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PubMed1979

[Present-day serological diagnosis of syphilis: comparison of TPHA and FTA-ABS tests with classical flocculation and complement-fixation reaction (author's transl)].

Twelve laboratories in the north Rhine-Westphalia participated in comparing TPHA and FTA-ABS tests with the so-called classical syphilis reactions (VDRL test, cardiolipin and pallida complement-fixation reaction, as well as Meinicke clearing reaction II). TPHA and FTA-ABS tests proved to be superior to the conventional methods both as regards specificity and sensitivity. Present-day serological tests of syphilis can thus be limited to the TPHA test to exclude syphilis, the FTA-ABS test as a confirmatory reaction and the VDRL test to judge the need or effectiveness of antisyphilitic treatment. These reactions which supersede the conventional syphilis tests serve for rational, reliable and cheap serological diagnosis of syphilis.

Cardiolipins↗
PubMedDate not supplied

Evaluation of five serologic tests for antibody to Neisseria gonorrhoeae.

Sera from 1,167 individuals were tested for antibody to Neisseria gonorrhoeae by use of five different serologic tests. These were complement fixation, the indirect fluorescent antibody test, Gonosticon Dri-Dot, fluorescent gonorrhea test-heated, and gonorrhea screen test. Parallel cultures of material from the throat, urethra, cervix, and rectum were also done. The results were analyzed by a technique intended to separate test effects from population effects. Test specificities ranged from 81.3% for the Dri-Dot test to 96.1% for the indirect fluorescent antibody test. Sensitivities ranged from 55.6% for the Dri-Dot test to 81.5% for the fluorescent gonorrhea test-heated.

Adolescent↗