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At least 343 records · Page 19Linked to original sources
PubMed1980

Unilateral odontodysplasia.

A case of malformation of five permanent teeth in the right maxilla is described. The asymmetrical malformations were probably caused by an early local trauma of the right maxilla. This trauma led to defective mineralization of the deciduous tooth germs, which was verified roentgenologically. The resulting early osteitic process caused injury to the permanent germs at a sensitive mineralization period. Mineralization disturbances of 13, 14, 15, 16 and 17 were established roentgenologically. In the other halves of the jaws the development was entirely normal. Endocrinological examination showed normal values and there were no signs of hypothyreosis or Turner's syndrome. Acute symptoms in the right maxilla at the age of 9 necessitated extraction of germs 14 and 16. As subsequent roentgenograms showed that 13 and 15 were not developing normally in respect of mineralization, these were extracted at, respectively, 12 and 13 years of age. For the same reason 17 was extracted two years later. The histopathological examination showed in all involved teeth a pronounced malformation with disturbances both of the morpho- and histodifferentiation of the various dental tissues.

Child↗
PubMed1983

Remineralization in human premolars of different posteruptive age.

In human premolars with posteruptive ages varying from 6 months to 4 years demineralized enamel was remineralized for 3 days at 37 degrees C in a recalcifying medium containing 2 mM Ca2+, 1.2 mM phosphate, 0.05 mMF- and 150 mM NaCl (pH = 7). The Ca, P and Ca/P molar ratio of the mineral gained were determined at various distances from the enamel surface. Whereas, particularly at 30 micrometers from the surface remineralization was higher and more extensive in young demineralized enamel, no difference could be found in Ca/P molar ratio, suggesting precipitation of an apatitic mineral in both young and old demineralized human enamel. The probable nature of the precipitate is that of a fluoridated hydroxyapatite.

Age Factors↗
PubMed1983

Effect of oxygen tension on matrix formation and mineralization in hamster molars during development in vitro.

The effect of 3 oxygen tensions (20%, 50% and 95%) on the pre-eruptive tooth development in vitro was studied biochemically and histologically in 2nd maxillary molars of the hamster. The specific uptakes (uptake per microgram dry weight) of 3H-proline and 45Ca were used as parameters for matrix production and mineralization, respectively. The best results were obtained at 50% O2. Histologically, considerable amounts of predentine, dentine and enamel matrix were found in these molars. Biochemically, appreciable synthesis of matrix and mineralization were measured. In an atmosphere containing 20% O2 less predentine, dentine and enamel matrix were formed. Moreover, production of the matrices occurred in a less regular way. In particular, dentinogenesis in the deeper parts of these molars was affected. The odontoblasts in these areas showed an abnormal and decreased matrix production and eventually dedifferentiated. Biochemically, a lower matrix synthesis and mineralization were measured in these molars.

Amelogenesis↗
PubMed1983

Studies of alkaline phosphatase inhibition by p-bromotetramisole in non-mineralizing and mineralizing neonatal hamster tooth germs in vitro.

The effects of l and d-, p-bromotetramisole (pBTM) on alkaline phosphatase were studied in relation to 45Ca2+, 32phosphate and 3H-thymidine uptakes in non-mineralizing second (M2) and mineralizing first (M1) maxillary hamster molar tooth germs under the conditions of organ culture. At the concentration used in culture (10(-3)M), l-pBTM completely inhibited alkaline phosphatase activity in tooth germ homogenates. About 30% of the enzyme activity was inhibited by d-pBTM at the same concentration. In culture, there were no significant differences between the effects of l and d-pBTM isomers on all the parameters measured. In the non-mineralized M2 molars, l and d-pBTM significantly reduced both TCA-soluble and TCA-insoluble 32phosphate uptakes but not 45Ca2+. However, 3H-thymidine uptake was also significantly decreased. In M1 molars, the pBTM isomers significantly reduced the uptake of TCA-soluble 32phosphate and 45Ca2+ but not TCA-insoluble 32phosphate. Ouabain, a specific inhibitor of Na+-K+-ATPase (but not alkaline phosphatase), also significantly reduced 3H-thymidine uptake to the same extent as the pBTM isomers in the non-mineralizing M2 molars, but it did not significantly affect either 32phosphate (TCA-soluble and TCA-insoluble) or 45Ca2+ uptake. Although this inhibitor significantly reduced both 45Ca2+ and TCA-soluble 32phosphate uptake in the mineralizing M1 molars, this effect was much less dramatic than was the case with the pBTM isomers. The reduced 45Ca2+ uptake in the M1 molars is probably a consequence of reduced mineralization since in the non-mineralizing M2 molars calcium uptake was not significantly affected by the pBTM isomers.(ABSTRACT TRUNCATED AT 250 WORDS)

Alkaline Phosphatase↗
PubMedDate not supplied

Prenatal fluoride tablet supplementation and improved molar occlusal morphology: part V.

This article is a report of an in vivo clinical study in which the relationship of sodium fluoride supplementation during pregnancy to the improved occlusal morphology of molar teeth seen in an animal model was determined. Two hundred randomly selected children composed the study population. The mothers of 100 of them had been on the prenatal supplementation (PNF) regimen and 100 whose mothers were not were found to have statistically significant differences in their occlusal molar morphology. Ninety-eight percent of the PNF children have a smooth, naturally sealed appearance to the occlusal surfaces of their primary molars and permanent first molars. The authors conclude that pitted and fissured molars are produced as a result of fluoride deficiency during the secretory phase of crown formation.

Child↗