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At least 343 records · Page 19Linked to original sources
PubMed1998

Germ cell tumors.

Germ cell tumors in children are different from those in adults and often differ from each other in the site of the tumor and the age of the child. The appropriate gross examination and processing of these tumors by pathologists are described, and differences according to site and/or age are highlighted. Useful special studies such as immunohistochemistry and cytogenetics are identified, and the appropriate methods for processing material for these studies are discussed. Handling of small biopsy specimens or fine-needle aspirates is also addressed. Staging of germ cell tumors by site according to Pediatric Oncology Group and Children's Cancer Study Group treatment protocols and the most recent adaptation of grading of immature teratomas are outlined.

Adolescent↗
PubMedDate not supplied

Rapid demonstration of cytomegalovirus in clinical specimens.

An assay is described for handling clinical specimens for the detection of cytomegalovirus. It consists of low-speed centrifugation of the specimen on human embryonic lung cells, using a technique adapted from chlamydial culture, followed by detection using a monoclonal antibody against the cytomegalovirus early antigen in an immunofluorescence technique. This assay was compared with the conventional cell culture system. 161 specimens obtained from 52 patients were studied; from 14 patients CMV was isolated in at least one specimen (in total 28 specimens). The centrifugation technique led to positive results generally within 24 to 48 h, whereas the cell culture took an average of 16.5 days to develop the typical cytopathic changes. No cross-reactions between the cytomegalovirus monoclonal antibody and other viruses present (herpes simplex virus and adenovirus) were observed. The centrifugation technique is a reproducible and rapid method in the diagnosis of cytomegalovirus infection.

Antigens, Surface↗
PubMed2004

Handling and pathology reporting of specimens with carcinoma of the urinary bladder, ureter, and renal pelvis.

OBJECTIVE: Pathologists play a pivotal role in the diagnosis and in the report of the pathological features related to prognosis. METHODS: To meet these endpoints, the following issues must be accomplished: adequate information about the patient history, proper handling of the specimens, identification of the reliable histopathological techniques necessary to reach the more detailed diagnostic information and evaluate the prognostic variables, and a standardized pathological report. RESULTS: Recent efforts to standardize the histopathological evaluation have generated significant confusion among the urological and pathological communities as well. No consensus has been achieved about the optimal pathological grading of urothelial tumors, to date. CONCLUSION: A proposal for standardization of sampling and reporting of the urothelial tissues achieved within Uropathology follows. The urologists have a great role in assisting pathologists in the proper examination by providing them with clinical information.

Biopsy↗
PubMed2004

Handling and pathology reporting of specimens with carcinoma of the urinary bladder, ureter, and renal pelvis. A joint proposal of the European Society of Uropathology and the Uropathology Working Group.

Pathologists play a pivotal role in the diagnosis and in the report of the pathological features related to prognosis. To meet these endpoints, the following issues must be addressed: adequate information about the patient history, proper handling of the specimens, identification of the reliable histopathological techniques necessary to reach the more detailed diagnostic information and evaluation of the prognostic variables, and standardized pathological reporting. In this review we discuss a proposal for standardization of sampling and reporting of the urothelial tissues achieved within uropathology. The urologists have a great role in assisting pathologists in the proper examination by providing them with clinical information.

Carcinoma↗