Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “THERAPEUTICS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 343 records · Page 19Linked to original sources
PubMed1977

[Gilbert's jaundice. Current clinico-nosographic, physiopathological and therapeutic aspects. III. Therapeutic action of enzyme inductors with reference to unconjugated bilirubin icterus].

The value of phenobarbital in the treatment of free bilirubin icterus is demonstrated by a series of clinical experiments in which the drug was administered to patients with bilirubinaemia, even at high levels, the situation being brought back to normal within about two weeks. The percentage excreted with the urine in a conjugated form of various drugs proved higher in subjects treated with phenobarbital than in controls, thus proving that the drug acts as an enzymic inductor. Moreover it is ineffective in patients genetically lacking in the capacity to synthesize glycuronyltransferase. The induction of this latter enzyme, however, does not exhaust the effects of the barbiturate for it has been shown that phenobarbital is capable of speeding up the disappearance of exogenous bilirubin from the plasma in animals, of stimulating bile flow and increasing uptake of the pigment by the liver. The increase in bile flow is of the order of 30% and takes place by way of a modification in the flow fraction independent of bile salts. It would also appear that the drug is capable of increasing the activity of 7-alpha-hydroxylase, an enzyme that represents the rate limiting step in the synthesis of biliary salts. Other drugs commonly used in the treatment of free bilirubin icterus such as ethanol, rifampicin and uridindiphosphoglucose are considered. Finally the case of a female patient who from birth had presented persistent free bilirubin icterus of about 8 mg% is reported. After 14 days treatment with phenobarbital (100 mg X 2) blood levels of the pigment had returned to normal.

Adult↗
PubMed1995

[Therapeutic observance in arterial hypertension. Reliability of indirect methods assessing therapeutic compliance].

OBJECTIVE: To validate six indirect methods which evaluate observance of therapy for arterial hypertension (AHT). DESIGN: Prospective study. SETTING: Urban health centre, Huelva. PATIENTS: 90 individuals (25 men and 65 women) (average age 59.2 +/- 11) chosen at random from the AHT clinic. MEASUREMENTS AND MAIN RESULTS: Home-based survey and review of clinical records. We counted hypotensive tablets at the start of the study and after a month. The indirect methods studied were: Self-communicated compliance (SC), attendance for appointments (AA), control of arterial pressure (CP), Morinsky-Green test (MG), knowledge of the illness (KI) and medical opinion (MO). We used the counting of tablets as the standard method. We studied the prevalence of non-observance, validity (2 x 2 table) and the concordance of the different methods. Prevalence of non-compliance was 16.7% (p = NS for age and gender). The average Systolic AP and Diastolic AP of compliers and non-compliers were 137 and 147 mmHg (p < 0.035) and 83 and 90 mmHg (p < 0.006), respectively. CONCLUSIONS: We found a high level of compliance. The SC underestimated non-compliance, which was overestimated by the other methods. We recommend SC and MO for detecting the non-complier, as they have greater specificity and better positive predictive values; and KI for detecting the complier, as it has greater sensitivity and negative predictive value. However these conclusions should be treated cautiously, since concordance of the different tests regarding the counting of tablets is weak.

Adult↗
PubMed1997

[Therapeutic trial, clinical research and therapeutic freedom--medical aspects].

In the history of medicine, the approach has changed from prevention to curative medicine- hand in hand with the availability of the pharmacologic findings. Prior to the era of a medicine based on natural science, drugs were found by an empirical trial- and error approach resulting in a steadily growing of drugs. With the upcoming natural sciences, medicine reached new levels in drug treatment by extensive and systematic research in experimental and clinical trials. For scientific and regulatory acceptance, national and international guidelines and the rules of "Good Clinical Practice" have to be met. On the basis of the respect for the "Oath of Hippocrates", the commitment to "salus aegroti suprema lex", the responsibility of "nil nocere" and the duty of information are elementary. The regulations of the "social legislation" define rights and duties of patients and physicians. In spite of all these rules, the physicians' autonomy is undeniable because of individualism of patients in contrast to the clinical trials based on national and international guidelines.

Clinical Trials as Topic↗