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PubMedDate not supplied

Periosteal fasciitis of the mandible.

BACKGROUND: Periosteal fasciitis is rare in the head and neck. We believe only two cases of fasciitis-induced erosion through the mandibular cortical plate have previously been reported. RESULTS: Management of a case of periosteal fasciitis with bone erosion at the mandibular angle is reported in a 38-year-old man. CONCLUSIONS: Misdiagnosis of fasciitis in the past has led to inappropriate management and unnecessary morbidity. The principles of diagnosis and management of this unusual and confusing disorder are highlighted.

Adult↗
PubMed2002

Matrix engineering for osteogenic differentiation of rabbit periosteal cells using alpha-tricalcium phosphate particles in a three-dimensional fibrin culture.

Tissue engineering using periosteal cells is a promising approach for bioactive bone repair. Of central importance in tissue engineering is the cell-matrix interaction. In the present study we tested in vitro the influence of alpha-tricalcium phosphate (alpha-TCP) particles on the expression of osteogenic markers in rabbit periosteal cells embedded in specially manufactured fibrin beads. After cell isolation from tibial periosteum of New Zealand White rabbits, and following monolayer culture, cells were embedded in alginate-fibrin beads containing 7.5% alpha-TCP particles and, as a control group, in beads without particles. The alginate was extracted immediately after polymerization. The beads were cultivated for at least 53 days. The DNA content, alkaline phosphatase activity, and osteocalcin level were determined. In monolayer culture the number of cells increased 6.5-fold. DNA content increased in both three-dimensional culture groups but was significantly higher in the beads containing alpha-TCP. Alkaline phosphatase activity increased in both groups without significant differences. Osteocalcin content was significantly higher in the beads containing alpha-TCP than it was in those without alpha-TCP. These observations indicate that matrix engineering using inorganic particles in fibrin culture can influence the osteogenic differentiation of mesenchymal cells. The three-dimensional culture system presented here facilitates the preparation of grafts for bone reconstruction.

Alkaline Phosphatase↗
PubMed1988

On how the periosteal bone of the delphinid humerus becomes cancellous: ontogeny of a histological specialization.

In cetaceans, the bones of the flippers lack a free medullary cavity and have a cancellous texture, with compact cortices reduced or absent. The present work discusses the ontogenetic basis of these characters in terms of the ontogeny of the structure and textural bone compactness (TBC) of the humeral diaphysis in a growth series of common dolphins (Delphinus delphis). The texture of the primary periosteal deposits is compact; soon after their accretion, the deposits undergo an extensive erosion that turns them into a cancellous tissue. A diffuse endosteal front of resorption expands in parallel with the growth of the cortex and acts as small units scattered within the cortices. Starting soon after birth and continuing throughout the life of the animals, the compactness of the periosteal cortex decreases at both general and local levels. This trend correlates strongly with the increase in size of the diaphyseal section and reflects the fact that relatively more bone is eroded than deposited during growth in the cancellous parts of the cortex. In the broad sense, this is basically an osteoporotic process, which is not identical, however, to senile or disuse osteoporoses.

Animals↗
PubMed1998

Osteogenic potential of cultured periosteal cells in a distracted bone gap in rabbits.

Osteogenesis of cultured periosteal cells was investigated in a bone-defective gap that was created artificially by distraction in the tibia of 12-week-old rabbits. A 10-mm circumferential length of periosteum was stripped from each stump of the osteotomized tibia, and the tibia was distracted rapidly (2 mm/day), resulting in disturbance of callus formation. Periosteal-derived cells, which were isolated from the contralateral tibia, were introduced into cell culture, subcultured twice to a population of 5 x 10(7) cells, and then injected into the defective bone gap when distraction was complete. Following inoculation of the cultured cells, significant new bone formation in the bone gap was observed. The control group which did not undergo cell transplantation showed only slight new callus formation which is supposed to be formed by osteogenic cells from the bone marrow. The bone mineral content of newly formed bone between the distracted tibia was analyzed quantitatively on radiographs. Histologically, the transplanted cells initially formed a mass at the injected site and then gradually differentiated into bone tissue from the peripheral region. Bromodeoxyuridine immunohistochemical stain was utilized to investigate the localization of the transplanted cells. The present study confirms that the orthotopically implanted periosteum-derived cells facilitate osteogenesis in a bone defect created using distraction in rabbits.

Animals↗
PubMed1993

Case report 793. Periosteal osteosarcoma of the clavicle.

A case of periosteal osteosarcoma in an 18-year-old boy has been reported. This is the first reported case of periosteal osteosarcoma arising in the clavicle. The radiological features in this case were entirely similar to those in long bones such as the femur and tibia. In addition to the radiological features and pathologic findings, various clinical aspects and prognosis were also discussed.

Adolescent↗
PubMed1994

Case report 819: Periosteal Ewing's sarcoma of the tibia.

An exceptionally rare case of periosteal Ewing's sarcoma involving the mid shaft of the right tibia was reported. In this case, MRI was the technique that confirmed the integrity of the bone marrow. The clinical, radiographic, and histopathologic features of Ewing's sarcoma have been discussed, as has the differential diagnosis of the periosteal type of this tumor.

Adolescent↗
PubMed1994

Noninvasive loading of the rat ulna in vivo induces a strain-related modeling response uncomplicated by trauma or periostal pressure.

Adaptive changes in bone modeling in response to noninvasive, cyclic axial loading of the rat ulna were compared with those using 4-point bending of the tibia. Twenty cycles daily of 4-point bending for 10 days were applied to rat tibiae through loading points 23 and 11 mm apart. Control bones received nonbending loads through loading points 11 mm apart. As woven bone was produced in both situations, any strain-related response was confounded by the response to direct periosteal pressure. Four-point bending is not, therefore, an ideal mode of loading for the investigation of strain-related adaptive modeling. The ulna's adaptive response to daily axial loading over 9 days was investigated in 30 rats. Groups 1-3 were loaded for 1200 cycles: Group 1 at 10 Hz and 20 N, Group 2 at 10 Hz and 15 N, and Group 3 at 20 Hz and 15 N. Groups 4 and 5 received 12,000 cycles of 20 N and 15 N at 10 Hz. Groups 1 and 4 showed a similar amount of new bone formation. Group 5 showed the same pattern of response but in reduced amount. The responses in Groups 2 and 3 were either small or absent. Strains were measured with single-element, miniature strain gauges bonded around the circumference of dissected bones. The 20 N loading induced peak strains of 3500-4500 mustrain. The width of the periosteal new bone response was proportional to the longitudinal strain at each point around the bone's circumference. It appears that when a bone is loaded in a normal strain distribution, an osteogenic response occurs when peak physiological strains are exceeded. In this situation the amount of new bone formed at each location is proportional to the local surface strain. Cycle numbers between 1200 and 12,000, and cycle frequencies between 10 and 20 Hz have no effect on the bone's adaptive response.

Animals↗
PubMed1996

Periosteal chondroma developing in a rib at the side of a chest wall wound from a previous thoracotomy: report of a case.

We describe herein the case of a 45-year-old man who developed a periosteal chondroma in a rib at the site of a thoracotomy that had been performed 24 years previously. To our knowledge, this is only the third case of a periosteal chondroma in a rib to be documented in the world literature. Some authors have suggested that trauma, including that of surgery, may induce chondroma formation and this association could have been an important contributing factor in the induction of the tumor in this patient.

Bone Neoplasms↗
PubMed1994

Time-dependent effects of parathyroid hormone and prostaglandin E2 on DNA synthesis by periosteal cells from embryonic chick calvaria.

Both PGE2 and PTH (1-34) caused a time- and concentration-dependent stimulation of proliferation by embryonic chick periosteal cells. Cells were exposed to the agents for different periods of time, the medium was replaced with fresh medium, and 3H-TdR incorporation was measured after 16 hours. Challenge with 10(-6) M prostaglandin E2 (PGE2) or 10(-7) M parathyroid hormone (1-34) (PTH) for 5 minutes produced 4- and 5.5-fold increases in 3H-TdR incorporation, respectively. Longer exposures, however, produced diminishing responses and after 45 minutes, only minimal effects or slight inhibitions were seen. These time-dependent effects were also seen with forskolin and dibutyryl-cAMP; TPA on the other hand stimulated DNA synthesis after both short- and long-term exposure. Both PGE2 and PTH (1-34) stimulated cAMP synthesis in periosteal cells but neither could be shown to stimulate protein kinase-C (PKC) at concentrations required for stimulation of proliferation, and dibutyryl-cyclic AMP (cAMP) effectively inhibited endogenous PKC activity. It is possible that the stimulation of proliferation by short-term exposure to PGE2 and PTH (1-34) is mediated by cAMP and that the time dependency possibly stems from the inhibition of endogenous PKC activity by increased intracellular cAMP levels.

Animals↗
PubMed1992

(Sub)periosteal Ewing's sarcoma of bone.

Ewing's sarcoma is a small malignant round-cell tumour that arises from mesenchymal cells, predominantly in the medullary cavity of bone. In exceptional cases it originates in the soft tissues and subsequently invades the underlying bone. A (sub) periosteal origin of Ewing's sarcoma is a very rare condition: only a few cases have been published so far. Three cases of (sub)periosteal Ewing's sarcoma, having received neoadjuvant chemotherapy and radiation therapy as well as wide excision, are reported.

Adolescent↗
PubMed1976

Changes in alkaline phosphatase activity in periosteal cells in healing fractures.

The quantitative changes in alkaline phosphatase activity in the periosteal cells close to the fracture in rat metatarsal bones has been measured during the first 5 days postfracture. This study has been made possible by two technological advances, firstly the development of cryostat microtomy for cutting unfixed, undemineralised bone, and secondly the use of scanning and integrating microdensitometry for quantifying the activity in each periosteal cell. The results showed a loss of alkaline phosphatase activity close to the fracture site, with activity rising to normal values 0.8-1.0 mm from the site. No alkaline phosphatase activity was found in the cells which proliferated from the periosteum. It is suggested that reduced glutathione could cause such inhibition.

Alkaline Phosphatase↗
PubMed1986

Unilateral mid-femoral periosteal newbone of varying aetiology in children. Radiographic analysis of 25 cases.

Thigh pain is a serious condition in childhood and should be promptly and thoroughly investigated. Twenty-five cases of thigh pain lasting between 1 day and 7 months with mid-femoral periosteal thickening were analysed. There were 10 patients with Ewing's sarcoma, 7 with eosinophilic granuloma, 1 with osteoid osteoma, 1 with leukaemia, 3 with osteomyelitis, 1 with myositis and 2 with post-traumatic periosteal reaction. It was shown that patients with Ewing's sarcoma and eosinophilic granuloma have certain patterns of X-ray changes of high diagnostic value, which allow a proper diagnosis in most cases.

Adolescent↗
PubMed1981

Virally induced periosteal osteogenesis in mice.

Inoculation of Moloney murine sarcoma virus (M-MSV) into shank muscles of adult NMRI mice resulted in localized sarcoma and periosteal membrane proliferation with subsequent periosteal bone formation. Newly formed bone arose from outer surface of shank bones. Two weeks after M-MSV inoculation the width of bone cortex increased nearly 4 times. The spaces between newly formed bone ossicles were filled with bone marrow. In the later stages these bone marrow cavities were merged with medullar cavities. No extraskeletal bone formation was observed. The regression of M-MSV-induced sarcomas coincides with cessation of the proliferation of bone therefore allowing the maturation and rebuilding of bone. Newly formed bone was not resorbed during a 6-month observation period.

Animals↗
PubMed1985

Differences in periosteal and corticoendosteal bone envelope activities in spayed and intact beagles: a histomorphometric study.

Resorptive and formative characteristics of the periosteal and corticoendosteal envelopes of the ribs of intact and spayed Beagle dams were studied. Six 4-year-old Beagle dams were spayed at source and kept under observation for 12 months. Four intact age- and weight-matched Beagle dams were used as controls. Before euthanizing, all dams received tetracycline labeling of their bones. Histomorphometric analyses of resorptive and formative parameters of the periosteal and corticoendosteal envelopes were carried out blind. The results indicated that following oophorectomy, there is an increase in resorptive surfaces on the periosteum and corticoendosteum, and a decline of formative activity on these same envelopes. These changes were manifested to a greater extent on the corticoendosteum. The lack of ovarian hormones contributes to an increase in the mineralization lag-time on the periosteum. Although in both control and spayed dams a similar pattern of surface activity was observed on both envelopes investigated, the differences in degree may be attributable to the ovarian hormone withdrawal.

Animals↗
PubMed1986

Surface activity on the periosteal and corticoendosteal envelopes following continuous progestogen supplementation in spayed beagles.

Resorptive and formative characteristics on the periosteal and corticoendosteal bone envelopes were assessed on the ribs of intact, spayed and medroxyprogesterone acetate (MPA)-supplemented Beagle dams. Histomorphometric analyses of the alterations on surface activities of these two envelopes were carried out using tetracycline labeling. It was found that continuous administration of progestogen decreased the extent of resorptive surfaces on the corticoendosteal surfaces of progestogen-treated animals vs. spayed animals. On the periosteal surfaces the progestogen-treated dogs showed a marked increase in formation when compared to spayed and intact dogs. As a result of continuous progestogen treatment, mineralization lag time was shortened on the corticoendosteum and periosteum of progestogen-treated animals when compared to the same surfaces on the bones of intact and spayed animals.

Animals↗
PubMed2003

Combination of microfracture and periostal-flap for the treatment of focal full thickness articular cartilage lesions of the shoulder: a prospective study.

Focal full-thickness articular cartilage lesions of the shoulder are less common than those of the lower extremity but are often symptomatic and may progress to degenerative osteoarthritis. This prospective study evaluated our clinical results for cartilage repair in five patients with chondral defects localized at the humeral head using a combination of microfracture and periostal flap, all by deltoidopectoral approach. Mean follow-up was 25.8 months (range 24-31) and consisted of a clinical examination, Constant score examination, radiography, and magnetic resonance imaging; three patients underwent a second-look arthroscopy an average of 8 months following cartilage repair. We found the Constant score significantly improved over the preoperative level, from 43.4% to 81.8%. Pain was reduced significantly to 18.6 points. Radiography and magnetic resonance imaging showed progression of the osteoarthritis in two patients. Second-look arthroscopy revealed a significantly reduced cartilage lesion. This is the first report of a combination of microfracture and a periostal flap for repair of focal full-thickness cartilage lesions at the shoulder. Short-term follow-up clinical results were satisfactory. It is essential to address the underlying pathology. Results must be reconfirmed in a long-term study.

Adolescent↗
PubMed2006

Periosteal transplantation to the rabbit patella.

Autologous periosteal transplantation (without chondrocyte cell transplantation) for treating traumatic articular cartilage defects of the patella gives pain relief in uncontrolled clinical studies. To study the whole transplanted area macroscopically and microscopically, animal studies are motivated. In this pilot study, we reproduce the surgical technique for periosteum transplantation on human patella to a rabbit model. A full-thickness cartilage defect of the whole patella was created in eight adult female rabbits. The defect was treated with autologous periosteal transplantation. After surgery, the rabbits were allowed free activity. This is the difference compared to the treatment in humans, where our group uses CPM for 5 days and non-weight-bearing for 12 weeks. After 21 weeks, there was a diffuse synovitis in all transplanted knees, and in five of eight knees there were signs of osteoarthritis in the patello-femoral joint. Histologically, in three animals, small islands of hyaline cartilage surrounded by fibrocartilage were seen in the transplanted area. In the other five animals, fibrocartilage was the predominant tissue. In contrast to previous experimental studies using a rabbit model, we did not achieve hyaline cartilage resurfacing.

Animals↗
PubMed1998

Treatment of deep cartilage defects of the patella with periosteal transplantation.

Twenty-six consecutive patients (19 men and 7 women) with a mean age of 31.5 years (range 19-52 years) who suffered from an isolated full-thickness cartilage defect of the patella (area ranged from 0.75 to 20.0 cm2) and disabling knee pain were treated with autologous periosteal transplantation (without any chondrocytes). The duration of symptoms was 59 months (range 11-144 months). During the first 5 postoperative days all patients were treated with continuous passive motion (CPM). This was followed by active motion, slowly progressive strength training, and slowly progressive weight-bearing. After a mean follow-up of 42 months (range 24-76 months), 17 patients (65%) were graded as excellent (were painfree), 8 patients (31%) as good (had pain with strenuous knee-loading activities), and 1 patient as poor (had pain at rest). Twenty-two patients (85%) had returned to their previous occupation. Twelve patients (46%) had resumed sports or recreational activities at their former level. Repeated magnetic resonance imaging (MRI) investigations showed progressive, and finally complete, filling of the articular defects. Biopsies taken in five randomly selected cases showed hyaline-like cartilage. Patients with full-thickness cartilage defects of the patella and disabling knee pain can be treated with autologous periosteal transplantation (without any chondrocytes), followed by CPM, and slowly progressive strength training and weight-bearing. We believe this is a good method to accomplish regeneration of articular cartilage and satisfactory clinical results.

Adult↗