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First branchial cleft anomalies have relevance in otology and more.

INTRODUCTION: First branchial cleft anomalies account for less than 8% of all branchial abnormalities. Their rarity and diverse presentations have frequently led to misdiagnosis and inappropriate treatment. In a trend towards specialisation/subspecialisation, first branchial cleft duplication anomalies, with their varied clinical manifestations, may possibly present to an Otology, Head and Neck Surgery, Paediatric Otolaryngology, Maxillofacial or even a General Paediatric and General Surgery practice. There is a need to highlight the clinical features which can aid in accurate diagnosis. CLINICAL PICTURE, TREATMENT AND OUTCOME: A case of an adult with Work Type 2 first branchial cleft duplication anomaly presenting as a collaural fistula is described. It first presented as a recurrent upper neck abscess in childhood. The diagnosis had previously been missed although the patient was able to clearly establish a correlation between digging of the ipsilateral ear and precipitation of the abscess. Instead of an epidermal web, a myringeal lesion in the form of a fibrous band-like was present. The lesion was completely excised with no further recurrence. CONCLUSION: This case highlights useful diagnostic features both from the history and physical examination. The specialist/subspecialist must be aware of this condition and be mindful of its possible cross specialty/subspecialty symptoms and signs. Together with a good understanding of the regional embryology and anatomy, the lesion can be diagnosed early at initial presentation with the potential for best treatment outcomes.

Branchial Region↗

Assessment of antibacterial activity of some topical otological solutions.

OBJECTIVES: Otological solutions have long been used in the treatment of the bacterial and fungal infections of the ear. We investigated antibacterial activity of some otic solutions against the most common bacteria isolated from discharging ears. STUDY DESIGN: Three solutions were used (Castellani's, Burrow's, and 2% salicyl alcohol) for 20 fresh isolates of each of the following organisms: Staphylococcus aureus, Proteus mirabilis, Pseudomonas aeruginosa, Escherichia coli, and Enterobacter spp.. The activity of each solution was determined by the size of the zone of inhibition of bacterial growth. RESULTS: The Castellani's solution showed significantly larger average inhibition zones than the other solutions did (p<0.001). CONCLUSION: The Castellani's solution may be considered a good option against bacterial or mixed infections (bacterial and fungal) of the ear.

Administration, Topical↗

[Chemical content analysis of specimens of human head temporal portion commercially distributed for otological surgery lessons].

Specimens of the human head temporal portion are provided in the United States and distributed commercially for lessons in otological surgery via the internet. Many otologists have obtained and used these specimens in Japan. According to our chemical content analysis, these specimens were found to contain harmful substances as well as large molecule aldehydes and fatty acid methylesters, which are not or only rarely included in the human cadaveric specimens prepared in Japan. We discuss the suggested treatment of these imported specimens, how trial preparation of specimens are much better than the imported items, and the background of the rapid and wide distribution of the imported items in Japan.

Alcohols↗

[Biomaterials in otology].

Biomaterial may be biological or non-biological in origin. Only the latter will be considered here. Their possible use in otology is threefold: ossiculoplasty: the author recalls the different materials used during the past 30 years. Today, it seems that only certain ceramics are able to compete with auto and homografts. Hydroxylapatite ossicles are a perfectly good alternative; canal wall reconstruction in radical operations: in this context their role appears to be less satisfactory than that of autografts; cavity obliteration: very useful and effective when performed in the correct situation and under certain well-defined technical conditions. After outlining the different materials used in the past 30 years, the author draws upon the experience of his own school to give his personal opinion.

Biocompatible Materials↗

False ankylosis of the temporomandibular joint after otologic and neurotologic surgery.

Two cases of ankylosis of the temporomandibular joint (TM) after otologic and neurotologic surgery involving an approach through the temporal fossa are reported. The etiology is believed to be that of fibrous contracture within the temporalis muscle, which is incised during the procedure. If the possibility of this rare complication is anticipated, the immediate instigation of prophylactic jaw exercises and forced opening with tongue depressors can significantly limit morbidity. If the condition is allowed to become established, then surgical correction by coronoidectomy may be necessary.

Adult↗

Anomalous facial nerve: the otologic surgeons' abyss.

Iatrogenic injury to the facial nerve is certainly the most apparent if not the most feared complication faced by the otologic surgeon. The temporal bone with its tightly packed sensory structures is no place for the "occasional operator". A thorough knowledge of temporal bone anatomy is of course required. On occasion, as in other areas of life, one encounters the unexpected and must be prepared to "adjust" to the situation at hand. An instructional case involving an anomalous facial nerve is presented. A review of the developmental anatomy of the facial nerve, preoperative diagnostic imaging and landmarks for determining the course of the main facial nerve trunk are discussed.

Aged↗

[Efficacy of Cefsulodin in pyocyanic otologic infections, apropos of 55 cases].

Our work consists of a comparative study of 4 therapeutic protocols for treatment of otological infection from the pyocyanic bacillus, and more specifically of 19 patients with a necrotizing malignant otitis, 24 patients with perichondritis and 12 patients suffering from a post-operative infection. The association of Cefsulodin (a 3rd generation Cephalosporin) and Gentamicin gave the best results. A major decrease of the time of treatment and a total absence of infectious complications were in fact recorded. The adjuvant therapies were duly observed for the 4 protocols, in particularly the surgical treatment and the treatment of the site (diabetes).

Bacterial Infections↗

[Otological manifestations of leukemia. Apropos of a clinical case].

The authors describe a clinical case of acute lymphoblastic leukemia, showing major leukemic infiltration of the cochlea and the acoustic nerve. The patient however didn't present any otological symptom. A brief literature review is added (clinical aspects, histopathological aspects ...). The authors stress on performing routine audiometric examinations in leukemia, especially in the acute forms of the disease.

Adult↗

Routine intraoperative facial nerve monitoring during otologic surgery.

We have used intraoperative monitoring and stimulation of facial nerve function routinely in 301 consecutive otologic and neurotologic cases. The device has been safe, simple to use, and practical. Facial contraction is detected by a strain-gauge sensor in the corner of the mouth and is signalled audibly to the surgeon. Electrical stimulation of the facial nerve can be delivered through a sterile probe, which produces a constant-current-square-wave impulse. The device has several advantages: it signals unintentional mechanical stimulation of the facial nerve during surgery; it allows mapping of the nerve through soft tissue, tumor, and bone; it predicts dehiscences in the bony covering of the nerve; and it allows confirmation of the electrical integrity of the nerve before and after surgery. In this paper we present a technical description of the device, relevant intraoperative electrical measurements, and illustrative case examples. Although the device does not replace anatomic knowledge and surgical ability, it provides a margin of security during ear surgery. This system for intraoperative facial monitoring is practical, and the authors encourage its routine use.

Adolescent↗

[Titanium osteo-integrated fixtures. Otologic applications].

The osteofixtures developed by P.I. Branemark are pure titanium screws implanted percutaneously and intraosseously in the mastoid region. The mechanical properties and biocompatibility towards bone and soft tissues of these titanium fixtures were studied after 80,000 cases of human application, essentially in the field of dentistry. The authors present their preliminary results in the otological field: firstly, the auditory prosthesis with a mean gain of 20 dB over classical prostheses via air and bone transmission and, secondly, the epiprosthesis of the external ear in cases of aplasia with scarred skin.

Adolescent↗

Otologic findings in an Inuit population of cleft palate children.

Otitis media with effusion is almost universal in infants with cleft palate. Inuit children have a very high incidence of otitis media. The otologic problems of Inuit infants and children with cleft palate have not previously been reported. The current study presents 14 Inuit children with cleft palate. All show significant otitis media with effusion or chronic otitis media with tympanic membrane perforation. The management of otitis media in this special population of cleft palate children is discussed.

Adolescent↗

Applications of magnetic resonance imaging in otology.

Magnetic resonance (MR) has been employed for the study of patients with peripheral and retrolabyrinthine otologic pathology. Its usefulness has been compared with that of computed tomography (CT). CT remains at present the best study for the assessment of patients with conductive hearing loss and sensorineural hearing loss or vestibular disorders of the peripheral type. However, MR is the study of choice of retrolabyrinthine pathology occurring in the internal auditory canals, cerebellopontine cisterns, and brainstem.

Cerebellar Neoplasms↗

Tension pneumocephalus: a case following otologic surgery.

Asymptomatic pneumocephalus associated with cerebrospinal fluid drainage through a dural defect following extensive skull base surgery is not uncommon. Its occurrence following otologic surgery, however, is rare. Tension pneumocephalus, if not recognized, can rapidly lead to death due to increased intracranial pressure. A case of tension pneumocephalus is presented to demonstrate its clinical features and surgical management. The pathophysiology, diagnosis, and management of tension pneumocephalus are reviewed.

Cholesteatoma↗

[Dyslexia and late dyslexia and analphabetism from the otologic-audiologic-phoniatric viewpoint].

The special dyslexia in childhood may be interpreted as a functional disorder. Foundation of each treatment is the difference to pseudodyslexia. The exclusion of a conduction hearing loss or sensorineural hard of hearing including the recognition of a verbal communication disturbance should be made regularly. The late dyslexia amongst youth and the illiteracy of adults increases more and more. There should be the integration of otologic-audiologic-phoniatric assessment and a multifaceted diagnosis and treatment concept.

Agraphia↗

Labetalol as a hypotensive agent in otological operations.

The usefulness of labetalol, a new combined alpha and beta adrenoceptor antagonist as a hypotensive agent in otological operations was studied in 18 otherwise healthy patients. After a single 1.0 mg/kg i.v. dose the maximum decrease in systolic (18%) and diastolic (8%) blood pressure occured between 5 to 15 minutes (mean 11 min), and the pretreatment blood pressure values were reached in 15 to 55 min (mean 26 min). Similarly, after a single 2.0 mg/kg i.v. dose the maximum blood pressure decrease (32%/20%) was observed in 5 to 40 minutes (mean 23.5 min) lasting 30 to 95 minutes (mean 60.1 min). Generally, a moderate decrease in blood pressure without a concomitant increase in heart rate or excessive hypotension was found.

Adrenergic alpha-Antagonists↗

Tissue response to Plasti-Pore and Proplast otologic implants in the middle ears of cats.

Plasti-Pore (high density polyethylene) and Proplast (polytetrafluoroethylene-carbon fiber composite) are porous materials that have been employed for the fabrication of ossicular replacement prostheses. Despite many years of clinical experience with these otologic implants, questions remain regarding the tissue response elicited by these materials in the middle ear. The objective of this study was to evaluate histologically the tissue response to Plasti-Pore and Proplast implants in the middle ears of cats through one year of implantation. Plasti-Pore and Proplast total ossicular replacement prostheses, trimmed to "T" shapes, were inserted in fourteen cats, replacing the superstructure of the stapes. One Plasti-Pore and one Proplast implant were implanted in each animal. Cats were killed after two weeks, one, three, and six months, and one year. The histologic response to the Plasti-Pore and Proplast implants was similar. A fibrous capsule contained within a flattened epithelial cell sheath enveloped both types of implants. The mucosa enveloping the devices was continuous with the lining of the tympanic cavity and served to stabilize the implants. Fibrous tissue from the capsule infiltrated larger surface pores. Multinucleated giant cells and macrophages were the predominant cell types in the porosity of both types of implants. The relatively small pores of the devices did not appear to be able to accommodate both the phagocytic cells, which were responding to the particulate features of the materials, and fibrous tissue.

Animals↗

Allergy testing in otology.

The allergic etiologic factors in many otologic diseases are becoming increasingly apparent. Recent advances in the understanding of mechanisms in atopic allergic reactions have resulted in the development of highly accurate diagnostic tools. The development of the radioallergosorbent test (RAST) for determining specific IgE has lead to very effective techniques of immunotherapy. Unfortunately, the mechanisms involved in nonatopic sensitivity, such as that found in food and chemical allergies, are still poorly understood. It is hoped that research will reveal the mechanisms of nonatopic disease and lead to effective in vitro diagnosis and treatment. Regardless of which techniques are used in diagnosis and treatment, education of the allergy patient is imperative to ensure that long-lasting good results are obtained.

Drug Hypersensitivity↗