, then randomizing the phase of modulation reduces the effective depth of modulation within that critical band, and the effect of modulation is thereby lessened.
Adult↗
The role of frequency modulation in the perceptual segregation of concurrent vowels.
Two experiments investigated the effect of frequency modulation on the identification of vowel sounds presented concurrently with interfering vowels. In experiment 1, identification thresholds were measured for each of five target vowels, masked, in each trial, by one of ten masking vowels. Both target and masking vowels were synthesized using harmonically spaced frequency components. Inharmonic spacing was used in order to prevent powerful grouping processes which exploit fundamental frequency from dominating the results. The target vowels were synthesized with sinusoidal frequency modulation on each frequency component which was either coherent (same phase) or incoherent (random phases). The masking vowels were synthesized with components which were either modulated in the same way as the target vowel or were unmodulated. Identification thresholds were lower when the masking vowel had no modulation. The effect occurred for both coherent and incoherent frequency modulation, indicating that it is mediated by the movement of each component independently, rather than by grouping of coherently modulated components. This result is consistent in some respects with judgments of the prominence of competing vowels [S. E. McAdams, J. Acoust. Soc. Am. 85, 2148-2159 (1989)], which show that modulated vowels are more prominent than unmodulated vowels regardless of the type of modulation applied to the competing vowels. Experiment 2 used a paradigm similar to that developed by McAdams, in order to compare more directly the effect of FM on vowel identification and vowel prominence. On each trial, three vowels were presented concurrently. Either none, one, or two of the vowels were modulated throughout, while modulation was applied to another vowel (the target) halfway through the stimulus. The vowels were either harmonic (with different fundamental frequencies) and coherently modulated or inharmonic and incoherently modulated. Accuracy of identification of the target vowel was not significantly different in the harmonic/coherent and inharmonic/incoherent conditions and declined, in each case, as the number of modulated background vowels increased. Overall, the results of experiments 1 and 2, and of McAdams' prominence judgment data, suggest that there is an auditory mechanism for detecting frequency modulation which can alert the listener to the presence of frequency modulated sounds, but which is insensitive to across-frequency differences in the pattern of that modulation.
Auditory Threshold↗