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Information processing: a new model for understanding cognitive disturbances in psychiatric patients.

Information processing models are influenced by the information sciences and by computer technology, which progressed in the 1960s and 1970s. During the last decade these models have formed the theoretical basis for much of the experimental research on cognitive dysfunctions in psychiatric patients. An essential element in all of these models is that information is processed in several discrete stages. Different experimental paradigms have been developed in order to tap information about the processes taking place in each of these stages. Most of the research so far on pathological groups has been done on schizophrenic patients. Some deficits found in schizophrenics seem to be symptom-related. This is the case with performance deficits on the Continuous Performance Test with low processing load. Other dysfunctions might be vulnerability indicators, such as deficit performance on the forced choice Span of Apprehension task and the Continuous Performance Test with high momentary processing load, backward masking, serial recall for items that involve active rehearsal, and eye movement dysfunctions. However, information processing deficits do not seem to be specifically related to schizophrenia. Deficits can be found in other psychiatric syndromes too, especially in manic patients. Generally speaking, the dysfunctions emerge in a milder form in nonschizophrenic patients.

Attention↗

Clinical impact of renin-angiotensin system blockade: angiotensin-converting enzyme inhibitors vs. angiotensin receptor antagonists.

Clinical trials have proved that blockade of the renin-angiotensin-aldosterone system (RAAS) offers primary and secondary protection of the cardiovascular system, brain, and kidneys. Drugs that interrupt the RAAS do so by several diverse mechanisms but it remains to be fully proved whether these mechanistic differences are associated with meaningful differences in clinical outcomes. This review summarizes current information about the basic mechanisms of action of three classes of anti-RAAS drugs: angiotensin-converting enzyme (ACE) inhibitors, combined ACE-neutral endopeptidase inhibitors, and angiotensin receptor antagonists as well as results of major clinical outcome trials with these agents. Basic and clinical science information is then blended with insights from the clinical pharmacology of anti-RAAS drugs to address four current controversies in clinical medicine: whether ACE inhibitors and angiotensin receptor antagonists are interchangeable, optimal dosing of available agents, potential justification of ACE inhibitor/angiotensin receptor antagonist combinations, and first-line use of anti-RAAS drugs in antihypertensive therapy.

Angiotensin II Type 1 Receptor Blockers↗

Parents explain more often to boys than to girls during shared scientific thinking.

Young children's everyday scientific thinking often occurs in the context of parent-child interactions. In a study of naturally occurring family conversation, parents were three times more likely to explain science to boys than to girls while using interactive science exhibits in a museum. This difference in explanation occurred despite the fact that parents were equally likely to talk to their male and female children about how to use the exhibits and about the evidence generated by the exhibits. The findings suggest that parents engaged in informal science activities with their children may be unintentionally contributing to a gender gap in children's scientific literacy well before children encounter formal science instruction in grade school.

Chi-Square Distribution↗

Ecologies, outreach, and the evolution of medical libraries.

QUESTION: What are some of the forces shaping the evolution of medical libraries, and where might they lead? DATA SOURCES: Published literature in the fields of library and information sciences, technology, health services research, and business was consulted. MAIN RESULTS: Medical libraries currently have a modest footprint in most consumers' personal health ecologies, the network of resources and activities they use to improve their health. They also occupy a relatively small space in the health care, information, and business ecologies of which they are a part. Several trends in knowledge discovery, technology, and social organizations point to ways in which the roles of medical libraries might grow and become more complex. CONCLUSION: As medical libraries evolve and reach out to previously underserved communities, an ecological approach can serve as a useful organizing framework for the forces shaping this evolution.

Community-Institutional Relations↗

Information-seeking behavior of health sciences faculty: the impact of new information technologies.

This paper reports on an ongoing investigation into health sciences faculty's information-seeking behavior, including their use of new information technologies. A survey was administered to all faculty in medicine, nursing, and pharmacy at the University of Illinois at Chicago. It was similar to one administered to the same population in 1991. The survey asked about faculty's use of electronic resources, documented any shift from the use of print to electronic formats, and measured the utilization of library training. The response rate was 48.5% for medicine faculty, 45.0% for nursing, and 62.5% for pharmacy. The study found that use of the print Index Medicus among faculty was in transition: While 30.5% continued to use the print resources, 68.0% of faculty accessed MEDLINE through electronic means. Faculty preferred accessing electronic databases from their offices to doing so from the library. Health sciences faculty used a wide variety of databases, in addition to MEDLINE, to fill their information needs. Most faculty did not take advantage of either in-house or electronic training sessions offered by librarians. The study concluded that the training preferences of faculty need to be further explored.

CD-ROM↗

Anatomical informatics: Millennial perspectives on a newer frontier.

One of the most ancient of sciences, anatomy has evolved over many centuries. Its methods have progressively encompassed dissection instruments, manual illustration, stains, microscopes, cameras and photography, and digital imaging systems. Like many other more modern scientific disciplines in the late 20th century, anatomy has also benefited from the revolutionary development of digital computers and their automated information management and analytical capabilities. By using newer methods of computer and information sciences, anatomists have made outstanding contributions to science, medicine, and education. In that regard, there is a strong rationale for recognizing anatomical informatics as a proper subdiscipline of anatomy. A high-level survey of the field reveals important anatomical applications of computer sciences methods in imaging, image processing and visualization, virtual reality, modeling and simulation, structural database processing, networking, and artificial intelligence. Within this framework, computational anatomy is a developing field focusing on data-driven mathematical models of bodily structures. Mastering such computer sciences and informatics methods is crucial for new anatomists, who will shape the future in research, clinical knowledge, and teaching.

Anatomy↗

[Trends in the improvement of the medical documentation system].

The paper reports on the general and specific functions of medical records, as well as on the need to improve medical recording and the circulation of medical records in health units. The economic medical and social advantages of keeping accurate records are highlighted. Recent breakthroughs in information science permit unifying and standardizing medical records, making them more problem-oriented, developing technical equipment and extending its use in archives, expanding the role of the computer in clinical recording.

Documentation↗

Staffing intelligence services: a survivor's guide.

Work at the Department of Health on the information needs of District Health Authorities as purchasers demonstrates the need for co-ordinated information services that handle both numeric and text data--termed intelligence. The DHA Project has built information implications into its health needs assessment protocol and has shown, through pilots, the steps involved in developing co-ordinated provision. These developments contrast sharply with the long-established NHS dichotomy between the roles of librarians--often narrowly perceived, and those of information officers--equally narrowly defined but with a greater command of resources. Consideration of how intelligence services are to be staffed raises issues which involve appreciating wider changes in information education. Most current courses no longer perpetuate the skills divide between those who will be at ease handling text information (librarians) and those who are able to create and use database management systems holding numeric data (information officers). Skills needed for the intelligence function cross the boundary. Some librarians are already able to encompass the required range of skills, but without retraining many will face unequal competition with the new generations of graduates from information management and information science courses. Local training opportunities are essential, but there is also a growing number of higher degree courses which can be used for career enhancement and some of them are available on a distance learning basis. The NHS Training Directorate has begun the process of assisting courses it deems relevant to NHS information management training, but the Department of Health should specify the staff competencies required as part of quality assurance standards for intelligence services.

Education, Graduate↗

Emergency protocols in prehospital emergency medicine in Slovenia.

Emergency medicine is a branch of medicine in which prompt and accurate information is of crucial importance, because a patient's survival and the final outcome of a treatment very often depends on it. Therefore the standardization of prehospital emergency service administration with uniform documentation, methods of annotation of technical data as well as uniform gathering and data analysis are necessary. Wanting to process a fair amount of data and specially to disburden personnel, a need for computer aided processing is evident. Application that was developed in strong collaboration with EMS project team and information science engineers definitely improves data quality. Firstly when team members, especially physicians, are constrained to fulfill paper forms and secondly when data are entered into the computer, because all inconsistencies are being reconsidered and corrected if necessary. The developed application also gave the opportunity to the emergency team for prompt and accurate information.

Data Collection↗

Selective dissemination and indexing of scientific information.

Selective dissemination of information to individuals provides a new and promising method for keeping abreast of current scientific information. Since SDI services are directed to the information needs of each individual, they are a significant step beyond grouporiented services and products, which require considerable expenditure of effort by each user as he sorts useful information from trash. However, SDI systems do require a high degree of precision in matching scientists against documents. They must operate more efficiently and economically than many current systems which occasionally provide a useful item of information to users. To meet these stringent requirements for quality, precision, efficiency, and economy, more research must be devoted to comparing and improving indexing methods, which are the basic component of all information storage and retrieval systems. It is incredible that so much money has been spent on the development and operation of scientific information systems before basic data on the comparative performance of various indexing methods have been gathered, analyzed, and confirmed by multiple investigators. The design of an effective information system would seem to require this type of basic knowledge, just as basic properties of alternative materials must be known before an engineer can design a building, bridge, or factory. Yet, except for the few studies mentioned in the previous section, research on indexing methods has been greatly neglected. Bourne's comment about studies of indexing languages is still an appropriate description of the situation: "In almost all the experimental reports, the investigator worked with an indexing language different than that of other experimenters. Consequently, no one has ever had his test results verified, or expanded, or made more precise by another experimenter" (47). Most existing information systems are based on keyword indexing, with concepts broken into isolated terms during input operations and recombined to synthesize the original concept during search and retrieval. Such systems tend to involve imprecise indexing, with a high level of "noise" in retrieved documents, difficult search strategy involving extensive post-coordination, and lengthy, complex computer manipulations. This situation reflects the fact that many producers of indexed data originally focused the design of their systems on the production of a published product with entries printed under short, concise index headings. Production of magnetic tapes as a by-product of the publication process, and their use for retrospective searching or for SDI services, was a much later development, almost an afterthought. Yet use of these tapes is growing so rapidly that it may be time to redesign the tape-producing systems, with ease of tape use for SDI services and retrospective searching as the primary consideration, and with publication of abstract and index bulletins or title listings relegated to secondary importance (49). The use of keywords to index documents creates a high degree of disorganization in information search and retrieval operations: Information is scattered under the many different terms that can be used to index different aspects of a concept. If the large-scale, comprehensive abstracting and indexing services were based on enumerative classifications with assignment of documents to logical hierarchical categories at the time of initial indexing, then many of the specialized information centers (50) and the 1300 abstracting and indexing services (3) would be unnecessary, and much of the reindexing and reprocessing of documents, the repackaging and reworking of abstracts and index data, and the resulting overlap and duplication characteristic of current information processing could be terminated. Partly because of the disorganization resulting from keyword indexing, the cost of a 5-year retrospective search of information on just one data base on magnetic tapes is a major investment (16). The effort and cost required to find a few items of useful information scattered among 1,285,000 abstracts indexed on 116 full reels of magnetic tape (11 million characters per reel) which will be needed for the 5-year Eighth Collective Index to Chemical Abstracts (1967-1971) (51) staggers the imagination. In contrast, when HICLASS systems based on enumerative hierarchical classifications are used, concepts that might be useful for later retrieval are identified and related items of information are grouped together during the indexing process. These enumerative classifications, with single-hit matching, make it possible to index and retrieve ideas as intact units and to perform simple sequential searches of the very small segment of a file that deals with a given topic (31). The experiments at both the Science Information Exchange and the National Cancer Institute, as described in this article, demonstrate that automated HICLASS systems are feasible and can operate at a very satisfactory level of performance. Although considerable effort may be required for the development and constant updating of detailed enumerative classifications, HICLASS categories may facilitate organization of data at the time of input, improve the precision of matching documents with users, and greatly simplify search logic and computer manipulations. If so, then output savings and performance would more than justify input costs, and the development and use of enumerative classifications would be a better solution to information problems than the current keyword-and-coordination approach. It is time to think beyond the ease of the single input step in information systems and to take a hard look at ways of easing retrieval problems for the multitude of information systems that process the indexed data (52). Indexing effort is expended only once, whereas search and retrieval effort is required by every user of a system. If information were better analyzed and organized during input operations, if more basic research were devoted to the effect of indexing methods on the performance of information systems, and if more emphasis were placed on the quality and usefulness of retrieved information, then the magnitude of problems related to the storage and retrieval of scientific information might be considerably reduced.

Abstracting and Indexing↗

Threshold-based resource management: a framework for comprehensive ecosystem management.

The problems posed by adaptive management for improved ecosystem health are reviewed. Other kinds of science-informed ecosystem management are needed for those regions of conflict between rapid human population growth, increased resource extraction, and the rising demand for better environmental amenities, where large-scale experiments are not feasible. One new framework is threshold-based resource management. Threshold-based resource management guides management choices among four major science and engineering approaches to achieve healthier ecosystems: self-sustaining ecosystem management, adaptive management, case-by-case resource management, and high-reliability management. As resource conflicts increase over a landscape (i.e., as the ecosystems in the landscape move through different thresholds), management options change for the environmental decision-maker in terms of what can and cannot be attained by way of ecosystem health. The major policy and management implication of the framework is that the exclusive use or recommendation of any one management regime, be it self-sustaining, adaptive, case-by-case, or high-reliability management, across all categories of ecosystems within a heterogeneous landscape that is variably populated and extractively used is not only inappropriate, it is fatal to the goals of improved ecosystem health. The article concludes with detailed proposals for environmental decision-makers to undertake "bandwidth management" in ways that blend the best of adaptive management and high-reliability management for improved ecosystem health while at the same time maintaining highly reliable flows of ecosystem services, such as water.

Conservation of Natural Resources↗

Healthcare informatics research: from data to evidence-based management.

Healthcare informatics research is a scientific endeavor that applies information science, computer technology, and statistical modeling techniques to develop decision support systems for improving both health service organizations' performance and patient care outcomes. The analytical strategies include (1) the formulation of a data warehouse for exploration, (2) data mining, (3) the application of confirmatory statistical analysis, (4) simulation via an interface with computer and information system technologies, and (5) translational research. Healthcare informatics research will help to direct evidence-based strategic management.

Decision Support Systems, Clinical↗

Examination of instruments used to rate quality of health information on the internet: chronicle of a voyage with an unclear destination.

OBJECTIVE: This study updates work published in 1998, which found that of 47 rating instruments appearing on websites offering health information, 14 described how they were developed, five provided instructions for use, and none reported the interobserver reliability and construct validity of the measurements. DESIGN: All rating instrument sites noted in the original study were visited to ascertain whether they were still operating. New rating instruments were identified by duplicating and enhancing the comprehensive search of the internet and the medical and information science literature used in the previous study. Eligible instruments were evaluated as in the original study. RESULTS: 98 instruments used to assess the quality of websites in the past five years were identified. Many of the rating instruments identified in the original study were no longer available. Of 51 newly identified rating instruments, only five provided some information by which they could be evaluated. As with the six sites identified in the original study that remained available, none of these five instruments seemed to have been validated. CONCLUSIONS: Many incompletely developed rating instruments continue to appear on websites providing health information, even when the organisations that gave rise to those instruments no longer exist. Many researchers, organisations, and website developers are exploring alternative ways of helping people to find and use high quality information available on the internet. Whether they are needed or sustainable and whether they make a difference remain to be shown.

Evaluation Studies as Topic↗

Medical informatics. An emerging academic discipline and institutional priority.

Information management constitutes a major activity of the health care professional. Currently, a number of forces are focusing attention on this function. After many years of development of information systems to support the infrastructure of medicine, greater focus on the needs of physicians and other health care managers and professionals is occurring--to support education, decision making, communication, and many other aspects of professional activity. Medical informatics is the field that concerns itself with the cognitive, information processing, and communication tasks of medical practice, education, and research, including the information science and the technology to support these tasks. An intrinsically interdisciplinary field, medical informatics has a highly applied focus, but also addresses a number of fundamental research problems as well as planning and policy issues. Medical informatics is now emerging as a distinct academic entity. Health care institutions are considering, and a few are making, large-scale commitments to information systems and services that will affect every aspect of their organizations' function. While academic units of medical informatics are presently established at only a few medical institutions in the United States, increasing numbers of schools are considering this activity and many traditional departments are seeking and attracting individuals with medical informatics skills.

Career Choice↗

Statistical-mechanical iterative algorithms on complex networks.

The Ising models have been applied for various problems on information sciences, social sciences, and so on. In many cases, solving these problems corresponds to minimizing the Bethe free energy. To minimize the Bethe free energy, a statistical-mechanical iterative algorithm is often used. We study the statistical-mechanical iterative algorithm on complex networks. To investigate effects of heterogeneous structures on the iterative algorithm, we introduce an iterative algorithm based on information of heterogeneity of complex networks, in which higher-degree nodes are likely to be updated more frequently than lower-degree ones. Numerical experiments clarified that the usage of the information of heterogeneity affects the algorithm in Barabási and Albert networks, but does not influence that in Erdös and Rényi networks. It is revealed that information of the whole system propagates rapidly through such high-degree nodes in the case of Barabási-Albert's scale-free networks.

Journal Article↗

Text-mining and information-retrieval services for molecular biology.

Text-mining in molecular biology -- defined as the automatic extraction of information about genes, proteins and their functional relationships from text documents -- has emerged as a hybrid discipline on the edges of the fields of information science, bioinformatics and computational linguistics. A range of text-mining applications have been developed recently that will improve access to knowledge for biologists and database annotators.

Computational Biology↗

Entanglement in quantum critical phenomena.

Entanglement, one of the most intriguing features of quantum theory and a main resource in quantum information science, is expected to play a crucial role also in the study of quantum phase transitions, where it is responsible for the appearance of long-range correlations. We investigate, through a microscopic calculation, the scaling properties of entanglement in spin chain systems, both near and at a quantum critical point. Our results establish a precise connection between concepts of quantum information, condensed matter physics, and quantum field theory, by showing that the behavior of critical entanglement in spin systems is analogous to that of entropy in conformal field theories. We explore some of the implications of this connection.

Journal Article↗

The study of nursing informatics.

A framework for organizing the study of nursing informatics is presented. The management and processing of nursing data, information science and nursing science is proposed as an area for study. The premises for such study and the key concepts and relationships are discussed. Nursing informatics would support the practice of nursing and delivery of nursing care.

Education, Nursing↗