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PubMedDate not supplied

A short review of the relationship between intestinal permeability and inflammatory joint disease.

The potential aetiological relationship between increased intestinal permeability and inflammatory joint disease is reviewed. The known physiology of intestinal permeability is outlined and the alterations which occur in different disease states are described. A rationale is given for the hypothesis that the gut is the likely source of the antigens causing inflammatory arthritis, and the studies of this hypothesis to date are reviewed.

Arthritis↗

PubMed1987

Cartilage proteoglycans in degenerative joint disease.

Cartilage content of proteoglycans decreases early in induced degenerative hip joint disease. Remaining molecules show structural changes indicating fragmentation. Fragments lost from the articular cartilage are released to the synovial fluid, where they can be quantified by enzyme linked immunosorbent assay. Their amounts are related to the activity of the disease process.

Animals↗

PubMed1996

[Pathogenesis and pathologic anatomy of degenerative knee joint disease].

Etiopathogenesis of degenerative disease of knee joint has been presented in this work. The role of instability of the joint, disturbances of biochemical processes of cartilage, synovial membrane or joint fluid and microinjuries in pathogenesis of this disease has been discussed as well.

Cartilage, Articular↗

PubMed1983

Natural killer cell activity in inflammatory joint disease.

The natural killer (NK) cell activity of unfractionated peripheral blood and synovial fluid mononuclear cells from patients with inflammatory joint disease was measured in a short-term assay using the human tumour cell line, K562, as the target. The mean values for peripheral blood NK activity of the various groups (controls, rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA] were similar although the rheumatoid group showed the widest range. However, the NK activity of PsA patients (23.74 +/- 10.14) was significantly lower than that of the controls (31.63 +/- 10.8, 0.05 greater than P greater than 0.01). Almost without exception, NK activity was found to be considerably lower in synovial fluid than in paired blood samples (p less than 0.01).

Arthritis↗

PubMed2006

Clinical efficacy and tolerance of an extract of green-lipped mussel (Perna canaliculus) in dogs presumptively diagnosed with degenerative joint disease.

AIM: To evaluate the efficacy and tolerance of an extract of green-lipped mussel (GLME) in the management of mild-to-moderate degenerative joint disease (DJD) in dogs. METHODS: Eighty-one dogs presumptively diagnosed with DJD were treated orally daily with either GLME or a placebo for 56 days, in a double-blind, placebo-controlled study. In an uncontrolled open-label extension to the study, all dogs were treated with GLME for an additional 56 days (from Days 57-112). Clinical signs were subjectively scored by the owners, and findings of detailed musculoskeletal examinations were scored by one veterinarian. Efficacy was assessed from a qualitative comparison of the proportion of dogs with improved clinical signs, and a quantitative comparison of the scores of the musculoskeletal examinations, between groups. Haematological and biochemical analyses and reports by owners of possible adverse drug reactions were used to screen for evidence of toxicity. RESULTS: There was close agreement between assessments by the veterinarian and owners. The clinical signs of DJD in both GLME-treated and placebo groups improved significantly over baseline by Day 28; this improvement continued over the entire course of the study. There were no significant differences between groups on Day 28. On Day 56, a higher proportion of dogs in the GLME-treated group had improved clinical signs (p=0.018), and GLME-treated dogs had marginally better (p=0.053) musculoskeletal scores than dogs in the placebo group. The differences between the groups were no longer apparent by Day 112, by which time the former placebo group had been receiving GLME for 56 days in the open-label phase of the study. The proportion of dogs in the former placebo group that had improved by Day 112 (29/32; 91%) was significantly greater (p=0.012) than the proportion improved at Day 56 (15/37; 41%). No signs of toxicity were apparent. CONCLUSIONS AND CLINICAL RELEVANCE: GLME had a beneficial effect on the clinical signs of dogs presumptively diagnosed with mild-to-moderate DJD. Long-term therapy may be required before improvement is apparent.

Animals↗

PubMed1993

In vitro release of prostaglandins and leukotrienes from synovial tissue, cartilage, and bone in degenerative joint diseases.

OBJECTIVE: To determine the major source of eicosanoid release in arthritic joint tissues and to examine the modulation of this release by indomethacin and diclofenac. METHODS: Release of prostaglandin E2 (PGE2), 6-keto-PGF1 alpha, leukotriene B4 (LTB4), and LTC4 was measured in supernatants of synovial tissue, cartilage, and bone incubates from patients with osteoarthritis, active rheumatoid arthritis (RA), inactive RA, and pseudogout. Radioimmunoassay (RIA) was used to determine the levels of the eicosanoids. RESULTS: Addition of the divalent cation ionophore A23187 resulted in significant release of all eicosanoids measured from synovial tissue, but not from cartilage, cortical bone, or cancellous bone. PG release was significantly inhibited by the addition of indomethacin or diclofenac at either 10(-5) moles/liter or 10(-7) moles/liter. The amount of LTC4 released from cartilage and bone was only slightly above the detection limit of the RIA, whereas large amounts were released from synovial tissue. Neither indomethacin nor diclofenac had an effect on LTC4 release. LTC4 release from synovial tissue of patients with inactive RA was significantly decreased in comparison with the levels from synovial tissue of patients with the other joint diseases. There was no significant difference in PG release among patients in the various disease groups. CONCLUSION: Synovial tissue appears to be the major source of eicosanoids in synovial fluid. Indomethacin and diclofenac inhibit the release of PG, but not LT, from various joint tissues.

Arthritis↗

PubMed1997

Pain, tenderness, mandibular mobility, and anterior open bite in relation to radiographic erosions in temporomandibular joint disease.

The relationship between radiographic changes and clinical signs and symptoms of the temporomandibular joint (TMJ) was investigated in 39 patients with joint diseases. Radiographic erosions were found in 33% of the TMJ joints, and overall frequency of radiographic changes including remodeling was 47%. Fifty-four percent of the patients had an anterior open bite (AOB). The AOB showed statistically significant correlation to the extension of erosion of the TMJ. Pain expressed by means of a visual analog scale, tenderness to palpation of the TMJ, and pressure pain threshold showed no significant correlation to erosion, but mandibular mobility showed significant negative correlation to erosive changes. In conclusion, AOB is correlated with erosive radiographic changes in this patient group. However, the degree of local pain and tenderness showed no correlation to radiographic changes.

Adult↗

PubMed1983

Relationship of angiogenesis factor in synovial fluid to various joint diseases.

A low-molecular-weight freely dialysable angiogenesis factor has been isolated from 49 synovial fluids obtained from patients with various joint diseases. An analysis of disease type and incidence of freely dialysable angiogenesis activity showed that the osteoarthrotic group had a significantly higher incidence than all the other groups (p = 0.0332). Angiogenesis factor has also been detected in a bound form in the retentates of fluids which gave positive results for dialysable factor. The possibility that an imbalance between carrier-bound and free factor may have a causative role in disease is discussed.

Angiogenesis Inducing Agents↗

PubMed1991

Arthroscopic treatment of degenerative joint disease of the knee.

The role of arthroscopy in the management of degenerative conditions of the knee continues to evolve. This study was undertaken to: (1) assess the efficacy of arthroscopic treatment, (2) identify significant prognostic factors, and (3) further define the indications for treatment. A retrospective review of charts and operative videotapes along with follow-up evaluation was obtained for 43 knees in 40 patients. Average age was 54 years. Average follow up was 24 months; 72.1% of patients had good results at follow up, 16.3% had fair results, and 11.6% were treatment failures. Preoperative clinical status, severity of degenerative changes, and number of pathologic entities encountered at the time of surgery correlated with the results of treatment. We believe that arthroscopic debridement is an effective means of treatment for mild to moderate degenerative joint disease after failure of conservative measures. By using this treatment option, more extensive surgical procedures may be delayed or avoided.

Arthritis, Rheumatoid↗

PubMed1992