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At least 343 records · Page 19Linked to original sources
PubMed2001

The role of fine-needle aspiration biopsy in the diagnosis and management of juvenile hemangioma of the parotid gland and cheek.

BACKGROUND: The current recommendation for the management of juvenile hemangiomas (JH) is to delay treatment in the hope of spontaneous regression. However, accurate diagnosis is necessary before considering conservative management. Traditionally, the diagnosis of JH has required excisional biopsy. The cytology literature on this relatively rare neoplasm is sparse. OBJECTIVE: To present our experience with fine-needle aspiration in the diagnosis and management of JH. DESIGN: Three cases with a cytologic diagnosis consistent with JH of the parotid gland and cheek were identified from our cytopathology files. Aspirate smears, immunohistochemical studies, computed tomographic scan findings, and clinical follow-up were reviewed. RESULTS: Patients were female infants ranging in age from 3 to 9 months and presented with an oval firm mass (size range, 2.0-5.0 cm) involving the parotid gland (2 cases) and cheek (1 case). Computed tomographic scan with contrast demonstrated homogeneous enhancement. Aspirate smears revealed spindle-shaped cells in sheets and clusters in a background of blood. The parotid gland aspirates and cell block preparations revealed ductal structures entrapped in sheets of spindle-shaped cells. Immunohistochemical studies revealed prominent vascular spaces lined by CD34 and factor VIII-positive flattened endothelial cells. The diagnosis of JH was rendered on the basis of the cytologic findings in conjunction with the radiologic and clinical findings. On clinical follow-up (8-24 months), none of the patients has shown any progression of the lesion. CONCLUSIONS: Fine-needle aspiration, in conjunction with imaging studies, is a useful tool in the diagnosis and management of JH. It eliminates the need for surgical excision for diagnostic purposes and allows for clinical follow-up of patients with JH.

Antigens, CD34↗
PubMed2006

Severe postburn contracture of cheek mucosa leading to false temporomandibular joint ankylosis.

A case of burn injury to lips and cheek mucosa is reported who developed severe contracture of cheek mucosa leading to inability to open mouth. Patient was misdiagnosed as a case of temporomandibular ankylosis and was managed on those lines to no relief. When the contracture was released and soft tissue defect repaired with nasolabial flap, patient gained near normal mouth opening.

Adult↗
PubMed1999

The superficial subciliary cheek lift, a technique for rejuvenating the infraorbital region and nasojugal groove: a clinical series of 71 patients.

The superficial subciliary cheek lift is an aesthetic operation to rejuvenate the infraorbital region and midface. It smoothes and rejuvenates the nasojugal groove, the nasolabial fold, and cheekpad with a direct pull upward. This technique is a technically straightforward procedure that does not involve dissection at a subperiosteal level, endoscopic equipment, a formal canthotomy, or drill fixation. It does not produce superior displacement of the lateral canthus. The entire operation is performed through an extended subciliary incision. Fixation is accomplished to the intermediate temporal fasciajust lateral to the lateral orbital rim. No reliance is placed on the lower eyelid for tightening the midface region. The superficial subciliary cheek lift can be performed as a separate operation or in conjunction with a face lift. It is an aesthetic procedure that is an adjunct to a subciliary lower blepharoplasty when rejuvenation of the upper midface and nasojugal area is also required. A series of 71 patients is presented, with excellent 6-month to 3-year results and an acceptably low complication rate.

Adult↗
PubMed2000

Alveolar soft-part sarcoma of the cheek: report of a case with a review of the literature.

An alveolar soft-part sarcoma (ASPS) occurring in the cheek is described, with a review of the literature. The subject was a 25-year-old woman who presented with a large swelling in the left cheek. The lesion, initially diagnosed as a benign tumor on radiographic and computed tomographic examinations, was surgically excised. Histopathological examination of the mass revealed a nest-like or organoid cellular arrangement as confirmed by three-dimensional computer graphic reconstruction. The cytoplasm of the large polygonal tumor cells contained abundant diastase-resistant, PAS-positive inclusions, ultrastructurally confirmed to be crystalloid materials. The tumor cells were immunoreactive for anti-myoglobin, sarcomeric actin, and neuron-specific enolase antibodies, suggesting a myogenic origin.

Adult↗
PubMed1975

Survival and differentiation of canine mammary tissues in the hamster cheek pouch.

The survival and differentiation of canine normal, atypical nodular (preneoplastic, and neoplastic mammary tissues were examined after transplantation to the cheek pouches of immunosuppressed female golden hamsters. Without immunosuppression, none of the mammary transplants, survived 40 days of transplantation. With either prednisolone or antilymphocyte serum immunosuppression, 78% of the mammary transplants that were recovered from the cheek pouch survived at least 35 to 45 days.

Animals↗
PubMed2001

Boron neutron capture therapy for the treatment of oral cancer in the hamster cheek pouch model.

We have proposed and validated the hamster cheek pouch model of oral cancer for boron neutron capture therapy (BNCT) studies and shown that boronophenylalanine delivers potentially therapeutic 36.9 +/- 17.5 ppm boron to tumor tissue with tumor:normal tissue and tumor:blood ratios of 2.4:1 and 3.2:1, respectively. Here we report the first evidence of the usefulness of BNCT for the treatment of oral cancer in an experimental model. We assessed the response of hamster cheek pouch tumors, precancerous tissue, and normal oral tissue to boronophenylalanine-mediated BNCT using the thermalized epithermal beam of the RA-6 Reactor at the Bariloche Atomic Center. BNCT leads to complete remission by 15 days posttreatment in 78% of tumors and partial remission in an additional 13% of tumors with virtually no damage to normal tissue.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed2001

The hamster cheek pouch as a model of oral cancer for boron neutron capture therapy studies: selective delivery of boron by boronophenylalanine.

Herein we propose and validate the hamster cheek pouch model of oral cancer for boron neutron capture therapy (BNCT) studies. This model serves to explore new applications of the technique, study the biology and radiobiology of BNCT, and assess the uptake of boron compounds and response of tumor, precancerous tissue, and clinically relevant normal tissues. These issues are central to evaluating and improving the therapeutic gain of BNCT. The success of BNCT is dependent on the absolute amount of boron in the tumor, and the tumor:blood and tumor:normal tissue boron concentration ratios. Within this context, biodistribution studies are pivotal. Tumors were induced in the hamsters with a carcinogenesis protocol that uses dimethyl-1,2-benzanthracene and mimics spontaneous tumor development in human oral mucosa. The animals were then used for biodistribution and pharmacokinetic studies of boronophenylalanine (BPA). Blood, tumor, precancerous pouch tissue surrounding tumor, normal pouch tissue, tongue, skin, cheek mucosa, palate mucosa, liver, and spleen, were sampled at 0-12 h after administration of 300 mg BPA/kg. The data reveal selective uptake of BPA by tumor tissue and, to a lesser degree, by precancerous tissue. Mean tumor boron concentration was 36.9 +/- 17.5 ppm at 3.5 h and the mean boron ratios were 2.4:1 for tumor:normal pouch tissue and 3.2:1 for tumor:blood. Higher doses of BPA (600 and 1200 mg BPA/kg) increased tumor uptake. Potentially therapeutic absolute boron concentrations, and tumor:normal tissue and tumor:blood ratios can be achieved in the hamster oral cancer model using BPA as the delivery agent.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed2001

[Bilobed flap in the reconstruction of cheek defects].

The bilobed flap is a reliable means for the reconstruction of facial defects in one stage. This reconstruction technique has been applied on a 69-years-old man affected by carcinoma of the cheek, involving overhanging skin and underlying oral mucosa. Stensen's duct reconstruction was also performed with a vein graft and, 8 months later, deviation of the rima oris was corrected by inserting a goretex strip at the level of the upper lip elevator muscle. The present work considers the bilobed flap as a means for cheek defects reconstruction compared with other reconstruction techniques.

Aged↗
PubMed1998

[Expression of P21 and P185 in benign and malignant epithelia of cheek mucosa].

To analyze the expression of P21 and P185 in normal epithelia, chronic non-specific inflammatory epithelia, squamous cell carcinoma and epithelia immediately adjacent to carcinoma of cheek mucosa, immunohistochemistry technique and image analysis technique were used. The results showed: there was excellently higher expression of P21 and P185 in squamous cell carcinoma and epithelia immediately adjacent to carcinoma than in normal and inflammatory epithelia of cheek mucosa, which were compactly correlative.

Carcinoma, Squamous Cell↗
PubMed2002

Ultrastructural study of the cheek oral mucosa of rats submitted to experimental chronic alcoholism.

Ultrastructural features of the cheek oral mucosa of rats (Rattus norvegicus) submitted to experimental chronic alcoholism were studied by transmission electron microscopy. Sixty male rats aged three months and with a mean body weight of 250 g were divided into two experimental groups. The control group received a solid diet (Purina rat chow) and tap water ad libitum. The alcoholic group received the same solid diet but was only allowed to drink sugar cane liquor dissolved in 30 degrees Gay Lussac (v/v). The animals of the two groups were weighed and sacrificed after 60, 120, and 180 days of treatment. Samples of the oral mucosa from the cheek region were dissected and processed for ultrastructural analysis. The results showed cell alterations in the basal and intermediate layer of the mucosal epithelium. The most frequent alterations observed were an increased intercellular space, the presence of lipid droplets in the cytoplasm, and irregular nuclei with a pyknotic aspect.

Alcoholism↗
PubMed1975

Studies of the hemopoietic microenvironment. IV. In vivo microscopic and histochemical study of allografts of bone marrow in the hamster cheek pouch chamber.

Within a transparent chamber enclosing subcutaneous tissue of the hamster cheek pouch, allogeneic femoral marrow was grafted. This permitted in vivo microscopic study of the grafts for 14 days. Five to seven days after grafting, blood flow was established within sinusoids arranged in interconnecting polygonal networks, a pattern characteristic of marrow. All vessels appeared to have a complete and continuous endothelial lining. The graft contained foci of erythropoiesis, granulopoiesis, and megakaryocytopoiesis, but no osteogenic activity. Degeneration of the grafts began to occur between days 9 and 13 after implantation. Generally, this was preceded by infection within the chamber, fibroblastic proliferation, and an accumulation of acid mucopolysaccharide in the stroma. The concomitant loss of hemopoiesis and accumulation of acid mucopolysaccharides was consistent with our hypothesis reported previously that excessive concentrations of acid mucopolysaccharide in the hemopoietic microenvironment are not conducive to supporting hemopoiesis, especially erythropoiesis. Degeneration of the grafts probably was the result of infection since there was no evidence of an immunologic response to the graft, and in chambers not containing grafts, similar infections and changes in the connective tissue were observed. The technique of grafting marrow into the hamster cheek pouch chamber provides a model for long-term, in vivo microscopic study of bone marrow. However, methodologic improvements, especially in the control of infections, are needed.

Animals↗
PubMed1992

[Adherence in vitro of Candida albicans to cheek mucous membrane cells in children with immune disorders].

Evaluation regarded adherence of a strain of Candida albicans to epithelium of cheek mucous membrane, obtained from 31 children aged between one and 14 years with disturbance of immunity and from 10 healthy children. All children were tested immunologically by determination of total leukocytosis, granulocytosis, absolute lymphocytosis, active and total rosette tests, spontaneous and stimulated nitroblue-tetrazolium (NBT) tests and immunoglobulin A, G and M levels in serum. Adherence of C. albicans in vitro of epithelial cells of cheek mucous membrane was significantly higher in children with disturbance of immunity as compared with healthy control group (p < 0.001).

Adolescent↗
PubMed2006

[Hamster's cheek pouches as a model for investigation of the oral mucosa permeability].

The technique of permeability assessment for high-molecular compounds is presented in present work. Isolated hamster cheek pouches as a simple and convenient model for the transport studies were used. It was shown that a mucous membrane is permeable for alpha-interferon, insulin but not for nucleic acids and peroxidase. Buccal permeability for insulin is provided by its transport through the intercellular ways. Data obtained in experiments with use of rodent keratinized mucous membrane could not be directly extrapolated to human buccal mucous permeability due to significant differences in the nature and organization of intercellular lipids in these species. However, we supposed that freshly isolated hamster cheek pouch could be employed as initial step of assessment for the fast screening of buccal permeability for the high-molecular compounds.

Animals↗
PubMedDate not supplied

The S.O.F.T. Cheek method: an approach to lower eyelid and midface rejuvenation.

Procedures to rejuvenate the lower eyelids and cheek are amongst the most common aesthetic surgeries performed today. Rejuvenation should be individualized based on the patients concerns, anatomic deformity, and medical condition. A balanced and natural clinical result often requires a combination of techniques designed to address each patient's individual pattern of aging, while maximizing patient safety. We present the S.O.F.T. Cheek method of analysis and treatment, which utilizes well-developed principles and techniques, to consistently maximize clinical results and patient satisfaction.

Adipose Tissue↗
PubMed1990

The hamster cheek pouch as a model in microcirculation research.

Hamster cheek pouches are bilateral invaginations of the oral mucosa and can easily be everted with their blood flow intact and are, therefore, well suited for intravital microscopy. The preparation has been used extensively for studies of inflammation, tumour growth, vascular smooth muscle function, blood flow regulation, and cellular behaviour at the microcirculatory level. The introduction and use of fluorescein-labelled dextrans (FITC-dextran) as tracers of macromolecular permeability changes have provided evidence that macromolecular permeability is subject to physiological and pharmacological regulation by gap formation between endothelial cells in the postcapillary venules. Studies with clinically used asthma drugs like isoprenaline, terbutaline, budesonide, theophylline and cromoglycate have shown that they all counteract histamine-induced permeability increase in postcapillary venules and, furthermore, that budesonide and terbutaline inhibit increased permeability caused by bradykinin, LTB4 and phorbol-dibutyrate, tertiary butylhydroperoxide and ischaemia. Pharmacological studies on the inhibition of mediator-induced leakage and migration of neutrophils in the cheek pouch could be of value not only for a better understanding of the inflammatory process in general but also for the characterization of asthma drugs having an anti-inflammatory action on the airways.

Animals↗
PubMed1990

[Choice of methods for reconstruction of the cheek after carcinologic excision based on a retrospective study of 32 cases in 8 years from 1980 to 1987 at the Gustave Roussy Institute].

In this article, after reviewing the different possibilities for cheek reconstruction consecutive to carcinologic excision, we specify the choice method for closure, according to the anatomical type of substance loss incurred. In all cases, endobuccal skin covering is needed. --As regards small lesions, there is no such thing as "the" ideal flap. --As far as tegumental cheeks are concerned, the deltopectoral flap is the choice one. --In case of mucous reconstruction, submental flaps afford elegant solutions. --With large lesions, musculocutaneous flaps are best used. Lastly, it seems that the first surgical treatment (excision, curage and plasty) followed or not by radiotherapy, depending on anatomopathological findings, brings acceptable and prompt restoration of function and morphology.

Adult↗
PubMed1989

[The use of the platysma and the skin of the neck as a myocutaneous flap in reconstructing cheek defects. Technic and results apropos of 5 cases].

Skin defects of the cheek are commonly the result of a radical surgical resection of extensive neoplasms of the parotid gland, the mandible or the skin, such as melanomas and squamous cell carcinomas. For the reconstruction of these defects, we have devised a myocutaneous flap which enables us to perform a radical neck dissection at the same operation. The transposed flap which involves the cervical skin, the platysma muscle and the superficial cervical fascia, has a wide pedicle on the lateral and dorsal side of the neck near the upper border of the Trapezius muscle. The border of the flap runs from the distal part of the defect and travels parallel and close to the midline of the neck down to the middle of the sternum. The border of the flap runs parallel and nearly 3-4 cm below the clavicle and as far as its acromial end. The advantages of this flap are: 1) better operative field for radical neck dissection; 2) good vascularization; 3) does not prolong the operative time; 4) does not need any "delay" procedure; 5) gives a good functional and cosmetic result, as it covers; the thickness of the cheek defect as well as protecting the neurovascular bundle of the neck.

Aged↗
PubMed1989

[Comparison of carrageenan-induced experimental inflammation in cheek and on dorsum of guinea-pigs].

Carrageenan is a high molecular weight sulfated polygalactose extracted from the marine algae and several biological and immunological properties. Carrageenan granuloma induced subcutaneously in guinea pigs has been widely used in connective tissue studies. Carrageenan is also commonly used as an excellent phylogistic agent for inducing experimental edema. In the present investigation carrageenan granuloma produced on the dorsum of guinea was compared with the inflammatory reaction produced in the cheek. The histopathologic investigations showed that the inflammatory reaction occurred in the buccal tissues was more powerful and the healing manifestations appeared earlier and continued more rapidly in the cheek.

Animals↗