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At least 343 records · Page 19Linked to original sources
PubMed2000

[Analysis of 19 cases adenoid cystic carcinoma of the nasal cavity].

OBJECTIVE: To study the biological features of adenoid cystic carcinoma of the nasal cavity in order to provide a basis for its clinical treatment. METHOD: A retrospective analysis was made to 19 cases which were treated with operation combined with preoperative chemotherapy and radiation. RESULT: 5, 8, and 10 years' follow-ups conducted post treatment showed the local recurrence rates were 5.3%, 21.1%, and 31.6% respectively. CONCLUSION: Adenoid cystic carcinoma of the nasal cavity is highlighted because of high-degree local infiltration, the specific anatomy of the cavity, and the difficulty of wide-ranging surgical resection. Preoperative chemotherapy combined with radiation has the advantages of extinguishing the recessive cancerous foci, inhibiting the primary foci and lowering local recurrences and cancerous metastases. Thus it constitutes an effective way to deal with this malignancy.

Adult↗
PubMed1985

Hydrolysis of leucine enkephalin in the nasal cavity of the rat--a possible factor in the low bioavailability of nasally administered peptides.

In order to investigate the utility of intranasal administration of peptides for systemic medication, the nasal absorption of the model peptide, leucine enkephalin (Tyr-Gly-Gly-Phe-Leu), was studied in the rat. At a concentration of 60 micrograms/ml in Ringer's buffer the pentapeptide was found to undergo, extensive hydrolysis in the nasal cavity. The hydrolysis rather than the polarity of the pentapeptide appears responsible for limiting the nasal absorption of this model compound. In the presence of dipeptides, the hydrolysis of leucine enkephalin was significantly inhibited. These results suggest that the nasal administration of peptides may become an important route for drug administration provided that the peptidases in the nasal mucosa can be transiently inhibited via coadministration of pharmacologically inactive peptidase substrates.

Absorption↗
PubMed1981

Clinical effects of endonasal sinusectomy with reconstruction of the nasal cavity (Takahashi's method).

A follow-up investigation of the results of endonasal sinusectomy with reconstruction of the nasal cavity (Takahashi's method) was carried out in 535 of 1338 patients who underwent endonasal sinusectomies during the 6-year period from 1967 to 1972. The subjective results were as follows: cured 196 (36.6%); improved 234 (47,5%); unchanged 69 (12.9%); aggravated 12 (2.2%). In other words, 450 (84.1%) of the patients were satisfied with the results of the operations. Good results have similarly been obtained in allergic nasal disorders spreading in Japan of late, and concomitant reconstruction of the nasal cavity and desensitization therapy have resulted in improved response.

Follow-Up Studies↗
PubMed2002

Progesterone receptor expression in angioleiomyoma of the nasal cavity.

In recent years sex steroid receptors have been identified in several types of human neoplasia. Angioleiomyoma of the nasal cavity and paranasal sinus is an extremely rare benign neoplasm which is more common in females (3.75:1 female:male ratio). To the best of our knowledge, only approximately 25 cases have been described. We describe a new case of angioleiomyoma of the nasal cavity that was found to be progesterone-receptor positive and oestrogen-receptor negative on immunohistochemical analysis. We suggest that the growth of this tumour may be hormone-dependent.

Aged↗
PubMed1994

A nose stud retainer clip lost within the nasal cavity discovered on dental radiographs.

It is fairly common for a dental surgeon to come across patients with foreign bodies in the nasal cavity. In this paper we report an unusual case of a nose stud retainer clip being displaced into the nasal cavity by trauma, and its discovery on radiographs taken to assess dental injuries. We also present a review of the literature since 1982, and assess the possible sequelae to nasal foreign bodies.

Adolescent↗
PubMed2000

Nasal cavity and paranasal sinus bony variations: a computed tomographic study.

Variations of the nasal cavity are very important for the otolaryngologist in functional endoscopic sinus surgery. To provide data on bony variations of this region, we performed high resolution computed tomography images of paranasal sinuses on 82 adult patients without sinus pathology and on 90 adult patients with sinus disease. We observed paradoxical curvature of the middle concha in 11 (12.22%) sinus patients and 6 (7.31%) in non-sinus patients. Concha bullosa was observed in 26 sinus patients (28.88%) and 22 (26.83%) in non-sinus patients, deviated nasal septum in 20 (22.22%) sinus and 10 (12%) non-sinus, Haller's cell in 5 (5.55%) sinus and in 3 (3.65%) non-sinus, agger nasi cell in 7 (7.77%) sinus and 4 (4.88%) non-sinus patients. Pneumatisation of cristae galli was observed in 8 (8.88%) sinus and 2 (2.44%) non-sinus, of the anterior clinoid process in 5 (5.55%) sinus and 1 (1.22%) non-sinus patients, pneumatisation of the nasal septum in 7 (7.77%) and of the pterygoid recess in 12 (13.33%) sinus patients. We did not find any correlation between age intervals and paranasal sinus variations, and also no statistically significant difference was observed between males and females. These data provide very important information to guide the otolaryngologist and/or radiologist in the evaluation of patients with coronal CT which guides functional endoscopic sinus surgery.

Adult↗
PubMed1993

Recovery from changes in the blood and nasal cavity and/or lungs of rats caused by exposure to methanol-fueled engine exhaust.

One group of male, pathogen-free, Fischer 344 rats was exposed to about 17-fold diluted exhaust generated by an M85 methanol-fueled engine (methanol with 15% gasoline) without catalyst for 8 h, and then the rates of recovery from the resulting increased levels of plasma formaldehyde and carboxyhemoglobin in their erythrocytes were measured. The carboxyhemoglobin level in the erythrocytes was restored within 4 h, whereas the plasma formaldehyde level was still elevated after 4 h but was restored to the normal level within 8 h. No methanol or formic acid was detected in the plasma. Another group of rats was exposed to the same dilution of exhaust for 8 h/d for 7 d, and then the recovery from histopathological damage of the nasal cavity and lungs was also examined. Hyperplasia/squamous metaplasia and erosion of the respiratory epithelium lining the nasoturbinate, maxilloturbinate, or nasal septum, and infiltration of neutrophils into the submucosa at level 1 (level of the posterior edge of the upper incisor teeth) were observed immediately after the exposure period. Lesions of the respiratory epithelium at level 2 (incisive papilla) were less than those at level 1. Slight lesions at levels 1 or 2 were still noticed 1 wk after exposure, but not 4 wk after exposure. Just after exposure, decreases of Clara cells in the terminal bronchiolus and of cilia in the bronchial/bronchiolar epithelium were also observed. Moreover, focal hypertrophy of alveolar walls and increase of macrophages were observed in parts adjacent to respiratory bronchiolus. One week after the exposure period, these changes were no longer seen. These results indicate that changes in the blood and in the nasal cavity and lungs caused by methanol-fueled engine exhaust are reversible. However, complete recovery from damage of the nasal cavity caused by 7-d exposure to the exhaust takes 4 wk, and recovery from elevated plasma formaldehyde and erythrocyte carboxyhemoglobin levels caused by a single 8-h exposure takes 4-8 h.

Animals↗
PubMed1995

Clinical assessment of squamous cell carcinoma of the nasal cavity proper.

The subjects were 14 patients with squamous cell carcinoma or undifferentiated carcinoma of the nasal cavity treated at Nihon University Hospital between October 1984 and November 1991, who were followed for at least 3 years. The site of the tumor origin within the nasal cavity was the lateral wall in 8 patients, the nasal septum in three patients, and unknown in three patients. Histologically, there were 13 squamous cell carcinomas in (3 well differentiated, 7 moderately differentiated, and 3 poorly differentiated) and 1 undifferentiated carcinoma. Treatment was by a combination of radiotherapy, chemotherapy, and surgery in 8 cases, a combination of radiotherapy and surgery in 5 cases, and surgery alone in 1 case. The 3-year and 5-year Kaplan-Meier survival rates were 86 and 69%, respectively. A total of 6 patients suffered a recurrence, with local recurrence occurring in 4 patients and pulmonary metastasis in 2 patients. Tumor control was achieved in 3 of the 4 cases of local recurrence by reoperation, and by surgery in 1 of the 2 cases of pulmonary metastasis. The duration of the recurrence-free interval in the patients who developed local recurrences, 18 to 46 months after the completion of the initial course of therapy, was of considerable interest.

Carcinoma, Squamous Cell↗
PubMed2003

Expression of cyclooxygenase-1 and -2 is limited to the nasal glands in the guinea pig nasal cavity.

OBJECTIVES: To clarify the localization of cyclooxygenase (COX)-1 and -2 in the nasal cavity of guinea pigs and ascertain their physiological roles. MATERIAL AND METHODS: The distribution of the enzymes was investigated using immunohistochemistry. RESULTS: Immunoreactivities for COX-1 and -2 were limited to the nasal glands, and no expression was noted in the surrounding vascular endothelial cells, olfactory glands, respiratory epithelium, olfactory epithelium, submucosal tissue or nerves. To confirm the specificity of the reaction, the kidneys of the same animals were prepared as positive controls. The results demonstrated localization of COX-1 and -2 in uriniferous tubules. CONCLUSION: Our findings suggest that COX is involved in the secretion of nasal discharge from the nasal glands and that prostaglandins in the nasal discharge are probably secreted directly from the nasal glands.

Animals↗
PubMed2005

[To incise the dentigerous cyst on the floor of nasal cavity (affiliated 2 cases)].

OBJECTIVE: To report 2 cases of the rare disease-the dentigerous cyst on the floor of nasal cavity and explore etiology, the method of diagnosis and treatment. METHOD: To review the literature briefly and discuss the lesions' pathology, diagnosis and surgical approach. RESULT: One case originated from the supernumerary teeth on the floor of left nasal cavity, and the other left reversed lateral incisor. Both had the medical history of upper lip and para-nose swelling. CT scan or X-ray showed radiopaque mass, surrounded by a radiolucent cyst like lesion. Both were incisied by nasal endoscope. CONCLUSION: The dentigerous cyst may originate from impacted or supernumerary teeth. It's diagnosed by clinical feature, X-ray or CT scan. It is a selective and suitable surgical approach to incise the dentigerous cyst by nasal endoscope.

Adult↗
PubMed2003

[Respiratory epitheloid adenomatoid hamartoma of the nasal cavity--case report and review of the literature].

BACKGROUND: Hamartomas are tumour-like malformations, resulting from excessive proliferation of otherwise normal local tissue components. Hamartomas of the nasal cavity and paranasal sinuses are relatively rare, especially respiratory epithelial adenomatoid hamartomas. This benign lesion is characterized by a glandular proliferation originating from the surface of the respiratory epithelium. In the German speaking literature this entity has not been described before. PATIENT AND RESULTS: We report the case of a 51-year-old white female, presenting with a respiratory epithelial adenomatoid hamartoma of her left nasal cavity. The patient suffered from nasal obstruction. The CT scan showed a soft tissue like lesion obstructing the patient's left choana. After local resection of the tumour, which originated from the superior turbinate through functional endoscopic sinus surgery the patient's symptoms were gone. Follow-up after six months showed no evidence of recurrence. CONCLUSION: The histopathological differential diagnosis of respiratory epithelial adenomatoid hamartomas includes inverted papilloma and adenocarcinoma. Therefore the histological recognition of these hamartomas impacts on therapy. Misinterpretation as a true neoplasm may result in unnecessarily radical surgery. Local surgical resection is the treatment of choice for this lesion.

Adenocarcinoma↗
PubMedDate not supplied

Study of bacteria in the nasal cavity and nasopharynx during naturally acquired common colds.

It was the purpose of this study to examine whether the number of bacteria in the nose and nasopharynx changes during a common cold. Samples for bacteriological culture were taken from the nasal cavity of 29 and from the nasopharynx of 26 adult patients with naturally acquired colds. The bacteriological samples were taken on days 2, 4, 8 16, 32 and 64 after the first nasal symptoms. The results showed that there were few pathogenic bacteria in the nasal cavity and nasopharynx. There was no tendency to an increase in the number of positive cultures during the cold, although most patients had macroscopically purulent discharge on days 3-5. In conclusion, the study indicates that during an uncomplicated common cold, a bacterial infection is not responsible for the occurrence of purulent nasal discharge which may be a direct consequence of the viral infection.

Adult↗
PubMed2003

Anatomy of the nasal cavity in the chinchilla.

There is currently great interest worldwide in developing noninvasive methods for the delivery of vaccines for upper respiratory tract diseases, including middle ear infection (otitis media, OM). One such noninvasive approach believed to have great potential for the prevention of diseases of the airway is to deliver vaccines by the intranasal (i.n.) route. Induction of a local, mucosal immune response in the upper respiratory tract, and particularly in the nasopharynx, would be a highly efficacious approach to prevention of OM. The chinchilla is the preferred rodent host for studying OM. However, although the anatomy of the chinchilla vomeronasal organ, inner ear, middle ear and Eustachian tube have been well-studied, to date there have been no reports in the literature of a similar complete analysis of the nasopharynx and nasal cavities of the chinchilla. In order to develop a relevant animal model of i.n. delivery as a potential immunization approach for the prevention of OM and to use these models for preclinical assessments of various vaccine candidates, it was important that we better understand the anatomy of the chinchilla nasal cavities and nasopharynx. Our anatomical studies revealed that the naso- and maxilloturbinates of the chinchilla nasal cavity more closely resemble the simple turbinates found in other rodents rather than the branched or complex turbinates seen in dogs, cats, and rabbits thus facilitating the i.n. delivery of vaccine candidates. The chinchilla nasal mucosa also contains numerous lymphoid aggregates like that of other rodents. Our findings thus suggest that we will be able to deliver i.n. vaccines effectively to chinchillas and that these vaccines will likely be able to induce specific immune responses.

Animals↗
PubMed1989

Malignant salivary gland tumors of the paranasal sinuses and nasal cavity. The UCLA experience.

Between 1962 and 1985, 35 patients with malignant salivary gland tumors of the paranasal sinuses and nasal cavity were treated with curative intent at UCLA. They were staged according to the American Joint Committee (TNM) classification for squamous cell carcinoma of the paranasal sinuses: 27 of 35 (77%) patients presented with T3-4 disease. Adenoid cystic carcinoma was the diagnosis in 24 (68%) patients, while adenocarcinoma accounted for half of the cases involving the ethmoid sinuses and nasal cavity. Eleven patients were treated with surgery alone, 13 with combined surgery and radiation, and 11 with radiation therapy alone. All patients were followed from 40 to 216 months. Analysis by treatment modality revealed a local control of 18% (2 of 11) in the surgery alone group, 62% (8 of 13) in the combined group, and 9% (1 of 11) in the radiation alone group. The group undergoing combined treatment achieved the highest local control rate despite having a higher proportion of patients with advanced stage and residual disease at the surgical margins. In patients with positive surgical margins, the tumor recurred locally in 4 of 6 (67%) unirradiated patients, compared with 3 of 10 (30%) of those undergoing postoperative irradiation. Patients with adenoid cystic carcinoma had poorer results, with only 25% remaining relapse-free, compared with 45% of patients with adenocarcinoma. The 5-, 10-, 15-, and 20-year actuarial survival for all cases was 73%, 60%, 32%, and 20%, respectively. We conclude that post-operative radiation improves the results of treatment in all patients with malignant salivary gland tumors in this location, compared with the results of surgery alone.

Adenocarcinoma↗
PubMed2001

[Nasal cavity dimensions in the infants measured with acoustic rhinometry].

OBJECTIVE: To investigate the range of normal value of minimal cross-sectional area (MCA) of the nasal cavity, distance of minimal cross-sectional area from the nostril (DCA), total nasal cavity volume(NV) and total nasopharyngeal cavity volume (NPV) of healthy infants. METHOD: One hundred and seventy-five healthy infants and one hundred and eight infants suffered from acute upper respiratory tract infection were measured with acoustic rhinometry. RESULT: The range of total MCA of healthy infants was 0.2-0.5 (cm)2, DCA was 1.93-2.47 cm, NV was 2.69-4.75 cm3 and NPV was 3.83-8.92 cm3. Comparing healthy infants with infants suffered from acute upper respiratory tract infection, there all were significant differences in MCA, DCA and NV. CONCLUSION: Acoustic rhinometry suit objective assessment of the nasal airways in infants. It is demonstrated that these data can provide available information for the study of nasal physiology and pathophysiology, well as for the diagnosis and judgement of therapeutic effectiveness of nasal diseases.

Child, Preschool↗
PubMed2001

Intranasal absorption of sumatriptan and naratriptan: no evidence of local transfer from the nasal cavities to the brain arterial blood in male rats.

Nasal administration to rats of small molecules (tritiated water, tyrosine, and propanol) results in a higher concentration in the brain arterial blood than in other arteries. The preferential distribution is based on a counter current transfer, which takes place between nasal vein blood and brain arterial blood in the cavernous sinus-carotid artery complex. This model was used to investigate whether the antimigraine 5HT(1B/1D) receptor agonists sumatriptan and naratriptan may also be transferred by the system. The ratio of 'head':'heart' plasma concentrations obtained from two carotid catheters after intranasal administration was not different from 1.00 for either compound, and thus, there was no experimental evidence of a preferential local transfer of drug from the nose to the carotid artery circulation. However, plasma concentrations increased from the first minute after intranasal dosing suggesting that sumatriptan and naratriptan are absorbed into the general systemic circulation from the nasal cavity in rats in a first-order fashion with no lag time. This is consistent with the clinical onset of efficacy of sumatriptan after an intranasal dose which occurs as early as 15 min post dose.

Absorption↗
PubMed1983

Sublabial surgical approach to the nasal cavity and paranasal sinuses.

A sublabial approach to the nasal cavity, paranasal sinuses and the nasopharynx degloving the middle third of the face has been described. Its major advantages over the other approaches have been compared and the usefulness of this approach has been stressed. The incidence of complications from this approach has been described and found to be acceptable.

Humans↗