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At least 343 records · Page 19Linked to original sources
PubMed1994

[Formation of a neofascia after implantation of a composite patch in the inguinal region].

In this study, a novel patch material composed of polyglactin 910 and polydioxanon was tested in animal experiments for its use in the surgical repair of hernias. The material was implanted laparoscopically into the inner inguinal region of three hybrid running-pigs. No postoperative complications were observed. The animals were killed 14 and 48 days after surgery. Both the macroscopic and microscopic examination showed a de novo formation of connective tissue at the site of implantation, which may be regarded as a new fascia. Due to the cooperation of fibroblasts and free cells of the connective tissue, new intercellular matrix was formed after the resorption of the implanted material. A model of this cell cooperation is outlined in the study. The technical advantages of the implantation material are demonstrated and its benefits for minimally invasive surgery emphasized. Because of its special properties, the material may be recommended for later clinical traits in the surgery of fascia.

Animals↗
PubMed1994

[Do resorbable suture materials permit safe vascular anastomoses?].

Vascular surgery in growing organisms is still problematic. Especially in surgical therapy of coarctation of the aorta, high restenose rates are documented if non-absorbable polypropylene and running suture technique ist used. Theoretically, absorbable suture material allows a running suture technique with less restenose rates. Our study compares absorbable (polyglyconat and polydioxanon) with non-absorbable (polypropylene) suture material for repair of aorta in growing dogs. Anastomoses performed with absorbable suture material show after one year very good functional results without any local complications. In conclusion we can say that absorbable suture material allows formation of safety vascular anastomoses and doesn't impair growth of anastomoses.

Age Factors↗
PubMed1994

[PDS cord fixation of sternoclavicular dislocation and para-articular clavicular fractures].

Sternoclavicular joint dislocation and para-articular fractures of the clavicle are rare injuries. Because severe complications of dorsal dislocations have often been seen and because functional impairment has often followed ventral dislocations, we treat most patients with such injuries operatively. Internal fixation with K-wires frequently leads to severe complications. We present our operation techniques with a resorbable 2 mm polydioxanon cord. This pack up technique can be used in both dislocations and para-articular fractures with no risk of implant dislocation.

Clavicle↗
PubMed1994

Laparoscopic knot substitutes. An assessment of techniques of securing sutures through the laparoscope.

Advanced interventional laparoscopy has required the development of new methods of securing sutures as alternatives to the three-throw reef knot. A tensiometer was designed to measure the forces required for distraction of various knots or securing devices with different sutures. A three-throw reef knot was used as a control. Each device was tested 15 times, and the tension at which the "knot" slipped was recorded. Titanium clips (Ligaclip, Ethicon), locking polydioxanone clips (Absolok and Lapra-ty, Ethicon), malleable collars, Roeder knots and biocompatible glue (Histoacryl, B Braun Melsungen AG) were all assessed. Sutures secured with Ligaclips, Absolok clips and glue were significantly weaker than the three-throw reef knot. Sutures secured with malleable collars and Lapra-ty clips were as strong as the three-throw reef knot and have potential for use as knot substitutes.

Enbucrilate↗
PubMed1994

[Resorbable synthetics (PDS foils) for bridging extensive orbital wall defects in an animal experiment comparison].

In a long term animal study (min 2 weeks; max 48 weeks) on 6 minipigs, clinical related defects of the medial orbital wall extending in the orbital roof (2.5 cm x 3.5 cm) were created. The defects were bridged by slowly resorbable polydioxanon implants (so called PDS-foils, Ethicon) of different thickness (0.25/0.50 mm) and compared to control defects of identical size. The histological findings reveal: 1. After 29 weeks the resorption of both PDS-implants had been completely finished. Only the morphological intact implants had osteoconductive capabilities. 2. The osseous regeneration of the orbital defects started from the osteotomized margins of the orbital wall. The regenerates were covered by unaffected mucosa. 3. The bony regeneration was supported by the activated periosteal membrane. 4. The resorbed PDS-implants were being replaced by a tight scar tissue, which did not had any adjection to the orbital content. 5. The control defects showed a prolapse of the soft tissue with resulting enophthalmos. 6. According to the material specific characteristics, PDS-foils allow a sufficient bridging of even great and anatomically demanding orbital defects. 7. Notice: The hydrolytical broken down implant material may produce an irritation of the surrounding tissue causing a foreign body granuloma.

Animals↗
PubMed1993

[Influence of the suture technique and material on the mechanical behavior of a reinforced Mac Intosh graft].

The anterior cruciate ligament reconstruction by a biological graft augmented by a synthetic device allows theoretically to increase the strength of the composite graft during the remodeling period. The technical realization of the reinforcement is still controversial because it is difficult to obtain a mechanical compromise between a real effect of protection of the graft and a load sharing to favour the remodeling. When the graft and the augmentation device are tied together the ligature between them plays a fundamental mechanical role. The first goal of the present study was to define by calculation and experimentation the influence of the suturing method on the strength of the graft-device ligature. The second goal was to appreciate the possibility of using absorbable suture in such an application. Calculation allowed to show that the weakest area of the composite graft was the junction between the augmented and unaugmented parts of the graft. When increasing number and anchorage of sutures in this critical area it was possible to double the resistance of the ligature. To define the outcome of absorbable suture the strength decrease was measured during the resorption period. Two threads were tested: the polyglactin 910 (Vicryl) and the polydioxanon (PDS). The strength decrease was sudden and rapid for the Vicryl (50 p. cent in 3 weeks). For the PDS the strength loss was more gradual (50 p. cent in 8 weeks). With these two threads the strength duration appeared as incompetent to allow the augmentation to protect the graft during all the remodeling period.

Adult↗
PubMed1994

[Experience with surgical treatment of ruptures of the symphysis pubis].

Ten patients with symphyseal rupture and dehiscence of more than 10 mm who underwent different surgical procedures were reexamined between 8 and 59 months after surgery. In case of treatment within 3 weeks after the accident (n = 7) banding with completely absorbable Polydioxanon (PDS) cord (n = 4), PDS cord and crossing K-wires (n = 1), PDS-banding and plate-fixation for concomitant pubic fractures (n = 1), and wire banding (n = 1) were performed. In case of delayed operation (9 till 12 weeks after the injury n = 3) autologous bone grafts from the iliac crest were placed into the symphyseal split after removal of fibrous tissue, and double plate fixation (n = 2) respectively plate fixation and wirebanding (n = 1) were performed. There were no intraoperative and only 2 minor postoperative complications. The follow up revealed good and satisfactory results in 9 patients, and failure in one case. These results are better than to be expected from conservative management of this kind of injury. Banding with cord is a noteworthy alternative to wire banding and plate fixation.

Adult↗
PubMed1994

[Histologic studies of replacement of the anterior cruciate ligament with PDS-augmented patellar tendon transplants].

The bone-patellar tendon-bone graft is currently the best substitute for the anterior cruciate ligament (ACL). To improve the results we compared a modified Jones procedure with an additional PDS augmentation. In 25 sheep the ACL was reconstructed in the left knee after total resection. The only resection of the ACL was done in all right knees. One year postoperative 21 sheep remained in the experiment and came to evaluation. There were 10 modified Jones procedures and 11 PDS augmentations. In both groups, the central one-third of the patellar tendon was implanted through a femoral and tibial drill hole for reconstruction of the anterior cruciate ligament. The transplants were fixed on both ends with a 1-mm cord of polydioxanon (PDS), a soft preload of 50 N was given with a spring balance and the ends of the cords were fixed with a screw and a washer. In the second group we did an additional augmentation with a doubled cord of 2 mm PDS. Early mobilization and weight-bearing was allowed. Throughout the observation period all animals were labelled for fluorescence microscopy. One year after resection of the ACL without reconstruction there were totally destroyed joints. Histology showed damaged menisci and joint surfaces without any cartilage as a sign of severe arthrosis. The macroscopic aspect of the transplants showed strong ligaments coated totally by a synovial membrane with good vascularization. Only little signs of degeneration were to be seen.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1993

[Results of treatment after different surgical procedures for management of acromioclavicular joint dislocation].

Sixty-four patients underwent surgery for acromioclavicular (AC) disruption, Tossy type III, at the Department of Surgery, University of Heidelberg, between January 1983 and May 1990. Surgery consisted of a suture of the AC and coracoclavicular ligaments. Fixation of the joint was achieved with three different techniques: tension band wire with two Kirschner wires, special hook-plate (Wolter), double tension band fixation using polydioxanon (PDS) cordula. The early postoperative complication rate was higher following tension band wires (42.9%) and hook plate (58.3%) than after tension band PDS cordula (16.7%). The patients were re-examined after an average of 35.3 months. An instability of the AC joint was found in 31.8% of patients with tension band wire, 50.0% of patients with Wolter plate, and 23.8% of patients with tension band PDS cordula. The comparison of these results with those after conservative treatment, as reported in the literature, emphasizes the need for limiting surgery to young adults and athletes. The long term results of AC joint fixation are better using PDS cordula than tension band wire or hook plate. PDS cordula has the additional advantages, that dislocation and fracture of metal implants do not occur, and metal removal is avoided. Therefore, tension PDS cordula is associated with a marked reduction of the overall hospitalization period. Further improvements of results of AC joint fixation can be expected using the described technique of double tension band PDS cordula.

Acromioclavicular Joint↗
PubMed1993

A totally diverting loop colostomy.

A technique is described where the distal limb of a loop colostomy is tied with nylon or polydioxanone. This ensures total faecal diversion and dispenses with the supporting rod, enabling early application of stoma appliances. The technique does not interfere with the traditional transverse closure of a loop colostomy.

Colostomy↗
PubMed1996

[Treatment of acromioclavicular dislocation with resorbable fixation material].

The demand of biological treatment of acromioclavicular luxations is met by the use of Polydioxanon strips (PDS). Artificial damage of the joint does not occur and the bond is elastic. Thus removal of metal which ensures rigid fixation of the joint is eliminated. This makes it possible to achieve within a short period a normal range of movements.

Absorption↗
PubMed1998

Absorbable PDS-II suture and nonabsorbable polypropylene suture in aortic anastomoses in growing piglets.

The long-term outcome of vascular anastomoses in children can be compromised by stenosis when the growth of the anastomosis does not match that of the vessels. This can be influenced by the suture material. We evaluated the suitability of the new generation of polydioxanone (PDS-II), an absorbable synthetic monofilament suture, in vascular surgery, in terms of permitting normal growth of aortic anastomoses. Ten piglets underwent primary end-to-end anastomosis of the thoracic aorta, five with PDS-II suture and five with conventional polypropylene (Prolene) suture. Six months after surgery, an aortogram was obtained for each animal. The piglets were then killed and the aortas were sent for pathologic examination. Complete absorption of suture material with slight dilatation of the anastomoses was found in all five pigs in the PDS-II suture group. We also found thrombus formation in one pig in this group. Mild stenosis of the anastomotic site was noted in all five pigs in the polypropylene suture group, but no intraluminal thrombus formation was seen. The degree of dilatation or stenosis within each group was not significantly different when intraluminal diameters were compared at three distinct sites in the reconstructed aorta (p > 0.05). The differences in vascular growth between the two groups were also not significant (p > 0.05). Histologic examination revealed less tissue reaction in the PDS-II suture group than in the polypropylene suture group. Thus, PDS-II seems to be a suitable suture material for anastomoses as far as vascular growth is concerned, but the possibility of aneurysm formation secondary to dilatation of the anastomotic site should be kept in mind.

Anastomosis, Surgical↗
PubMed2001

A Schwann cell-seeded intrinsic framework and its satisfactory biocompatibility for a bioartificial nerve graft.

To optimize the internal environment of a collagen nerve tube, we designed a Schwann cell-seeded intrinsic framework and its biocompatibility was investigated. We fixed 6-0 polyglactin woven filaments (Vicryl) or polydioxanone monofilaments (PDS) on a silicone ring in a net fashion. It was coated with matrigel and then incubated with cultured newborn or adult Schwann cells. Furthermore, we implanted 1.5-cm-long filament-filled collagen tubes in a rat model. Using a live/dead fluorescent assay and electron microscopy, we found that adherent Schwann cells onto filaments remained viable and oriented longitudinally along filaments. The preliminary in vivo study indicated that a mild inflammatory reaction was present around the tube wall. However, nerve regeneration occurred around and between filaments. We concluded that the arrangement of Schwann cell columns onto filaments was achieved, mimicking Bünger bands. It was shown that the biomaterials did not impede nerve regeneration.

Animals↗
PubMed2002

Bone morphogenetic proteins promote cartilage differentiation and protect engineered artificial cartilage from fibroblast invasion and destruction.

OBJECTIVE: An important role in joint and cartilage homeostasis in adults has been demonstrated recently for morphogenetic factors of the transforming growth factor beta family. Therefore, this study was undertaken to investigate the potential of bone morphogenetic proteins (BMPs) in chondrocyte differentiation using current technologies of tissue engineering. METHODS: Complementary DNAs of recombinant human BMPs 2, 4, 5, 6, and 7 were transfected into primary bovine articular chondrocytes. Transgenic chondrocytes were assembled 3-dimensionally in alginate or in bioresorbable co-polymer fleeces of vicryl and polydioxanon embedded in low-melting-point agarose. Redifferentiation and formation of cartilage tissue in vitro or after subcutaneous transplantation into nude mice were assayed by semiquantitative reverse transcriptase-polymerase chain reaction, histology, and in situ hybridization, and findings were compared with those in unmodified or control-transfected primary chondrocytes. RESULTS: Compared with other BMPs and control vector, BMP-7 induced a decrease in type I collagen expression in artificial cartilage, while transcription of the cartilage-specific type II collagen remained stable. In transplantation experiments, BMP-7 transgenic cartilage revealed the greatest amount of matrix synthesis, and BMP-7 was the only morphogen to suppress the infiltrative response of mouse fibroblastic cells into engineered cartilage, thereby preventing transplant destruction. CONCLUSION: Cartilage differentiation and matrix maturation are promoted by BMPs in cartilage engineering. The inhibitory effect of BMP-7 on a nonspecific infiltrative response in immunocompromised nude mice further suggests that individual morphogens not only may contribute to cartilage maturation, but also may protect it from nonspecific inflammation and invasive destruction. These properties advance BMPs as promising tools for engineering of cartilaginous joint bioprostheses and as candidate biologic agents or genes for cartilage stabilization in arthritis.

Animals↗
PubMed1987

Suture materials in contaminated wounds: a detailed comparison of a new suture with those currently in use.

The relationship between five different suture materials (expanded polytetrafluoroethylene (PTFE), polypropylene, polyglycolic acid, polydioxanone and polyglactin 910) and infection has been studied in 540 guinea-pig wounds contaminated with synergistic enteric organisms. The recently introduced expanded PTFE suture has been studied because, unlike the others, it has not previously been studied under these contaminated conditions. The incidence of wound infection in the control series was 26 per cent and all suture materials increased this figure significantly. The infection rate using expanded PTFE of 51 per cent was similar to all other sutures except polyglycolic acid, which produced an infection rate of 41 per cent. This difference was not statistically significant at the 5 per cent level. This confirms other studies including our own which show that the presence of most suture materials in contaminated wounds increases the incidence of infection. It further demonstrates that expanded PTFE is no different from other materials in this regard.

Animals↗
PubMed1992

Knotting technique and suture materials.

Three groups of knots were examined using six no. 1 (metric 4) suture materials to identify the most effective and efficient knotting techniques. The three groups were the square or reef knot, the surgeon's knot and a double throw knot. Sequential single additional throws were added to these in order to determine when the strength of the knot reached the breaking force of the material, thus nullifying the need for additional throws. This strength was reached in all cases by a maximum of two additional throws. Suture materials examined were the non-absorbable monofilaments nylon and polypropylene, the absorbable monofilaments polyglyconate and polydioxanone and the braided materials polyglactin and polyglycolic acid, both coated. These were examined for their knot-holding capacity and breaking force to determine the best materials, which were polypropylene, polyglyconate and polyglycolic acid.

Suture Techniques↗
PubMed1992

Closure of laparotomy wounds: skin staples versus sutures.

To investigate the routine use of a skin stapling device for the closure of midline abdominal wounds, 48 patients were randomized to receive skin staples or subcuticular polydioxanone sutures. The mean (range) time for closure with staples was 8.0 (3.4-14.8) s cm-1 while subcuticular closure took 12.7 (9.6-28.0) s cm-1. The mean time saved per patient with skin staples was 77 s. Wound pain and requirements for analgesia were significantly lower in the sutured group. The mean cost per patient was 1.41 pounds for subcuticular closure and 7.72 pounds for stapling; the latter also incurred an additional cost of 6.27 pounds for staple removal. No clear benefit derives from the use of staples in the closure of abdominal wounds.

Adult↗
PubMed1996

Randomized trial of blunt-tipped versus cutting needles to reduce glove puncture during mass closure of the abdomen.

Eighty-five consecutive patients were randomized to undergo mass closure of the abdomen with no. 1 polydioxanone mounted on either a blunt-tipped (n = 46) or cutting (n = 39) needle. Gloves were changed before closure and tested for perforation afterwards using standard air or water techniques. Fourteen pairs of gloves were punctured when using a cutting needle, and three pairs when a blunt-tipped needle was used. The majority of punctures were to the non-dominant glove. The surgeon was aware of the puncture in eight of the 14 instances involving a sharp needle and in one of the three involving a blunt-tipped needle. Blunt-tipped needles, while not eliminating the risk, significantly reduced the incidence of surgical glove puncture (P < 0.001, Fisher's exact test). The use of cutting needles for abdominal closure should be abandoned.

Abdomen↗