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Results for “SUCCINIC ACID”

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At least 343 records · Page 19Linked to original sources
PubMedDate not supplied

[The effect of an extract of Baikal skullcap (Scutelleria baicalensis) on succinic acid oxidation by the brain mitochondria in rats with hypoxia].

Oxidative phosphorylation in the mitochondria of rat brain in normobaric hypercapnic hypoxia and preventive administration of Scutellaria baicalensis extract was studied by polarography. Hypoxia causes diminution of energy of the rat brain mitochondria with separation of oxidative phosphorylation and inhibition of the reactions of rapid metabolic cluster of Krebs' cycle. Scutellaria baicalensis extract prevents diminution of energy of the brain mitochondria in hypoxia, inhibits restriction of succinate dependent energy production, and preserves intactness of the mitochondrial membranes.

Animals↗
PubMedDate not supplied

[Correction of free radical processes by a succinic acid drug (reamberine) in intensive care of patients with acute neurotropic poisoning].

Sixty-six patients with acute poisonings with neurotropic toxins (soporiphics, neuroleptics, antidepressants, ethanol and its surrogates) were examined and treated. Clinical data and correction of disorders in free-radical processes in acute poisonings with these toxins indicate the efficiency of adding reamberine to combined therapy of this patient population.

Acute Disease↗
PubMed2005

The 6-derivative of beta-cyclodextrin with succinic acid: a new chiral selector for CD-EKC.

6-O-Succinil-beta-cyclodextrin (CDsuc6) was synthesized with very good yield by one pot synthesis and characterized by NMR spectroscopy and ESI-MS. It was used as a chiral selector in capillary electrophoresis to resolve catecholamine racemates, namely norepinephrine, epinephrine, terbutaline and norphenilephrine. The CE experiments at pH 5.6 show very promising selector ability by 6-O-succinil-beta-cyclodextrin for the chiral recognition of all the catecholamines tested, while at pH 9.2, only racemic terbutaline was successfully separated.

Chromatography↗
PubMed2004

[Efficacy of derivatives of 3-hydroxypyridine and succinic acid in diabetic patients with the diabetic foot].

A prospective placebo-controlled study was performed to examine the effects of emoxipine, reamberine, and mexidole on the severity of neuropathic and anxiety-depressive symptom clusters, by simultaneously evaluating the parameters of the lipid peroxidation-antioxidative defense protection (LPO-AOD) system in diabetic patients with the diabetic foot. The 14-day use of all the test drugs was found to cause a significant attenuation of diabetic neuropathy and to abolish concomitant anxiety and depression. The positive clinical effect of emoxipine and reamberine was shown to be associated with the stimulation of AOD and with the limitation of LPO. Mexidole is not inferior to emoxipine and reamberine in its clinical efficacy, but it did not change the parameters of the LPO-AOD system as compared with placebo.

Adult↗
PubMed1966

Studies on the biochemistry of Penicillium charlesii. Influence of various dicarboxylic acids on galactocarolose synthesis.

1. It has been shown that Penicillium charlesii continues to synthesize galactocarolose when l-malic acid, malonic acid, succinic acid, fumaric acid, maleic acid or oxaloglycollic acid is substituted for dl-tartaric acid in the Raulin-Thom nutrient medium. 2. The quantity of galactocarolose synthesized per g. of mycelia was markedly decreased by substitution of l-malic acid, malonic acid, succinic acid, fumaric acid or maleic acid for dl-tartaric acid. Substitution of oxaloglycollic acid for dl-tartaric acid did not depress the galactocarolose synthesized/g. of mycelia; however, the quantity of fungal mass formed was decreased approximately fivefold. 3. Based upon (14)C incorporation into galactocarolose, succinic acid, fumaric acid or malonic acid did not serve as direct precursors of galactose as did tartaric acid. Oxaloglycollic acid, l-malic acid and maleic acid were not tested. 4. The relative quantity of galactocarolose synthesized per g. of mycelia decreased as the concentration of diammonium dicarboxylate added to the growth medium was increased. Tartaric acid, oxaloglycollic acid, fumaric acid and malonic acid were tested. 5. The quantity of mycelia formed and the quantity of galactocarolose synthesized per g. of mycelia were greater when the growth medium contained l-tartrate than when it contained d-tartrate.

Carbon Isotopes↗
PubMed1978

The metabolism of [14C]bicarbonate by Streptococcus lactis: the synthesis of succinic acid.

Whole cells of Streptococcus lactis C10, when incubated with an energy source, converted fumarate to succinate and malate to lactate. Cell-free extracts of Str. lactis C10 contained fumarate reductase, but no aspartase, adenylosuccinate synthetase and lyase or argininosuccinate synthetase and lyase activity could be detected. Cells grown in the presence of [14C]bicarbonate produced labelled succinate during the synthesis of purine bases. However, the amount of succinate produced by this pathway only accounted for approximately one-sixth of the succinate produced by the cells.

Bicarbonates↗
PubMedDate not supplied

[The role of succinic acid in neuron reaction to synaptic activation].

It has been shown on Retzius neuron of the leech that after preintroduction of sodium succinate the reaction to synaptic stimulation expressed in increased frequency of the impulse activity proceeds more intensively than in the norm. In connection with the fact that against the background of succinate effect reaction to acetylcholine increases it is suggested that this very mediator is responsible for slower decrease of the impulse activity frequency at synaptic activation.

Acetylcholine↗