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PubMed2006

Prostate cancer incidence and intake of fruits, vegetables and related micronutrients: the multiethnic cohort study* (United States).

OBJECTIVE: To describe the relationship between the intake of fruits, vegetables, and related vitamins and antioxidants, and the risk of prostate cancer in male participants in a large multiethnic cohort study. METHODS: Food and nutrient intakes in 1993-1996 were calculated from a detailed food frequency questionnaire (FFQ) designed to account for the food and nutrient intake of the ethnic groups represented in the study (82,486 African-American, Japanese-American, Native-Hawaiian, Latino and White males included here). Follow-up for incident cancers utilized local SEER registries. Vital status was ascertained using state death files. Data on PSA utilization from a later questionnaire was also examined. RESULTS: A total of 3,922 incident cancer cases were ascertained during follow-up. Modestly increased risks of prostate cancer were observed in relation to higher intakes of several food items including light green lettuce and dark leafy green vegetables. Notably, no significant protective associations of any foods were seen, including tomato intake; and intakes of two complex foods containing tomato sauce (pizza and Spanish rice) were associated with modest increases in risk. PSA test use was significantly and positively related to intake of some of these same items, implying a degree of disease detection-bias. Analysis of non-localized and high grade disease (1,345 cases) showed no significant protective associations with overall fruits and vegetables intake, related micronutrients, or with intake of selected complex food items. CONCLUSIONS: We found no statistically significant evidence of a protective effect against prostate cancer of higher levels of intake of any of these foods, associated micronutrients or supplements. A possible explanation for the positive associations with risk of several of the foods normally considered to be healthy is detection bias, since "healthy" dietary intake was related to greater use of the PSA test.

Black or African American↗
PubMed2005

Manganese and other micronutrient additions to improve yield of Agaricus bisporus.

Previous experiments have demonstrated that significant increases in yield of Agaricus bisporus mushrooms were achieved by adding a micronutrient rich fertilizer, Micromax, to the compost. This study was performed to determine the mineral(s) that are responsible for this yield improvement. An initial experiment determined that manganese was the mineral of primary importance; addition of 184 mg kg-1 Mn increased yield by 10.8%, compared to the control. Subsequent experiments demonstrated that the addition of manganese to the compost has a stimulatory effect on mushroom yields. Significant yield increases, ranging from 9.6% to 11.8% (compared to the control), were observed as a result of manganese additions varying between 50 and 300 mg kg-1. Also, data from the last set of experiments indicated that Micromax additions always resulted in greater yields indicating that micronutrients in Micromax, in addition to manganese, may be responsible for increasing yields.

Agaricus↗
PubMed2005

Reference range for micronutrients and nutritional marker proteins in cord blood of neonates appropriated for gestational ages.

BACKGROUND: Reference values of numerous micronutrients at different gestational ages (GA) have not been yet reported based on large series. AIMS: This study aimed to establish the reference range for zinc, copper, selenium, vitamin A, vitamin E, retinol binding protein, transthyretin, albumin, transferrin and ceruloplasmin in neonates and to give the profiles according to gestational age. STUDY DESIGN: A total of 510 infants appropriate for gestational age were included in the study. The determinations were done using the serum cord blood of 262 term and 248 preterm infants (gestational age of 37 to 42 and 26 to 36 weeks, respectively). RESULTS: All nutrients correlated significantly with birth weight and gestational age but different patterns were highlighted. Vitamin A, retinol binding protein and prealbumin showed a triphasic pattern with a cut-off at about 36 to 39 weeks. In this period, these parameters rised significantly (P<0.001). Albumin and selenium showed a biphasic pattern with a significant positive correlation (P<0.001) between weeks 26 to 38. Transferrin and ceruloplasmin associated with copper showed a continuous increase with GA (P<0.001). On the opposite, zinc and vitamin E decreased. Zinc showed a biphasic pattern with a significant negative correlation (P<0.001) between the 26th to 34th weeks. Vitamin E presented a triphasic pattern with a cut-off at about 32 to 35 weeks (P<0.001). CONCLUSION: The large number of data allow the build-up of reference ranges and charts for the evaluation of micronutrients and proteins in high-risk neonates.

Biomarkers↗
PubMed2005

A comparison of the dietary and total intake of micronutrients in a group of pregnant Greek women with the Dietary Reference Intakes.

OBJECTIVE: We compared the dietary and total (diet and supplement) intake of micronutrients with the Dietary Reference Intakes (DRIs) from the USA in a population of pregnant Greek women. METHODS: Two hundred pregnant women participated in a nutritional survey, 98 in the second trimester and 102 in the third trimester in a random sampling. To examine dietary intake we used two questionnaires, the nutritional questionnaire for pregnant women from the California Department of Health Services, and a semi-quantitative questionnaire (Walter Willet) with modifications for use in Greece. Dietary intake analysis was performed using the Diet Analysis Plus software, Version 3, ESHA Research. Statistical analysis was performed with Minitab for Windows, Release 12. A simple complementary questionnaire concerning demographic and socio-economic features was also completed. RESULTS: The average total intake of vitamins A, B(1), B(2), B(3), B(6), B(12) and C, calcium and phosphorus was higher than the respective DRIs. Folic acid and iron intake exceed the highest values specified for pregnancy. Vitamin E and zinc was lower than the DRIs, while vitamin D, magnesium and thiamin did not differ. CONCLUSIONS: The results of our study suggest that in a Greek population, sufficient micronutrients appear to be received in adequate amount from diet, except for folic acid and iron, which also had to be taken in the form of nutritional supplements.

Adult↗
PubMed2006

Potential for misclassification of micronutrient status in children participating in a Head Start program.

OBJECTIVE: To evaluate relations among measures of iron and zinc status, C-reactive protein (CRP), and leukocytes in low-income children participating in the Head Start program. DESIGN: Cross-sectional correlational study with samples collected at Head Start centers in May 2003. SUBJECTS/SETTING: Forty-seven children (aged 3 to 5 years) attending Head Start centers in three rural communities. MEASURES: Zinc, ferritin, CRP, and complete blood count were analyzed in nonfasting blood samples. STATISTICAL ANALYSES: Correlations were computed among leukocyte levels, CRP levels, and measures of micronutrient status. Children having two abnormal measures (ie, leukocytes and CRP) were compared by univariate analysis of variance with children having zero or one abnormal measure. RESULTS: Most (72%) of the children had elevated CRP levels. Four percent were anemic (hemoglobin<11.0 g/dL [<110 g/L]); 11% had low iron stores (serum ferritin<or=15 ng/mL [<or=33.7 pmol/L]); and 77% had low iron stores when a reference value that accounts for the presence of infection was used (serum ferritin<or=30 ng/mL [<or=67.4 pmol/L]). Twenty-one percent had low plasma zinc levels. Children with two measures that indicated infection had higher serum ferritin and lower plasma zinc levels than children with zero or one indicator of infection. CONCLUSIONS: The link between measures of infection and serum ferritin levels suggests low-income preschool children with low iron stores are not identified by the <or=15 ng/mL (<or=33.7 pmol/L) criterion. The link between zinc and infection suggests possible overestimations of zinc deficiency in low-income children. Thus, in this population, the presence of infection (as indicated by CRP levels and leukocyte counts) should be determined to assess micronutrient status.

Analysis of Variance↗
PubMed2006

The relationship between micronuclei in human lymphocytes and selected micronutrients in vegetarians and non-vegetarians.

A vegetarian diet results in higher intake of vitamins and micronutrients, which - although providing antioxidant defence - may lead to deficiency in other micronutrients involved in DNA metabolism and stability (such as vitamins belonging to the B group). The principal difference among various vegetarian diets is the extent to which animal products are avoided. We have performed a pilot study to determine the relationship between the micronucleus frequency in lymphocytes and diet, and we compared the levels of Vitamins C and E, beta-carotene, B(12), folic acid, homocysteine and total antioxidant capacity in healthy vegetarians and non-vegetarians. The vegetarian group, consisting of 24 volunteers (13 women and 11 men), were matched for age and sex with 24 volunteers (12 women and 12 men) with a traditional dietary habit. Among the vegetarians were 13 lacto-ovo-vegetarians with average duration of vegetarian diet 10.8 years (ranging from 5 to 26 years) and 11 lacto-vegetarians with average duration of vegetarian diet 8.2 years (ranging from 3 to 15 years). Homocysteine, Vitamins C and E and beta-carotene levels in plasma were assayed by HPLC, and serum folate and Vitamin B(12) were determined with Elecsys Immunoassay tests. The total antioxidant capacity of plasma was estimated by measuring the ferric-reducing activity in a spectrophotometric assay. Micronuclei were measured in cytokinesis-blocked lymphocytes. Vegetarians had significantly higher levels of Vitamin C and beta-carotene (but not Vitamin E) in plasma compared with non-vegetarians (P<0.001). There were no significant differences in serum levels of folic acid and Vitamin B(12) between the monitored groups. Levels of folic acid in vegetarians correlated with length of vegetarianism (r=0.62, P=0.001, N=24). Vegetarians had elevated levels of homocysteine compared with non-vegetarians (P=0.007), as did vegetarian women compared with non-vegetarian women (P=0.031). We did not find any differences in total antioxidant capacity or in micronucleus frequency between the groups. Micronuclei correlated with age (r=0.62, P<0.001, N=48), women having higher frequencies than men. Multifactorial regression analysis showed significant effects of age, sex and total antioxidant capacity on micronucleus frequency (N=48, P<0.001).

Adult↗
PubMed2004

Effects of a low-fat vegan diet and a Step II diet on macro- and micronutrient intakes in overweight postmenopausal women.

OBJECTIVE: This study investigated the nutrient intake of overweight postmenopausal women assigned to a low-fat vegan diet or a Step II diet. METHODS: Fifty-nine overweight (body mass index, 26 to 44 kg/m2) postmenopausal women were randomly assigned to a self-selected low-fat vegan or a National Cholesterol Education Program Step II diet in a 14-wk controlled trial on weight loss and metabolism. Nutrient intake, which was measured per 1000 kcal, was the main outcome measure. Statistical analyses included within-group and between-group t tests examining changes associated with each diet. RESULTS: Consumption of a low-fat vegan diet was associated with greater decreases in fat, saturated fat, protein, and cholesterol intakes and greater increases in carbohydrate, fiber, beta-carotene, and total vitamin A intakes than was a Step II diet. The low-fat vegan group also increased thiamin, vitamin B6, and magnesium intakes more than the Step II group, and both groups increased folic acid, vitamin C, and potassium intakes. If considering only food sources of micronutrients, the low-fat vegan group decreased vitamin D, vitamin B12, calcium, selenium, phosphorous, and zinc intakes compared with baseline. However, with incidental supplements included, decreases were evident only in phosphorous and selenium intakes. No micronutrient decreases were found in the Step II group. CONCLUSIONS: Individuals on a low-fat vegan or Step II diet should take steps to meet the recommended intakes of vitamin D, vitamin K, folic acid, calcium, magnesium, and zinc. Individuals on a low-fat vegan diet should also ensure adequate intakes of vitamin B12, phosphorous, and selenium.

Adult↗
PubMed2005

Apparent absorption of eight micronutrients and phytic acid from vegetarian meals in ileostomized human volunteers.

OBJECTIVES: Apparent absorption of eight micronutrients and degradation of phytic acid were studied in human subjects who underwent ileostomy. The prominent factors affecting micronutrient absorption from vegetarian Indian meals (n = 11) were identified. METHODS: Levels of beta-carotene, ascorbic acid, riboflavin, and thiamine in food and ileostomy contents were estimated by spectrophotometry and spectrofluorometry. Contents of zinc, iron, copper, and manganese were estimated by atomic absorption spectrometry and that of phytic acid by gradient elution ion exchange chromatography. Statistical analyses were done with SPSS 10.0. RESULTS: Absorption of beta-carotene, ascorbic acid, riboflavin, and thiamine was 63% to 75.6%. There was a negative non-significant trend in values of beta-carotene absorption with increased intake of beta-carotene (r = - 0.51, P > 0.1) and iron (r = -0.67, P = 0.1) but a positive significant trend with riboflavin intakes (r = 0.84, P = 0.018). Percentage of absorption of ascorbic acid showed weak positive associations with intakes of riboflavin (r = 0.71) and ascorbic acid (r = 0.5). Percentage of absorption of ascorbic acid was positively correlated with percentage of absorption of beta-carotene (r = 0.80, P < 0.05), iron, and riboflavin (r = 0.64, P = 0.086), indicating some common influencing factors. Percentages of absorption for zinc (20.2), iron (9.9), and copper (17.6) was comparable with those reported for soy protein-based, high phytate diets. Pattern of phytic acid in the meals and output indicated partial degradation and absorption (34%). CONCLUSIONS: For vegetarian Indian meals, apparent absorptions of beta-carotene and ascorbic acid were 76% and 73.5% and of riboflavin and thiamine was 63%. Zinc, copper, and iron showed a lower absorption (10% to 20%).

Adult↗
PubMed2006

Effect of micronutrient supplementation on health and nutritional status of schoolchildren: growth and morbidity.

OBJECTIVE: We evaluated the effect of a micronutrient-fortified beverage on growth and morbidity in apparently healthy schoolchildren. METHODS: This was a double-blind, placebo-controlled, matched-pair, cluster, randomized study in semi-urban middle-income residential schoolchildren aged 6 to 16 y. Anthropometrics (height and weight), clinical symptoms of deficiency, and morbidity data were collected at baseline in the supplemented group (n = 446 in 10 grades) and the placebo group (n = 423 in 10 grades) and after 14 mo of supplementation (n = 355 in the supplement group and n = 340 in the placebo group from nine pairs). RESULTS: After 14 mo of supplementation, there was a significant increase in mean increments of height and weight z scores of -0.04 and 0.02, respectively, in the supplemented group compared with -0.14 and -0.09 in the placebo group. Velocity of weight (3.56 versus 3.00) was significantly (P < 0.01) higher with supplementation. Although there were no differences in the incidence of common childhood diseases such as fever, cough and cold, diarrhea, and ear infections elicited for a reference period of 1 mo at every quarterly follow-up examination, the mean duration of illness (calculated per person per year) was significantly shorter (5.0 d) in the supplemented group than in the placebo group (7.4 d). CONCLUSIONS: The micronutrient-fortified beverage was beneficial in promoting growth and decreasing duration of common illnesses among middle-class residential schoolchildren who had adequate energy and protein intakes.

Adolescent↗
PubMed2004

Association between serum concentrations of micronutrients and lower urinary tract symptoms in older men in the Third National Health and Nutrition Examination Survey.

OBJECTIVES: To evaluate the association of serum micronutrients with lower urinary tract symptoms (LUTS). METHODS: We included 2497 men, 60 years old and older, who participated in the Third National Health and Nutrition Examination Survey from 1988 to 1994 and for whom serum concentrations of vitamins A, C, and E, carotenoids, and selenium had been measured previously. Cases were men with three or four of the following symptoms: nocturia, hesitancy, incomplete emptying, and weak stream, but who had never undergone noncancer prostate surgery. Controls were men without symptoms, who had never undergone noncancer prostate surgery. We adjusted for age and race in logistic regression models and used sampling weights. RESULTS: Serum concentrations of vitamin E (P = 0.03), lycopene (P = 0.06), and selenium (P = 0.03) were lower in men with LUTS compared with controls. Men in the top four quintiles of vitamin E, lycopene, and selenium had a nonstatistically significant 25% to 50% reduced odds of LUTS compared with men in the bottom quintile. Inverse associations were not seen for the other carotenoids or vitamin A. A high serum vitamin C concentration was associated with a lower odds of LUTS in current smokers, but with a nonstatistically significant greater odds in those who never smoked and in former smokers. CONCLUSIONS: Greater circulating concentrations of vitamin E, lycopene, and selenium, antioxidant micronutrients that are supported in published reports as protecting against prostate cancer, were observed also to be inversely associated with LUTS. The effect modification of the association with vitamin C by cigarette smoking warrants additional examination.

Aged↗
PubMedDate not supplied

Antimutagens in food plants eaten by Polynesians: micronutrients, phytochemicals and protection against bacterial mutagenicity of the heterocyclic amine 2-amino-3-methylimidazo[4,5-f]quinoline.

We have previously suggested that differences in cancer incidence between Polynesians (including Maoris and people from several Pacific islands) and Europeans in New Zealand may at least partially relate to differences in the species of food plants (fruits, vegetables and cereals) preferentially eaten by these groups. Twenty-five food plants that are typically eaten in different amounts by these two population groups were selected for detailed study. Antimutagenic properties of three extracts from each of the selected plants were investigated using a preincubation mutagenicity assay with Salmonella typhimurium strain TA1538 against the mutagenicity of the heterocyclic amine 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). The data revealed strong antimutagenic properties in several of the food plants commonly eaten by Polynesians, especially rice, watercress, pawpaw, taro leaves, green banana and mango. Using the New Zealand food database, a number of nutrients and micronutrients with antimutagenic and anticarcinogenic potential were identified from the selected food plants. Some of these were tested for antimutagenic potential in parallel experiments to those done with the food plant extracts. Although some of these micronutrients are antimutagens against IQ, their concentrations in the food plants failed to explain the protection against mutagenicity found in the experiments with extracts of the food plants. Thus, other types of chemical, not identified in the database, must be leading to antimutagenesis. Possible active molecules include chlorophylls, carotenoids, flavonoids and coumarins, many of which are also known to be anticarcinogens. If human cancer data are to be interpreted in terms of cancer protection, these components need urgently to be quantified in food plants in the New Zealand diet, especially in those food plants eaten in large amounts by Polynesians.

Animals↗
PubMed2000

Selected micronutrients and colorectal cancer. a case-control study from the canton of Vaud, Switzerland.

The association between dietary intake of various micronutrients and colorectal cancer risk was analysed using data from a case-control study conducted between 1992 and 1997 in the Swiss Canton of Vaud. Cases were 223 subjects (142 (64%) males, 81 (36%) females; median age 63 years) with incident, histologically confirmed colon (n=119; 53%) or rectal (n=104; 47%) cancer, and controls were 491 subjects (211 (43%) males, 280 (57%) females; median age 58 years; range 27-74) admitted to the same university hospital for a wide spectrum of acute non-neoplastic conditions, unrelated to long-term modifications of diet. Dietary habits were investigated using a validated food frequency questionnaire (FFQ). Odds ratios (OR) were obtained after allowance for age, sex, education, smoking, alcohol, body mass index, physical activity, and total energy and fibre intake. No significant association was observed for calcium, retinol, folate, vitamin D or E. The risk of colorectal cancer was directly associated with measures of iron intake (OR=2.43 for the highest tertile, 95% confidence interval (CI): 1.2-5.1) and inversely associated with vitamin C (OR=0.45; 95% CI: 0.3-0.8), and non-significantly with total carotenoids (OR=0.66, 95% CI: 0.4-1.1). Among various individual carotenoids considered, inverse associations were observed for alpha-carotene, beta-carotene and lutein/zeaxanthin. These findings were consistent across the strata of gender and age, and support the hypothesis that selected micronutrients have a favourable effect on colorectal carcinogenesis.

Adult↗
PubMed2002

Consequences of Helicobacter pylori infection on the absorption of micronutrients.

Recent studies have suggested a relationship between Helicobacter pylori infection and various important micronutrients, including iron and vitamin B12, suggesting likely biological factors in the association between Helicobacter pylori and microcytic or macrocytic anaemia. There is some evidence that direct or indirect consequences of Helicobacter pylori gastritis on acid secretion account for the role of the bacterium in the absorption process of iron and Vitamin B12. The plasma, intragastric and mucosal concentration of different antioxidant compounds such as ascorbic acid, a-tocopherol and beta-carotene is also affected by Helicobacter pylori gastritis supporting the possible role of Helicobacter pylori in the multistep cascade leading to gastric carcinogenesis. The relationship between Helicobacter pylori infection and micronutrients is, therefore, a promising and, until now, poorly investigated field of research.

Antioxidants↗
PubMed2000

Micronutrients in the severely-injured patient.

The trace element and vitamin requirements of severely-ill injured patients depend on a complex interaction of the status of the patient at the time of admission, ongoing losses and the potential benefit of supplying large amounts of individual micronutrients. Characteristic clinical deficiency states are now uncommon, but subclinical deficiency is of growing concern. The main effects of subclinical deficiency are: (1) an altered balance of reactive oxygen species and antioxidants, leading to oxidative damage of polyunsaturated fatty acids and nucleic acids, and possibly to increased activation of the transcription factor nuclear factor-kappaB, with increased production of pro-inflammatory cytokines: (2) impaired immune function with increased likelihood of infectious complications. Laboratory tests to optimize intake in such critically-ill patients lack sensitivity and specificity, this situation being made worse as a result of the acute-phase response. Recent studies have indicated the clinical benefit of providing large amounts of certain micronutrients in burned and head-injured patients. Further clinical studies are now required to define optimal levels of provision in different disease states, with a particular emphasis on markers of tissue function and clinical outcome.

Avitaminosis↗
PubMed1999

Micronutrients and ageing: intakes and requirements.

Ageing (and related diseases) may be described as a process which results from impaired immunological, genetic, neurological or endocrinological functions. Oxidative mechanisms may play an important role in the ageing process. It is important, therefore, to emphasize the relationship between health and nutrition in the elderly, particularly with regard to antioxidant micronutrient requirements. Indeed, accelerated ageing may be related to a deficit in the intakes of antioxidant vitamins (tocopherols, carotenoids and vitamin C) and trace elements (Zn and Se), as well as to an impaired adaptative mechanism against oxidative stress. Physiological modifications occurring during the lifetime and environmental influences are significant factors contributing to the impairment of micronutrient status, and these factors have to be considered when defining the specific requirements of the elderly. For Fe there is no evidence of benefit of supplementation in healthy subjects, but in the present state of knowledge combined supplementation, including Zn, Se, vitamins C and E and carotenoids, could be the best way to prevent accelerated ageing and reduce the risk of several common age-related diseases.

Aged↗
PubMed2003

Micronutrients and laryngeal cancer risk in Italy and Switzerland: a case-control study.

OBJECTIVE: To investigate the relation between various micronutrients and laryngeal cancer risk. METHODS: A case-control study was conducted in Italy and Switzerland between 1992 and 2000. Cases were 527 patients with incident cancer of larynx, admitted to the major teaching and general hospitals of the study areas. Controls were 1297 subjects admitted for acute, non-neoplastic diseases to the same network of hospitals. Dietary habits were assessed using a validated food-frequency questionnaire. Odds ratios (OR) and their corresponding 95% confidence intervals (CI) were computed using multiple logistic regression. RESULTS: Significant inverse relations emerged between laryngeal cancer risk and intake of vitamin C (OR = 0.2, for the highest versus the lowest intake quintile; 95% CI: 0.2-0.4), beta-carotene (OR = 0.2; 95% CI: 0.2-0.4), alpha-carotene (OR = 0.3; 95% CI: 0.2-0.5), lutein/zeaxanthin (OR = 0.4; 95% CI: 0.3-0.6), vitamin E (OR = 0.4; 95% CI: 0.3-0.6), beta-criptoxanthin (OR = 0.4; 95% CI: 0.2-0.5), folic acid (OR = 0.4; 95% CI: 0.2-0.6), thiamin (OR = 0.4; 95% CI: 0.3-0.6), glutathione (OR = 0.5; 95% CI: 0.4-0.8), reduced glutathione (OR = 0.6; 95% CI: 0.4-0.8), vitamin B6 (OR = 0.6; 95% CI: 0.4-0.9) and potassium (OR = 0.6; 95% CI: 0.4-0.9). Direct associations were found with zinc (OR = 1.5; 95% CI: 1.0-2.2) and vitamin D (OR = 1.8; 95% CI: 1.2-2.6). Combining low intakes of vitamin C, carotene, vitamin E, and folate with heavy smoking and drinking led to ORs between 80 and 170. CONCLUSIONS: This study provides further support that, independently from smoking and alcohol consumption, the intake of several micronutrients, including selected antioxidants, is inversely related to laryngeal cancer risk.

Adult↗
PubMed2001

Blood micronutrients in Algeria, relationships with sex and age.

Despite trace elements and vitamins are major public health problems in some African countries, there are few studies reporting micronutrient status in North Africa. Therefore, it could be interesting to evaluate plasma concentrations of vitamin A, E and beta-cartene, along with zinc, copper, selenium erythrocyte glutathione peroxidase and superoxide dismutase in Algeria. Volunteers were randomly recruited in Constantine, Batna and Mila. Vitamins, trace elements and enzymes were measured in the University Hospital of Grenoble. 455 persons were included in the study. Subjects were divided in 3 groups: group I: 15 girls and 12 boys who were 6 to 12.9 years old, group II: 190 women and 192 men 13 to 49.9 years old, group III: 24 women and 24 men 50 to 65 years old. Plasma concentrations of micronutrients and enzymes are close to those commonly observed in Europe, except for vitamin A concentrations. Indeed, retinol levels are 30-35% lower than those reported in European countries, moreover almost 8% of the population showed retinol concentrations less than 1.05 mumol/l. beta-Carotene levels were also lower than in the French average population. Ten per cent of the population had plasma zinc levels lower than 10.6 mumol/l. Vitamin E, copper and selenium status seems satisfactory in Algeria. Vitamin A is not a public health problem, however a significant percentage of residents exhibits impaired vitamin A levels and may benefit from retinol supplementation. Larger studies are needed, and particularly in children, to detect possible higher prevalence of vitamin A deficiency in poor socio-economical classes and in inner geographic areas.

Adolescent↗
PubMed2002

Efficacy of a multi-micronutrient dietary intervention based on haemoglobin, hair zinc concentrations, and selected functional outcomes in rural Malawian children.

OBJECTIVE: To investigate the efficacy of enhancing the content and bioavailability of micronutrients in diets of stunted rural Malawian children on their growth and body composition, morbidity, anaemia and hair zinc concentrations. DESIGN: A quasi-experimental design with non-equivalent control group involving 410 intervention and 220 control children aged 30-90 months. SETTING AND SUBJECTS: Children from two intervention and two control villages in Mangochi District, Southern Malawi participated in a 6 month dietary intervention. Anthropometry, malarial screening, haemoglobin, and hair zinc were measured at baseline and after 12 months, as well as socio-economic status at baseline, and common infections monthly post-intervention. RESULTS: Groups were comparable at baseline. Post-intervention children had greater Z-scores for lean body mass (mid-upper arm circumference -0.75 vs -1.05; arm muscle area: 0.63 vs -1.03, P<0.001) than controls but Z-scores for weight-for-height and height-for-age were similar. After controlling for baseline variables, mean haemoglobin was higher (107 vs 102 g/l, P<0.01), whereas the incidence of both anaemia (62 vs 80%) and common infections (based on a median overall illness score for fever, diarrhoea, upper and lower respiratory infections) were lower in intervention compared to controls, with no change in hair zinc concentrations or malaria status post-intervention. CONCLUSION: Improvements in the micronutrient adequacy of diets of post-intervention children were associated with a favourable increase in indices of lean body mass and reductions in the incidence of anaemia and common infections in these rural Malawian stunted children.

Anemia↗