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PubMed1999

[New hearing test for functional deafness--the procedure to estimate the genuine hearing threshold].

This report describes a new procedure for examining functional deafness with binaural sound stimulation. This new hearing test can estimate the genuine pure tone hearing threshold quantitatively at every frequency by using the ordinary audiometer. In the case of the nonorganic deafness, even if the hearing disorders are bilateral or hemilateral, we believe that measuring auditory threshold separately, causes the deterioration of the threshold. Therefore, this procedure is designed so that the subject may not be aware of testing the auditory acuity of each ear, and utilizes the response of the phantom sound image in the head by simultaneous binaural presentation of sound stimulation. Our strategy is based on the following facts. If the normal subject has the same pure tone threshold level in both ears, the phantom sound image is formed in the median plane of the head by the equal suprathreshold tone level presented simultaneously in each ear. In the case of a unilateral auditory disorder, the sound image is localized to the center of the head only when sound stimulation louder than the threshold level of affected ear is given to both ears at the same time. Simultaneous binaural sound stimulation at a lower level than the threshold of the affected ear forms a lateralized sound image to the unaffected ear in the head. For patients with bilaterally similar hearing loss, the sound image is not formed if the stimulation is less than the threshold level of the pure tone. The band noise in the phase of each frequency with 50 dB HL was given binaurally to 10 normal hearing subjects, and the localization of the sound image formation was examined. This experiment confirmed that around the occipital region of the median plane in all subjects. Furthermore, comparing the formation threshold of the median plane image with the pure tone auditory threshold, proved that there was no significant difference statistically in either value. As a next step, 15 patients with unilateral sensorineural deafness were examined with this technique and we knew that the median sound images would not be formed with stimulation less than the pure tone auditory threshold of the affected ear. For clinical application, patients were classified into two groups with unilateral (6) and bilateral (2) functional deafness, and examined. Midline sound images definitely were formed with the lower magnitude of sound than the pure tone threshold by hemilateral nonorganic deafness. The difference of the forming threshold of the median sound image and the average of pure tone hearing level of the affected ear were maximum 100 dB, minimum 35 dB, and mean 69.4 dB. Furthermore, the difference of the median image forming threshold and the average hearing level of the unaffected ear were maximum 35 dB, minimum 0 dB, and mean 15.4 dB. In bilateral disorders, the midline plane sound image was formed with the corresponding level of the pure tone value in one subject, though the other one was determined by the maneuver method because it did not form a midline sound image. In conclusion, this examination can be readily used to estimate the genuine hearing threshold of the functional deafness.

Acoustic Stimulation↗
PubMed1976

Evidence in support of the duplex theory of mechanoreception.

Psychophysical thresholds were measured as the frequency, size and duration of vibration on the thenar eminence was varied. The results supported the theory that there are two functionally distinct receptor systems in the skin for the perception of mechanical disturbances. Spatial and temporal summation were found for the detection of high- but not low-frequency stimuli. Furthermore, magnitude estimation data revealed that temporal summation occurs for the perception of high-frequency stimuli presented over a wide range of suprathershold values. On the other hand, temporal summation was absent for low frequency stimuli that were presented at 5, 10, 15, and 20 db above threshold.

Differential Threshold↗
PubMedDate not supplied

Threshold adaptation of hearing and vibratory sensation.

Bekesy tracings were obtained in three normal subjects for vibratory sense of the midfinger before and after cooling by ethyl chloride, and for hearing levels after pure tone stimulation of the ear. After a mild cooling was applied on the finger, there were no observable differences in Bekesy tracing amplitude width or pulsed stimulus threshold when compared to before-cooling tracings. For steady stimuli, however, there was reduction in the amplitude width only at the top portion of Bekesy spikes without affecting the bottom portion. After a profound cooling, there was an elevation of thresholds for both pulsed and steady stimuli, and the reduction in amplitude widith for steady stimuli. The reduction in amplitude width seemed to appear before threshold shift. During the recovery, these changes returned to original conditions in the reverse order. Similar results were found in hearing after stimulation of the ear by a pure tone. The above findings are explained on the basis of perstimulatory fatigue of rapid form.

Acoustic Stimulation↗
PubMed2002

Threshold behaviour of the maximum likelihood method in population decoding.

We study the performance of the maximum likelihood (ML) method in population decoding as a function of the population size. Assuming uncorrelated noise in neural responses, the ML performance, quantified by the expected square difference between the estimated and the actual quantity, follows closely the optimal Cramer-Rao bound, provided that the population size is sufficiently large. However, when the population size decreases below a certain threshold, the performance of the ML method undergoes a rapid deterioration, experiencing a large deviation from the optimal bound. We explain the cause of such threshold behaviour, and present a phenomenological approach for estimating the threshold population size, which is found to be linearly proportional to the inverse of the square of the system's signal-to-noise ratio. If the ML method is used by neural systems, we expect the number of neurons involved in population coding to be above this threshold.

Artifacts↗
PubMed1978

Visual acuity for single lines as a function of hue and age.

176 students in grades 2-12 were tested for visual acuity as a function of minimally resolvable red, yellow, green, and blue lines. A 3-way mixed analysis of variance revealed significant differences among the colors, with better acuity for longer wavelengths. Significant age effects as well as a sex X condition interaction were also found. Post hoc analysis revealed a significant quartic trend for age. It is argued that the differential acuity thresholds for hue and the curvilinear age trend may depend upon the coordination of the accommodation and refractive power of the eye, which are affected by differential growth rates of the lens and the axial length of the eye.

Accommodation, Ocular↗
PubMed1997

B cell responses to a peptide epitope: III. Differential T helper cell thresholds in recruitment of B cell fine specificities.

Th cell requirements in the individual stages comprising a murine humoral response to a synthetic peptide were examined. Induction of a T-dependent IgM response was readily achieved in the presence of unprimed or low numbers of Ag-primed T cells. In contrast, class switch to the IgG isotype of Abs demanded a markedly elevated frequency of primed T cells and occurred concomitantly with B cell differentiation into an membrane-bound IgG+ memory population. These results indicated that induction and progression of a T-dependent humoral IgG response were comprised of a single rate-limiting step represented by that involving Ab isotype switch. Subsequent studies established that this also represented the principal step where antibody-purifying mechanisms operate. This was enforced by imposing a threshold barrier for Th cell recruitment by early Ag-activated B cells to enable class switch and consequent retention as the response progresses. The quantum of this threshold, however, was not invariant, but, rather, was described as a balance between the affinity of B cell receptor for Ag and the frequency of Ag-specific Th cells.

Adjuvants, Immunologic↗
PubMed2006

[Auditory brainstem response in children before and after myringotomy with grommet insertion].

OBJECTIVE: To explore the characteristics of auditory brainstem response (ABR) in children with otitis media with effusion (OME) before and after myringotomy with grommet insertion. METHOD: ABR were recorded in 37 cases (74 ears) before receiving myringotomy with grommet insertion for OME (treating group). For comparison, 30 age-matched healthy children were also tested with ABR (control group). To evaluate the immediate effect of tube placement, 74 ears were tested immediately the day after tube insertion. The characteristics of ABR before and after operation were compared with the control group. Thirty-seven cases were further divided into two groups: the group with poor wave differentiation and the group with better wave differentiation. The threshold of wave V, course of disease were compared between the two groups. RESULT: (1) Wave differentiation and eliciting rate were influenced by OME and were improved after operation. The group with poor wave differentiation had elevated threshold of wave V and had longer duration of the disease. (2) The prolonged peak latencies (waves I, III and V) were decreased significantly (P < 0.05) in the day after tube placement. However, no statistically significant change was found in the transmission time between waves. (3) When comparing to the control group, the abnormal peak latencies and transmission time between waves before and after myringotomy with grommet insertion were observed. CONCLUSION: The abnormal ABR can be observed in children with OME and improved after myringotomy with grommet insertion, but it can't reach the normal level.

Case-Control Studies↗
PubMed1981

Morphine differentially affects ventral tegmental and substantia nigra brain reward thresholds.

In order to differentiate the roles of the nigrostriatal and mesolimbic-mesocortical dopamine systems in the action of opiates on dopaminergically mediated intracranial self-stimulation (ICSS), the effects of chronic morphine administration and acute naloxone administration on ICSS were tested in rats with electrode placements in the substantia nigra pars compacta (A-9) and the ventral tegmentum (A-10). Acute morphine (5.0 mg/kg SC) did not affect ICSS thresholds of rats with electrodes in the A-9 nucleus when tested 1, 3, 5, and 23 hours after administration. With repeated daily administration, though, these animals showed increases in thresholds which grew progressively larger with each day of morphine treatment. This threshold elevation was not reversed by naloxone given 0.5 hour after the final morphine treatment on the fifth day. In contrast, acute morphine significantly lowered self-stimulation thresholds in rats with A-10 placements. Tolerance to this facilitatory effect was evident with chronic administration. Naloxone attentuated the lowering of threshold caused by opiate administration in these A-10 animals. The present data suggest a specificity of action of opiates on different brain systems subserving reward and reinforcement. These findings also suggest that the mesolimbic-mesocortical system may play an important role in mediating the rewarding properties of morphine.

Animals↗
PubMed1993

Reduction of structured population models to threshold-type delay equations and functional differential equations: a case study.

It is shown by way of a simple example that certain structured population models lead naturally to differential delay equations of the threshold type and that these equations can be transformed in a natural way to functional differential equations. The model examined can be viewed as a model of competition between adults and juveniles of a single population. The results indicate the possibility that this competition leads to instability.

Age Factors↗
PubMed1998

The differential expression of low-threshold sustained potassium current contributes to the distinct firing patterns in embryonic central vestibular neurons.

The principal cells of the chick tangential nucleus are second-order sensory neurons that participate in the three-neuron vestibulo-ocular and vestibulocollic reflexes. In postnatal animals, second-order vestibular neurons fire repetitively on depolarization. Previous studies have shown that, although this is an important feature for normal reflex function, it is only acquired gradually during embryonic development. Whereas at 13 embryonic days (E13) the principal cells accommodate after firing a single spike, at E16 a few principal cells repetitively can fire multiple action potentials on depolarization. Finally, in the hatchling, the vast majority of principal cells is capable of nonaccommodating firing on depolarization. As a first step in understanding the mechanisms underlying developmental change in excitability of these second-order vestibular neurons, we analyzed the outward potassium currents and their role in accommodation, using brainstem slices at E16. The principal cells exhibited transient and sustained potassium currents, with both of these containing calcium-dependent components. Further, both high- and low-threshold sustained potassium currents have been distinguished. The low-threshold dendrotoxin-sensitive sustained potassium current (IDS) is associated with principal cells that accommodate and is not expressed in those that fire repetitively. Finally, blocking of IDS transforms accommodating cells into neurons capable of firing trains of action potentials on depolarization. These findings indicate that suppression of IDS during development is sufficient to transform accommodating principal cells into nonaccommodating firing neurons and suggests that developmental regulation of this current is necessary for the establishment of normal vestibular function.

Action Potentials↗