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A measure to aid in the interpretation of published clinical trials.

The published literature contains numerous reports of clinical studies. A problem in their interpretation is that studies in which the observed efficacy of the treatment is high are much more likely to be reported than those in which the observed efficacy is average or poor. This phenomenon has had the consequence of generally discrediting the reliability of the literature, especially that of non-randomized studies. In this paper a model is developed which permits estimation of the potential magnitude by which the reported efficacy of a treatment might be inflated. This quantity is termed the publication bias. The magnitude of the bias depends on the sample size of the study and the number of similar studies conducted concurrently. Tabulated values of the bias are presented, permitting easy computation. The new measure may have potential use for physicians in clinical decision making in that it characterizes the reliability of results from a specific published study, especially when there are no definitive randomized studies. However, correction of publication bias in this manner is not a substitute for a well controlled or a randomized study. The technique merely assists in the interpretation of available evidence from the literature. Moreover, it must be used with due caution in recognition of the assumptions and approximations involved in the calculation.

Attitude↗

Comparison of 500 spontaneous and 500 published reports of adverse drug reactions.

The information and case quality of 500 spontaneous and 500 published adverse drug reaction (ADR) reports were compared, including a study of the most common criteria used in different causality assessment methods. The criteria were more often of positive value in the published reports. Nevertheless, spontaneous reports play an important role in the detection of new ADRs.

Drug-Related Side Effects and Adverse Reactions↗

Subject descriptions, control groups, and research designs in published studies of language-impaired children.

We reviewed the 1983-1988 issues of six journals that frequently publish papers including specifically language-impaired (LI) subjects. A total of 92 research reports provided data for our review. The research reports included experimental studies, ex post facto studies, and intervention studies. These studies represent a broad spectrum of the theoretical and empirical foundations of knowledge regarding LI children. The analysis of the published research centered on subject descriptions and the use of control groups. A descriptive analysis of the data showed few consistent trends among the studies with respect to subject selection, subject description, and the number and types of control groups. We discuss the importance of more complete subject descriptions in studies of LI children as well as the importance of the choice of matching criteria for control groups in between-subjects designs.

Child↗

The completeness of MEDLINE for papers published and abstracted in the Journal of Emergency Medicine.

The purpose of this paper is to assess whether MEDLINE, a common source for reviewing the medical literature, is complete with regard to referencing papers published and abstracted in The Journal of Emergency Medicine (JEM) over a 10-year period. In that time, 1178 abstracts and 843 original contributions were included in JEM. All papers were reviewed and classified as either a review of subject, case report with review of literature, editorial, or prospective or retrospective original research. Results showed 98.5% of all original work published in JEM and 99.74% of all abstracts referenced in JEM were found in MEDLINE, thus supporting the hypothesis that MEDLINE is a complete and thorough database for current literature.

Abstracting and Indexing↗

The Open Access initiative in scientific and biomedical publishing: fourth in the series on editorship.

PURPOSE: To provide basic information about the Open Access concept and its historical development, define the benefits and challenges inherent in this new model, and identify the value of the traditional print model and its movement towards more open access. DESIGN: Review of current information on the subject from numerous sources. METHODS: Medline search and Internet search engines on the topic of Open Access Publishing. RESULTS: The Open Access initiative derives from several premises: medical libraries can no longer afford journal subscriptions; society benefits from the open exchange of ideas; society has in large part already paid for this research; the Internet provides an available venue. The traditional journal publishers model, however, has functioned well over many years with a robust peer review system and increasing Internet digital components permitting search and cross referencing, including elements of the Open Access model. CONCLUSIONS: It will be difficult to maintain the costs of both the traditional journal system and the fully implemented Open Access model. Any decisions that are made must ensure that the archive of prior medical knowledge is not lost, that financial barriers do not restrict publication, and that research continues to be available to those who need it, in the media that they prefer.

Access to Information↗

Society for Maternal-Fetal Medicine meeting presentations: what gets published and why?

OBJECTIVES: The purpose of this study was to determine the publication rate and factors influencing publication among presentations to the Society for Maternal-Fetal Medicine (SMFM) from 1991 through 2000. STUDY DESIGN: Plenary presentations matched to an equal number of concurrent presentations were examined for publication rate and associated factors by univariable and multivariable analysis, respectively. The National Library of Medicine online library, PubMed, was searched for authors and/or subject to determine publication. Various characteristics of meeting abstracts were examined related to eventual publication. RESULTS: There were 88 presentations in each group, with plenary presentations published at a higher rate (81% vs 56%, P=.004) and in more prominent journals (21% vs 1%, P <.001) than other presentations. This publication rate is higher than that reported for most other medical society meetings. Multivariable analysis identified prospective design, plenary presentation, and originality as independent predictors of publication. CONCLUSION: The SMFM meeting selection process identifies presentations likely to be published, and therefore presumably of high quality. The overall publication rate of concurrent presentations appears to be better than that of many other medical society meetings.

Congresses as Topic↗

Publishing characteristics of chairpersons of physical medicine and rehabilitation departments.

Previous studies note that specific factors intrinsic to an academic department of physical medicine and rehabilitation influence the academic productivity of individual faculty members. To determine whether one of these factors is related to the productivity of departmental chairpersons, this issue was studied for the period from 1983 to 1993. The productivity of chairpersons serving 4 or more consecutive years in the same department significantly declined. Moreover, the productivity of long-term chairpersons (greater than 10 years) was significantly below that of the group of high-frequency publishing chairpersons. Departments with long-term chairpersons also had fewer publications than departments with high-frequency publishing chairpersons. The academic productivity of the chairperson is a factor likely to influence the productivity of the department.

Administrative Personnel↗

Are published manuscripts representative of the surgical meeting abstracts? An objective appraisal.

Abstracts accepted for presentation at a pediatric surgical meeting usually result in publication. This study attempts to evaluate the relationship of abstracts to the finished, published manuscript. Thirty-three papers published in the Journal of Pediatric Surgery over a 2-year period were randomly selected and compared with their original program abstracts. Only 10 of 33 (30%) had the same title and authors as their abstract. Nine manuscripts underwent revisions of their title and two had different first authors. Nine (27%) had one more author, two had 2 more authors, and 3 had one less author. Only 11 of 33 (33%) had the same data in the paper and in the abstract. Fifteen (45%) had numbers that were mathematically inconsistent with their abstracts. (Range was from 75% fewer cases to 210% more patients.) Ten papers had smaller numbers of patients or experiments while nine had larger numbers than their respective abstracts. Of the seven experimental papers, four had smaller numbers than their original abstract. The conclusions stated in the papers were similar to the program abstracts in 23 of 33 comparisons. In the remaining ten, the conclusions were not only different but rather routinely weaker than in the abstract. In no instance were the data or conclusions stronger. Two papers bore little relationship to their abstract. These facts suggest a need for change in the current evaluation process wherein a highly competitive abstract leads to a presentation, which leads to publication. At the very least, the need is shown for authors to evaluate data completely before submitting an abstract, so that the program committee actually reads the true data.(ABSTRACT TRUNCATED AT 250 WORDS)

Abstracting and Indexing↗

Health care implications and space allocation of research published in nursing journals.

PURPOSE: To examine how research is disseminated through nursing journals and to examine characteristics of published research. DESIGN: A cross-sectional descriptive survey was conducted with manuscripts from 78 nursing journals that publish research. METHOD: The final issue for 1999 was examined. Pairs of independent raters content-analyzed all research manuscripts. DISCUSSION: Research studies comprised 241 (42.9%) of the manuscripts and 51.4% of the journal space. Many empirical studies omitted validity and reliability. Few manuscripts reported the date for completion of data collection, and fewer than one third contained the length of time from acceptance to publication. CONCLUSIONS: Enhanced instrumentation reporting, shorter time from data collection to publication, and an increase in journal space devoted to research might enable nurses to make more cutting-edge clinical decisions.

Bibliometrics↗

[Use of antihypertensive agents in Cantabria, Spain [1995-2002]: discrepancy with the published evidence].

OBJECTIVE: To ascertain the pattern of prescription of antihypertensive drugs in Cantabria and its variation from published evidence between 1995 and 2002. METHOD: We reviewed the database of the pharmaceutical data processing system of the Cantabrian Health Service on the consumption and cost of the drugs indicated in the treatment of hypertension. Consumption data is expressed in defined daily doses per thousand inhabitants and day (DID). RESULTS: Consumption of antihypertensive agents was 130.2 DID in 1995 and was 235 DID in 2002. The contribution of diuretics to overall consumption fell from 34.3% in 1995 to 25.8% in 2002, and that of beta-blockers fell from 6.5% in 1995 to 5.9% in 2002. The most commonly used group in all years was angiotensin converting-enzyme inhibitors, which represented 36.8% of consumption in 2002. Angiotensin-II antagonists showed the biggest rise, accounting for 13.2% of prescriptions in 2002 and for 26% of expenditure on antihypertensive agents. The pattern of use of the drugs utilized in the major published trials during this period showed no change or even fell, except in the case of enalapril. CONCLUSIONS: The present study confirms that the prescription antihypertensive drugs has considerably increased and that the consumption pattern of these drugs has changed. The discrepancy between these findings and those of the major trials could have significant economic implications.

Antihypertensive Agents↗

Influence of a scientific program for undergraduated medical students upon the published scientific production of professors.

Medical literature has emphasized the role of scientific research and publications in medical education. This study had the aim to detect the impact of PIC (program of scientific support) upon scientific published production of the professors teaching at Universidade Federal Fluminense. The group comprised 32 professors that participated in the PIC for at least 4 semesters. Each issue published was registered as one "product". Between 1996 and 2003, 8 years were considered for the registration of the "products" by each professor. The mean point of this period was the moment when each professor entered the program. For each professor we counted the products during the 4 years before he entered the program and during the 4 years after this occurred. Finally we summed up the products of all professors for the period before entering the program and had the mean. The same was done for the period after entering the program. Applying the paired t test, two means were reached for the two periods of scientific productivity. The same procedure was followed for two subgroups of professors: masters and doctors. The professors had 25.13 products after and 16.81 before the PIC (P< or =0.001); those with a master degree presented 16.36 products after PIC versus 5.18 before (p< or =0.08); doctors, 29.71 products after versus 22.9 products before PIC (p< or =0.028). The authors concluded that the PIC increased written production of professors, either with degree of master or doctor with relevance for those with degree of master.

Brazil↗

Noise pollution in textile, printing and publishing industries in Saudi Arabia.

A study of 20 factories belonging to textile, printing, publishing and paper products industries in Jeddah was conducted. Data on Leq, Maximum and Minimum SPL at different octave bands, as well as dBA, were collected. It has been found that textile, publishing and paper products industries are the most noisy industries. The paper is concluded with suitable recommendation for noise control and worker protection.

Humans↗

Peer review: an essential step in the publishing process.

Among the many steps involved in publishing a professional paper, peer review of the submitted manuscript presents both a challenge and an opportunity. Peer review is essential to ensuring that published papers meet appropriate research, scholarship and journal criteria. Peer review is also a valuable resource, providing detailed, professional evaluations that help authors carry out and present scholarship of the highest quality. When combined with the commitment of the Journal of Genetic Counseling to encourage and mentor authors, it is also a resource for developing writing skills.

California↗

On raising the international dissemination of German research: Does changing publication language to English attract foreign authors to publish in a German basic psychology research journal?

It has been proposed that German basic psychology journals should change publication language to English in order to facilitate access to research from German-speaking countries. However, to truly increase the dissemination of German research, it seems crucial to progress towards an internationalization of authors and readers. We applied bibliometric analysis to investigate the impact of the transition to English on the rate of foreign authors publishing in Zeitschrift für Experimentelle Psychologie/Experimental Psychology, as well as possible associated changes in citation patterns. There was an increase in the rate of articles published by foreign authors from 14.6 and 8.7 per cent, respectively, for the last biannual periods as German-language journal, to 52.7 per cent in the first biannual period as English-language journal. Regarding citations patterns, the clearest changes emerged for domestic authors. The results illustrate possible consequences of a transition to English as publication language, and reveal that Experimental Psychology has successfully established certain prerequisites for an increase of the international dissemination of German psychology research.

Bibliometrics↗

A profile of regional psychiatry publishing: home and away.

OBJECTIVE: Previous reports have profiled Australian psychiatry publishing in high-ranking international journals over the last two decades. An audit of selected high ranking and regional psychiatric journals was therefore undertaken to obtain a current profile of Australasian publishing. METHODS: Journals were selected on the basis of impact factors for the year 2000, with the top five regional, generalist and specialist journals being selected, and with publication numbers over a two-year period (1999-2000) compared with numbers from other major geographical regions. RESULTS: Of the 4573 papers identified in the 15 journals, Australasian authors contributed 269 to the regional journals (with two-thirds in the Australian and New Zealand Journal of Psychiatry), 47 to the generalist journals (with two-thirds in Psychological Medicine) and very few (23) to the specialist journals. Representation in the so-called "dominant four" international journals has increased since the 1986-1989 audit. When analysis was made of the "top nine" international journals, the Australasian representation rate was a low 1.8% and lower than most regions examined. CONCLUSIONS: If Australasian psychiatry is to advance its international presence, a greater representation rate in top-ranking international journals should be set as an objective.

Australia↗

Is the scientific publishing of complementary and alternative medicine objective?

Bias expressed by conventional journals against the field of "alternative," "integrative," or "complementary" medicine has been said to drive the appearance of new journals dedicated to this field. We examined two examples of recent articles on complementary and alternative medicine that appeared in two major medical journals in 1998. One is an editorial on the risks of alternative medicine, published in The New England Journal of Medicine and the other is a study on Therapeutic Touch, published in the Journal of the American Medical Association. We evaluated whether information and opinions presented in this editorial and article are objective or not. We found that these examples reflect, at best, misinformation or misunderstanding of the field, or at worst, disingenuousness. We consider the possibility that this apparent bias may be due to the fact that some of the concepts implicit in alternative medicine are outside the current biomedical framework. Yet, it is only by exploring knowledge outside the boundaries of existing dogmas that real (as opposed to incremental) progress can occur.

Complementary Therapies↗

A history of music therapy journal articles published in the English language.

Music therapists have had an interest in bibliographic research for over 20 years, beginning with Jellison's 1973 analysis of the frequency and types of articles appearing in the existing music therapy literature. Since then, several other researchers have continued in this line of inquiry. The purpose of this study was to (a) identify historical trends in the types of articles that have been published in major music therapy periodicals in the English language, (b) identify historical trends for each type of article within each music therapy journal, (c) to compare percentages of article types within each music therapy journal and (d) to compare percentages of article types across journals. Specifically, how many quantitative, qualitative, historical, philosophical/theoretical, clinical and professional articles have been published throughout the history of the following journals: Journal of Music Therapy, Music Therapy: Journal of the American Association for Music Therapy, Music Therapy Perspectives, The Arts in Psychotherapy, Journal of the Association for Music & Imagery, The Australian Journal of Music Therapy, The Nordic Journal of Music Therapy, The British Journal of Music Therapy, and The New Zealand Society for Music Therapy Journal.

Bibliometrics↗

Publishing the research report.

Although research is not finished until it is published, many investigators fail to report their research. The purpose of this article is to discuss the dissemination of research findings via the published manuscript. Barriers to publication are reviewed and strategies for overcoming these barriers are presented. Selection of a target journal is discussed, along with the purpose of the query letter. The format of the research report is addressed and specific information is provided regarding the literature review and the use of illustrative materials. Practical tips are provided for each stage of the writing process.

Correspondence as Topic↗