Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Systems Integration”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 343 records · Page 19Linked to original sources

[The systemic integration of human functions: new approaches to the diagnosis and correction of stressor states].

The paper provides evidence for a new principle of the systemic organization of human functions. Instead of the concepts of man as a set of organs which are bound up with nervous and humoral regulation, the author considers on the basis of the functional systems theory the human body as a total combination of various interacting systems of different levels of organizations, each yields body's useful adaptive responses on the principles of multiparametric and successive interactions with other functional systems. The paper reveals the principles of interaction of functional systems in the whole organism. Problems in the evaluation of human physiological functions in the place of work, systemic principles of detection of stress states and their rehabilitation are considered in the context of functional systems.

Adaptation, Physiological↗

A model system: Integrated work injury prevention and disability management.

Effective and cost efficient work injury prevention and disability management requires an integrated process that involves a number of components. Each component needs to be linked into a continuum or system. Components by themselves will not provide satisfactory solutions. This article addresses some of the key components that need to be included in an effective work injury management system. The goals of a management system are discussed and how each component plays a part in achieving these goals.

Journal Article↗

The karyotypic structure of cell populations in vitro as an integral system.

This review describes regularities of karyotypic variability maintaining karyotypic stabilization of continuous cell lines. Statistical analysis of individual karyotypes of "marker" and "markerless" cell lines show that survival of cell population in vitro is maintained by a certain ratio of cells with different structural variants of karyotype (SVK). Characteristic feature of karyotypic variability in the "markerless" cell lines during long-term cultivation under various conditions is dicentric formation due to telomeric associations. These dicentrics seem to form genetical structures providing adaptation to conditions in vitro of the cell population as an autonomous system. Correlations between the numerical variability reflecting in SVK, and structural variability (dicentric formation) are manifestations of an integral cell-populational function. Experimental data allow to suggest that integrity of the karyotypic structure of cell populations is maintained not only by selection of random variations, but also by programmed (adaptive) changes of karyotype. As a whole, in the cell population the state is realized that can be called karyotypic homeostasis; the observed phenomena characterize processes maintaining such homeostasis.

Adaptation, Physiological↗

Child and family focus. Working together to develop integrated systems of care.

We've all heard the jokes about the nature of committee work: "A camel is a horse designed by committee." Or, "A committee is a group of the unwilling unprepared to do the unnecessary." In the current case, nothing could be farther from the truth. Over the past year, we were very fortunate to be able to gather a group of experts who were more than willing, and prepared, to do the very necessary. Representing all areas of children's behavioral healthcare, these respected leaders of the field worked assiduously to produce a blueprint for how child mental health and welfare workers, public purchasers, families, managed care leaders, and other stake-holders can work together to create well-managed "systems of care." The article they coauthored reflects some of the best thinking on the problems of emerging multiple managed care systems and the specific actions urgently needed to protect children and their families. We are pleased to present their recommendations to you in this month's Child and Family Focus. We feel that the hard work that went into this collaboration, and the resulting consensus, demonstrates that integration can, does, and must work to create better systems of care.

Adolescent↗

[Organization of integrated systems of conditioned reflexes in dogs with a damaged temporal cortex].

By means of the classical alimentary secretory method, a study was made of the characteristics of formation and preservation of complex systems of conditioned reflexes in dogs with a preliminarily lesioned cortex of the auditory analyser. It has been shown that a rhythmic-mozaic stereotype of conditioned reflexes to acoustic signals can be elaborated in the operated dogs, although conditioned activity is on a very low functional level. However, integration of two complex stereotypes into one single system is not achieved. The formation of a new stereotype in the operated dogs, in contrast to the intact animals, is not accompanied by an enhanced functional state (tone) of the brain, which points to an insufficiency of the self-regulating mechanisms of the cerebral cortex. It is suggested that special activating mechanisms which participate in controlling the functional state of the auditory system, are present in the cortical structures of the auditory analyser.

Animals↗

Viewing health care as an integrated system.

Although still in its early stages, disease management is already proving to be effective in decreasing health care expenditures by increasing compliance and normalizing utilization patterns. For the greatest benefit to be realized over the long term, however, a disease management program must target the 80 percent of the identified population not yet in the action stage. Only by appropriate interventions designed to move individuals incrementally from stage to stage will disease management fulfill its promise of appropriately lowering health care costs by cutting across the established component system.

Chronic Disease↗