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PubMed1999

The extrinsic/intrinsic classification of two-dimensional motion signals with barber-pole stimuli.

The perceived direction of different barber-pole stimuli was assessed by adjusting an arrow on the screen. The terminator ratio (TR: number of terminators moving along the long side divided by the number of terminators moving along the small side) was either one or three. In this latter case, the aperture orientation was either vertical or horizontal. The grating was either in the same plane as the aperture (intrinsic condition) or behind the aperture--the frame containing the aperture had a crossed disparity relative to the grating--(extrinsic condition). A nested design with 120 observers was used for the whole study. Five grating orientations were intermingled within any session. With a terminator ratio of three, the results depend strongly on the aperture's orientation. When the rectangular aperture is horizontal, the perceived direction of an intrinsic grating is horizontal (the typical barber-pole illusion), whereas it is only slightly biased towards orthogonal one-dimensional (1D) motion signals (Vp) in the extrinsic condition. When the aperture is vertical, the perceived direction in the intrinsic condition is largely biased toward Vp, and on average it is close to Vp in the extrinsic condition. In this latter case, however, analysing the distributions of responses shows that many responses do not lie around Vp but are clustered near vertical or horizontal. This motion capture depends on the grating's orientation. With a terminator ratio of one, motion capture is present in both the extrinsic and intrinsic conditions. Moreover, a global bias toward horizontal is observed: this horizontal bias is much larger in the extrinsic condition. Altogether, these results suggest that binocular disparity alone is a weak determinant of the extrinsic/intrinsic classification of two-dimensional (2D) motion signals compared to the occlusion cues provided by unpaired regions in binocular images. Second, truly extrinsic 2D motion signals are not suppressed but rather actively compete against each other to capture the 1D motion signals. This results in a perceptual multistability which is much stronger with extrinsic signals. Finally, given the inherent multistability of barber-pole stimuli, high-level factors can alter the strength of this competition and prime any of the 2D motion signals.

Discrimination, Psychological↗

PubMed2001

Pseudohypoaldosteronism associated with ureterocele and upper pole moiety obstruction.

A 2-month-old girl was diagnosed with a febrile urinary tract infection. Subsequent studies revealed a right renal duplication anomaly with a poorly functioning upper pole moiety subtended by an intravesical ureterocele. The patient was also found to have hyperkalemia, hyponatremia, and elevated serum aldosterone. After antibiotic therapy, the urinary tract infection resolved, although the electrolyte and hormonal abnormalities persisted. At 4 months of age, a right upper pole heminephrectomy was performed. The patient's electrolyte and hormonal levels normalized. This case represents an unusual case of pseudohypoaldosteronism presenting with urinary tract infection and obstructed upper pole moiety that resolved after surgical intervention.

Anti-Bacterial Agents↗

PubMed2002

Prolapsed ureterocele after upper pole heminephrectomy.

Prolapse of a ureterocele through the external meatus is uncommon, and a prolapsed ureterocele occurring after upper pole heminephrectomy is extremely rare. We describe such a case, occurring 2 months after surgery. The ureterocele was excised with the upper pole ureteral stump, and the lower pole ureter was reimplanted with a good outcome.

Female↗

PubMed2003

Laparoscopic upper pole partial nephrectomy with concomitant en bloc adrenalectomy.

OBJECTIVES: To report our experience with laparoscopic partial nephrectomy for renal tumor with concomitant adrenalectomy. An upper pole renal tumor may contiguously involve the adrenal gland, requiring concomitant adrenalectomy. Although commonly performed in the setting of laparoscopic radical nephrectomy, concomitant adrenalectomy has not been described during laparoscopic partial nephrectomy. METHODS: Four patients with an upper pole renal tumor and suspected adrenal involvement underwent laparoscopic partial nephrectomy with concomitant ipsilateral adrenalectomy. Preoperative three-dimensional computed tomography revealed the renal tumor to be closely abutting the adrenal gland in 3 patients and a 4-cm adrenal mass in 1 patient. The mean renal tumor size was 3.2 cm (range 1.4 to 6.6). To maintain oncologic principles, our transperitoneal laparoscopic technique excises the adrenal gland en bloc with the renal tumor. As such, adrenalectomy is performed first, followed by partial nephrectomy, incorporating hilar control, tumor excision, and sutured renal reconstruction. RESULTS: All four procedures were performed without open conversion or intraoperative complications. The mean renal warm ischemia time was 36 minutes, estimated blood loss 169 mL, total operating time 3.9 hours, and hospital stay 3.2 days. One patient developed a transient urinary leak postoperatively. Pathologic examination of the renal tumor revealed renal cell carcinoma (n = 1), dystrophic calcification with ectopic bone formation (n = 1), adult mesoblastic nephroma (n = 1), and subcapsular heterotopic adrenal cortex with cyst (n = 1), all with negative surgical margins. Pathologic examination of the adrenal gland revealed adenoma in 1 case and a normal adrenal gland without malignant involvement in 3 cases. All patients were disease free at last follow-up (mean 6.2 months, range 2 to 12). CONCLUSIONS: In patients with an upper pole renal tumor and radiologically suspected adrenal involvement, laparoscopic partial nephrectomy with concomitant adrenalectomy can be performed efficaciously respecting oncologic principles.

Adenoma↗

PubMed2001

Asymmetric spindle pole localization of yeast Cdc15 kinase links mitotic exit and cytokinesis.

The inactivation of mitotic cyclin-dependent kinases (CDKs) during anaphase is a prerequisite for the completion of nuclear division and the onset of cytokinesis [1, 2]. In the budding yeast Saccharomyces cerevisiae, the essential protein kinase Cdc15 [3] together with other proteins of the mitotic exit network (Tem1, Lte1, Cdc5, and Dbf2/Dbf20 [4-7]) activates Cdc14 phosphatase, which triggers cyclin degradation and the accumulation of the CDK inhibitor Sic1 [8]. However, it is still unclear how CDK inactivation promotes cytokinesis. Here, we analyze the properties of Cdc15 kinase during mitotic exit. We found that Cdc15 localized to the spindle pole body (SPB) in a unique pattern. Cdc15 was present at the SPB of the mother cell until late mitosis, when it also associated with the daughter pole. High CDK activity inhibited this association, while dephosphorylation of Cdc15 by Cdc14 phosphatase enabled it. The analysis of Cdc15 derivatives indicated that SPB localization was specifically required for cytokinesis but not for mitotic exit. These results show that Cdc15 has two separate functions during the cell cycle. First, it is required for the activation of Cdc14. CD14, in turn, promotes CDK inactivation and also dephosphorylates of Cdc15. As a consequence, Cdc15 binds to the daughter pole and triggers cytokinesis. Thus, Cdc15 helps to coordinate mitotic exit and cytokinesis.

Cell Cycle Proteins↗

PubMed2001

S. pombe cdc11p, together with sid4p, provides an anchor for septation initiation network proteins on the spindle pole body.

BACKGROUND: The signal for the onset of septum formation in the fission yeast Schizosaccharomyces pombe is transduced by the septation initiation network (SIN). Many of the components of the SIN are located on the spindle pole body during mitosis, from where it is presumed that the signal for septum formation is delivered. Cdc11 mutants are defective in SIN signaling, but the role of cdc11 in the pathway has remained enigmatic. RESULTS: We have cloned the cdc11 gene by a combination of chromosome walking and transfection of cosmids into a cdc11 mutant. Cdc11p most closely resembles Saccharomyces cerevisiae Nud1p and is essential for septum formation. Cdc11p is a phosphoprotein, which becomes hyperphosphorylated during anaphase. It localizes to the spindle pole body at all stages of the cell cycle, in a sid4p-dependent manner, and cdc11p is required for the localization of all the known SIN components, except sid4p, to the SPB. Cdc11p and sid4p can be coimmunoprecipitated from cell extracts. Finally, like its S. cerevisiae ortholog Nud1p, cdc11p is involved in the proper organization of astral microtubules during mitosis. CONCLUSIONS: We propose that cdc11p acts as a bridge between sid4p and the other SIN proteins, mediating their association with the spindle pole body.

Cell Cycle↗

PubMed2005

Impact of lower pole anatomy on stone clearance after shock wave lithotripsy.

This study retrospectively analyzed patients treated with shock wave ithotripsy (SWL) for lower calyceal stones, to determine the influence of the lower pole anatomy and stone size in predicting the clearance of fragments. Between June 2000 and March 2002, we reviewed excretory urography (IVU) of 59 patients with isolated lower pole stones treated with SWL. A total of 44 men and 15 women, with an age ranging between 23 and 78 years (mean, 55 years), were included in the study. The patients were divided into two groups, either a stone-free group or residual-stone group. After SWL, overall stone rate was 57.6%, and clearance for stones less than 10 mm in diameter was 64.5%, whereas clearance was 50% for stones between 10 and 20 mm in diameter. Intrarenal anatomy on IVU, such as infundibular width and infundibulopelvi-ureteric angle showed no significant difference between the stone-free and residual-stone groups. Our analysis showed that three significant variables were relevant to stone clearance: infundibular length, stone size and stone burden. We conclude that SWL is the best treatment for lower pole kidney stones 10 mm or less in diameter, showing lower complication and acceptable stone-free rates.

Adult↗

PubMed1991

Combined study to assess the role of calcium alginate swabs and ligation of the inferior tonsillar pole in the control of intra-operative blood loss during tonsillectomy.

Bleeding is the major source of morbidity and mortality of tonsillectomy and most operative time is spent securing haemostasis. Calcium alginate reduces experimental wound blood loss. This study assessed the efficacy of alginate swabs during tonsillectomy and inferior tonsillar pole ligation in the control of blood loss during tonsillectomy. Ninety-nine tonsillectomy patients were randomized to gauze or alginate swab use. A haemoglobinometer measured blood losses collected by suction during dissection and by swab until haemostasis was secured. Operative time, complications and healing were also assessed. Mean total blood losses and operative times were similar for the two groups. Swab blood loss was significantly lower for surgeons who ligated the lower tonsillar pole, compared with surgeons who used a snare. This finding was independent of swab type. Independent assessment showed no difference in the healing rate. Alginate swabs offer no advantage over gauze in terms of blood loss, operative time or complications of tonsillectomy. The results show that routine lower pole ligation significantly reduces post-dissection blood loss. We suggest that this technique should be more widely adopted.

Adolescent↗

PubMed2002

Investigation of the volatile organic substances that cause the characteristic odor of pentachlorophenol treated wood utility poles.

The nature of the volatile organic compounds that could be at the origin of the characteristic odor of treated wood utility poles was investigated by the study of compositional changes in the chromatographic profiles of fresh-pentachlorophenol (PCP) solvent samples and weathered samples collected from an in-service red pine pole. Over 99 peaks were identified in the chromatogram of the fresh solvent from which a large portion of the C3-, C4-, C5-, C6-alkylbenzene isomers and early eluting n-alkanes was missing from the analysis of weathered samples. Three domains in the chromatographic profile (volatile, semivolatile, and nonvolatile components) were confirmed by assessing the headspace of fresh-PCP solvent samples using direct syringe sampling and solid-phase microextraction. A first level of field validation was achieved using an emission cell for measuring substances emanating from sapwood specimens at different temperatures. The average latent heat of vaporization (deltaHvap) of the PCP-solvent components was estimated at 99.9 kJ/mol from these results. Finally, the analysis of airborne substances at a treating plant and a utility pole storage site confirmed that the C4-, C5-, and C6-alkylbenzene isomers could contribute to the characteristic odor perceived by humans.

Air Pollutants↗

PubMed2006

Significant enhancement of the optical second harmonic generation in a poled azopolymer thin grating.

Nonlinear optical properties of an electrically poled surface relief grating inscribed on a thin film of azopolymer have been investigated. The linear and nonlinear optical far-field diffraction patterns of the grating are compared, and they show a clear angular separation of the fundamental (lambda = 1.064 mum) and second harmonic generated beams that are diffracted at different angles. The intensity of the zero order transmitted second harmonic generation (SHG) beam from inscribed surface relief grating (SRG) areas has been recorded using the Maker fringe technique and compared to the response from flat areas that were only poled. Poled gratings exhibit a sharp second harmonic generation enhancement for coupling angles of theta(i) = +/-52 degrees due to a quasi-phase matching process. A simple phenomenological model allows one to explain both the second harmonic intensity generated from the thin polar film and the dispersion curve observed under "pp" polarization due to the mismatch of the angular coupling condition: this gives us a good indication of the intensity enhancement of the SHG beam in the forward direction.

Letter↗

PubMed2000

Evidence that kinetochore fibre microtubules shorten predominantly at the pole in anaphase flea-beetle spermatocytes.

Kinetochore spindle fibres in flea-beetle metaphase primary spermatocytes have two regions with distinct morphologies. As seen after staining with antibodies against tubulin, the kinetochore microtubules are tightly bundled in the 5 microm closest to the kinetochore but they splay out in the region closest to the pole. This morphology persists throughout anaphase. This distinct morphology allows one to deduce the site where kinetochore microtubules depolymerise during anaphase. During poleward movement of the autosomes in anaphase, the bundled region shortens by about 0.25 microm for each 1 microm the chromosome moves poleward; this suggests that, during anaphase, 75% of the kinetochore microtubule shortening occurs at the pole end. Sex chromosomes in metaphase cells are separated from the autosomes and do not move poleward at the same time as the autosomes: they are reported to move poleward when the autosomes are in metaphase, to stop part way to the poles, and to move poleward again as the autosomes do (Virkki 1970). Kinetochore microtubules of the sex chromosomes also have bundled and splayed regions; measurements of those regions suggest that these chromosomes may move poleward before the autosomes enter anaphase, but not afterwards.

Anaphase↗

PubMed2004

Case report: Minimally invasive treatment of an unusual obstructive ectopic upper pole ureter.

An 18-year old man presented with left loin pain and recurrent urinary tract infections. Ultrasound and IVU revealed a duplex left kidney with hydronephrosis of the upper pole moiety. F-15 Mag-3 renography confirmed obstruction of the upper pole moiety. Cysto-urethroscopy identified the site of ectopic insertion to be adjacent to the verumontanum in the prostatic fossa. Retrograde ureterography showed the level of obstruction and dilation of the stricture was carried out. Post operatively, the patient became asymptomatic and remains so at 5-year follow up. This is an unusual case of obstructive upper pole ureter with an ectopic insertion into the prostatic fossa. We also demonstrated that dilatation of a stricture at this site can achieve good long term outcome.

Adolescent↗

PubMed2000

Functional stabilization of unstable fixed points: human pole balancing using time-to-balance information.

Humans are often faced with tasks that require stabilizing inherently unstable situations. The authors explored the dynamics of human functional stabilization by having participants continually balance a pole until a minimum time criterion was reached. Conditions were manipulated with respect to geometry, mass, and characteristic "fall time" of the pole. Distributions of timing between pole and hand velocities showed strong action-perception coupling. When actions demonstrated a potential for catastrophic failure, the period of hand oscillation correlated well with the perceptual quantity "time to balance" (tau(bal) = theta/theta), but not other quantities such as theta and theta alone. This suggests that participants were using available tau(bal) information during critical conditions, although they may not have been attending to this type of perceptual information during typical, noncritical motions of successful performance. In a model analysis and simulation, the authors showed how discrete tau(bal) information may be used to adjust the parameters of a controller to perform this task.

Adolescent↗

PubMed2000

Localization of the histidine kinase PilS to the poles of Pseudomonas aeruginosa and identification of a localization domain.

Transcription of the type IV pilus subunit gene of Pseudomonas aeruginosa is controlled by a two-component signal transduction system. PilS, the histidine kinase, is membrane bound and PilR, its cognate response regulator, is cytoplasmic. The signal that activates PilS is unknown. PilS has three domains: (i) The N-terminus, predicted to form six transmembrane (TM) helices; (ii) a central linker domain; and (iii) the C-terminal transmitter domain containing all the conserved residues of sensor kinases. A translational fusion of the gfp gene (green fluorescent protein) to the 3' end of pilS was used to determine the position of PilS in the bacterial cell. Epifluorescence microscopy revealed that PilS is retained to the poles of P. aeruginosa but is distributed evenly about the membrane of Escherichia coli. Deletions of the PilS-GFP fusion revealed that the TM domain was sufficient and necessary to bring GFP to the membrane of P. aeruginosa and E. coli but was not sufficient to confine GFP to the poles. Retention to the poles of P. aeruginosa required both the TM and linker domains. Replacement of the PilS TM domain with an E. coli membrane protein, MalG, still allowed polar localization. Therefore, the PilS TM domain positions the linker domain close to the membrane allowing it to interact with the putative polar anchor which is specific to P. aeruginosa.

Bacterial Proteins↗

PubMed2003

Penicillin-binding protein PBP2 of Escherichia coli localizes preferentially in the lateral wall and at mid-cell in comparison with the old cell pole.

The localization of penicillin-binding protein 2 (PBP2) in Escherichia coli has been studied using a functional green fluorescent protein (GFP)-PBP2 fusion protein. PBP2 localized in the bacterial envelope in a spot-like pattern and also at mid-cell during cell division. PBP2 disappeared from mid-cell just before separation of the two daughter cells. It localized with a preference for the cylindrical part of the bacterium in comparison with the old cell poles, which are known to be inert with respect to peptidoglycan synthesis. In contrast to subunits of the divisome, PBP2 failed to localize at mid-cell when PBP3 was inhibited by the specific antibiotic aztreonam. Therefore, despite its dependency on active PBP3 for localization at mid-cell, it seems not to be an integral part of the divisome. Cells grown for approximately half a mass doubling time in the presence of the PBP2 inhibitor mecillinam synthesized nascent cell poles with an increased diameter, indicating that PBP2 is required for the maintenance of the correct diameter of the new cell pole.

Cell Division↗

PubMed1999

Extracorporeal shock wave lithotripsy for lower pole calculi: our experience.

INTRODUCTION: This study was performed in order to evaluate the immediate and long-term outcome of patients undergoing extracorporeal shock wave lithotripsy (ESWL) for isolated lower pole calculi. METHODS: Three hundred and seventy renal units of 350 patients (240 men and 110 women; mean age 55 years) with isolated lower pole renal stones of smaller than 2 cm2 were studied. Follow up ranged from 1 to 52 months (mean, 15 months) to time of censorship, significant period of secondary urologic evaluation. RESULTS: Out of 370 renal units in 350 patients, 212 (57, 29%) were stone-free 1 month after ESWL and 21 (5.67%) spontaneously became stone-free within another 1-52 months (mean, 15 months). Intervention was required after 1-52 months (mean, 17.5 months) and accomplished by ESWL alone (30/350 patients 8.57%) or combined with retrograde endoscopy (10/350 patients 2.85%) while retrograde manipulation was necessary in two of the 350 patients (0.57%). CONCLUSION: Extracorporeal shock wave lithotripsy is the initial treatment of choice in patients with lower pole stones < 2 cm2, because the overall stone-free rate is acceptable and because even in the residual calculi, the risk of suffering symptomatic episodes requiring secondary intervention is low.

Female↗

PubMed1997

Histology of the upper pole in complete urinary duplication--does it affect surgical management?

OBJECTIVE: To review the histological change in the upper pole of excised duplex kidneys and assess whether ante-natal diagnosis might predispose to more conservative surgical management of this abnormality. PATIENTS AND METHODS: Fifty consecutive patients undergoing upper pole hemi-nephroureterectomy for ectopic ureter or ectopic ureterocele between 1980 and 1992 had their histology reviewed and assessed for dysplastic, inflammatory and obstructive change. RESULTS: Segmental scarring and chronic and acute inflammatory change occurred consistently and the degree of inflammation seemed unaffected by antenatal diagnosis. Dysplasia was seen in 70% of patients with ureterocele and in only 30% of those with ectopic ureter. One patient had normal histology. CONCLUSION: There was no evidence of reversible histological change in patients with ectopic ureter and ectopic ureterocele who were diagnosed ante-natally. Preservation of the upper pole of the kidney does not seem justified in the light of the histological evidence.

Cicatrix↗

PubMed2006

[Nordic pole walking injuries--nordic walking thumb as novel injury entity].

BACKGROUND: Nordic pole Walking (NW) as trend sport is associated with beneficial effects on the cardiovascular system. Data regarding the injury and overload injury rates are pending. METHODS: 137 athletes (74 % females, 53 +/- 12 years, weight 73 +/- 13 kg, height 169 +/- 11 cm) were prospectively ask using a two-sided questionnaire. Mean NW experience was 212.8 weeks with 2.9 +/- 1.8 hours/week. The overall exposure was 29 160 h. RESULTS: NW injury rate was 0.926/1000 h. Falls were evident in 0.24/1000 h. The upper extremity was involved more frequently (0.549/1000 h) than the lower extremity (0.344/1000 h). The most severe injury was a concomitant shoulder dislocation and luxation of the proximal interphalangeal joint of the index finger after a fall. The most frequent injury in NW was a distorsion of the ulnar collateral ligament of the thumb (0.206/1000 h) after fall. Shoulder injuries account for 0.171/1000 h with 0.069/1000 h shoulder dislocations. Distal radius fractures were rare as ankle sprains and shinspints (0.034/1000 h). Muscle injuries were encountered only at the gastrocnemius muscle (0.137/1000 h). No knee ligament injuries were noted. In 5%, NW injuries caused interruption of the performance, with all patients returning to sport within 4 weeks on the same level as before. DISCUSSION: Nordic Walking is safe. Most frequently, a Nordic walking thumb is encountered during a fall with the athlete holding on to the NW pole until the very last moment before the hand hits the ground with the pole handle as hypomochlium that forces the thumb into abduction and extension. Modifications of the grip construction as well as information of the athlete and behaviour changes may be preventive measures.

Accidental Falls↗