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At least 343 records · Page 19Linked to original sources
PubMed1985

Prevalence of papillomarvirus infection in colposcopically directed cervical biopsy specimens in 1972 and 1982.

A total of 1264 consecutive cervical biopsy specimens obtained at the Parkland Memorial Hospital Dysplasia Clinic during 1972 were reviewed. Histopathologic specimens were assessed with special reference to changes induced by human papillomavirus. In 1972, only 0.7% of biopsy specimens were reported as consistent with human papillomavirus infection. Upon review, however, 36.5% of these specimens were found to demonstrate histologic criteria for the diagnosis of human papillomavirus infection. Approximately half of biopsy specimens reclassified as human papillomavirus were originally interpreted as inflammation; the others were interpreted as cervical intraepithelial neoplasia. Patients with human papillomavirus infection were significantly younger than patients with cervical intraepithelial neoplasia (24.9 versus 30.2 years). These findings were compared with 965 cervical biopsy specimens obtained in 1982. Thirty-four percent of these biopsy specimens revealed human papillomavirus infection. These observations support the concept that human papillomavirus infection of the cervix is not a new entity but a previously unrecognized finding whose prevalence has been relatively stable over a 10-year period.

Adult↗
PubMed1989

Octadeca-9,11-dienoic acid in cervical intraepithelial neoplasia: a colposcopic study.

488 women were studied to evaluate the use of the molar ratio (%MR) of octadeca-9,11-dienoic acid (18:2(9, 11] to linoleic acid (18:2(9, 12] as a new screening method for cervical cancer and pre-cancer. A combination of Papanicolaou cytology, colposcopy and %MR 18:2(9, 11)/18:2(9, 12) were employed. 86 women (17.6%) were found to have histologically proven cervical intraepithelial neoplasia (CIN). The %MR was obtained in 452 cases (92%). There was no significant difference in %MR in cervical cell scrapes from women with or without CIN. The %MR of cervical scrapes in some women with anaerobic vaginosis was significantly elevated suggesting bacterial generation of 18:2(9, 11). The %MR of 18:2(9, 11)/18:2(9, 12) is unsuitable for the diagnosis of cervical intraepithelial neoplasia.

Adult↗
PubMed1987

Colposcopic findings of gland openings in cervical carcinoma: their histological backgrounds.

During the past 8 years 1501 colposcopies were performed paying a special attention to cervical glands for diagnosis of cervical intraepithelial neoplasia (CIN) and carcinoma. Normal openings could exclude these diseases at the error rate of only 5.1%, while atypical openings could identify them at the high confidence rate of 96.3%. False positive evaluations were mostly attributable to a marked degree of squamous metaplasia in the glands. The absence of gland openings in the main portion of the lesions amounted to 88.6% in invasive carcinomas but to only 12.4% in CIN. Adenoma malignum was a highly characteristic exception.

Carcinoma in Situ↗
PubMed1993

Human papilloma virus types in routine cytological screening and at colposcopic examinations.

Certain types of human papillomaviruses (HPV) play a crucial role in the development of anogenital cellular dysplasia and cancer. We have searched for a broad spectrum of HPV-types by PCR in cervical cell samples from 230 women aged 20-29 years enrolled at routine gynecological health control and 506 women referred to colposcopy due to suspected cytological changes. Thirteen percent of the health control women had HPV DNA of identified types. Half of the colposcopy patients showed benign histology with corresponding HPV DNA prevalence of 18%, while among the patients with cervical intraepithelial neoplasia between 61% and 78% had HPV DNA. Among both women with normal cytology or histology and those with various degrees of cervical dysplasia, cancer-related HPV types represented about 85% of the types found. The strong correlation between HPV infections and development of cervical dysplasia is an argument for HPV DNA testing of certain patient groups.

Adult↗
PubMed1986

Human cervical and hamster oral epithelial neoplasia--colposcopic similarities.

Epithelial dysplasias and squamous carcinomas were experimentally produced in the cheek pouches of Syrian hamsters. These lesions were observed and photographed in the living animals with the aid of a stereoscopic microscope at magnifications of 20 and 40 times. Very apparent similarities were noted in the vascular patterns and epithelial configurations between the hamster oral dysplasias and carcinomas and the corresponding lesions seen in published cases of cervical intraepithlial neoplasia and invasive squamous carcinoma. It is speculated that these similarities reflect common factors in the interaction between neoplastic squamous epithelium and its blood supply. These findings are important in understanding the biology of cervical neoplasia and may be useful in the diagnosis and management of human oral neoplasia.

Animals↗
PubMed1986

The use of the colposcope in the diagnosis of sexual abuse in the pediatric age group.

This brief communication by Woodling and Heger on the use of colposcopy in the assessment of children who may have been sexually exploited raises some interesting and exciting new dimensions to our diagnostic approach. These are presented by the authors as early findings. The readers should note that standards have not yet been established completely, and findings in normal children need to be further delineated, especially for young girls who are athletically inclined, e.g., gymnists as well as victims of accidental genital trauma. Our field urgently awaits these data.

Child Abuse↗
PubMed1997

Colposcopic evaluation of a vaginal gel formulation of iota-carrageenan.

There is an urgent need to develop safe, effective, and acceptable vaginal products for the prevention of sexually transmitted infections. Preliminary in vitro results suggest that vaginal formulations of sulfated polysaccharides, including iota-carrageenan, have the potential to block mucosal transmission of human immunodeficiency virus (HIV). Twenty-five women in five sites participated in Phase I trials to evaluate the safety of a formulation containing iota-carrageenan (PC 213). The results of this study indicate that a 5 mL 2% gel formulation of iota-carrageenan is not associated with significant irritation of the female reproductive tract when administered once daily in the absence of sexual intercourse. Given the small number of participants in this initial study, careful observation for potential irritation must also be included in larger studies of this and other vaginal formulations.

Administration, Intravaginal↗
PubMed1997

The influence of the cervix on smear quality. I: Atrophy. An audit of cervical smears taken post-colposcopic management of intraepithelial neoplasia.

Out of 951 smears taken from women attending a hospital cytology clinic, 122 were found to be of poor quality. Twenty-eight percent of these were associated with clinical and/or cytological atrophy, and in 91% of these the main adverse factor affecting smear quality was scantiness. The relative risk of obtaining a scanty smear was found to be 4.8 times greater in women in whom clinical atrophy was identified when compared with those with no atrophy. It is suggested that a reduction in the number of scanty, and hence potentially inadequate, smears in the screening programme may be achieved by the use of more appropriate sampling implements in all women in whom there is clinical evidence of atrophy. Further review of alternative sampling methods is indicated.

Adult↗