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PubMedDate not supplied

Changes in WGA-lectin binding sites on sperm during epididymal transit in the Chacma baboon (Papio ursinus) and the vervet monkey (Cercopithecus aethiops).

Epididymal maturation of sperm entails molecular changes to the sperm plasma membrane. These changes are reflected by changes in lectin binding. The wheat germ agglutinin (WGA) lectin was used, since it binds to acetylglucosamine and sialic acid, which are involved in sperm function. The objective was to study changes in WGA-lectin binding during epididymal passage and in the ejaculate of the Chacma baboon and vervet monkey. The intensity and location of lectin binding on sperm from the ejaculate and the caput, corpus, and cauda epididymidis of 5 adult males from each species were studied. In both baboon and monkey sperm, the acrosomal region had the highest intensity stain and the equatorial region had the lowest intensity. Significant differences in staining of the different regions of sperm were found for the different epididymal sites and the ejaculate of both species. It was concluded that changes in the molecular composition of the sperm membrane, taking place during epididymal maturation, can at least in part be monitored by studying WGA-lectin binding on sperm. The changes noted are probably important for the organization of a membrane of the correct molecular conformation and mandatory for complete sperm function.

Animals↗
PubMed1974

Experimental louse-borne relapsing fever in the grivet monkey, Cercopithecus aethiops. III. Crisis following therapy.

Eight grivet monkeys infected with Borrelia recurrentis received tetracycline (12.5mg/kg body weight) on the 3rd or 4th day of spirochetemia. Leukopenia, fever, hyperpnea, and tachycardia developed within 2 hours as spirochete counts fell to undetectable levels. These events closely simulated the crisis in human louse-borne relapsing fever in both timing and extent.

Animals↗
PubMedDate not supplied

[Changes in the blood serum aminotransferase activity in the experimental infection of Cercopithecus aethiops monkeys with the Marburg virus].

Aminotransferase levels in the peripheral blood serum of African green monkeys were studied after aerosol infection with lyophilized virus preparation. A correlation between aminotransferase activity and other symptoms of hemorrhagic fever was shown. Considerable variations in the features of aminotransferase activity in severe and mild cases of the disease were observed.

Alanine Transaminase↗
PubMed1991

The brachial plexus in the vervet monkey (Cercopithecus pygerythrus).

The brachial plexus in ten embalmed, mature vervet monkeys was dissected to document the structure and branching pattern of this nerve plexus in this frequently used research animal. In general, the brachial plexus in the vervet monkey was similar to the plexus of other Old World monkeys. However, several aspects were comparable to those observed in domestic animals. Thus the quadrupedal and bipedal abilities of the vervet monkey was reflected in the structure of its brachial plexus.

Animals↗
PubMed1990

T-cell lymphosarcoma in a female African green monkey (Cercopithecus aethiops).

A female African green monkey developed a generalized lymphosarcoma spontaneously that clinically and pathologically resembled malignant lymphoma in human beings infected with human T-lymphotropic virus type I. The monkey was serologically positive for simian T-lymphotropic virus. Immunocytochemical analysis of routinely fixed and paraffin embedded tumor tissue demonstrated neoplastic cells that stained positive with antihuman monoclonal UCHL1 which recognized a T-cell-restricted isotype of leukocyte common antigen.

Animals↗
PubMed1978

Some infectious diseases of wild vervet monkeys (Cercopithecus aethiops pygerythrus) in South Africa.

Our surveys indicate that nearly all batches of vervet monkeys arriving at the National Institute for Virology from various areas of South Africa, are infected with foamy viruses and there is evidence that intra-urterine infection also occurs. Monkeys from certain areas of South Africa are apparently infected with the protozoal parasite Entopolypoides macaci in a sub-clinical state which becomes active when the monkeys are splenectomised. Serological studies indicate that infections with schistosomes, tick-bite fever (Rickettsia conori), chlamydsiae and occasionally by leptospirae, occur in monkeys in the Kruger National Park. Complement fixation tests for antibodies to R. mooseri and R. prowazeki were also sometimes positive; a finding of doubtful importance. There was a high percentage with positive antibody tests to chikungunya virus in a certain age group suggesting that there had been an outbreak of this disease in the Kruger Park in the late summer and autumn of 1976. This coincided with a human outbreak. Large numbers of vervet and baboon sera were tested for antibodies against SA 12 virus, a polyoma virus. A high percentage of baboons but only a small number of monkeys was found to be positive and it is concluded that SA 12 is probably a baboon virus which is occasionally transmitted to monkeys by contact. It is pointed out that these studies only indicate diseases from which monkeys recover and they do not indicate prevalence of severe disease causing grave illness or death.

Animal Population Groups↗
PubMed1989

Cercopithecus aethiops monkey as a reliable model for in vitro study of T cell depletion of bone marrow with Campath-1 plus complement.

T-lymphocyte markers of peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of C. aethiops monkeys were studied by using anti-human monoclonal antibodies. The results show that C. aethiops T lymphocytes express surface markers which react specifically with anti-human MoAbs including CD3, CD4, CD8, CD2. However, very few CD3-positive cells were found, in contrast to the abundance in CD8+ cells. There is a high conservation of receptors forming E rosettes with AET-treated SRBCs, and antigens reacting with the anti-human T and B cell monoclonal antibody (Campath-1). The present findings indicate that C. aethiops can be used as a new experimental model for studies on T-cell depletion from bone marrow with Campath-1 MoAb + rabbit C.

Animals↗
PubMed1989

Efficacy of a new Hoffmann-La Roche compound (Ro 15-5458) against Schistosoma mansoni (Gezira strain, Sudan) in vervet monkeys (Cercopithecus aethiops).

Some compounds of the class 9-acridanone-hydrazones have recently been developed by Hoffmann-La Roche (Basel-Switzerland) and were shown to have antischistosomal effects. One of these compounds (RO 15-5458/000) was administered at two dose levels (25 mg and 15 mg/kg body-weight) to S. mansoni (Gezira strain-Sudan) infected vervet monkeys. The faecal egg-output was terminated, worm-burden killed and tissue egg-counts were greatly reduced as compared with the untreated control monkey. Severe necrotic changes were seen around dead worms in sections from treated animals' livers. The efficacy of this compound as an antischistosomal is encouraging and deserves further studying.

Acridines↗
PubMed1977

Effect of oral estramustine phosphate on pituitary, gonadal, and adrenal function in the green monkey (Cercopithecus aethiops sabaeus).

We studied the effects of estramustine phosphate on pituitary, gonadal, and adrenal function in the green monkey. A 2-week course of estramustine phosphate (75 mg per day) reversibly suppressed the luteinizing hormone and testosterone response to luteinizing hormone-releasing hormone but did not affect pituitary-adrenal function assessed by the 11-deoxycorticosterone response to metyrapone. Treatment with oral estramustine phosphate also resulted in a significant increase in corticosteroid-binding globulin but did not affect a series of liver enzymes nor hematology. The results are consistent with a pure estrogen effect produced by hydrolysis of the carbamate-ester bona at a site distant from estrogen target tissues and could explain most of the reported in vivo effects of this compound.

Administration, Oral↗