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At least 343 records · Page 19Linked to original sources
PubMed1993

Detection of collagenase mRNA in odontoclasts of bovine root-resorbing tissue by in situ hybridization.

The odontoclast, which is morphologically similar to osteoclast, is thought to play a major role in root resorption of deciduous teeth. High collagenolytic activity has been detected in the root resorbing tissue. In order to identify collagenase-producing cells and the role of collagenase in root resorption of deciduous tooth, in situ hybridization of collagenase mRNA in bovine root-resorbing tissue sections was performed using a digoxigenin-labeled, nonradioactive RNA probe. Collagenase mRNA expression was clearly observed in odontoclasts in addition to the macrophages, fibroblasts, odontoblasts, and cementoblasts. Multinuclear odontoclasts showed intense tartrate-resistant acid phosphatase (TRAP) activity. We also examined interleukin-1 (IL-1) mRNA expression in the root-resorbing tissue by in situ hybridization. IL-1 transcripts were found to be expressed in odontoclasts, fibroblasts, and macrophages suggesting that IL-1 might be an important factor for promoting root resorption. These results suggest that the collagenase produced by odontoclasts may play a key role in dentin collagen degradation in root resorption.

Acid Phosphatase↗
PubMed1999

Enamel hypoplasia of primary teeth in chronic renal failure.

Chronic renal failure (CRF) in the first years of life is associated with developmental defects of enamel in the permanent dentition. We investigated if CRF also affects the primary (deciduous) dentition. Thirty-one children with CRF on conservative treatment (n = 12) or on renal replacement therapy (n = 19) underwent dental inspection. In addition, 18 CRF children provided an exfoliated deciduous tooth for microscopic examination. Enamel defects were detected in a total of 12 children (31%), either clinically or microscopically. Of the 7 children affected clinically, 6 (19% of all examined) presented localized hypoplasia of the primary canines, which was found only in 3% of healthy control children: 1 patient had generalized pitted enamel hypoplasia. By microscopy, 5 of 10 primary canines examined showed enamel hypoplasia localized exclusively in enamel formed after birth. The "birth line," a visible structure within the primary enamel, was always present, which excludes a prenatal onset of the defects. Of the 12 patients with an enamel defect, 9 had a documented onset of CRF within the first 7 weeks of life. We conclude that renal disease leading to CRF may affect enamel formation of primary teeth in early postnatal life, resulting in lesions different from those observed in the secondary dentition.

Adolescent↗
PubMed1981

Occlusal variation in a rural Kentucky community.

Some major theories concerning the etiology of malocclusion and its modern increase in frequency include genetic explanations, such as inbreeding, racial crossing, and accumulation of mutations, as well as such environmental causes as "habits," allergies, and caries causing reduced arch space of premature deciduous tooth loss. Reduction of masticatory stress resulting from modern urbanism is less often considered as an agent. Many examples of acquisition of gross malocclusion in aboriginal peoples immediately following dietary "modernization" contradict the genetic explanations. A rural population from central Kentucky presents several propitious social characteristics for epidemiologic study of occlusion. They have experienced almost no professional dental care, they are highly inbred (but less so during the last 30 years), and their diet included many difficult-to-chew foods until the recent introduction of industry to the area. Occlusion was evaluated according to the criteria of the Treatment Priority Index. The temporal change and correlates of occlusal variation were assessed on wax-bite impressions of thirty-four persons, informant dietary histories, and other information. The older inhabitants raised on more traditional diets show significantly better occlusion. Dietary consistency provides the most powerful explanation for the transition in occlusal variation, through it was not conclusive in these data.

Adolescent↗
PubMed1984

Occlusal variation in Chinese immigrants to the United Kingdom and their offspring.

Occlusal variations of immigrant Chinese parents, raised in less developed areas, were compared with their children who were born and bred in the United Kingdom. Of 11 occlusal traits, nine were significantly more variable or less well developed in the offspring. Because genetic factors were unchanged, the deterioration in occlusion in the offspring indicates environmental influences such as dietary consistency, premature deciduous tooth loss from caries and oral respiration.

Adolescent↗
PubMed1975

Double bilateral dens invaginatus in the maxillary incisor region.

Two cases of bilateral double dens invaginatus in the maxillary incisor region have been reported. One of the patients (Case 1), a 12-year-old boy, had double invaginations in both of the erupted teeth in the maxillary lateral incisor region. The other patient (Case 2), a boy 8 years of age, had double invaginations in each of the two partially developed supernumerary teeth that were impacted in the palate in the maxillary central incisor region. Double bilateral dens invaginatus would appear to be a most unusual occurrence.

Child↗