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Relationship between serum carotenoid levels and cancer death rates in the residents, living in a rural area of Hokkaido, Japan.

The relationship between serum carotenoid levels and cancer death in rural Japanese residents, aged more than 39 years, was examined epidemiologically. The follow-up subjects participated in the comprehensive health examinations, every August from 1986 to 1989, were 929 males and 1424 females, living in a rural area of Hokkaido, Japan. During 2-8 years to December 1994, the ninety-eight deaths were observed among the cohort; that is, deaths from all causes were 67 males and 31 females, and cancer deaths were 34 males and 10 females. Serum samples at fasting were collected at the entry of the cohort and serum levels of beta-carotene, alpha-carotene and lycopene were measured by the HPLC method. The relation between the mortality rates and serum carotenoid levels was estimated statistically using the Cox's proportional hazard model. The results were as follows; the hazard ratio with the overall on high serum beta-carotene levels to those of lower was 0.46 (95% C.I.: 0.27-0.78) for all causes and 0.33 (95% C.I.: 0.14-0.75) for cancer deaths. This result suggested that high levels of serum beta-carotene may play some roles on preventing cancer death.

Adult↗

Death rate from pulmonary embolism following joint replacement surgery.

This paper comprises a retrospective study of the incidence of death from pulmonary embolism following total hip and total knee replacement surgery in a unit which does not employ routine prophylactic anticoagulation. There were a total of 1569 patients, of whom 1362 had total hip replacements and 207, knee replacements. Fatal pulmonary embolism occurred in six patients. The need for routine prophylactic anticoagulation is questioned.

Anticoagulants↗

Death rates from ecstasy (MDMA, MDA) and polydrug use in England and Wales 1996-2002.

The present study reports on all deaths related to taking ecstasy (alone, or in a polydrug combination) occurring in England and Wales in the time frame August 1996-April 2002. Data presented here are based on all information recorded in the National Programme on Substance Abuse Deaths (np-SAD) database. The np-SAD regularly receives all information on drug related deaths in addicts and non addicts from coroners. A total of 202 ecstasy-related fatalities occurred in the chosen time-frame, showing a steady increase in the number of deaths each year. The ratio male:female was 4:1 and 3 of 4 victims were younger than 29. In 17% of cases ecstasy was the sole drug implicated in death and in the remaining cases a number of other drugs (mostly alcohol, cocaine, amphetamines and opiates) have been found. According to toxicology results, MDMA accounted for 86% of cases and MDA for 13% of cases; single deaths were associated with MDEA and PMA. This is the largest sample of ecstasy related deaths so far; possible explanations are given for the observed steady increase in ecstasy-related deaths and a tentative 'rationale' for this polypharmacy combination is then proposed.

3,4-Methylenedioxyamphetamine↗

A prospective study of mortality among middle-aged diabetic patients (the London Cohort of the WHO Multinational Study of Vascular Disease in Diabetics) I: Causes and death rates.

The 497 members of the London Cohort of the WHO Multinational Study of Vascular Disease in Diabetics have been followed for mortality from 1975 to 1987. During this period 92 patients died. The most common cause of death was myocardial infarction: 36 (39.1%) deaths, heart disease was responsible for 51.1% of deaths and all cardiovascular disease for 55.4%. Neoplastic disease accounted for 25% of the deaths and diabetic nephropathy for 5.4%. Age-standardised mortality rates were higher in men than in women in both Type 1 (insulin-dependent) diabetes and Type 2 (non-insulin-dependent) diabetes. Standardised mortality ratios for the first and second five year follow-up periods were higher for men than for women in Type 2 diabetes but were higher for women than men in Type 1. The results suggest that the female survival advantage seen in the general population may persist in Type 2 but not in Type 1 diabetes.

Adult↗

The effect of health services on mortality: decline in death rates from amenable and non-amenable causes in Finland, 1969-81.

The impact of the Finnish health services on mortality from natural causes amenable to interventions by them was estimated for the period 1969 to 1981. During this period, mortality from amenable causes fell by 63% among males and 68% among females aged 64 years or less. The respective decreases for non-amenable natural causes of death were 24% and 29%. The rate of decline in mortality from amenable causes was similar for the two sexes. It was assumed that the decline in mortality from nonamenable causes reflects the joint influences of environmental, social, nutritional, and genetic factors and that the difference between this and the decline in mortality from amenable causes approximates to the true effect of the health services. Health services were estimated to account for 50% of the total decline in mortality from amenable causes for both sexes.

Adolescent↗