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Primary gastrinomas have been reported in lymph nodes within the gastrinoma triangle. We report a 56-year-old woman with possible primary lymph node gastrinoma in the jejunal mesentery. Six months after excision of the tumor, she is asymptomatic and serum gastrin level is normal.
Myxoid liposarcoma, unlike other types of liposarcoma, has an unusual propensity to metastasize to extrapulmonary sites including the abdominal cavity. Metastatic myxoid liposarcoma is an important condition because it may indicate distant micrometastatic disease. We report the case of a 47-year-old woman with a metastatic myxoid liposarcoma in the mesentery. Surgical excision with a tumor-free margin was achieved, but cardiac and liver metastases developed. We review the available literature and discuss what is still debated about this disease.
The aim of the study was to evaluate nicotine-induced microlymphatic responses in rat mesentery in vivo with time-resolved transmission microscopy. Male Fisher rats weighing 150-200 g were used in all experiments. The experiments revealed that changes of lymphatic function under direct nicotine impact (continuous topical application of nicotine in the concentration ranges of 0.001 mM, 10 mM and 100 mM for 15 minutes) were dose- and time-dependent. A nicotine dose of 10 mM caused an immediate short-term constriction of 100% of lymphangions. At the highest concentration of nicotine (100 mM), similar constriction as well as inhibition of lymph flow, local stable constriction of lymph microvessels, stasis in blood microvessels, and disturbances of respiration were observed. Application of chronic nicotine (0.23 ml from a 10 mM solution) injection for 14 days via a miniosmotic pump did not substantially change the function of lymphatic and blood microvessels. Our data show for the first time that the acute effect of nicotine is accompanied by significant changes in microlymphatic function. We conclude that the observed effects are due to the direct action of nicotine on lymphatics. The mechanism by which nicotine induces this response remains to be investigated further.
We report the case of an 82-year-old woman who presented with an ill-defined mass and tenderness in the right lower quadrant of the abdomen. On computerized tomography scan, she had an irregular large bosselated mass of the mesentery located medial to the cecum and associated with multiple loops of small intestine. Preoperative differential diagnoses included leiomyosarcoma, lymphoma and gastrointestinal stromal tumor. The mesenteric mass was resected and identified as a leiomyosarcoma. This patient's tumor is typical of a mesenteric leiomyosarcoma and recurred with hepatic metastases two years after its initial removal. Such tumors usually do not become symptomatic until late in the course of disease, often after distant metastases have occurred. Mesenteric leiomyosarcomas are rare and have a reported incidence of 1: 350,000.
The effect of dietary zinc deficiency of two weeks duration on the synthesis of collagen and of other proteins in wounded rat mesentery was investigated 1, 3, 5, 7, and 10 days after operation. Collagen synthesis was maximal on postoperative day 5. There were no significant differences between zinc-deficient and pair-fed control rats at any time in either collagen synthesis or that of other protein. On the contrary, zinc-deficient rats tended to synthesise more protein than control rats. Collagen concentration (measured as hydroxyproline) in scar tissue on day 10 did not differ between zinc-deficient and control rats. In summary, the earlier reported decreased collagen/protein synthesis associated with zinc deficiency seems to be region dependent.
Histamine, bradykinin and prostaglandin E1 increase the permeability coefficient of albumin; this effect is mimicked by dibutyryl-cAMP and by theophylline. They also cause a significant rise in the cAMP levels of the incubated tissue. Serotonin has lesser activities on these parameters. Presumably, the first three mediators control the transcellular passage of albumin by increasing the cAMP content of the tissue, serotonin being less effective. These findings on the mesentery seem to have a couterpart in vascular tissue as shown by others using different methods.
The casein inhibitor of gastric secretion, when applied to the mesentery of anesthetized rat at doses 0.01-10.0 micrograms in 0.1 ml activated the lymph flow due to enhanced contraction of lymphatic microvascular wall and valves. Moreover, casein inhibitor administrated intraintestinally at doses 5 mg in 0.5 ml on rat keep its lymphotropic activity.
Three Holstein cows were admitted on postpartum day 3 with signs of abdominal pain, inappetence, and decreased milk production. All 3 were depressed, tachycardic, and dehydrated. Right paralumbar fossa laparotomy was performed on each cow. At surgery, a rent in the proximal portion of the jejunal mesentery, with perforation of the jejunum adjacent to the mesenteric rent, was found in all 3 cows. All had evidence of severe peritonitis and gross contamination of the abdomen with digesta. Because of severe peritonitis and inability to exteriorize the affected segment of jejunum, all 3 cows were euthanatized. We postulate that the mesenteric rent occurred at the time of parturition, resulting in ischemia and jejunal perforation in the segment of jejunum adjacent to the rent.
A sensory unit with one or two Pacinian corpuscles was isolated from cat mesentery and square wave mechanical stimulation (duration 5-10 sec), sinusoidal frequency stimulation (duration 4-130 sec, frequency 0.06-300 Hz) and ramp mechanical stimulation (duration 5-10 sec) were applied to the Pacinian corpuscles. When the temperature exceeded 27 degrees C, the sensory unit caused a sustained discharge after on-response to the square wave stimulation. The sustained discharge lasted until the off-response. The sustained discharge was considered to be generated by an oscillation of the receptor potential in the Pacinian corpuscles. The results were as follows: 1. Sensory units with two Pacini corpuscles of cats from young (20 days after birth) to adult were found to respond with both fast-adapting and apparent slow-adapting responses at room temperature (27 degrees C). 2. The two Pacini corpuscles showed the characteristics of fast-adapting mechanoreceptor and vibrator. It was confirmed that the apparent slow-adapting responses from the sensory units were not artifacts induced by vibration from the stimulating bar or experimental table or experimental room, but were originated by an unknown mechanism in the corpuscles. 3. Some sensory units with two Pacinian corpuscles also responded with both fast-adapting and apparent slow-adapting responses in the range of 27-29 degrees C. The apparent slow-adapting responses were caused by pressure and vibratory stimulations above a strength level, but not by dumping of the stimulating bar. 4. The sensory unit evoked only the fast-adapting discharges near the threshold level of stimulus strength at less than 27 degrees C. In the temperature range of 27-40 degrees C, the sensory unit showed an increase in frequency of the apparent slow-adapting discharge by increased displacement and velocity of the stimulus. 5. The sensory unit responded with repeated firing to low-frequency stimulation (0.1-0.06 Hz) at the temperature range and the impulse number was increased by increased strength of the low-frequency stimulation. 6. At the 27-40 degrees C, the sensory units with Pacinian corpuscles evoked after discharge and spontaneous discharges and the impulse number was increased by increased displacement, velocity and frequency of the mechanical stimulus. Thus it is difficult to call the response of Pacinian corpuscles observed at more than 27 degrees C a slow-adapting one, judging from the duration of the receptor potential. We considered that these discharge responses resulted from an electrical oscillation of the receptor potential in the corpuscles.(ABSTRACT TRUNCATED AT 400 WORDS)
The contractile activity of the wall and valve of lymphatic microvessels (LM) of the rat mesentery were studied biomicroscopically by optic photometry. Opioid peptides-Leu-enkephalin and dalargin-stimulated LM. Preliminary application of naloxone on the LM prevented the appearance of the LM contractions following the Leu-enkephalin-application. Naloxone did not inhibit contractions of LM previously activated by Leu-enkephalin. It is supposed that opioid mechanisms are involved in the regulation of the LM contractile activity.
Using the electronograms of Pacinian corpuscle capsule of the cat mesentery the authors have studied in details the structure of its layers and lamellae. The thickness of the capsule lamellae ranged between 30 nm-320 nm, the mean width being 150 nm. On the surface they are overlaid by means of lamina basalis. The capsule is formed by circular layers composed, most often, by 1-2 lamellae, less frequently, by larger number of lamellae. The width of the space between the layers of lamellae is 150-820 nm. A number of lamellae is provided with longer or shorter processes. They are directed more often to the adjacent lamella with which they can be also connected by means of membrane specialization. However, they are also directed into the space between individual layers of the capsule. The importance of these processes has not been known. Furthermore, the authors have studied the reciprocal link-up of the lamellae within one layer. The lamellae are connected either side-to-side, by inserting the end of one lamella into the infolding of the other, end-to-side or end-to-end. Rich pinocytotic activity (rich occurrence of caveolae) was observed in the lamellae of the capsule. Therefore the authors are of the opinion that the capsule and its lamellae have not only mechanical significance or the function of the transfer system and filter, but they form an important component (subsystem) of the whole metabolic system in the sensory corpuscle.
The authors present a case of hemangiopericytoma of the rectal mesentery, this is an uncommon type of vascular tumor, exceptional in this localization. We analyze the difficulty of a preoperative diagnosis, the lack of specificity of the clinical signs and the importance of the radical resection linked to the biological aggressiveness and the frequency of local recurrences and distant metastases.
The technique of intravascular autoradiography of 3H-thymidine labeled nuclei of microvessels endothelia was developed. The density difference of labeled cells in microvascular bed of mesentery was estimated. The maximal density of labelled nuclei was found in pre- and postcapillary vessels, and minimal--in capillaries and large arteries and veins of mesenteric bed. The number of labeled nuclei per vessel was found to be relatively constant. The density of labeled cells in 4-months old rats is less than that in 3 weeks-old ones.
The effects of synthetic atrial natriuretic factor (ANF) on noradrenergic neurotransmission were assessed in the in situ blood-perfused rat mesentery. Synthetic ANF was infused (.003-1 micrograms/min) directly into the mesenteric artery, and vascular responses to periarterial (i.e., sympathetic) nerve stimulation (PNS) and exogenous norepinephrine (NE) were elicited. Synthetic ANF did not significantly alter vascular responses to PNS and only slightly suppressed responses to exogenous NE at blood levels greater than 10 ng/ml. In contrast, under similar conditions, low doses of adenosine attenuated vascular responses to PNS without reducing responses to exogenous NE, and high doses of adenosine nearly abolished responses to both PNS and exogenous NE. We conclude that synthetic ANF exerts very little influence on noradrenergic neurotransmission in the rat mesenteric vascular bed.
3 cases of desmoid tumours of the mesentery occurring as part of Gardner's syndrome are reported. In 2 cases, CAT scanning was carried out. We underline the value of this examination compared to other imaging methods. It allows the establishment of a diagnosis, investigation for complications, the operability to be assessed and is useful for monitoring patients. Its major value is in avoiding an unnecessary laparotomy, a factor certain to produce recurrence, in certain patients. Other alternative therapy may then be proposed.
The case of a twelve year-old boy suffering from "common ileocolic mesentery" with surgical finding of very serious splanchnic venous dilatation is presented. Mesenteric arteriography was the most useful test for diagnosis. The surgical technique has been compared with that described by other Authors.
Fluoride-resistant acid phosphatase (extralysosomal) activity has been investigated in Pacinian sensory corpuscles from cat's mesentery. The activity was found in the innermost and intermediate layers of the capsular system, but it is not possible to establish its exact localization. The central axon and the inner core were FRAP negative. The authors discuss the possible functional significance of FRAP activity in sensory corpuscles.
A 36-year-old man is described with idiopathic emphysema of the mediastium, neck, subcutaneous tissue of the chest and abdomen followed by pneumatosis cystoides of the intestine, mesentery, greater omentum and peritoneum with good outcome.