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At least 343 records · Page 19Linked to original sources
PubMed2006

Assessment of factors contributing to changes in the incidence of antimicrobial drug resistance in Salmonella enterica serotypes Enteritidis and Typhimurium from humans in England and Wales in 2000, 2002 and 2004.

An investigation into changes in the occurrence of antimicrobial resistance in Salmonella enterica serotypes Enteritidis and Typhimurium from human infection in England and Wales in 2000, 2002 and 2004 has shown that the incidence of strains of S. Enteritidis with resistance to nalidixic acid coupled with decreased susceptibility to ciprofloxacin has more than doubled between 2000 and 2004, whereas the overall levels of resistance in S. Typhimurium have fallen by ca. 25%. In relation to published data on veterinary sales of antimicrobials in the UK, the findings demonstrate that changes in the incidence of resistance do not correlate with changes in veterinary usage. For S. Enteritidis, important factors in the increased incidence of resistance were foreign travel and the consumption of imported foods contaminated with drug-resistant strains. For S. Typhimurium, the most important factor has been an overall decline in the occurrence of multiple drug-resistant S. Typhimurium definitive phage type 104. These studies have demonstrated that changes in the incidence of resistance in predominant salmonellas in humans in England and Wales from 2000 to 2004 are multifactorial. The findings also demonstrate that, in order to combat drug resistance in zoonotic salmonellas causing infections in humans, controls on the use of antibiotics in food animals analogous to those in operation in the UK should be implemented in countries that regularly import food into the UK.

Ampicillin↗
PubMed2004

Mortality from hypertrophic cardiomyopathy in England and Wales: clinical and screening implications.

OBJECTIVES: Hypertrophic cardiomyopathy is considered a relatively common cause of death in the young. Screening for the disorder has been advocated, but its potential value cannot be assessed because the number of deaths in asymptomatic cases in the general population has not been investigated. We determined the annual number of deaths (and death rates) from hypertrophic cardiomyopathy in England and Wales according to age, sex and the presence or absence of symptoms so that an affected individual's risk of dying from the disorder and the implications of screening could be assessed. METHODS: Ascertainment of all deaths from hypertrophic cardiomyopathy over a 3-year period (1996-1998), using death certification data from the Office of National Statistics. Deaths in people without symptoms were identified from coroner's reports and correspondence with pathologists who conducted the necropsies. RESULTS: There were 184 deaths per year from hypertrophic cardiomyopathy in England and Wales (about 15% of all deaths from cardiomyopathy) of which one third (65) were in people without symptoms. Most (110) of the 184 deaths each year were in people over age 55. Under age 55 there were only 37 deaths each year in asymptomatic people, out of an estimated 60,000 people with the disorder in the population. Of the 37 deaths, 14 (20%) occurred in relation to physical activity and 2 after competitive sport. CONCLUSIONS: In young people without symptoms hypertrophic cardiomyopathy is fairly common (1 in 500) but it rarely causes death; the case-fatality rate is about 6 per 10,000 per year. Current risk estimates from the study of patients in tertiary referral centers or general hospital clinics (420 and 110 deaths per 10,000 per year, respectively) are not applicable to asymptomatic people in the general population; such people, if incidentally identified can be reassured of their low risk of death. Screening would not be worthwhile unless a satisfactory test becomes available that can detect those few cases likely to die.

Autopsy↗
PubMed2005

Treating the vulnerable in England and Wales: the impact of law reform and changing policy.

This article considers the role of treatment in the provision of mental health care in England and Wales. The current legislative position with regard to the making of treatment choices following compulsory commitment will be examined. Consideration will also be given to the position of the informal hospitalised patient, as in the case of R v. Bournewood Community and Mental Health NHS Trust, ex parte L and finally, the role of the common law in establishing (in)capacity in relation to the non-consensual provision of treatment for physical conditions. Attention will then be given to the reform process, which is currently ongoing in England and Wales, and its likely impact on treatment provision. The Mental Capacity Act 2005 received Royal Assent on the 7th April 2005, while the draft Mental Health Bill 2004 underwent detailed examination by the Joint Scrutiny Committee, a report of which was published on the 23rd March 2005. On the 13th July 2005 the British Government outlined its response following the publication of the Scrutiny Committee's recommendations and despite it accepting many of the recommendations put forward, some significant areas of concern remain making the draft Mental Health Bill 2004 "a long way from acceptable legislation".

Commitment of Persons with Psychiatric Disorders↗
PubMed2006

An ecological study of factors associated with rates of self-inflicted death in prisons in England and Wales.

This study describes ecological associations between self-inflicted death rates and prison-level environmental indicators over the period 2000-2002 in England and Wales. The objective was to assist in the development of interventions for reducing the incidence of self-inflicted deaths in prisons in England and Wales, by identifying risk factors, including overcrowding, positive drug tests, the number of assaults, purposeful activity, offending behaviour programmes, and cost per prisoner. Poisson regression was used to estimate associations between self-inflicted death rates and these potential risk factors, controlling for different categories of prison. The annual rate of self-inflicted death during 2000-2002 was 1.14 per 1000 (95% CI 0.98 to 1.34), with no evidence for a difference in the two years. Highest rates were in the Male Local and Women's prisons at 1.86 (95% CI 1.42 to 2.26) and 2.27 (95% CI 1.35 to 3.84) per 1000 respectively. In a multivariate analysis, overcrowding, assault rate and purposeful activity were significant. In an analysis controlling also for prison category, only purposeful activity remained independently significant, as a protective factor (RR 0.57, 95% CI 0.35 to 0.92, p=0.02) with weaker evidence for a positive association with positive drug tests (RR 1.41, 95% CI 0.96 to 2.05, p=0.08). Despite concerns about the quality of routinely collected data and the interpretation of ecological associations, this study suggests that a higher level of purposeful activity is independently associated with lower rates of self-inflicted death, whatever the prison category. This adds support to other studies conducted at the level of the individual prisoner.

Activities of Daily Living↗
PubMed2006

Price of beer and violence-related injury in England and Wales.

OBJECTIVES: Relationships between violence-related injury and potential risk factors in England and Wales were investigated over a five-year period, 1st May 1995 to 30th April 2000. METHODS: Records from all 10 economic regions of England and Wales relating to price of alcohol, youth real income, wealth, ethnic density, dates of major sporting events and seasonality were studied with reference to violent injury data derived from 58 Emergency Departments (EDs) over the same period. Panel estimation and multi-level modelling was used to evaluate associations between variables. RESULTS: Overall, 353,443 violence-related A&E attendances were identified over the five-year period. High regional violence-related injury rates correlated with low real price of alcohol as measured by price of beer. Rates of violence were higher during summer months and on days of major sporting events. CONCLUSIONS: Risk of injury in violence was closely linked to alcohol price. Beer price rises should therefore reduce violent injury. Injury reduction efforts should be intensified during the summer and on days of major sports events.

Alcohol Drinking↗
PubMed2004

Modelling hydroenvironmental and health risk assessment parameters along the South Wales Coast.

This paper highlights the increasing concerns relating to hydroenvironmetal issues and cites recent examples of the challenges now being regularly faced by hydroenvironmetal scientists and engineers. The limitations and restrictions of both physical (or laboratory) and numerical (or computer based) hydraulic models used in the planning and management of aquatic basins are discussed. General details are given of numerical models used for flow and water quality concentration predictions in estuarine waters, with particular application to the challenges occurring along the South Wales coast. A highly accurate and non-diffusive finite difference scheme that solves the transport equation for predicting water quality indicators and suspended sediment concentration distributions is also discussed. In particular, details are outlined of the extension of the water quality indicators of faecal coliforms, as required to comply with the EU Bathing Water Directive, to predict health risk assessment, in the form of predicting the risk of gastroenteritis. Three example research projects along the South Wales coast are described; the projects involve the application of two-dimensional and three-dimensional hydroenvironmetal models to predict flow patterns and water quality indicator organism distributions in the coastal receiving waters. These studies include: (i) a curvilinear finite difference approach to modelling flows in the Bristol Channel, (ii) coastal health risk predictions in Swansea Bay using combined water quality and epidemiological models, and (iii) combined sewer overflow discharges into Cardiff Bay.

Computer Simulation↗
PubMed2006

The current burden of pneumococcal disease in England and Wales.

OBJECTIVE: To evaluate the potential impact of various pneumococcal conjugate vaccination strategies, it is critical to ascertain the pre-vaccination epidemiology and to have a detailed evaluation of the current burden of pneumococcal disease. METHOD: A variety of national data sources and GP sentinel surveillance systems were used to estimate the incidence, number of hospital admissions, deaths, and GP consultations due to pneumococcal disease in England and Wales. Clinical outcomes included pneumococcal meningitis, bacteraemia, pneumonia and otitis media. A statistical model was used to attribute GP consultation recorded as pneumonia and acute otitis media to specific aetiological causes when these were not recorded. RESULTS: The burden of pneumococcal disease is considerable, with incidence rates of both invasive and non-invasive disease peaking in children (<5 years) and in the elderly (75+ years). Around 5800 hospitalisations specifically mentioning Streptococcus pneumoniae are estimated to occur annually in England and Wales, almost 40,000 for lobar pneumonia and over 15,000 for otitis media. There may be an additional 70,000 GP consultations for pneumococcal related community acquire pneumonia and over 630,000 for otitis media. A significant proportion of hospitalisations and GP consultations for pneumococcal disease occur among high-risk groups, with over 80% of hospital admissions reporting more than one diagnosis.

Adolescent↗
PubMed2006

Assessing the burden of influenza and other respiratory infections in England and Wales.

OBJECTIVES: To estimate the burden of influenza in England and Wales, in terms of general practice consultations, hospital admissions and deaths. METHODS: Multivariable regression was used to estimate the influenza attributable fraction of general practice consultations recorded in the general practice research database, of hospital admissions from hospital episode statistics and of deaths recorded by the Office of National Statistics. RESULTS: An estimated 779,000 (95%CI+/-258,000)-1,164,000 (95%CI+/-425,000) general practice consultations, 19,000 (95%CI+/-5000)-31,200 (95%CI+/-11,000) hospital admissions and 18,500 (95%CI 2500)-24,800 (95%CI+/-2500) deaths annually are attributable to influenza infections. In primary care, the bulk of the burden falls on those under the age of 45, whereas the elderly are more likely to be hospitalised and to die. CONCLUSIONS: Although there are significant uncertainties, and considerable year on year variations, it is clear that the burden of influenza is considerable. Although much of this burden falls on the elderly, significant numbers of general practice consultations, hospitalisations and even some deaths occur annually in children in England and Wales.

Adolescent↗
PubMed2005

A health impact assessment of increased aspirin use in Wales.

AIM: To estimate the likely magnitude of health impact if all individuals at increased risk of cardiovascular events in Wales (total population 2.9 million) took low-dose aspirin. METHODS: Data from a variety of different sources were collected and systematically combined using simple methods and conservative assumptions. RESULTS: Aspirin may reduce cardiovascular mortality by 2-25% and avoid 330-3250 deaths per annum after allowing for a small number of fatal undesirable effects. COMMENT: Wales might lead the way in developing an aspirin programme.

Aspirin↗
PubMed2005

Trends in survival from muscular dystrophy in England and Wales and impact on respiratory services.

Respiratory failure is an important terminal event in muscular dystrophy, but increasingly is effectively treated by non-invasive ventilation. This study was designed to assess mortality statistics in this patient group in order to get an indication of future demand. Mortality data for all deaths from muscular dystrophy registered by death certification in England and Wales between 1993 and 1999 were analysed. In total, 817 deaths from muscular dystrophy were registered between 1993 and 1999. Annual number of deaths was unchanged over this period. Median age at death (interquartile range) for all cause muscular dystrophy increased from 20 (17-42.5) years in 1993, to 26 (17.5-63) years in 1999. Respiratory failure was the primary or contributory cause of death in 82% of cases. Two thirds of these deaths were during acute infection. We can expect 100 patients with muscular dystrophy to develop respiratory failure in England and Wales each year, so non-invasive ventilation services probably need to be able to provide for 0.2 new patients per 100,000 population annually. Respiratory services also need to provide adequate monitoring and early treatment of infection in these patients.

Adolescent↗
PubMed2005

The physicochemical characterisation of microscopic airborne particles in south Wales: a review of the locations and methodologies.

As part of the NERC-URGENT thematic programme, research was undertaken into the physicochemistry and bioreactivity of microscopic airborne particulate matter in south Wales. This paper reviews the collecting and characterisation methods used in the research; some of the results obtained are shown as examples. Four main collecting locations were chosen: Cardiff (urban); Port Talbot (urban/industrial); Park Slip West coal opencast pit (industrial/rural); the Black Mountains (rural/background). Collections initially used a 30-l/min Negretti PM10 filter collection system, however in the later stages of the project increased use was made of a 1100-l/min impaction system (nicknamed the super-sucker). This latter device was developed at Harvard University USA, however was adapted and optimised at Cardiff University. Methods for the extraction of PM10 off polycarbonate filters and polyurethane substrates were developed, with particular attention being paid to minimise physical or chemical changes during the extraction, and the extracts being in an appropriate state for bioreactivity assessment. Physicochemical characterisation of the PM10 included the empirical measurement of shape and size using electron microscopy and semi-automated image analysis. The determinations of the water-soluble and -insoluble chemical components were undertaken by ion chromatography and inductive coupled plasma-mass spectrometry. The bioreactivity of south Wales airborne particles is not covered by this review.

Air Pollutants↗
PubMed2006

Survival analysis of 459 adult patients with primary spinal cancer in England and Wales: a population-based study.

BACKGROUND: Primary spinal gliomas are rare. Because data from the Cancer Registry of England and Wales covered larger numbers of patients and longer durations of follow-up, our objective was to define prognostic factors for survival at a national population level. METHODS: From 1971 to 1995, data on 459 adult patients (age, >15 years) with primary spinal cancer from the Cancer Registry of England and Wales were analyzed. Median survival and CSRs with respect to 7 variables (age, sex, morphology, WHO grade, socioeconomic status, geographic region, and period of diagnosis) were calculated using the Kaplan-Meier method. Cox regression was performed for estimating HRs for death. RESULTS: The median survival and the 1-, 5-, and 10-year CSRs for the population were 10.2 years, 78.7%, 59.7%, and 50.5%, respectively. Univariate analysis revealed that age at diagnosis, morphology, WHO grade, and period of diagnosis affected the CSR. Multivariate analysis demonstrated 3 factors influencing survival: older age (ie, >60 years; HR = 2.67; P < .001), non-ependymomas (HR = 3.51; P < .001), and high-grade tumors (HR = 3.01; P < .001). The improved survival in recent periods was associated with an increased number of diagnosed ependymomas. CONCLUSION: This study identifies old age, non-ependymomas, and high-grade tumors as negative prognostic factors for patient survival. The results from this population-based study are very helpful for comparison with those of other hospital-based studies and for public health purposes.

Adolescent↗
PubMed2005

Modelling the impact of prison vaccination on hepatitis B transmission within the injecting drug user population of England and Wales.

A vaccination programme offering hepatitis B (HBV) vaccine at reception into prison has been introduced into selected prisons in England and Wales. The work here considers the impact of prison vaccination on the incidence and prevalence of hepatitis B virus (HBV) in the injecting drug user (IDU) population of England and Wales. A dynamic model of the transmission of HBV in IDUs is developed with key model assumptions and parameters being subject to sensitivity analyses. The base case model (that assumes that the vaccination coverage on prison reception is 5% in 2002, 10% in 2003 and then increases linearly up to 50% of prison receptions being vaccinated by 2006) predicts that the incidence of HBV in IDUs might be reduced by almost 80% in 12 years, and the HBV prevalence (IDUs ever infected by HBV) may be reduced from approximately 18% in 2002 to 7% in 2015. The model presented here demonstrates that HBV vaccination on prison reception can have a significant impact on the prevalence and incidence of HBV in the IDU population over time.

Adolescent↗
PubMed2005

Profile of the physiotherapy profession in New South Wales (1975-2002).

This was the first study known to the authors exploring workforce data from the New South Wales Physiotherapists Registration Board over several decades. Labour force statistics were examined from various data sources over the years 1975 to 2002. The results indicate that the demographics and working patterns of physiotherapists in New South Wales have remained remarkably stable over time. The workforce continues to grow, however the growth rate has decreased markedly with only a 2.3% increase from 2001 to 2002. The proportion of men within the profession is steadily increasing; in 1975 men accounted for 5.2% of physiotherapists, in 2000 23.5% of physiotherapists were male. While the male workforce increases, the female workforce is ageing. The modal age for female physiotherapists has steadily increased from 25-29 years in 1975 to 40-44 years in 2001. Importantly, in relation to attrition, the degree of workforce participation has not undergone significant change since 1987. Although labour force analysis has demonstrated that the workforce is in shortage, attrition does not appear to be the major contributor to this situation. The proportion of the profession who are inactive has remained relatively stable since 1987. More pertinent to the current shortage is the slowing of the growth rate of the profession while demand for physiotherapy services continues to rise.

Adult↗
PubMed1996

The surgical care of cleft lip and palate patients in England and Wales.

The results of a postal survey in 1992 of surgeons in England and Wales undertaking primary repairs for babies born with cleft lip and palate are presented. 64 plastic surgeons undertaking primary cleft repairs were identified. The majority of cleft surgeons were low volume operators undertaking 10 or less lip repairs annually. Low volume operators were less likely to attend joint disciplinary clinics than high volume operators and those that did attended clinics with fewer specialities represented. None of the low volume operators collected standardised records for their patients. The recommendations of the Royal College of Surgeons of England for centralisation of cleft care in England and Wales on a regional basis and a minimum case-load per surgeon of 30 new cases per year are discussed.

Child, Preschool↗
PubMed2003

An audit of the management of induced abortion in England and Wales.

OBJECTIVES: To assess the quality of care provided to women undergoing induced abortion. METHODS: The design was a single round audit questionnaire aimed at the providers of abortion services throughout England and Wales (NHS hospitals, clinics under NHS, agency agreements and private units. The levels of care were assessed against agreed audit criteria. RESULTS: Responses were received from 240 (74%) of the 324 units providing abortion care in England and Wales. These units undertook 80% of the 176,000 termination procedures. Generally standards of care were appropriate, but there were clear areas for improvement including choice of method, infection screening, and delays in referral. A number of unnecessary investigations were still evident, including cross-matching, while lower doses and alternative drug regimens might reduce costs. Only half of the units audited procedures and complications. CONCLUSIONS: This audit was carried out prior to the publication of the RCOG evidence-based guideline and a further round of audit to assess the impact of the guideline should now be considered.

Abortion Applicants↗
PubMed1998

Use of physical restraints in nursing homes in New South Wales, Australia.

A 48 item postal survey was completed voluntarily by 285/445 (64%) Directors of Nursing (hereafter DONs) of nursing homes in New South Wales, Australia, to obtain information about the use of physical restraints. Of a total of approximately 16,397 (11,719 females; 4678 males) residents of nursing homes from which information was obtained, 15.3% (2516) were physically restrained. Females comprised 11.2% (1839) and males 4.1% (677) of this group. The commonest forms of physical restraint were vests (25.3%), restraining belts (18.9%), bedrails (17.2%), lap trays (14.4%) and gerichairs (10.5%). The commonest patient-oriented reason for using physical restraints was to 'prevent falls' (84.2%) and the commonest nurse-oriented reasons were 'because no alternative exists' (39.6%) and 'to reduce legal liability' (20%). The correlation between the size of nursing homes (bed numbers) and the number of residents who were physically restrained was weak (r = 0.1771, alpha = 0.05), suggesting that nursing home size did not predict the use of physical restraints. Correlations between the total number of staff, the total number of untrained staff (Assistants In Nursing) and the number of residents who were physically restrained were also weak (r = 0.1792; 0.0921 respectively; alpha = 0.05), suggesting that these factors also had little predictive influence on the use of physical restraints. The findings of this research indicate that the extent to which physical restraints are currently being used in nursing homes in New South Wales should be of concern.

Accidental Falls↗
PubMed1990

Modifiable risks for cardiovascular disease among general practitioners in Wales.

A random cluster sample of 520 general practitioners in Wales was invited to complete a postal questionnaire providing information on personal health status, and practice organisation and activities relating to the prevention of cardiovascular disease. Survey participants were also asked to provide a blood sample together with details of independently measured height, weight and blood pressure. 310 (60%) provided usable information and 280 (54%) provided blood samples. General practitioners in the study generally had better lifestyles and fewer coronary risk factors than the general population in Wales. Only 17% (43/251) of males were regular smokers, and 56% (134/239) of males and 32% (18/68) of females regularly take exercise. Few and uncontrolled elevated blood pressure. However, 39% (97/248) of males and 29% (15/52) of female GPs were overweight, and more than 40% (19/42) of male GPs aged 40-64 had cholesterol levels above 6.5 mmol. Six per cent (6/99) of male GPs aged 40-54 consumed greater than 35 units of alcohol each week. It is suggested that GPs have responded well to the challenges of reducing smoking among themselves and their patients, but that they have yet to recognise fully the risks to personal health associated with elevated cholesterol levels and high alcohol consumption.

Adult↗