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PubMed1995

Friends' influence of adolescents' adjustment to school.

Adolescents may be influenced both by their friends' behaviors and by the features of their friendships. To examine both types of influence, seventh and eighth graders (N = 297) were asked in the fall of a school year to report their involvement and disruption at school. The students also described the positive and negative features of their best friendships. Teachers reported on the students' involvement, disruption, and grades. These assessments were repeated in the following spring. Students whose friends in the fall described themselves as more disruptive increased in self-reported disruption during the year. Girls' self-reported disruption was more influenced by that of their very best friend than was boys'. Students whose very best friendships had more positive features increased in their self-reported involvement during the year. Students whose friendships had more negative features increased in their self-reported disruption, but only if their friendships also had many positive features. The theoretical and practical implications of these findings, and the adequacy of different methods for estimating friends' influence, were discussed.

Adolescent↗
PubMed1993

Similarity in drug use patterns between adolescents and their friends.

The literature indicates that peer influence is important in understanding adolescent drug use. The nature of peer interactions predicts a high degree of similarity in drug use among friends. To test that hypothesis, a detailed analysis of this correspondence was conducted on a large sample of junior and senior high school students. Findings indicated that a youth who used specific drugs in the last thirty days almost invariably has friends who also use those same drugs, but is considerably less likely to have friends who use other drugs or no drugs. In addition, friends' use is strongly associated with the adolescent's use of marijuana, uppers, cocaine, downers, and PCP across five distinct drug use styles.

Adolescent↗
PubMed1995

Camping with a friend. Helping adolescents cope with diabetes.

The Florida Camp for Children and Youth With Diabetes sponsored a weekend in which teenagers with diabetes invited a friend of the same sex without diabetes to participate in a two-day retreat. This program was designed to encourage friends to take an active role in motivating the teen with diabetes to perform his or her diabetes-related tasks in a responsible manner. Forty-six patients ranging in age from 12-17 years brought friends. Those with diabetes participated in rap sessions as well as educational sessions attempting to teach independence in self-care. The friends were taught the basics of diabetes as well as given an opportunity to inject saline and monitor their own blood glucose levels. A choice of activities was interspersed with education.

Adaptation, Psychological↗
PubMed1996

Adolescent girls' relationships with mothers and best friends.

The present study examined factors associated with harmony in adolescent girls' relationships with their mothers and their best friends. A framework was proposed in which relationship harmony was expected to be related to individual characteristics of each partner and the match between the individual characteristics of each partner. 60 adolescent girls, their mothers, and their best friends participated in self-report and observational tasks. Harmonious mother-daughter partners (vs. disharmonious ones) had more similar needs, felt their needs were better met, perceived their partners as more socially skilled, and had more similar interests. Harmonious friends (vs. disharmonious ones) had more similar needs, and target adolescents perceived partners to be more socially skilled and better at meeting their needs. Observational ratings of attunement, positive affect, and power negotiation were greater in harmonious relationships with both mothers and friends. Discussion focuses on the value of a common framework for studying different relationships.

Adolescent↗
PubMed1996

Why talk about mental states? The significance of children's conversations with friends, siblings, and mothers.

Natural language data from 38 47-month-olds recorded at home in unstructured observations were analyzed and comparisons made of characteristics of mental state term use in child-friend, child-sibling, and child-mother dyads. Significantly more references to mental states were made by the children in conversations with siblings and friends than with mothers. Frequent use of mental state terms by both partners was related to cooperative interaction in both child-friend and child-sibling dyads and several associations were found with measures of language fluency, gender, and maternal education, although these varied across the 2 dyads. Children's use of mental state terms in conversations with siblings and friends was correlated with their performance on two false belief measures. Results highlight the importance of extending investigations into the social implications of the development of children's "theories of mind."

Child↗
PubMed1996

Age differences in support processes in conversations between friends.

The purpose of this study was to examine age differences in the use and effectiveness of social support processes emitted during conversations about real life negative events between preadolescent, adolescent, and adult friends. Age differences were found for 3 forms of support. Older supporters made more excuses and engaged in less distraction than preadolescent supporters, and adult supporters validated more excuses than younger supporters. Talking to friends alleviated negative affect in subjects of all ages, however factors predicting reductions in negative affect differed across age. Preadolescents felt better when friends distracted them from their problems, and adults felt better when friends helped them evade responsibility for their problems. Specific support processes did not predict affect changes for adolescents, but adolescent girls felt better after the conversation than adolescent boys. Results are explained in terms of age differences in self-validation and intimacy needs, experience co-constructing reality and providing social support, and refinement of social skills.

Adolescent↗
PubMed1998

Perceptions of emotional support from mother and friend in middle childhood: links with social-emotional adaptation and preschool attachment security.

Children's (N = 58) perceptions of emotional support from mother and best friend were assessed at age 8. Perceptions of support from mother were predicted by attachment security at age 4, suggesting continuity in the children's internal working model of self in relation to mother. Preschool attachment security predicted age 8 perceptions of maternal support better than the mother's actual behavior at age 8. Identification of the best friend as a member of one's emotional support network was not related to security, but was positively related to social competence. However, among insecurely attached children, the greater the reliance on the best friend for emotional support, the greater the externalizing problems. Compensatory effects of best friend support on the social-emotional adaptation of insecurely attached children were not found.

Adaptation, Psychological↗
PubMed1979

Protective effect of immunization with nonviral antigens against Friend leukemia virus in mice.

DBA/2 mice immunized with poly(A).poly(U) complexed with methylated bovine serum albumin and emulsified in Freund's complete adjuvant were protected against challenge with Friend leukemia virus. There was no correlation between the level of antibody to the immunogen in the prechallenge serum and induced resistance to the virus. Although prechallenge sera of mice given the same amount of the duplex in a single inoculum bound 9.7% of poly(A).poly([(3)H]U) input, as compared to 45.3% bound by the prechallenge sera of mice given the immunogen in divided doses, both groups of mice were equally resistant to infection. Immunization with two other nonviral agents, bovine serum albumin fraction V or dinitrophenylated keyhole limpet hemocyanin, induced the same level of protection. A sparing effect of approximately 10(1.5) in infectivity was afforded the immunized mice. Immunization with either poly(A).poly(U) alone or with the carrier methylated bovine serum albumin was ineffective. In addition to antibodies to the respective immunogens, the prechallenge sera of the immunized mice also contained antibody to Friend leukemia virus gp71. The presence of such viral antibodies was not always related to resistance to infection by Friend virus. Some immunized mice that survived infection did not have gp71 antibody in their serum before challenge, and mice immunized with poly(A).poly(U) alone were susceptible to infection, although their prechallenge sera contained antibody to gp71. The mechanism involved in the induction of resistance to infection is not known. The effect may be mediated through a modification of the expression of both endogenous and exogenous type C viruses and affect immunological mechanisms controlling cellular responses.

Animals↗
PubMed1985

Rat cells infected with anemia-inducing Friend leukemia virus contain integrated replication-competent but not defective proviral genomes.

The integrated proviral DNA in five murine cell lines transformed by the anemic strain of Friend leukemia virus (FLV-A) was examined by Southern hybridization to a cloned Friend virus (F-MuLV) probe. Kpn I fragments 9 kilobases (kb) and 5.7 kb long were observed for each cell line. However, the number of copies of each fragment in the cell genome varied according to the cell type. As compared to the adherent epithelioid cell lines, the anchorage-independent erythroleukemic cell lines contained more copies of the 5.7-kb fragment than of the 9-kb fragment, suggesting that the former may be biologically significant and perhaps related to the growth of erythroid cells. The presence of Kpn I fragments of the same sizes, albeit in fewer copies, in normal mouse spleen DNA made it difficult to distinguish exogenous virus from endogenous viral sequences. Therefore, rat 3Y1 cells, which contained no murine endogenous viruses, were infected with FLV-A stock virus prepared directly from the spleens of leukemic mice. Only the 9-kb Kpn I fragment, representing replication-competent Friend virus component, was detected in the infected rat cell DNA. No hybridization was observed to a 0.6-kb fragment of the spleen focus-forming virus env gene that is specific for xenotropic and dual-tropic mink cell focus-forming viruses. Since the virus synthesized by the infected rat cells was leukemogenic in adult mice, these data suggest that the wild-type FLV-A is replicative and fully pathogenic in the absence of other competent virus components.

Animals↗
PubMed1970

Evidence for transformation of spleen cells one day after infection of mice with friend leukemia virus.

Proliferation and erythroid differentiation of transplanted DBA/2 marrow cells and Friend virus-induced leukemic cells were assessed in syngeneic, allogeneic (H-2 compatible), and (BALB/c x DBA/2)F(1) hybrid mice (CDF(1)). Measurements were made 5 days after transplantation of donor cells into nonirradiated or X-irradiated mice by the spleen colony or the (125)IUdR-(59)Fe uptake methods. Growth of DBA/2J (Jackson subline) marrow grafts was poor in irradiated CDF(1)J hybrids as compared with growth in syngeneic and allogeneic hosts. The DBA/2J transplants proliferated, however, without impairment in irradiated CDF(1) hybrids which were the progeny of DBA/2 male parents of other sublines, e.g. DBA/2Ha, DBA/2Cr, and DBA/2Cum. In contrast, tissue-cultured Friend leukemic cells of DBA/2J origin grew deficiently in all CDF(1) hybrids tested, regardless of irradiation and of the DBA/2 parent's subline. The growth pattern of transplanted DBA/2J cells was a manifestation of hybrid resistance. The results with DBA/2J and other DBA/2 subline grafts suggested that hybrid histocompatibility alleles were expressed to a greater extent in leukemic than in normal marrow cells, for the former were consistently recognized as "nonself" by CDF(1) mice, but not the latter cells. The property of deficient growth in irradiated CDF(1)Ha hybrids was acquired by DBA/2J hemopoietic cells within 6 hr from infection in vivo with Friend leukemia virus, and persisted during the following 8 days. It was ascribed to enhanced expression of hybrid histocompatibility gene(s) (Hh) induced by the virus. Autonomous growth potential of hemopoietic cells, manifested by proliferation in nonirradiated recipients, was first detected 24 hr from infection, and likewise persisted at the later intervals. At the same time, the infected cells grew deficiently also in nonirradiated CDF(1)Ha mice. The two irreversible cellular changes were regarded as the earliest signals of virus-induced transformation.

Animals↗
PubMed2005

Sexual activity among adolescents in romantic relationships with friends, acquaintances, or strangers.

OBJECTIVE: To explore the influence of preexisting social ties between romantic partners (ie, knowing the partner as a friend or acquaintance before a relationship was considered "romantic" by the adolescent) on sexual risk behaviors among adolescents. DESIGN, SETTING, AND PARTICIPANTS: By using data from 6658 adolescents from Wave II of the National Longitudinal Study of Adolescent Health, we examined associations between preromantic social ties between partners and several sexual risk behaviors using logistic regression analyses. MAIN OUTCOME MEASURES: Whether the couple had intercourse, and if they did have intercourse, whether the couple talked about contraception or sexually transmitted infections and whether one of them used some method of birth control every time they had sexual intercourse. RESULTS: Knowing one's partner as a friend (vs being acquaintances) before a romantic relationship was protective against engaging in sexual intercourse for male and female adolescents (odds ratios and 95% confidence intervals, 0.66 [0.51-0.86] and 0.76 [0.62-0.94], respectively). For female adolescents, sexually active relationships with partners they had not known before the romantic relationship began were less likely to include discussions of sexually transmitted infections or contraception, and were less likely to include consistent use of birth control (odds ratios and 95% confidence intervals, 0.37 [0.22-0.62] and 0.62 [0.39-0.99], respectively). Preromantic social ties did not play a statistically significant role for these outcomes among male adolescents (odds ratios and 95% confidence intervals of friends and of those who had not met, respectively, are 0.85 [0.60-1.18] and 0.90 [0.50-1.63] for talking about sexually transmitted infections or contraception and 0.93 [0.66-1.30] and 1.17 [0.71-1.96] for always using birth control). CONCLUSION: The existence and nature of an adolescent's prior relationship with a future romantic partner have significant implications for an adolescent couple's later sexual decisions, but patterns differ for male and female adolescents.

Adolescent↗
PubMed1981

Target cell heterogeneity in murine leukemia virus infection. II. Demonstration of Friend leukemia-virus-permissive and non-permissive subsets of splenic T cells.

The permissiveness of normal splenic lymphocytes to Friend murine leukemia virus was determined by enumeration of cells producing infectious MuLV following infection with Friend virus in vitro. The infection was enhanced greatly in the presence of mitogens in the culture medium. The number of infected cells in cultures stimulated with bacterial lipopolysaccharide increased progressively between days 1 and 7 whereas in cultures with concavalin A, the number of infected cells reached a maximum on days 3-4 post infection and then declined to the level observed in unstimulated cultures. The con-A-enhanced infection was absent in cultures of splenocytes from nude mice but was present in cultures from nude mice implanted with thymus glands 6 weeks or more before use as donors of spleen cells. The cells permissive to MuLV upon con-A stimulation segregated in the nylon-wool-adherent fraction (together with B cells involved in the LPS-dependent infection) whereas the nylon-non-adherent fraction, containing approximately 90% T cells, was refractory to in vitro infection. The con-A-dependent infectious centers were inhibited by cytotoxic treatment with anti-Thy 1.2 antibody plus complement. These results indicate the existence of two subpopulations of splenic T cells, a major nylon-non-adherent and a minor, nylon-adherent subpopulation, which are, respectively, non-permissive and permissive to MuLV-Friend.

Animals↗
PubMed1994

Therapeutic effects of D-aspartic acid beta-hydroxamate (DAH) on Friend erythroleukemia.

D-aspartic acid beta-hydroxamate (DAH), an aspartic acid analogue, exerts anti-tumoral activity against murine leukemia L5178Y both in vitro and in vivo. We show here that DAH displays activity against Friend leukemia cells (FLC) in vitro: a concentration of 2 mM results in a total inhibition of cell growth. DAH is also active in vivo against Friend virus (FV-P)-induced erythroleukemia. Treatment with DAH, given for 95 days as a single daily i.p. injection to DBA/2 mice 3 days following FV-P inoculation, induced a marked increase of 212% in the mean survival time (MST) of treated animals. Since FV-P-induced erythroleukemia is characterized by the proliferation of mature erythroid precursors, we examined the effect of DAH treatment on erythroid colony-forming cells (CFU-E) and observed that the number of CFU-E per spleen was 30 times lower in DAH-treated mice than in the controls. To gain further insight into the early effects of DAH treatment on the early phase of Friend disease, we examined the effects of short DAH treatment on spleen size, hematocrit and viremia in FV-P-infected mice. DAH treatment initiated 3 days post infection (p.i.) inhibited splenomegaly, prevented virus-induced polycythemia, and reduced serum viremia. Late DAH treatment (18 days p.i.) induced regression of FVP-induced disease as evidenced by reduction of spleen weight.

Animals↗
PubMed1994

Distribution of globin genes and histone variants in micrococcal nuclease-generated subfractions of chromatin from Friend erythroleukemia cells at different malignant states.

The distribution of the alpha and beta-globin genes and histone variants was examined in micrococcal nuclease-generated chromatin fractions of three Friend murine erythroleukemia cell types differing in malignant potential and inducibility to erythroid differentiation. A preferential concentration of globin gene sequences, as compared to satellite DNA, was noted in a physiological salt-soluble, histone H1-depleted, mononucleosomal chromatin fraction (Sup 120) in all Friend cell types, even those in which the globin gene was not capable of transcriptional activation by chemical induction. The level of globin gene enrichment in the Sup 120 fraction was highest in the most malignant and inducible cell type. The chemical induction of erythroid differentiation in this cell line did not change the distribution of globin genes in the chromatin fractions. The Sup 120 chromatin fraction prepared from mouse brain nuclei was not enriched in globin genes. Besides the previously reported low H2A. 1/H2A.2 ratio [Blankstein and Levy: Nature 260:638-640, 1976], chromatin from the most tumorigenic cell type showed the lowest H2B.2 to H2B.1 ratio, highest levels of histone H4 acetylation, and the most pronounced change in relative amounts of two major electrophoretic bands of histone H1 variants as compared to the less malignant cell types. The histone variant content of the micrococcal nuclease-generated chromatin fractions from the three Friend cell types reflected the core histone variant differences for the respective intact nuclei. However, the electrophoretic separation of mononucleosomes by size revealed several classes with different H2A variant ratios. The results demonstrate the existence of structural differences in globin gene and histone variants in erythroleukemia cell chromatin associated with distinguishable phenotypes during malignant cell progression.

Acetylation↗
PubMed1980

Cell surface molecules of Friend erythroleukemias: decrease in T200 glycoprotein expression after induction.

Monoclonal antibodies against the Thy-1 and T200 glycoproteins were used to study the expression of cell surface molecules on mouse hematopoietic cell lines. Friend erythroleukemias express T200 glycoprotein but do not express significant amounts of Thy-1 glycoprotein on their cell surface. The rate of T200 glycoprotein synthesis in maximally-induced Friend erythroleukemia 745.6 cells is less than 10% that in noninduced cells, although total protein synthesis shows only a twofold decline and induced cells express 2-6-fold less T200 glycoprotein on their surface compared to noninduced cells. T200 glycoprotein expression is reduced in a variant cell line obtained by selection for growth in dimethylsulfoxide, showing that the reduction in T200 glycoprotein synthesis characteristic of induced cells is an event that can be dissociated from commitment and hemoglobin synthesis. Analysis of T200 glycoprotein negative cell lines, isolated by cytotoxic immunoselection against T200 glycoprotein, indicates that the presence of T200 glycoprotein on the cell surface is not necessary for induction of hemoglobin synthesis and terminal differentiation of Friend erythroleukemias.

Animals↗
PubMed2007

Perceived helpfulness and impact of social support provided by family, friends, and health care providers to women newly diagnosed with breast cancer.

We evaluated the helpfulness of informational, emotional, and decision-making support received by women newly diagnosed with breast cancer from their family, friends, and health care providers. Data were collected at two time points via patient surveys: baseline on an average 2 months post-diagnosis and follow-up at 5 months post-baseline. In the period closer to diagnosis, majority of the women received helpful informational support from health care providers (84.0%); helpful emotional support from family (85%), friends (80.4%), and providers (67.1%); and helpful decision-making support from providers (75.2%) and family (71.0%). Emotional support at baseline and emotional and informational support at 5-month follow-up were significantly associated with patients' health-related quality of life and self-efficacy outcomes (p<0.01). Perceived helpfulness of informational, emotional, and decision-making support provided by family, friends, and providers however significantly decreased over time (p<0.001). Cancer patients' desire significant amount of support throughout their cancer journey. Our results show that while patients receive a lot of support during the period closer to diagnosis, receipt of helpful support drops significantly within the first year itself. In order to facilitate cancer patients' adjustment to their illness, efforts need to be made to understand and address their support needs throughout the cancer experience.

Adaptation, Psychological↗
PubMed2006

Requests for information by family and friends of cancer patients calling the National Cancer Institute's Cancer Information Service.

PURPOSE: To characterize their information needs, we examined the main topics of inquiry and discussion (subjects of interaction, SOI) of calls made by family and friends of cancer patients to the National Cancer Institute's Cancer Information Service's (CIS) 1-800-4-CANCER telephone information service and summarized differences by sociodemographic characteristics. DESIGN AND ANALYSIS: Data from 26 789 family or friends of cancer patients calling the CIS between September 2002 and August 2003 were analyzed. Frequencies, chi(2)'s, and logistic regressions were conducted to ascertain sample characteristics and sociodemographic correlates of each SOI. RESULTS AND CONCLUSIONS: The greatest proportion of calls concerned specific treatment information (54.9%) and general cancer site information (36.9%). Calls about specific treatment information were more likely among Asians, Hawaiian Natives, and Pacific Islanders (OR = 1.23, 1.04-1.45), and those with higher education (OR = 1.21, 1.18-1.25). As age increased, the odds of calls about specific treatment information also increased (OR = 1.05, 1.03-1.07). Females (OR = 0.78, 0.72-0.84), Hispanics (OR = 0.77, 0.67-0.89), African-Americans (OR = 0.68, 0.61-0.76), and American-Indians and Alaskan Natives (OR = 0.74, 0.58-0.93) were less likely to inquire about specific treatment information. Inquiries about general cancer site information were more likely among females (OR = 1.14, 1.06-1.23) and less likely among younger callers (OR = 0.95, 0.93-0.97) and African-Americans (OR = 0.87, 0.78-0.98). Differences in inquiries made by sociodemographic subgroups can inform the CIS' and other cancer-related organizations' efforts to develop and disseminate cancer information for family and friends of cancer patients.

Adult↗
PubMed1999

Protein kinase calpha is an effector of hexamethylene bisacetamide-induced differentiation of Friend erythroleukemia cells.

The program of biochemical and molecular events necessary for commitment to erythroid cell differentiation is particularly well characterized in murine Friend erythroleukemia cell lines. Commitment to hemoglobin synthesis in response to a variety of chemical inducers, including hexamethylene bisacetamide and dimethyl sulfoxide is completed by 24 h and proceeds to terminal differentiation by 96 h. Phorbol 12-myristate 13-acetate, a classical tumor promoter phorbol ester that binds to protein kinase C, blocks differentiation in a reversible manner, suggesting an important role for protein kinase C signaling pathways. The classical protein kinase C isoforms alpha, betaI, and betaII, play distinct roles in the transduction of proliferative and differentiative signals in human, as well as in murine, erythroleukemia cells. Protein kinase Calpha has been implicated in differentiation of human erythroleukemia cells although its translocation to the nucleus has not been observed. Taking advantage of the ability of phorbol 12-myristate 13-acetate to block differentiation in Friend erythroleukemia cells, we determined the localization of the predominant protein kinase C isoforms alpha and betaI during differentiation and in response to their blockade. The ability of phorbol myristate acetate to preferentially diminish protein kinase Calpha-protein localization to the nucleus by 24 h and thereby block differentiation induced by hexamethylene bisacetamide was paralleled by the ability of protein kinase Calpha antisense transfection to block differentiation. In addition, beta-globin transcription, assessed by polymerase chain reaction, was significantly decreased in protein kinase Calpha antisense-transfected cells compared to that seen in vector transfected ones. Taken together, these data suggest an important temporal role for nuclear protein kinase Calpha localization in Friend erythroleukemia cell differentiation.

Acetamides↗