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At least 343 records · Page 19Linked to original sources
PubMed1976

Serosal tears following colonoscopy.

After colonoscopic perforation, laparotomy was performed in a 28-year-old woman. Seromuscular tears and lacerations were found in an adjacent loop of sigmoid colon that appeared normal through the colonoscope. At laparotomy, the mucosa of that loop was entirely intact. Six weeks later, a laparotomy was again performed, revealing well-healed lacerations with extensive adhesion formation. The incidence of this complication in patients undergoing colonoscopy is unknown.

Adult↗
PubMed1992

Serosal mast cells maintain their viability and promote the metabolism of cartilage proteoglycans when cocultured with chondrocytes.

OBJECTIVE: To determine the consequences of mast cell (MC)-chondrocyte interactions. METHODS: Cocultured cells were analyzed histochemically, morphologically, biochemically, and functionally. RESULTS: Cocultured MC adhered to the chondrocytes and remained viable. Chondrocytes cocultured with nonactivated MC produced more proteoglycans than did chondrocytes cultured alone, and these proteoglycans possessed an intact hyaluronic acid-binding region. In contrast, most of the proteoglycans produced by chondrocytes cocultured with activated MC were degraded. CONCLUSION: These studies indicate that a complex interaction occurs in which the nonactivated MC stimulates biosynthesis and the activated MC degrades cartilage proteoglycans.

Animals↗
PubMed1991

Early postoperative intraperitoneal adriamycin as an adjuvant treatment for advanced gastric cancer with lymph node or serosal invasion.

Early postop intraperitoneal adriamycin may be a excellent adjuvant treatment, which, when combined with the R2 gastric resection, may markedly improve the survival of patients with gastric cancer. Even if its only effect were to decrease the local recurrence rates, a markedly improved quality of life for gastric cancer patients would be achieved. We suggest that these improved local treatments should be combined with aggressive systemic therapy in order to develop an optimal adjuvant approach to the treatment of gastric cancer.

Abdominal Neoplasms↗
PubMed1988

Characteristics of beta-endorphin-induced histamine release from rat serosal mast cells. Comparison with neurotensin, dynorphin and compound 48/80.

Rat peritoneal mast cells were exposed to the neurohormone and basic opioid peptide beta-endorphin. beta-Endorphin induced a dose-dependent release of histamine from the mast cells. A significant histamine release was found at 5 mumol/l of beta-endorphin and maximal release (35% of total) at 20 mumol/l. The histamine release process was very rapid and terminated within 30 s at 37 C, and in this sense is very similar to the histamine release induced by compound 48/80 or neurotensin. The histamine release was temperature-dependent showing an optimum release around 30 C, and it was independent of available extracellular calcium, but was inhibited in the presence of high extracellular calcium concentrations. Naloxone, only in very high concentrations (10 mmol/l), inhibited the release, and the very same concentration also inhibited the neurotensin - as well as the compound 48/80-induced histamine release. Cromoglycate and benzalkoniumchloride, a 48/80 antagonist, both produced a progressive dose-dependent inhibition of beta-endorphin-, neurotensin- as well as compound 48/80-induced histamine release. Taken together, the findings indicate that the opioid peptide beta-endorphin induces a selective, energy-dependent release of histamine from peritoneal rat mast cells. The pattern of release has much in common with that of compound 48/80 and other basic peptides, such as neurotensin and substance P. In addition this pattern of release is similar to that induced by dynorphin.

Animals↗
PubMed1980

Evidence for carrier-mediated uptake of sugars at the serosal side of lamb colon mucosa.

Sugar uptake through the basolateral membrane into epithelial cells was investigated in lamb colon stripped of serosa and muscle layers. Only the antiluminal surface of the mucosa was exposed to the incubtion medium. 2-Deoxy-D-glucose (2-DG) and 2-O-methyl-D-glucose (3-MG) were used as model substrates. Both sugars were taken up by a saturable process. Transport apparently occurred by facilitated diffusion. 2-DG uptake was inhibited by D-glucose and 3-MG, but not by D-galactose and alpha-methyl-D-glucoside and 3-MG uptake was inhibited by 2-DG and D-glucose but not by alpha-methyl-D-glucoside. Thus 2-DG, 2-MG and glucose appear to compete for a common transport mechanism. Carrier-mediated uptake of glucose through the basolateral membranes is probably important for the energy supply of colon epithelium.

Animals↗
PubMed1978

Concentrative amino acid uptake at the serosal side of colon mucosa.

Uptake of the nonmetabolizable model amino acid 2-aminoisobutyric acid (= AIB) through the basolateral membrane into epithelial cells was studied in sheep colon stripped of serosa and muscle layers. Only the antiluminal surface of the mucosa was exposed to the incubation medium. Thus AIB entry into epithelial cells could only occur through the basolateral membrane. AIB was taken up by a saturable process against a high concentration gradient. AIB uptake was inhibited by other neutral amino acids but not by sugars. In a low Na+ medium AIB uptake was impaired, indicating that active transport of amino acids through the basolateral membrane of colon epithelial cells is Na+-dependent. In the rat a saturable concentrative uptake of AIB through the basolateral membrane of colon epithelial cells has also been demonstrated. Concentrative uptake of amino acids through the basolateral membranes is probably important for the supply of colon epithelium with amino acids.

Amino Acids↗
PubMed1986

Dexamethasone and prostacyclin biosynthesis by serosal membranes of the rabbit peritoneal cavity.

The effect of 2.5 microM dexamethasone on prostacyclin biosynthesis in isolated peritoneal serosa of the rabbit was studied. Pretreatment with dexamethasone for 90 min or more led to suppression of the subsequent prostacyclin biosynthesis in the absence of dexamethasone. This inhibition and the formation of extracellular non dialysable inhibitors were dependent on protein biosynthesis. These results indicate that glucocorticoids can partly suppress prostacyclin biosynthesis, probably via formation of lipocortin-like activity.

6-Ketoprostaglandin F1 alpha↗
PubMed2000

Intravenous immunoglobulin therapy in a patient with lupus serositis and nephritis.

The use of intravenous immunoglobulin (IVIg) has been reported as an immunomodulating agent in several autoimmune diseases, including systemic lupus erythematosus (SLE). Herein we report a SLE patient with severe clinical presentation that included pericarditis, pleural effusion, nephrotic range proteinuria, leukopenia, and lymphopenia. The patient received one course of high-dose IVIg (2.8 g/kg body weight), and within a week of post-IVIg therapy, her condition significantly improved. One-month post-IVIg there were decreased proteinuria, elevated leukocytes and lymphocytes count, decrease in antinuclear and anti-dsDNA antibodies, and disappearance of pericarditis and pleuritis. This case demonstrates the efficacy of IVIg in severe SLE with various clinical manifestations.

Adult↗
PubMed2003

Reverse serosal demucosalized gastrocystoplasty.

A novel technique of augmentation cystoplasty is suggested. The patch which is advocated is less likely to cause electrolyte imbalance, is autologous and easily available. It will avoid all the gut-mucosa-related early and late postoperative complications.

Digestive System Surgical Procedures↗