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PubMed1984

Opioid antagonism of electroshock-induced seizures.

Morphine, beta-endorphin and [D-Ala2, D-Leu5] enkephalin administered intracerebroventricularly exerted a protective effect on electroconvulsive shock (ECS)-induced seizures in mice. This effect was reversed by intraperitoneal injections of naltrexone. The role of mu and delta receptors in ECS-induced convulsions is discussed.

Animals↗
PubMed1996

The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. VI. Seasonal influences on maximal electroshock and pentylenetetrazol seizure thresholds.

There is strong evidence for circadian rhythmicity in certain seizure types, whereas only a few studies have addressed the possibility of seasonal rhythms in convulsive activity. In the present experiments, seizure thresholds to different types of seizures were determined twice per month over a period of 13 months in mice under controlled environmental conditions, i.e., constant photoperiod, temperature, humidity, and food. Each group of animals was used for only one experiment, and the age of the mice used per month was the same throughout the study. Furthermore, all experiments were done at the same time in the morning to avoid circadian variation. Thresholds for the following seizure types were determined: (1) tonic hindlimb seizures induced by electrical (transauricular) stimulation; (2) myoclonic seizures induced by intravenous (i.v.) infusion of pentylenetetrazol (PTZ); (3) generalized clonic seizures in response to i.v. PTZ; and (4) tonic forelimb seizures induced by PTZ. A significant seasonality was determined for myoclonic and clonic PTZ seizure thresholds with highest thresholds between February and April and lowest thresholds between July and September. No clear seasonality was seen for chemically or electrically induced tonic seizures. Determination of plasma corticosterone did not disclose any seasonal rhythm in adrenal corticosteroid production that resembled the circannual variation in myoclonic and clonic seizure thresholds. In conclusion, our experiments suggest the existence of seasonal rhythms in PTZ seizure thresholds in laboratory animals despite standardized environmental conditions. A possible explanation for the findings may be the known seasonal alteration of the geomagnetic field which, by its effect on the pineal production of melatonin, may act as a seasonal synchronizor ("zeitgeber") in animals in the absence of other synchronizing forces, such as seasonal changes in photoperiod and ambient temperature.

Animals↗
PubMed2004

No evidence for oxidative damage in the hippocampus after acute and chronic electroshock in rats.

Although several advances has occurred over the past 20 years concerning the use of electroconvulsive therapy (ECT), little progress has been made in the mechanisms underlying its therapeutic or adverse effects. Thus, this work was performed in order to determine the level of oxidative damage and antioxidant enzyme activities early and late after acute and chronic electroconvulsive shock (ECS). We demonstrated a decrease in lipid peroxidation in the hippocampus immediately after and up to 30 days after a single or multiple electroconvulsive shock. This was also true for protein carbonyls in the acute protocol. We demonstrated an increase in catalase (CAT) and superoxide dismutase (SOD) activities at different time points after single and multiple electroconvulsive shock. Our findings, for the first time, demonstrated that after electroconvulsive shock, there is an increase in antioxidant enzyme activities and we cannot demonstrate oxidative damage in the hippocampus.

Adaptation, Physiological↗
PubMedDate not supplied

[Electroshock (ESK) and electroconvulsive therapy (ECT)].

OBJECTIVE: To discuss the ethical and legal basis of ECT use in Italy, one year after the regulation set up by the Minister of Health. METHOD: Literature review and presentation of authors' personal opinions. RESULTS: Despite being the oldest somatic therapy still practised in psychiatry, ECT effectiveness has been systematically evaluated only during the last 20 years, and its clinical indications have become progressively restricted. Yet there are wide variations between countries and within each individual country about the extension, the modalities and the indications for its use. ECT seems to be practised mainly in large scale public psychiatric hospitals and in private clinics, but its use in systems following a community approach is very limited. Wide variations exist also with reference to the severity of regulations imposed by governments or suggested by professional associations. The extent of education and auditing by university centres varies considerably, but is generally considered unsatisfactory. There are still some reports about possible political and repressive use of ECT in some countries, especially developing ones. CONCLUSIONS: The authors consider that every national system of care should have a clear policy and clear regulations about ECT. The provisions set up by the Italian Minister of Health seem to be consistent with Italian health policies and psychiatric community care.

Electroconvulsive Therapy↗