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Further observations on the extramacular chromatic mechanisms.

Monochromatic targets presented at 30 degrees excentricity on orange, magenta and blue backgrouds are used. A small monochromatic light, 476 nm on orange, 551 nm on magenta and 621 nm on blue, is flashed at 3 cps-1 on the centre of the targets. The size of the targets is varied and their luminance adjusted using neutral filters until the flashing light is just not visible. This method allows the study of chromatic mechanism sensitivity and of retinal interactions (summation and inhibition). Some observations in normal as well as in pathological conditions are presented.

Adult

The Mackenzie Memorial Lecture, 1977. Of divers colours.

I shall discuss the nature of the sensation of colour and the reason for our colour vision, leading on to the existence of defects in that sense. I will consider the different kinds of such defects and the arguments for the use of particular tests in varying circumstances. I report the result of a recent survey of the value of a careers advisory service for "colour blind" school children seen between 1965 and 1977 (primarily red-green blind). This leads to examples of the value of these tests in genetics, and in the early diagnosis of disease or toxicity. I shall also describe the various modifications I have made to the 100-hue test, with its eventual automation both for computation and recording. Finally, the recommendations I make for future progress cover routine examination, both on starting primary education and on entering secondary education, analysis of the colour task at work, and the adoption of an enlightened system of colour coding.

Adolescent

Clinical implications of color vision research.

The attributes of color and the mechanisms underlying normal and defective color vision are reviewed. The clinical implications of some research efforts bearing on congenital and acquired color defects, peripheral color vision, and the influence of photostable pigments on color vision and color vision tests is presented. This presentation is intended to illustrate how selected avenues of research have contributed to our understanding of color vision and to demonstrate the clinical utility of that research.

Color Perception

Colour vision tests and colour naming by thirteen incomplete achromats in Bishnupur.

As an exploratory study six colour vision tests were given to nine male and two female achromats from the Shankhabanik community in Bishnupur, and to two additional similar males. All thirteen subjects had severe photophobia, fixation nystagmus, extreme weakness of vision (4/24 to 3/60) and the red end of the spectrum was much shortened. This research indicates that they had a form of incomplete achromatopsia, varying from an almost complete to a very severe partial loss of colour vision. The condition is inherited as an autosomal recessive. The most likely interpretation of these cases is that they are incomplete rod achromats. Their performance on the colour vision tests is tabulated, and shows complete inability to do the Ishihara test; nearly complete inability on the HRR test, with a possible slight tendency to do better in the yellow-blue than the red-green sub-tests; on Sloan's test they show approximate accordance with her results for achromats; they have severe difficulty with the dichotomous and 100-hue tests, with a possible slight tendency to make fewer errors on the G/B sections. The anomaloscope shows little abnormality of mid-matching points, but great increases in average matching ranges above the normal, although not absolute loss of colour sense, but with extreme darkening or shortening of the red end of the spectrum. Their colour naming was carefully recorded, and was fairly good occasionally, sometimes erroneous without being wildly at fault, and most often completely wrong. The records of colour naming were made, not, of course, as a form of colour vision test, but simply to illustrate the ways in which such defectives make an effort to use colour names in general use among their friends and relatives.

Adult

[Color vision].

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Color Perception

Spectral sensitivity for observers with protanomalous, extreme protanomalous and protanopic colour vision.

Contemporary models of colour vision include a channel for luminosity arising from a combination of some or all of the cone outputs. Accordingly any alteration, reduction or loss at the cone level ought to affect the shape of the spectral sensitivity curve, yet there have been few reports of any significant differences being found between the curves of protanomalous and protanopic subjects. A modified minimum flicker technique was used to determine the spectral sensitivity curves of observers with protanomalous, extreme protanomalous and protanopic vision. Significant differences were found among the mean curves of these categories of vision from 550 nm upwards.

Adolescent

Wavelength discrimination deteriorates with illumination in blue cone monochromats.

Two types of incomplete congenital achromats were studied: one type (blue cone monochromats) has a conspicuous short wavelength cone mechanism, and the other type (deutan incomplete achromats) has a conspicuous long wavelength cone mechanism. The photoreceptor mechanisms were inferred from color matches and from test action spectra measured on rod-saturating backgrounds of different wavelengths. Interestingly, the illumination-dependency of color discrimination (for 5 degrees bipartite fields that were centrally fixated) differed between the two patient types, even though rhodopsin photoreceptors were common to both. As illumination level increased, the ability to discriminate wavelength differences deteriorated for the blue cone monochromats, whereas, for the deutan achromats, wavelength discrimination remained relatively constant even near 100,000 scotopic trolands. The performance decrement in the blue cone monochromats was probably not associated with rod saturation, as the field action spectrum to cause a just-noticeable-difference (jnd) decrement in discrimination was poorly fitted by a rhodopsin action spectrum. In addition, the blue cone monochromats had rhodopsin photoreceptors that did not saturate in bright illuminations. The authors hypothesize that the deterioration of wavelength discrimination at high illuminations is not an abnormality of blue cone monochromacy. Rather, it may be a property of the normal color mechanism through which signals from the short wavelength cones pass.

Adolescent