[Pre-neoplastic involvement. Its treatment].
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The authors report on their findings after analysing the results of an intermittent combination chemotherapy with Bleomycin (B.L.M.), Methotrexate (M.T.X.), Cyclophosphamide and corticoid (B.M.E.M.), in 117 cases of tumors of the Head and Neck. There were 30,0% of complete remission and 77,8% of responsiveness mors. Significant response rates were achieved with this B.M.E.M. combination therapy in: both advanced and not advanced tumors, both well and poor differentiated carcinomas; both exophitic and endophytic tumors.
The tissue polypeptide antigen test (TPA) was carried out in 25 patients with tumours of the maxillofacial region before and after surgery. Further control determination were performed for up to 14 months. A decrease in TPA values was found in only 4 patients after surgery, but a steep rise in TPA values was found with progressive tumor growth. No conclusion can yet be drawn from these initial results as to whether this test is of importance in tumours of the maxillofacial region.
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Under analysis were 111 patients with primary multiple tumors of digestive organs. Thirty four tumors were developing synchronously, 77 were metasynchronous. Twenty five patients had lesions of one organ, 81 patients - of two organs and 5 patients of 3 organs. The radical treatment was carried on in 64 patients. Twenty six of them (40,6%) survived for more than 5 years of observations.
The clinical observations of the higher incidence of recurrence after irradiation of skin cancer in the more furrowed and more articulated regions of the face are explained in part by physical-dosimetric measurements. We believe that the higher ratio of recurrences in these areas is attributable to several factors, such as the unfavorable patho-anatomical structure and the inherent difficulties in radiation therapy and to the inadequate determination of the tumor's depth extension.
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