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At least 343 records · Page 19Linked to original sources
PubMed2001

Advanced theory of mind in high-functioning adults with autism.

Twenty-four high-functioning adults with autism (16 men) who passed a first-order theory-of-mind task and 24 nonautistic adults (10 men) attributed mental states to recordings of various verbal intonations and to photos of people's eyes to assess advanced theory of mind. Participants with autism performed significantly worse than nonautistic participants on both tasks. Thus, the previously described inattention to others' eyes exhibited by adults with autism is not solely responsible for their inability to attribute mental states from eyes, as they also did not correctly attribute mental states from voices. These findings support the view that a core deficit for people with autism lies in their theory of mind, that is, their inability to attribute mental states to others.

Adolescent↗
PubMed1999

Concentration and mindfulness meditations: unique forms of consciousness?

Electroencephalographic (EEG) recordings from 19 scalp recording sites were used to differentiate among two posited unique forms of mediation, concentration and mindfulness, and a normal relaxation control condition. Analyzes of all traditional frequency bandwidth data (i.e., delta 1-3 Hz; theta, 4-7 Hz; alpha, 8-12 Hz; beta 1, 13-25 Hz; beta 2, 26-32 Hz) showed strong mean amplitude frequency differences between the two meditation conditions and relaxation over numerous cortical sites. Furthermore, significant differences were obtained between concentration and mindfulness states at all bandwidths. Taken together, our results suggest that concentration and mindfulness "meditations" may be unique forms of consciousness and are not merely degrees of a state of relaxation.

Adult↗
PubMed2003

Brief report: developmental change in theory of mind abilities in children with autism.

This longitudinal study investigated developmental change in theory of mind among 57 children with autism aged between 4 to 14 years at the start of the study. On an initial visit and one year later, each participant was administered a battery of tests designed to measure a broad developmental range of theory of mind abilities from early (e.g., desire) to more advanced (e.g., moral judgment) mental state understanding. Both group and individual data indicated significant developmental improvement in theory of mind ability, which was primarily related to the children's language abilities.

Adolescent↗
PubMed1998

Understanding mind and emotion: longitudinal associations with mental-state talk between young friends.

Developmental changes in children's understanding of mind and emotion and their mental-state talk in conversations with friends were examined in a longitudinal study of 50 children (M age at each time point = 3 years 11 months, 4 years 6 months, 5 years 0 months). Significant and related improvements over time were found for both theory-of-mind task performance and affective perspective taking. Associated with these cognitive developments were quantitative and qualitative changes in children's references to mental states in their conversations with friends. Individual differences in theory of mind, emotion understanding, and mental-state talk were strikingly stable over the 13-month period. Although there were no gender differences in children's task performances, girls showed more frequent and more developed mental-state talk than boys.

Child, Preschool↗
PubMed1998

Finding your marbles: does preschoolers' strategic behavior predict later understanding of mind?

The aim of this longitudinal study was to assess (a) stability of individual differences in preschoolers' executive function performance, (b) the external validity of 4 new simple executive function tasks, and (c) whether individual differences in early executive function performance could be used to predict later differences in theory of mind, or vice versa. Fifty children involved in an earlier study of relations between preschoolers' theory of mind, verbal ability, and executive function (C. Hughes, 1998) were followed up and tested 1 year later, using 1st- and 2nd-order false-belief tasks, a set of 4 simple executive function tasks, and a well-established executive test of planning: the Tower of London (T. Shallice, 1982). The results of the study support recent proposals (C. Hughes, 1996; J. Russell, 1996) that young children's understanding of mind is grounded in their growing competence in strategic planning and mental flexibility.

Age Factors↗
PubMed2004

How the mind hurts and heals the body.

The author reviews some of the social and behavioral factors acting on the brain that influence health, illness, and death. Supported with data from several areas of research, his proposal for understanding health and illness provides both the concepts and the mechanisms for studying and explaining mind-body relationships. The brain is the body's first line of defense against illness, and the mind is the emergent functioning of the brain. This mind-body approach incorporates ideas, belief systems, and hopes as well as biochemistry, physiology, and anatomy. Changing thoughts imply a changing brain and thus a changing biology and body. Belief systems provide a baseline for the functioning brain upon which other variables act and have their effects.

Attitude↗
PubMed1998

Culture, development, and theory of mind: comment on Lillard (1998)

In response to A. Lillard's (1998) suggestion that research on theory of mind does not adequately examine the cultural context of this thinking, the author proposes an extension of this view that emphasizes the development of theory of mind in sociocultural context. Questions about the study of theory of mind both across and within cultural communities are also raised.

Adult↗
PubMed1999

Topological regulation of cell division in Escherichia coli involves rapid pole to pole oscillation of the division inhibitor MinC under the control of MinD and MinE.

Placement of the Z ring at midcell in Escherichia coli is assured by the action of the min system, which blocks usage of potential division sites that exist at the cell poles. This activity of min is achieved through the action of an inhibitor of division, MinC, that is activated by MinD and topologically regulated by MinE. In this study, we have used a functional GFP-MinC fusion to monitor the location of MinC. We find that GFP-MinC is a cytoplasmic protein in the absence of the other Min proteins. The addition of MinD, a peripheral membrane protein that interacts with MinC, results in GFP-MinC appearing on the membrane. In the presence of both MinD and MinE, GFP-MinC oscillates rapidly between the halves of the cell. Thus, MinC is positioned by the other Min products, but in a dynamic manner so that it is in position to inhibit Z ring assembly away from midcell.

Adenosine Triphosphatases↗
PubMed2003

A role for division-site-selection protein MinD in regulation of internucleoid jumping of Soj (ParA) protein in Bacillus subtilis.

The Bacillus subtilis soj-spo0J locus encodes two proteins belonging to a family of proteins (the ParAB proteins) with dual roles in plasmid or chromosome segregation and transcriptional regulation. Soj protein was previously shown to be capable of abrupt subcellular relocation. The movement was highly co-operative and at any moment, most of the Soj in any cell formed a single large 'patch' covering all or part of one nucleoid. Movement, and co-operativity, in the sense of formation of a single patch, was dependent on Spo0J. Movement, but not co-operativity, was also shown to be dependent, directly or indirectly, on FtsZ protein. We now report that the ftsZ effect arises because jumping onto a nucleoid is promoted by proximity to a cell pole. Studies of other mutants affected in cell division suggest that the attraction to the cell pole is mediated by the division-site-selection protein, MinD (which localizes at the cell poles). It does not require MinC, the main effector of the division site selection system. A mutant form of Soj, putatively locked in the ATP form of the protein, interacts with the cell pole (dependent on MinD) but not with the nucleoid. These results identify a novel function for MinD and demonstrate an intriguing link between proteins involved in the cell division and chromosome segregation machineries.

Bacillus subtilis↗
PubMed2003

MinD and role of the deviant Walker A motif, dimerization and membrane binding in oscillation.

The ATPase activity of MinD is required for it to oscillate between the ends of the cell and spatially regulate cell division in Escherichia coli. It is a member of a functionally diverse subgroup of ATPases which are involved in activities ranging from nitrogen fixation (NifH) to plasmid segregation (ParA). All members of the subgroup have a deviant Walker A motif which contains a conserved 'signature' lysine that characterizes this subgroup. In the NifH homodimer the signature lysines make intermonomer contact with the bound nucleotides indicating a role in ATP hydrolysis. ATP binding to NifH leads to formation of an active dimer that associates with a partner that is also a dimer. Because ATP hydrolysis is coupled to formation of the complex, the complex is only transient. In the presence of ATP MinD binds MinC and goes to the membrane, however, the ATPase is not stimulated and the complex is stable. Subsequent interaction of this complex with MinE, however, leads to ATPase stimulation and release of the Min proteins from the membrane. The sequential interaction of MinD with these two proteins, which is dictated by the membrane, is critical to the oscillatory mechanism involved in spatial regulation of division.

Adenosine Triphosphatases↗
PubMed2001

Mind over matter? II: implications for psychiatry.

OBJECTIVE: To explore concepts of causality within the mind and aetiology of psychiatric disorders in the light of the proposed formulation of the mind-brain problem. METHOD: Taking the two propositions of this formulation as 'first principles' a logical analysis is attempted. RESULTS AND CONCLUSIONS: Neural activity cannot in principle be regarded as causing mental activity, or vice versa. Causal processes are most coherently conceptualised in terms of the 'mind-brain' system. Determination of causal and aetiological effects will always necessitate consideration of contextual evidence. Because of the 'explanatory gap' between explanation in neurophysiological terms and 'mentalistic' terms, whenever formulation in mentalistic terms is possible this will carry greater explanatory power; that is, it will carry meaning in the way a neural formulation cannot.

Brain↗
PubMed2002

[Patterns of Change--Transitions between "States of Mind" in a solution oriented brief therapy].

The concept of "states of mind" (configurational analysis by M. J. Horowitz) allows for a comprehensive phenomenological description of psychotherapy processes. The method is exemplified by a single case analysis of a 13-session solution oriented therapy. Some of the representative state-transitions and state-cycles are described. Additionally, the states-of-mind-approach is integrated into concepts of self-organization and pattern transitions in complex dynamic systems. States of mind can be defined as attractors of closely interconnected physiological, mental, and social processes. In this sense, psychotherapy would lead to changes in attractor constellations which represent important aspects of personality.

Humans↗
PubMed2005

Mind bomb-2 is an E3 ligase for Notch ligand.

The zebrafish gene, mind bomb (mib), encodes a protein that positively regulates of the Delta-mediated Notch signaling. It interacts with the intracellular domain of Delta to promote its ubiquitination and endocytosis. In our search for the mouse homologue of zebrafish mind bomb, we cloned two homologues in the mouse genome: a mouse orthologue (mouse mib1) and a paralogue, named mind bomb-2 (mib2), which is evolutionarily conserved from Drosophila to human. Both Mib1 and Mib2 have an E3 ubiquitin ligase activity in their C-terminal RING domain and interact with Xenopus Delta (XD) via their N-terminal region. Mib2 is also able to ligate ubiquitin to XD and shift the membrane localization of Delta to intracellular vesicles. Importantly, Mib2 rescues both the neuronal and vascular defects in the zebrafish mib(ta52b) mutants. In contrast to the functional similarities between Mib1 and Mib2, mib2 is highly expressed in adult tissues, but almost not at all in embryos, whereas mib1 is abundantly expressed in both embryos and adult tissues. These data suggest that Mib2 has functional similarities to Mib1, but might have distinct roles in Notch signaling as an E3 ubiquitin ligase.

Amino Acid Sequence↗
PubMed2006

Evidence for "Unertan Syndrome" and the evolution of the human mind.

A new family exhibiting "Unertan Sydnrome" was discovered. The pedigree analysis showed marriages between relatives. This family was similar to the first one (see Tan, 2006a), providing a firm evidence for the new syndrome. The affected children showed habitual quadrupedal walking gait, that is, they walked on wrists and feet with straight legs and arms. Their heads and bodies were mildly flexed; they exhibited mild cerebellar signs, and severe mental retardation. The pedigree demonstrated a typical autosomal-recessive inheritance. The genetic nature of this syndrome suggests a backward stage in human evolution (devolution), which would be consistent with theories of punctuated evolution. The results reflected a new theory on the evolution of human beings. That is, the evolution of humans would in fact be the evolution of the extensor motor system, responsible for upright posture, against the gravitational forces. This would be coupled with the emergence of the human mind, which can be considered a reflexion of the human motor system, in accord with the psychomotor theory (see Tan, 2005a). The most important characteristic of the newly emerged human mind was the resistance against gravitational forces. This was the resistive mind, the origins of human creativity.

Abnormalities, Multiple↗
PubMed2002

Narrative discourse and theory of mind development.

The authors examined experimentally whether exposure to social discourse about concepts related to mental states could promote changes in children's theory of mind understanding. In 2 studies, 3- to 4-year-old children were assigned to either a training or a no training control condition. All children were administered several theory of mind measures at pretest and 2 posttests. Training was not effective in improving performance in Study 1 (n = 37); but in Study 2 (n = 54), modifications of the training procedure led to significant improvements on measures of false belief and deception from pretest to 1st posttest. The findings support the influence of social discourse on children's theory of mind development.

Analysis of Variance↗
PubMed2003

Mood alterations in mindful versus aerobic exercise modes.

The results of most recent studies have generally indicated an improvement in mood after participation in aerobic exercise. However, only a few researchers have compared mindful modes of exercise with aerobic exercise to examine the effect of 1 single session of exercise on mood. In the present study, the authors assessed state anxiety, depressive mood, and subjective well-being prior to and following 1 class of 1 of 4 exercise modes: yoga, Feldenkrais (awareness through movement), aerobic dance, and swimming; a computer class served as a control. Participants were 147 female general curriculum and physical education teachers (mean age = 40.15, SD = 0.2) voluntarily enrolled in a 1-year enrichment program at a physical education college. Analyses of variance for repeated measures revealed mood improvement following Feldenkrais, swimming, and yoga but not following aerobic dance and computer lessons. Mindful low-exertion activities as well as aerobic activities enhanced mood in 1 single session of exercise. The authors suggest that more studies assessing the mood-enhancing benefits of mindful activities such as Feldenkrais and yoga are needed.

Adult↗
PubMed2005

Minding the baby a reflective parenting program.

Minding the Baby, an interdisciplinary, relationship based home visiting program, was initiated to help young, at-risk new mothers keep their babies (and themselves) "in mind" in a variety of ways. The intervention--delivered by a team that includes a nurse practitioner and clinical social worker--uses a mentalization based approach; that is, we work with mothers and babies in a variety of ways to develop mothers' reflective capacities. This approach--which is an adaptation of both nurse home visiting and infant-parent psychotherapy models--seems particularly well suited to highly traumatized mothers and their families, as it is aimed at addressing the particular relationship disruptions that stem from mothers' early trauma and derailed attachment history. We discuss the history of psychoanalytically oriented and attachment based mother-infant intervention, the theoretical assumptions of mentalization theory, and provide an overview of the Minding the Baby program. The treatments of two teenage mothers and their infants are described.

Adult↗
PubMed1992

Metaphor as illness: postmodern dilemmas in the representation of body, mind and disorder.

The search for a synthesis bridging the gap between materialist and idealist approaches in anthropological theory has been invigorated by recent efforts to develop a critical medical anthropology. Not limited to integrating class analysis and cultural interpretation, the "mindful body" paradigm also aims at empowering the ill, whose experience is denied by biomedical and psychiatric categories that locate disease either in the body or in the mind, and treat them separately from one another and independently of social context. However, missing from the "mindful body" discourse is a reflexive awareness of its contextual grounding in both popular and biomedical discourses of illness, with which it exchanges meanings and from which it borrows dominating power. The case of cancer as a metaphorized illness and a pathologized trope is used to illustrate this process.

Anthropology, Cultural↗