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PubMed2005

Contingency experiences of 3-month-old children and their relation to later developmental achievements.

In this study, the authors investigated the relation between early social contingency experiences and infants' competencies to detect nonsocial contingencies. In this study of 87 three-month-old infants, the authors operationalized early social contingencies as prompt, contingent maternal responses and coded microanalytically on the basis of video-recorded mother-infant interactions. The authors assessed competence to detect nonsocial contingencies by 2 methods: (a) the mobile conjugate reinforcement paradigm, which focuses on detecting contingencies between the infants' actions (kicking) and nonsocial consequences (mobile moving) and (b) the visual expectation paradigm, which focuses on detecting contingencies between 1 event (a smiley face projected on a screen) that was followed by a 2nd event (a complex picture projected on the other side of the screen). The results showed that early social contingencies are related to the competency to detect nonsocial action-consequence contingencies in the mobile conjugate reinforcement paradigm.

Achievement↗
PubMed1994

Mechanics of myosin motor: force and step size.

How motor proteins induce mechanical movement at the molecular level has been a focus of biophysicists for a long time. While the whole picture is yet to be completely revealed, recent developments in looking at nanometer-scale movement with millisecond-time resolution driven by single motors have revealed important new details about the moving step size and amount of force generated per molecule.

Adenosine Triphosphate↗
PubMed1993

Interchange and intra-nuclear architecture.

For chromatin lesions to interact to form exchanges of any sort, it is obvious that contact between them must be made. However, the probability of such interaction is conditioned by other factors like time, initial separation, metabolic activity, and, in the case of chemically induced lesions, scheduled DNA synthesis. The irradiated nucleus was, for a long time, regarded as a "bag of broken chromosomes" with the severed ends free to move around and find partners with which to form illegitimate reunions. Many of these would be seen at following metaphase as intra- and interchanges. Evidence is rapidly accumulating which indicates that this picture of the nucleus is false. We know now that chromosomes occupy highly localised domains with limited movement, and that there is no massive intermingling; that much of the chromatin is compacted and splinted with proteins and so precluded from exchange-type contact; that most of the chromatin is looped and "fixed" into an intra-nuclear protein scaffold or skeleton; that some chromatin is spun-out and associated with the nuclear envelope in the vicinity of the pore-complexes. Thus it would appear that movement, in the sense envisaged by early workers, is curtailed, and that only a proportion (probably a small proportion) of the chromatin is actually "at-risk" with respect to interchange formation. Where then does interchange take place? Are the "sites" pre-existent, or can proximity requirements be realised after radiation exposure? In what ways will the intra-nuclear architecture influence exchange? These are some of the questions which are considered in this paper.

Animals↗
PubMed2006

Self-attributed body-shadows modulate tactile attention.

Our body-shadows are special stimuli in the visual world. They often have anatomical resemblance with our own body-parts and move as our body moves, with spatio-temporal correlation. Here, we show that self-attributed body-shadows cue attention to the body-part they refer to, rather than the location they occupy. Using speeded spatial discrimination for tactile or visual targets at the hands, or for visual targets delivered near the hand-shadows, we demonstrate that mere viewing of task-irrelevant shadows can selectively facilitate tactile discrimination at the body-part casting the shadow (Experiment 1). In addition, such facilitation only develops through time for cast-shadows that have no resemblance with the body-part, but move in spatio-temporal correlation with it (Experiment 2). Conversely, facilitation fades away rapidly for shadow-like images that resemble the stimulated body-part, but are in fact static pictures (Experiment 3). Thus, recognising oneself as the owner of a shadow affects distribution of tactile attention.

Adult↗
PubMed2000

Acceptable levels of digital image compression in chest radiology.

The introduction of picture archival and communications systems (PACS) and teleradiology has prompted an examination of techniques that optimize the storage capacity and speed of digital storage and distribution networks. The general acceptance of the move to replace conventional screen-film capture with computed radiography (CR) is an indication that clinicians within the radiology community are willing to accept images that have been 'compressed'. The question to be answered, therefore, is what level of compression is acceptable. The purpose of the present study is to provide an assessment of the ability of a group of imaging professionals to determine whether an image has been compressed. To undertake this study a single mobile chest image, selected for the presence of some subtle pathology in the form of a number of septal lines in both costphrenic angles, was compressed to levels of 10:1, 20:1 and 30:1. These images were randomly ordered and shown to the observers for interpretation. Analysis of the responses indicates that in general it was not possible to distinguish the original image from its compressed counterparts. Furthermore, a preference appeared to be shown for images that have undergone low levels of compression. This preference can most likely be attributed to the 'de-noising' effect of the compression algorithm at low levels.

Humans↗
PubMed2002

Fast anomalous diffusion of small hydrophobic species in water.

Using Car-Parrinello molecular dynamics a structural diffusion mechanism for the simplest hydrophobic species in water, an H atom, is proposed. The hydrophobic solvation cavity is a highly dynamical aggregate that actually drives, by its own hydrogen-bond fluctuations, the diffusion of the enclosed solute. This makes possible an anomalously fast diffusion that falls only short of that of "Grotthuss structural diffusion" of H+ in water. Here, the picture of a static, i.e., "iceberglike," clathrate cage is a misleading concept. The uncovered scenario is similar to the "dynamical hole mechanism" found in a very different context, that is, large molecules moving in hot polymeric melts.

Diffusion↗
PubMed1986

Cephalometry with a video display computer.

A new technique to develop cephalometric analyses for orthodontic problems is illustrated. A digital analyzer of images is employed in our laboratory, and this allows us to get the X-ray picture digitized and displayed on both a black and white and a colour TV screen. All the cephalometric points are selected by an operator who watches a coloured cross which can be moved on the colour TV screen by means of a keyboard. A suitable software was developed to calculate linear and angular measurements. The cephalometric coloured lines appear at the top of the X-ray image and the data are displayed on a monitor, from which a print-out is obtained. Such a technique has some advantages: the X-ray image can be processed before the cephalometric analysis to enhance details, thus making the analysis more accurate; the cephalometric lines can be seen on the X-ray image displayed on the colour TV screen and can be photographed or stored on floppy or rigid disc.

Cephalometry↗
PubMed1983

[Symptomatology of pathologic inhibition in child and adolescent psychiatry].

We propose firstly to take a synchronic approach, looking at different classifications of the morbid features of inhibition, and at how aspects change according to the degree of inhibition. We will then move on to a diachronic approach, looking at how inhibition can be observed at the different stages of maturity of the child and adolescent, and at how the significance of the clinical picture alters according to the age of onset, and family, social and cultural background. The third part will consist of a pathogenetic approach to manifestations of inhibition. Finally, some case histories will be presented to provide concrete illustration of the theory discussed above.

Adolescent↗
PubMed1997

Dental unit waterline microbiology: a cautionary tale.

The question of dental unit waterline contamination now concerns the dental profession on a number of levels and has become part of the landscape in dentistry. Researchers have identified the problem, studied it, and published their results. Official organizations have reacted to the problem by issuing press releases and recommendations. In the mean time, dental companies have jumped into the fray, ensuring a proliferation of products designed to mitigate a problem that certain people feel is imaginary are artificially inflated. Despite the number of publications describing waterline contamination, we still face the challenge of determining whether are picture of the problem is truly accurate. For example, it has become almost customary to use the term contamination when talking about waterlines, even though it is inadequate. In addition, we are moving ahead with water quality standards for dental units at a time when certain fundamental questions remain unanswered. What should we be measuring and what methods should we be using? Do certain disinfection procedures have an opposite effect to the one desired? Finally, the question of health risks linked to the colonization of waterlines has not been adequately addressed by researchers.

Bacterial Infections↗
PubMedDate not supplied

[Earliest appearance and morphologic picture of lamellar bodies in the amniotic fluid].

The alveolar lamellar bodies (LB), being the main source of the Surfactant-phospholipids, are produced by the alveolar cells of type II and excreted, during the development of the fetal lungs, in the alveolar space. Hence the LB move free, isolated or in groups, to the amniotic fluid, where they could be found as multilamellar structures. It is already being observed that the LB may be present in the amniotic fluid at the 32th or at the 26th week of pregnancy at the earliest. The method of centrifugation, which is very important for the evaluation of the LB, should always be considered. According to TEM research on the morphological development of the fetal alveolar epithel, there is also disagreement about the first production of Surfactant or LB from the alveolar cells of typ II. Our TEM-observations on two sediments of amniotic fluid from the 19th week of pregnancy (after centrifugation of the AF in 6000 revs/min) showed the presence of the alveolar lamellar bodies already in this week. A lot of different types of LB were observed, ranging of the most "immature" to types being empty at the interior with some peripheral membranes ("mature"). Occasionally osmiophilous nucleus was noticed inside the LB.

Amniotic Fluid↗
PubMed2005

Patterns of genetic diversity and migration in increasingly fragmented and declining orang-utan (Pongo pygmaeus) populations from Sabah, Malaysia.

We investigated the genetic structure within and among Bornean orang-utans (Pongo pygmaeus) in forest fragments of the Lower Kinabatangan flood plain in Sabah, Malaysia. DNA was extracted from hair and faecal samples for 200 wild individuals collected during boat surveys on the Kinabatangan River. Fourteen microsatellite loci were used to characterize patterns of genetic diversity. We found that genetic diversity was high in the set of samples (mean H(E) = 0.74) and that genetic differentiation was significant between the samples (average F(ST) = 0.04, P < 0.001) with F(ST) values ranging from low (0.01) to moderately large (0.12) values. Pairwise F(ST) values were significantly higher across the Kinabatangan River than between samples from the same river side, thereby confirming the role of the river as a natural barrier to gene flow. The correlation between genetic and geographical distance was tested by means of a series of Mantel tests based on different measures of geographical distance. We used a Bayesian method to estimate immigration rates. The results indicate that migration is unlikely across the river but cannot be completely ruled out because of the limited F(ST) values. Assignment tests confirm the overall picture that gene flow is limited across the river. We found that migration between samples from the same side of the river had a high probability indicating that orang-utans used to move relatively freely between neighbouring areas. This strongly suggests that there is a need to maintain migration between isolated forest fragments. This could be done by restoring forest corridors alongside the river banks and between patches.

Animals↗
PubMed1976

High speed cinemicrographic studies on rabbit tracheal (ciliated) epithelia: determination of the beat pattern of tracheal cilia.

High speed cinemicrographs reveal that the ciliary configuration and beat pattern of rabbit tracheal cilia differ significantly from classid descriptions, although the basic forward and return pattern is still observed. The tracheal cilia are short and stout (about 6 mum in length) and are of a slightly bent original configuration bent original configuration. At the start of the forward stroke, the cilia bear about 75-90 degrees to the epithelial surface in the direction of the forward stroke. The forward stroke is planar and consists of a simple "bowing" movement, without showing any progressive bending and without changing the original ciliary configuration. The complete forward stroke sweeps through an arc of about 35-40 degrees, with the tips of the cilia penetrating the bottom of the mucous layer through an arc of about 5-8 degrees at the start of each forward stroke. The return stroke starts from close to the epithelial surface and returns to the starting position of the forward stroke by reversing the planer forward pathway at a reduced speed. The stout nature of the cilia, the original bent ciliary configuration, the near vertical starting position of the forward stroke, the extent of the angular sweeps of the strokes, the peculiar "bowing" forward stroke movement, and the nature of the return stroke all serve to enhance efficiency in moving fluid forward. It has been documented that each forward stroke of the tracheal cilia caused and maintains a swift forward movement of the intermediate serous (liquid) layer of the mucociliary system. This movement, in turn, reacts hydrodynamically with the top mucous layer, and together with the clawing action of the tips of the cilia at the start of the forward stroke, causes the mucous layer to move cephalad in the manner of a conveyor belt.

Animals↗
PubMed2000

Evidence for the duplex theory of tactile texture perception.

Three experiments are reported bearing on Katz's hypothesis that tactile texture perception is mediated by vibrational cues in the case of fine textures and by spatial cues in the case of coarse textures. Psychophysical responses when abrasive surfaces moved across the skin were compared with those obtained during static touch, which does not provide vibrational cues. Experiment 1 used two-interval forced-choice procedures to measure discrimination of surfaces. Fine surfaces that were readily discriminated when moved across the skin became indistinguishable in the absence of movement; coarse surfaces, however, were equally discriminable in moving and stationary conditions. This was shown not to result from any inherently greater difficulty of fine-texture discrimination. Experiments 2 and 3 used free magnitude estimation to obtain a more comprehensive picture of the effect of movement on texture (roughness) perception. Without movement, perception was seriously degraded (the psychophysical magnitude function was flattened) for textures with element sizes below 100 microns; above this point, however, the elimination of movement produced an overall decrease in roughness, but not in the slope of the magnitude function. Thus, two components of stimulation (presumably vibrational and spatial) contribute to texture perception, as Katz maintained; mechanisms for responding to the latter appear to be engaged at texture element sizes down to 100 microns, a surprisingly small value.

Adolescent↗
PubMed2000

Practical low-cost visual communication using binary images for deaf sign language.

Deaf sign language transmitted by video requires a temporal resolution of 8 to 10 frames/s for effective communication. Conventional videoconferencing applications, when operated over low bandwidth telephone lines, provide very low temporal resolution of pictures, of the order of less than a frame per second, resulting in jerky movement of objects. This paper presents a practical solution for sign language communication, offering adequate temporal resolution of images using moving binary sketches or cartoons, implemented on standard personal computer hardware with low-cost cameras and communicating over telephone lines. To extract cartoon points an efficient feature extraction algorithm adaptive to the global statistics of the image is proposed. To improve the subjective quality of the binary images, irreversible preprocessing techniques, such as isolated point removal and predictive filtering, are used. A simple, efficient and fast recursive temporal prefiltering scheme, using histograms of successive frames, reduces the additive and multiplicative noise from low-cost cameras. An efficient three-dimensional (3-D) compression scheme codes the binary sketches. Subjective tests performed on the system confirm that it can be used for sign language communication over telephone lines.

Algorithms↗
PubMedDate not supplied

Cardiac PACS: strategies for planning, integration & vendor selection.

Cardiologists are clamoring for better imaging techniques, the ability to view images from their office or home, and for the resulting improvement in efficiency which translates into increased profitability. The future is here; are you ready? Cardiac systems have developed into full-blown information management and digital imaging systems. Hospitals are moving aggressively to update their cardiac information systems and identifying the significant role the CIS (cardiac information system) plays in the selection process. It is important to plan the infrastructure of your cardiac PACS (picture archival communication system) and determine how it will integrate with the radiology PACS. Equally important is the integration potential with other hospital information systems such as the laboratory, pharmacy and billing, etc. Answers to these decision factors are provided in addition to information pertaining to the overall cardiac PACS planning process and vendor offerings.

Cardiovascular Diseases↗
PubMed1983

TSH secretion and regulation in endemic goiter and endemic cretinism.

In endemic goiter patients living in a chronic iodide deficiency area (less than 50ug/day) TSH basal levels and the TSH response to TRH is significantly higher (31 +/- 8uU/ml) than in normal controls (10 +/- 4uU/ml). There is a negative correlation between levels of iodine intake and serum TSH concentration and thyrotropin is thus increased when iodine decreased. Also it was shown that serum TSH levels correlate inversely with the serum concentration of T4 (r=0.69) but not with the usually normal or elevated serum concentration of T3 in endemic goiter patients. It has been postulated that in the absence of appropriate serum levels of T4 the pituitary thyrotrophs have an abnormally low T4 to T3 conversion and the pituitary-nuclear/serum T3 ratio does not increase sufficiently to compensate this phenomenon. On the other hand nuclear receptor saturation of T3 in tissues such as liver and kidney would remain at euthyroid levels due to the higher serum T3 concentrations. Endemic goiter patients when moving to an urban area where iodine intake is higher (greater than 150ug/day) than in the rural villages, had a blunted TSH response to TRH (15/23 subjects) or developed a mild clinical and laboratory picture of hyperthyroidism (7/23 individuals). Serum TSH levels and the TSH response to TRH is abnormally elevated in the myxedematous type of endemic cretinism but more than one third of the neurological goitrous cretins (euthyroid) have an exaggerated and sustained TSH response to TRH. This has been considered as a decreased thyroid reserve. Measurement of alpha subunits and TSH-beta in both types of endemic cretinism demonstrated that although these patients have a marked enlargement of the sella turcica the alpha subunits, although higher than normal (1.7-3.4 ng/ml) were not suggestive of a pituitary tumour. The pituitary enlargement was probably secondary to the long standing untreated thyroid failure.

Adult↗
PubMed1991

[Time-lapse microcinematographical analysis of the biological characteristics of a macrophage-like cell line--MMC-1].

By using time-lapse microcinematography, we recorded and conducted an analysis of the macrophage-like cell line MMC-1, including observations of the spreading, polarity, contact inhibition and mitosis common to cultured cells as well as the properties of phagocytosis and rosette formation unique to macrophage. We also found an MMC-1 cell which, after feeding, still stretched its finger-like filopodia towards surrounding red blood cells. The filopodia extended as red blood cells moved towards them. At the point of contact, red blood cell fragments were seen moving towards the cell body along the filopodia; a kind of cytolysis was progressing.

Animals↗
PubMed1983

Weight gain and movement patterns of very low birthweight babies nursed on lambswool.

34 very low birthweight babies (mean 1143 g) in incubators were randomly assigned to be continuously nursed on lambswool (n = 17) or ordinary cotton sheets (n = 17). The weight gain for the periods when babies were well was significantly larger for the wool group, 22.7 g/day vs 18.6 g/day for cotton control (p less than 0.02). The overall weight gain (which included weight change during periods of illness) revealed a similar picture in favour of the wool group, 21.5 g/day vs 18.2 g/day (p less than 0.05). Movement patterns for the two groups showed no differences, but for all babies a strong correlation was noted between moving and lying suspine (p less than 0.001), having eyes open (p less than 0.001), a cooler incubator (p less than 0.01), and faster weight gain (p less than 0.01). Lambswool seems to have advantages over cotton sheets as a bedding material for very low birth weight babies.

Animals↗