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Current medical, legal and demographic perspectives on artificial reproduction in Czechoslovakia.

This paper examines artificial reproduction (AR) within a broad comparative perspective and with specific reference to Czechoslovak law, medicine, and demography. It proceeds form an analysis of the social context that gives rise to technologies of AR to a review of the two principal technologies, artificial insemination (AI) and in vitro fertilization (IVF). A final section briefly discusses some of the implications of AR for new judicial conceptions of motherhood and fatherhood.

Czechoslovakia↗

Orofacial clefts in Czechoslovakia. Incidence, genetics and prevention of cleft lip and palate over a 19-year period.

The precise value of incidence was calculated based on the sample of 3,660 probands with orofacial clefts born in Bohemia between 1964-1982, as all cases born in this region and time were registered. For non-syndromic cases, the incidence of cleft lip was 0.4396 per 1,000 live birth, 0.7684 for cleft lip and palate and 0.6024 for isolated cleft palate. The sample of 4,950 of our older probands born between 1886-1963 was added and the whole sample of 8,250 individuals was evaluated with respect to sex-ratio, laterality, clinical severity, seasonal incidence and age of parents. The risk of recurrence and value of heritability were calculated as well. Based on these evaluations, a four-threshold multifactorial model for cleft lip and palate was suggested and also confirmed by our results of primary prevention of orofacial clefts using periconceptional supplementation with vitamins and folic acid.

Cleft Lip↗

Cross resistance to the ionophorous polyether anticoccidial drugs in Eimeria tenella isolates from Czechoslovakia.

Two field isolates of Eimeria tenella were isolated on farms where continuous outbreaks of coccidiosis in broilers had occurred over several years. The isolates were repeatedly tested for their sensitivity to ionophorous polyether drugs in floor pen trials lasting 7 wk. Hybro cockerels were inoculated with 25 x 10(3) oocysts/chicken at the age of 23 to 24 days. Total mortality, mortality caused by coccidia, live weights, feed conversion ratios, number of oocysts in litter, and titers of circulating antibodies against E. tenella were followed. Tested isolates were not controlled by the monovalent polyether drugs monensin, narasin, and salinomycin, but maduramicin, which is a monovalent monoglycoside polyether, and the bivalent polyether lasalocid controlled them effectively. This study indicates that coccidia that lose their sensitivity to a monovalent polyether drug lose the sensitivity to other monovalent polyethers, also, but might yet be effectively controlled by drugs from other classes of polyether antibiotics. This supports the hypothesis that there are differences in the mechanisms of anticoccidial activity of different classes of polyether antibiotics.

Animals↗

Trends in morbidity on the basis of newly-reported cases of malignant skin melanoma (172 ICD) and other skin neoplasms (173 ICD) in Czechoslovakia during the period 1961--1972.

According to newly-reported cases of all malignant neoplasms of the skin (172 + 173 ICD) morbidity rate for the period 1961--1972 showed a rising trend of statistical significance only in Bohemia; while in Slovakia it persisted at a practically steady level throughout the period followed. Malignant skin melanomas (172 ICD) were on the increase in both regions, the rate being of statistical significance only in men in Bohemia. Morbidity from other malignant skin neoplasms (173 ICD) during the same period showed a stable pattern in Slovakia while it rose steadily in a significant degree in both, males and females in Bohemia. The causes for these varying trends must be further analyzed.

Adolescent↗

Human infections caused by V. parahaemolyticus in Czechoslovakia.

Vibrio parahaemolyticus was isolated in two subjects with acute gastroenteritis. The patients history included stay in Pakistan or India. They probably contracted the infection on board an aeroplane where they ingested cold meal containing sea products. The possibility of this conditioned pathogen occurring also in an inland country is pointed out.

Adult↗

Human infections caused by V. parahaemolyticus in Czechoslovakia.

Vibrio parahaemolyticus was isolated in two subjects with acute gastroenteritis. The patients' history included stay in Pakistan or India. They probably contracted the infection on board an aeroplane where they ingested cold meal containing sea products. The possibility of this conditioned pathogen occurring also in an inland country is pointed out.

Acute Disease↗