Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “mitigation”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 343 records · Page 19Linked to original sources
PubMed1998

[Emergency measures on drinking water sanitation for mitigation of flood and waterlogging disasters].

This article reports the emergency measures for mitigation during flood and waterlogging disasters to ensure drinking water sanitation and to prevent infectious disease outbreaks. Five preparatory and preventive measures for flood and waterlogging disasters include the construction of dual-purpose water supply installation for ordinary and disaster use, the storage of qualified technicians and materials (or their inventories), and the formulation of predetermination programme for disaster relief, ect.

China↗
PubMed1976

Mitigation of Graft-versus-host disease in mice with xenogeneic antithymocyte serum and complement.

In vitro treatment of parental C57BL/6 lymphohematopoietic cell grafts with unabsorbed guinea pig anti-mouse thymocyte serum (ATS) and guinea pig complement (GPC), prior to inoculation into lethally irradiated B6D2F hybrid hosts, has proven to be of value in terms of mitigating graft-versus-host disease (GvHD). However, the beneficial effect of such a pregrafting procedure is limited to the prevention of acute GvHD. The late GvHD remains a continuing problem, and is probably due to the graft-versus-host activity (GvHA) of newly produced nontolerant lymphocytes from lymphoid precursors resistant to ATS. Possible ways to render these precursors sensitive to ATS and complement are discussed. The potential significance of thymic hormones and cyclic AMP in achieving this is emphasized.

Animals↗
PubMedDate not supplied

CD44s expression mitigates the phenotype of human colorectal cancer hepatic metastases.

Alterations in expression of the CD44 adhesion protein have been implicated in colorectal tumourigenesis. Overexpression of variant high molecular weight isoforms (especially CD44v6), as well as down-regulation of standard CD44 (CD44s), are postulated to result in increased tumourigenicity. We studied the metastatic phenotype produced by the expression of CD44s by stable transfection into a human colorectal carcinoma cell line, SW620, that shows absence of any CD44 expression. Splenic injection of 2 x 10(6) SW620 colon cancer cells into SCID mice was used to produce hepatic metastases. The animals were sacrificed at 6 weeks after injection and morphological end-points relating to macrometastases and micrometastases were studied CD44s expression was associated with decreased development of macroscopic tumours (0.9 vs 3.0 tumours/ mouse liver, p = 0.004), less extensive tumour replacement of the liver (2.6% vs 12.8%, p = 0. 04) and decreased numbers of micrometastases (3.8 x 10(-8) vs 7.9 x 10(-8) micrometastases/ microm2, p = 0.2). This study is the first to demonstrate the mitigating effect of CD44s expression on the hepatic metastatic phenotype in a colorectal carcinoma cell line that does not ordinarily express CD44.

Animals↗
PubMed2002

[Insulin mitigates the effect of free fatty acid to cause endothelial dysfunction in rat aortic rings].

OBJECTIVE: To investigate whether free fatty acid (FFA) directly and independently causes endothelial dysfunction and whether enhancing insulin action mitigates FFA-induced endothelial dysfunction. METHODS: Twenty-nine S-D rats were divided into 4 groups and infused by jugular catheterization with different solutions: 20% intralipid + heparin (0.72 IU/min) for 4 hours (FFA group, n = 9), short-acting insulin by hyperinsulinemic euglycemic clamp for 4 hours (Ins group, n = 5), intralipid + heparin and insulin by hyperinsulinemic euglycemic clamp for 4 hours (Ins + FFA group, n = 10), and normal saline (18 microliter/min) for 4 hours(C group, n = 5). After the infusion, the rats were killed and their aortic rings were resected and put into organ bath and connected to a force transducer and amplifier. PGF2a was added into the organ bath to constrict the rings until the constriction tension reached a balance. Then acethylcholine (Ach) and sodium nitroprusside (SNP) of increasing concentrations were added to relax the rings to record the endothelial dependent vasodilatation (EDV) and endothelium independent vasodilatation (EIV). RESULTS: The EDV value was 85.0% +/- 3.2% in C group and 54.8% +/- 2.5% in FFA group (C vs FFA, P = 0.002); 80.6% +/- 1.8% in Ins group (C vs Ins, P = ns); 72.8% +/- 2.1% in Ins + FFA group (FFA + Ins vs C P = 0.02, FFA + Ins vs FFA, P = 0.005). The EIV response in the three experimental groups was not different from that in the control group. CONCLUSION: FFA damages the endothelisal dependant vasodilatation of aorta, thus causing endothelial dysfunction by direct interaction with the endothelium. FFA may be proatherogenic. Hyperinsulinemia has salutary effects on endothelial function in the context of elevated FFA.

Acetylcholine↗
PubMedDate not supplied

Rationale for an HIV / AIDS prevention and mitigation strategy for Africa: combatting the multisectoral impact of the epidemic.

Unlike most infectious diseases in Africa, HIV/AIDS affects the urban elite as well as the rural poor, and generally during their most economically productive years. An increase in deaths among young adults of the magnitude predicted is likely to have substantial adverse effects on economic, political, and military/security stability throughout Africa. AIDS is causing increased stress on fragile African economic infrastructures as labor productivity declines, particularly in agricultural, labor-dependent economies. AIDS is causing obstacles to trade, foreign investment and tourism. Health systems and social coping mechanisms already are overburdened. High rates of HIV infection among police and military personnel threaten internal security. Furthermore, the demobilization of military forces in Africa may exacerbate the epidemic when HIV-infected soldiers return home and spread the virus. This presentation will illustrate why African AIDS Programs must be expanded to mitigate the multisectoral impact of the epidemic while preserving its spread.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

Mitigating the effects of gun violence on children and youth.

Countless children and youth are exposed to gun violence each year--at home, at school, in their communities, or through the media. Gun violence can leave lasting emotional scars on these children. This article reviews research regarding the psychological effects of gun violence on children and youth, and offers suggestions for how parents, school administrators, and mental health workers can mitigate these negative effects. Children exposed to gun violence may experience negative short- and long-term psychological effects, including anger, withdrawal, posttraumatic stress, and desensitization to violence. All of these outcomes can feed into a continuing cycle of violence. Certain children may be at higher risk for negative outcomes if they are exposed to gun violence. Groups at risk include children injured in gun violence, those who witness violent acts at close proximity, those exposed to high levels of violence in their communities or schools, and those exposed to violent media. Parents, school administrators, and mental health workers all can play key roles in protecting children from gun violence and helping them overcome the effects of gun-related trauma. The authors recommend a number of strategies that adults can adopt to help children cope with gun violence, such as increasing parental monitoring, targeting services to youth at risk of violent activity, and developing therapeutic interventions to help traumatized young people.

Adolescent↗
PubMed2002

Nonylphenol polyethoxylate adjuvant mitigates the reproductive toxicity of fomesafen on the freshwater snail Lymnaea stagnalis in outdoor experimental ponds.

The influence of nonylphenol polyethoxylates (NPEO), formulated as the adjuvant Agral 90, on the effects of the diphenyl ether herbicide fomesafen in the pond snail Lymnaea stagnalis was investigated, with particular attention to the reproductive performances and underlying energetic and hormonal processes. Separate short-term exposures to low concentrations of fomesafen and fomesafen-Agral mixture were performed in the laboratory. Outdoor experimental ponds (mesocosms) were used for long-term exposures to higher chemical concentrations. At the concentrations used in the studies, NPEO were known as nontoxic in L stagnalis. Fomesafen was mixed with the adjuvant in the 3:7 ratio recommended for agricultural uses (nominal herbicide concentrations of 22 and 40 microg/L in laboratory and mesocosm, respectively). In mesocosms, multiple application of fomesafen, leading to maximal herbicide concentrations of 60.33 +/- 2.68 microg/L in water, resulted in reduced number of egg masses and altered glycogen metabolism in contaminated snails. These changes, as well as affected steroid-like levels in fomesafen-exposed snails, support the hypothesis of impaired neuroendocrine functions. When Agral 90 was added to the herbicide, results obtained in mesocosms showed that the adjuvant softened the impact of fomesafen. In mesocosms treated with the fomesafen-Agral mixture, significantly lower herbicide levels were found in the water (30.33 +/- 14.91 microg/L at the end of the contamination period). Consequently, internal exposure of the snails to fomesafen was reduced when the herbicide was mixed with the adjuvant. Mitigation of the effects of fomesafen by the adjuvant may therefore result from nonionic surfactant activity of NPEO that prevented fomesafen from reaching the snails.

Animals↗
PubMed2002

Using a community-based approach for prevention and mitigation of national health emergencies.

Disaster management is most effective when developed at the community level. Community based planning, prevention, mitigation, and emergency response all engage the population to make choices that are commensurate with local needs and resources. Community based disaster management also offers a force multiplying effect by increasing the number of potential participants and leaders. This discussion of key community based developmental activities is meant to provide a primer for the public health practitioner beginning the study of emergency preparedness and response.

Benchmarking↗
PubMed2004

Mitigation of environmental problems in Lake Victoria, East Africa: causal chain and policy options analyses.

Lake Victoria is an international waterbody that offers the riparian communities a large number of extremely important environmental services. Over the past three decades or so, the lake has come under increasing and considerable pressure from a variety of interlinked human activities such as overfishing, species introductions, industrial pollution, eutrophication, and sedimentation. In this paper we examine the root causes for overfishing and pollution in Lake Victoria and give possible policy options that can help remediate or mitigate the environmental degradation.

Africa↗
PubMedDate not supplied

[Socio-psychological and ecological aspects within the system of nuclear radiation risk mitigation].

The authors bring into light several aspects of nuclear radiation risks, i.e. physical safety of nuclear technologies and ecology, place of operator within the nuclear radiation safety system (proficiency, protective culture, safety guides) and consider approaches to the human factor quantification within the system of mitigation of risks from nuclear technologies, and IAEA recommendations on probable risk estimation. Future investigations should be aimed at extension of the radiation sensitivity threshold, personnel selection as by psychological so genetic testing for immunity to ionizing radiation, development of pharmachemical and physical protectors and methods of enhancing nonspecific resistance to extreme, including radiation, environments, and building of radiation event simulators for training.

Ecology↗
PubMed2004

Environmental threats, mitigation strategies and high-mountain areas.

High-mountain areas suffer from increasing environmental threats. The causes are often global in dimension but lead to specific impacts under conditions of steep and/or high-altitude terrain with strong effects from snow and ice. This paper presents a global perspective, focussing primarily on observed and projected changes in climate and then goes on to discuss key messages of greatest relevance to the highest belts of mountain regions. The paper finishes with a brief discussion of mitigation strategies.

Altitude↗
PubMedDate not supplied

Protecting new health facilities from natural hazards: guidelines for the promotion of disaster mitigation.

The health sector is particularly vulnerable to naturally occurring events. The vulnerability of the health infrastructure (hospitals and clinics) is of particular concern. Not only are such facilities vulnerable structurally, but their ability to continue to provide essential functions may be severely compromised, thus leaving the stricken population without essential services. This paper summarizes a more detailed document, Guidelines for Vulnerability Reduction in the Design of New Health Facilities published by the Pan-American Health Organization (PAHO)/ World Health Organization (WHO). The current document summarizes these Guidelines emphasizing how they may be used, by whom, and for what purpose. Potential users of the Guidelines include, but are not limited to: (1) initiators of health facility construction projects; (2) executors and supervisors of health facility construction projects; and (3) financing bodies in charge of funding health facility construction projects. The Guidelines include: (1) implications of natural phenomena upon the health infrastructure; (2) guidelines for vulnerability reduction for incorporation into development project cycles; (3) definitive phases and stages within the phases for development projects including: (I) Projects Assessment (needs assessment; assessment of options, the preliminary project); (II) Investment (project design, construction); and (III) Operational Activities (operations and maintenance). In addition, investment in damage reduction measures, policies and regulations, training and education, and the role of international organizations in the promotion and funding of mitigation strategies are addressed.

Disaster Planning↗
PubMed2005

Interdisciplinary conflict analysis and conflict mitigation in local resource management.

Within the Swedish research program SUCOZOMA (Sustainable Coastal Zone Management) several conflict studies have been carried out. Whereas the detailed results of these studies are published separately, this paper reviews important results from conflict research in combination with a summarizing and generalizing discussion of approaches and main results of SUCOZOMA's resource and conflicts studies. After an analysis of interdisciplinary and theoretical research about environmental and resource use conflicts, the methodology used in SUCOZOMA is presented, a combined stakeholder and conflict analysis. It can be summarized in four main points: i) to map the stakeholders and their interests; i) to analyse the conflicts; iii) to develop methods for conflict mitigation and cooperation with stakeholders; iv) to integrate these components in a system for the management of natural resources. Exemplary case studies of resource use conflicts have been carried out at the Swedish west and east coast including coastal fishery, mussel culture, coastal planning and specific conflicts such as between species protection (seals) and coastal fishery. Researchers are involved as experts and as conflicting parties, and the role of scientists as stakeholders deserves special attention in conflict research. Conflict management is not only for the solution of present conflicts, but part of integrated resource management systems where knowledge transfer, institutional development, collective learning of scientific, political and administrative actors, and cooperation between scientists and resource users can occur.

Animals↗
PubMed2005

[Effects of elemental sulphur and dicyandiamide on mitigating NO3- -N leaching loss from vegetable soil].

In a pot experiment with allium as test plant and NH4HCO3 as nitrogen source, this paper studied the effects of element sulphur (S0) and dicyandiamide (DCD) on mitigating the NO3- -N leaching loss from soil and on soil inorganic nitrogen (NO3- -N and NH4+ -N) content. The results showed that within the 12 weeks of the experiment, the cumulative leaching loss of soil NO3- -N in treatments S0 + DCD and S0 was 83%-86% and 83% lower, while that of soil NH4+ -N was 16.8-21.0 mg x pot(-1) and 20.4-25.0 mg x pot(-1) higher than CK, respectively, and the cumulative loss of soil (NH4+ + NO3-)-N was 60% lower. By the end of the experiment, soil inorganic nitrogen content in treatments S0 + DCD and S0 was 79.9%-85.4% and 74.9-82.6% higher than CK, respectively. The cumulative leaching loss of inorganic N in treatment S0 + DCD was 4.6%-14.4% and 15.4%-30.1% lower, and the soil inorganic nitrogen content by the end of the experiment was 6.1% and 16.8%-36.0% higher than that of treatments S0 and DCD, respectively. Similar results were obtained when S0 was replaced by Na2S2O3, but not by Na2SO4. The fact that the application of S0 could obviously decrease the NO3- -N leaching loss from soil could be contributed to the inhibitory effects of S2O3(2-) and S4O6(2-) originated from S0 oxidation in soil on the nitrification of NH4+ -N. S0 could retard the decomposition of DCD due to the effect of its oxidized products S2O3(2-) and S4O6(2-), and thus, extend the inhibitory effect of DCD on NH4+ -N nitrification. It is suggested that S0 combined with DCD could be used as an effective nitrification inhibitor to control the NO3- -N leaching loss from vegetable soils.

Fertilizers↗
PubMed2005

Nitrite mitigates lipid peroxidation in rat gastric mucosa.

Sodium nitrite, a nitric oxide (NO) donor in the acid pH, has been found to mitigate lipid peroxidation in rat gastric mucosa, and it elevated both Cu, Zn- and Mn-forms of the superoxide dismutase in this tissue. Putrescine, a simple polyamine of anti-oxidant properties has been shown to normalize lipid peroxidation levels in nitrite-treated animals.

Animals↗
PubMed2006

Medical mitigation strategies for acute radiation exposure during spaceflight.

The United States Government has recently refocused their space program on manned missions to the Moon by 2018 and later to Mars. While there are many potential risks associated with exploration-class missions, one of the most serious and unpredictable is the effect of acute space radiation exposure, and the space program must make every reasonable effort to mitigate this risk. The two cosmic sources of radiation that could impact a mission outside the Earth's magnetic field are solar particle events (SPE) and galactic cosmic radiation (GCR). Either can cause acute and chronic medical illness. Numerous researchers are currently examining the ability of GCR exposure to induce the development of genetic changes that lead to malignancies and other delayed effects. However, relatively little has been published on the medical management of an acute SPE event and the potential impact on the mission and crew. This review paper will provide the readers with medical management options for an acute radiation event based on recommendations from the Department of Homeland Security (DHS), Centers for Disease Control (CDC), and evidence-based critical analysis of the scientific literature. It is the goal of this paper to stimulate debate regarding the definition of safety parameters for exploration-class missions to determine the level of medical care necessary to provide for the crew that will undertake such missions.

Acute Disease↗
PubMed1991

Objective antihistamine side effects are mitigated by evening dosing of hydroxyzine.

First-generation antihistamines have potency, pharmacokinetic, and cost advantages compared with nonsedating second-generation antihistamines. Bedtime dosing of hydroxyzine was investigated as a dosing strategy to minimize reaction time degradation and adverse subjective symptoms previously documented for hydroxyzine in divided doses. Hydroxyzine, 50 mg qhs, was compared with terfenadine, 60 mg bid, in this double-blind, placebo-controlled crossover study of 15 healthy, asymptomatic adults. Computer-based eye-hand reaction time tests of simple reaction time (SRT) and choice reaction time (CRT) were not statistically different among the three drugs. Drowsiness, dry mouth, and irritability were significant for hydroxyzine (P = .0001, .001 and .02, respectively) compared with terfenadine or placebo, but less than seen in a previous study of hydroxyzine, 25 mg bid. Symptom scores with terfenadine were comparable to placebo. Histamine skin test wheal and flare were both significantly and comparably suppressed by hydroxyzine and terfenadine (P = .0001). While wheal suppression by hydroxyzine was universal, four of the 15 subjects showed little or no suppression with terfenadine (P = .03). Although bedtime dosing of hydroxyzine did not eliminate subjective symptoms, it maintained skin H1-receptor antagonism the following morning and alleviated the prolongation of reaction times previously reported with hydroxyzine in divided doses. The significant adverse subjective symptoms and psychomotor performance degradations caused by first-generation antihistamines can be mitigated by creative dosing schedules.

Administration, Oral↗
PubMedDate not supplied

[Medical approaches to technogenic risks mitigation: instructive experience of space medicine].

Medical approaches to mitigation of technogenic extreme risks are analyzed by the example of space medicine experience in handling of the risks caused to humans by specific and non-specific extreme factors in space flight. Discussion is centered on the amalgamation of closely interconnected fundamental and applied risk researches with the ultimate aim of determining the strategy of risk minimization through optimization of environment, professional activity, and development of effective medical care and prevention instruments. One of the major achievements of the Russian space program was giving evidence of the possibility to control risks in extended orbital missions. As far as the Moon and Mars exploration projects are concerned, views of the U.S. NASA have been formulated in "Bioastronautics Critical Path Roadmap". Excerpts from the document illustrate possible approaches to the current and prospective technogenic extreme risks.

Aerospace Medicine↗