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Cellular immunity in patients with leprosy. Circulating T lymphocytes and their response to PHA in leprosy.

The ability of peripheral blood lymphocytes from polar lepromatous (LL), borderline lepromatous (BL) and borderline tuberculoid (BT) patients to transform in vitro in the presence of phytohemagglutinin was found to be significantly reduced. A significant reduction in the percentage and absolute number of T lymphocytes was observed in LL cases. In BL cases the number of T lymphocytes was decreased, but the reduction was proportional to the reduction in the total lymphocyte population was observed only in bacteriologically positive cases.

Female↗
PubMed1988

Secondary and primary dapsone resistant leprosy: an analysis of 199 patients from St. Thomas Hospital and leprosy project, Chettupattu, South India.

The occurrence of secondary and primary dapsone resistance in 199 patients in our control area and the influence of certain variables such as age, initial bacteriological and morphological indices, duration of regular dapsone monotherapy, on the emergence of dapsone resistance was investigated. Ninety one of 122 patients and 29 out of 77 showed secondary (SDR) and primary (PDR) resistance to dapsone respectively. Very low BI (BI:2.5) group also showed both SDR (60%) and PDR (40%). Low or high MI group exhibited the same degree of resistance. Multiplication of M. leprae was obtained even when the MI of the inocula was zero. Even in the group who had 1 to 5 years duration of regular dapsone treatment, 85% patients showed SDR. Significance of such results are discussed in relation to chemotherapy. The overall minimum prevalence of SDR was found to be 5.6% and 21% in the case of PDR in our control area.

Age Factors↗