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Results for “Phagocyte Bactericidal Dysfunction”

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At least 343 records · Page 19Linked to original sources
PubMed1976

[A rare cause of antro-pyloric stenosis in the child: septic granulomatosis. Concerning one case (author's transl)].

Presentation of a case of pyloric stenosis in a five year old boy due to a granuloma during the course of septic granulomatosis. The discussion must enable one to evoke the diagnosis when it is a known case of granulomatous disease, and consequently to treat it medically with antibiotics. In the opposite case where the disease is not known, it is a question of etiological discussion of pyloric stenosis. It is now worth thinking of septic granulomatosis routinely with the more classical causes of pyloric stenosis in the order boy.

Child, Preschool↗
PubMed1976

An inherited defect in granulocyte function: impaired chemotaxis, phagocytosis and intracellular killing of microorganisms.

The neutrophil granulocytes of a 1-year-old boy with severe recurrent infections were found to have almost no chemotactic responsiveness, impaired phagocytosis and reduced intracellular killing of Candida albicans "in vitro". During the course of a febrile illness of unknown etiology which was accompanied by a leukemoid reaction, phagocytic activity became normal; the chemotactic response was also increased but still remained slightly subnormal. Family studies suggested that the defect was an inherited autosomal recessive one.

Chemotaxis↗
PubMed2004

[Ehrlichiosis--a disease rarely recognized in Poland].

Ehrlichioses constitute a group of acute zoonoses caused by the infection with the microorganisms belonging to the genera Ehrlichia, Anaplasma and Neorickettsia (Rickettsiaceae). Presence of human granulocytic ehrlichiosis (HGE) caused by infection with Anaplasma phagocytophila (A. phagocytophila) and transmitted by Ixodes ricinus tick has been confirmed in Poland. All the cases described so far were noted in the area of endemic prevalence of Lyme borreliosis (north-east of Poland). Lack of characteristic symptoms makes the diagnosis of HGE difficult. It should be suspected in patients exposed to tick bites during the preceding few weeks, in whom acute, febrile illness accompanied by leucopenia and thrombocytopenia develops. The course of infection may be serious, or even life-threatening, in patients more than 40 years old; consequences of co-infection with A. phagocytophila and other tick-borne pathogens remain not well known. There is probably no risk of the development of chronic HGE. As specific diagnostic methods are not widely accessible in Poland, empirical therapy with doxycycline may be of benefit in suspected HGE cases.

Diagnosis, Differential↗
PubMed1975

Ultrastructural studies of parallel tubular arrays in human lymphocytes.

Parallel tubular inclusions were found in peripheral blood lymphocytes from 18 patients with various hematologic disorders, primarily lymphoproliferative processes, and 1 apparently healthy individual. The inclusions varied in size from 1000 to 6000 A and were usually membrane bounded. The microtubule-like structures comprising the inclusions ranged in size from 150 to 300 A and were packed in wall-to-wall contact with each other. Dense amorphous material and small dark crystalloids were frequently noted in the inclusions. There appeared to be a spatial and structural relationship of the inclusions with the centriole. The highest percent of lymphocytes with inclusionss (greater than 90%) were found in a patient with a lympho-proliferative disorder in whom 95% of the peripheral blood lymphocytes typed as T cells by spontaneous rosette formation with sheep red blood cells. (Am J Pathol 78:59-70, 1975)

Animals↗
PubMedDate not supplied

[Functional activity of polymorphonuclear leukocytes in systemic lupus erythematosus and periarteritis nodosa].

The functional activity of polymorphonuclear leukocytes (PMNL) was studied in the test of biochemical luminescence (BCL) in 43 patients including 31 patients with systemic lupus erythematosus (SLE) and 12 with nodular periarteritis (NP). Generation of the active forms of oxygen depended on the activity of the pathological process and the level of the circulating immune complexes (CIC). As established, under the conditions of hyperproductions IC PMNL in patients with SLE and NP preserve a rather high capacity to generate active forms of oxygen into intracellular space that allows one to speak about the role of oxygen radicals in the development of vascular lesions in patients with rheumatic diseases.

Adolescent↗
PubMed1990

[Clinico-morphological characteristics of the family of diseases: cytomegalic inclusion disease, iatrogenic thesaurismosis and septicemia].

The clinicomorphological manifestations of iatrogenic thesaurismosis that developed because of infusion therapy of patients with plasma substitutes were studied using autopsy and operative material from 44 deceased and 2 operated children aged 1 month to 3 years. An experimental disease was obtained in 16 rabbits. Cytomegalia was discovered in 23 deceased children with iatrogenic thesaurismosis and sepsis in 18 children. In 12 cases, sepsis was of iatrogenic nature. An assumption is worded about the three-member family of those diseases undergoing substantial pathomorphism.

Animals↗
PubMed1991

[Immune defenses of newborn infants].

Host defenses to bacterial infection are deficient in the neonate. This deficiency contributes to severe systemic infections in newborns. Phagocytosis of bacteria is decreased due to deficient activity of phagocytic cells and opsonines. Immunoglobulin secretion depending on B and helper T cell activities is strongly depressed due to immaturity of both populations. Therefore, maternal immunoglobulins of IgG type which cross placenta since 32 weeks of gestation play an important role in newborn defenses to bacteria even if this protection is incomplete.

Antibody Formation↗
PubMed1991

[Comparative analysis of functional activity of bronchoalveolar lavage fluid and peripheral blood cells in patients with acute lung abscesses].

Upon comparative evaluation of functional activity of bronchoalveolar lavage (BAL) cells and those of peripheral blood in patients with acute lung abscesses it was found that BAL cells reflect more pronounced changes in functional activity of immunocompetent cells. Investigation of immune status in acute lung abscesses demonstrated the significance of a clinical pattern of the disease and severity of purulent destruction. The relationship may be also inverse, i.e. the specific response of the immune system to antigenic loading ++pre-determines relevant form of the disease. The addition of pleural ++pyo-inflammatory side effects is probably due to phagocytic insufficiency. Functional derangements of phagocytic system are similar to those in gangrene though less distinct.

Acute Disease↗