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PubMed1975

The effects of electrosleep on insomnia revisited.

Ten subjects who had suffered from sleep onset insomnia for a minimun of 2 years participated in a double blind study of the effects of electrosleep on this disorder. This paper reports a 2-year follow-up of these subjects. Of the five subjects who received 24 live treatments, four appeared to be able to fall asleep with little difficulty and to awake feeling moderately to very well rested. Only one appeared to have relapsed during the 2-year-no-treatment period. Of those receiving sham treatment four were having quite a bit of difficulty falling asleep but three of the five awoke feeling moderately well rested. Although the number of subjects is small, the trends appear consistent with the interpretation that sleep habits were improved for most of the real treatment subjects and for few of those receiving sham treatment.

Clinical Trials as Topic↗
PubMed2005

Ophthalmology and vision science research. Part 1: Understanding and using journal impact factors and citation indices.

In an increasingly "publish or perish" clinical and academic environment, all clinicians and clinician-scientists involved in research must have a firm understanding of the measures commonly used to assess the quality of scientific journals and, by default, those extended to grade individual articles and authors. The publication of research is a vital part of clinical and experimental research, and citation analyses of research publications have increasingly been adopted as a means of assessing the apparent quality of journals and the research published therein. In the first of a series of articles for those embarking on ophthalmic and vision science research, this paper discusses the key features of citation analysis, concentrating on the 2004 Journal Citation Report figures for the field of ophthalmology that include 42 ophthalmology, vision science, physiological optics, and optometry journals. The Institute for Scientific Information (ISI) calculates a number of parameters including citation counts, Journal Impact Factor (JIF), Immediacy Index, and cited/citing half-life. This article discusses the methods of calculation and possible uses along with current controversies and potential abuses. The JIF and its relevance, potential bias, and limitations are discussed in depth as it has become the most widely used analysis of journal quality. The possible alternatives to ISI citation analysis are presented, and we conclude that citation analysis can be considered a reasonable measure of journal research quality only if used correctly.

Bibliometrics↗
PubMed1976

Effects of being observed on expressive, subjective, and physiological responses to painful stimuli.

Two experiments explored the effects of observation by another on responses to painful stimuli. It was anticipated that the intensity of pain-related non-verbal expressivity decreases under observation, while indices of arousal (skin conductance and self-report) increase. In Experiment 1, subjects' expressive responses to shock were attenuated when subjects were observed as compared to when they were alone, but the anticipated augmentation of arousal did not occur. Rather, the attenuation of expressive behavior was accompanied by a general decrease in subjective and autonomic responses to the painful stimuli. A second experiment replicated the results of the first study and, in addition, found no evidence for a differential impact of sex of observer on the three measures of arousal. An interpretation is discussed for the effect of observation on expressive behavior and for the relationships observed among expressive, autonomic, and subjective indices of pain.

Arousal↗
PubMed1994

Novel structure of a Chinese hamster polyubiquitin gene.

We isolated a polyubiquitin gene, CHUB2, from the V79 Chinese hamster genomic library, and determined its complete structure. Based on sequence homology to the human polyubiquitin gene UbC in the 5' and 3' untranslated region, the CHUB2 gene was characterized as the V79 Chinese hamster equivalent to the human UbC gene. However, the overall coding region structure of the CHUB2 gene was altered from the consensus structure of polyubiquitin genes, with the last ubiquitin coding unit being followed by 161 bp of partially deleted and mutated ubiquitin-like sequence. Although a similarly deleted and mutated polyubiquitin gene was recently reported in a partially sequenced cDNA of mouse (Finch et al. (1992) Cell Growth Differ. 3, 269-278), the present study describes the complete sequence of a polyubiquitin gene containing this unusual structure for the first time, and suggests that this structure is conserved in rodents. By employing both Southern and Northern analysis with a probe specific to the CHUB2 gene, it was found that a second, closely related gene is present in the Chinese hamster genome, and that both loci are transcriptionally active in V79 cells. The two genes, and their respective transcripts, differ in size because of variation in the relative number of repeating ubiquitin coding units.

Amino Acid Sequence↗
PubMed2003

Light chain crystal deposition as a manifestation of plasma cell dyscrasias: the role of immunoelectron microscopy.

Light chain crystal deposition disease is a rare and poorly characterized entity that can be confused with a number of different conditions, depending on where the disease process is manifested. The present study explored the role of ultrastructural immunogold labeling in the diagnosis of this condition. Seven cases of light chain crystal deposition (kappa light chain-related) are reported. Immunohistochemistry and immunofluorescence techniques play a rather limited role in the evaluation of these cases, as a result of the inability to detect monoclonal kappa light chains in association with the crystalline structures or high background staining. Ultrastructural labeling is the method of choice to fully characterize these cases. However, surgical pathologists must learn to recognize the findings associated with this condition to avoid misdiagnosis. If the diagnosis is at least suspected, then a complete hematologic workup may identify the underlying plasma cell dyscrasia. It must be emphasized that in some patients the plasma cell dyscrasia does not become clinically manifested until years after the diagnosis of light chain crystal deposition.

Adult↗
PubMed2000

E2F family members are differentially regulated by reversible acetylation.

The six members of the E2F family of transcription factors play a key role in the control of cell cycle progression by regulating the expression of genes involved in DNA replication and cell proliferation. E2F-1, -2, and -3 belong to a structural and functional subfamily distinct from those of the other E2F family members. Here we report that E2F-1, -2, and -3, but not E2F-4, -5, and -6, associate with and are acetylated by p300 and cAMP-response element-binding protein acetyltransferases. Acetylation occurs at three conserved lysine residues located at the N-terminal boundary of their DNA binding domains. Acetylation of E2F-1 in vitro and in vivo markedly increases its binding affinity for a consensus E2F DNA-binding site, which is paralleled by enhanced transactivation of an E2F-responsive promoter. Acetylation of E2F-1 can be reversed by histone deacetylase-1, indicating that reversible acetylation is a mechanism for regulation also of non-histone proteins.

Acetylation↗
PubMed1994

In vitro alteration of Schirmer's tear strip wetting by commonly instilled anesthetic agents.

The Schirmer's tear test is often performed with topical anesthesia to reduce reflex tearing. Fluress (Barnes-Hind, Sunnyvale, CA, U.S.A.) and Fluoracaine (Akorn, Abita Springs, LA, U.S.A.) are commonly used anesthetic-fluorescein preparations that contain viscous additives. Because the rate of Schirmer's strip wetting is dependent on capillary action, a property related to solution viscosity and surface tension, spurious results may be obtained if these agents are used for anesthesia. We report in vitro Schirmer's strip wetting rates for various concentrations of Fluress and Fluoracaine, as well as pure fluorescein solution using a tear substitute (Dacriose; IOLAB, Claremont, CA, U.S.A.) as a diluent. Results showed a direct concentration-dependent reduction of Schirmer's strip wetting with time for both Fluress and Fluoracaine dilutions compared with Dacriose alone (p < 0.001) or Dacriose-fluorescein solutions (p < 0.001). In addition, Schirmer's wetting with Dacriose-fluorescein solutions caused a separation of the Dacriose and fluorescein wetting fronts (p < 0.001) but did not affect the overall Dacriose wetting. These data have clinical implications concerning false-positive results when testing for dry eyes.

Anesthetics, Local↗
PubMed2002

Nursing homes and assisted living facilities as places for dying.

This chapter reviews the state of knowledge about nursing homes and assisted living facilities as places for dying. Reviewed are 25 published and unpublished research reports by nurse researchers and researchers from other disciplines that address the following questions: (a) What is known about how communication and shared decision-making about end-of-life care preferences occur? (b) How are symptoms assessed and managed at end-of-life? and (c) What are facility characteristics that influence end-of-life care services delivery? Reports were identified through searches of the following databases: MEDLINE, CINAHL, Health Star, PsychLit, Ageline, Ebsco, and PubMed. The following terms guided the search: advance directives, geriatric assessment or nursing, health services for the aged, hospice, residential facilities, palliative care, symptom management, and terminal care. Reports were included if published between 1990 and 2000, if relevant to nursing research on end-of-life care, if conducted on samples age 65 or older and living in nursing home or residential care settings, and if published in English. The studies reviewed were primarily descriptive. The findings indicate that little is known about end-of-life care in these settings, and that family and staff perspectives differ on the nature and quality of the services provided. Both external and internal factors influence the ability of facilities to provide end-of-life care. Recommendations are provided for further research related to nursing homes and assisted living facilities as places for dying.

Chronic Disease↗
PubMedDate not supplied

Molecular analysis of recrudescent parasites in a Plasmodium falciparum drug efficacy trial in Gabon.

Recrudescent Plasmodium falciparum parasites were sampled from 108 children taking part in a drug efficacy trial in Gabon. A finger-prick blood sample was taken from each child before treatment, and a post-treatment sample taken of the recrudescent parasites. Sample deoxyribonucleic acid was amplified by the polymerase chain reaction using primers specific to the P. falciparum antigen genes MSP-1, MSP-2 and GLURP. Seventy-seven children had identical parasites in their pre- and post-treatment samples, indicating genuine recrudescences of resistant parasites. Fourteen children had completely different parasites in their pre- and post-treatment samples, indicating either a fresh infection from a mosquito or growth of a population of parasites not detected in the pre-treatment sample, perhaps due to sequestration. The remaining 17 children had a mixture of pre-treatment and new parasites in their post-treatment samples. This study demonstrated the use of polymorphic markers to confirm whether parasites in patients with clinical recrudescences after drug treatment are genuinely resistant.

Adolescent↗
PubMed1988

Interviews or postal questionnaires? Comparisons of data about women's experiences with maternity services.

Surveys by personal interview are often assumed to be superior to those conducted by mail questionnaire. An experimental study of experiences and attitudes of 800 newly delivered mothers revealed surprising advantages to postal surveys: they are cheaper, more easily repeatable, and minimize interviewer effects. While response rates differed, the quality of responses was similar, except between middle- and working-class mothers. Postal surveys can be used with considerable assurance in national studies of fairly intimate experiences of pregnancy and delivery.

Asia↗
PubMed1991

Allergic contact dermatitis from 1,6-diisocyanatohexane in an anti-pill finish.

We report an outbreak of occupational allergic contact dermatitis from 1,6-diisocyanatohexane (old name hexamethylene diisocyanate or HDI), in the anti-pill finish Evafanol AS-1, in 2 clothing factories. The 19 operatives from 2 dressmaking mills all complained of work-related dermatitis. 5 of the subjects had positive patch tests to the fabric with which they were working, and when all 19 were patch tested to Evafanol AS-1 (1% aq.), 11 were positive. 6 of these 11 were patch tested to HDI (1% pet.) and all 6 were positive. It appears that HDI in our group of clothing workers acted as a potent sensitizer affecting around 10% of the workforce.

Cyanates↗
PubMed2001

Regulation of the catalase gene promoter by Sp1, CCAAT-recognizing factors, and a WT1/Egr-related factor in hydrogen peroxide-resistant HP100 cells.

Reactive oxygen species play a critical role in the onset of apoptosis induced by various extracellular stimuli, including ionizing radiation. Therefore active regulation of reactive oxygen species-metabolizing enzymes may be one response to an apoptotic stimulus. In this regard, HP100 cells, H(2)O(2)-resistant variants derived from human leukemia HL60 cells, display an interesting phenotype in which the activity of catalase is constitutively high, whereas its mRNA is reduced after X-ray irradiation. In the present study, we investigated the molecular mechanisms underlying this phenomenon. By combining analyses from nuclear run-on, reporter gene transient transfection, genomic footprinting, site-directed mutagenesis, electrophoretic mobility shift analysis, and Western blotting experiments, we found that constitutively elevated catalase expression is strongly regulated at the transcriptional level by both Sp1 and CCAAT-recognizing factors and that much higher levels of nuclear Sp1 and NF-Y are present in HP100 nuclei as compared with HL60 nuclei. In addition, we demonstrated an X-ray-inducible association of a WT1/Egr-related factor with an overlapping Sp1/Egr-1 recognition sequence located within the core promoter of the catalase gene. This association may lead to inactivation of the promoter by disturbing or competing with the transactivating ability of Sp1.

Base Sequence↗
PubMed1982

Occupational bladder cancer and cigarette smoking in West Yorkshire.

This paper reports results from a case-referent study on bladder cancer being conducted in parts of West Yorkshire; 991 cases have been incorporated in the results to date. Overall there was a significant risk of bladder cancer associated with smoking cigarettes. This habit showed a risk ratio of 1.8 (95% confidence limits of 1.5-2.3) for males. In addition there were significant overall risks associated with certain occupations; these include process workers in the dye manufacturing industry, who had a risk of 2.9 (95% confidence limits of 2.0-4.3) for males. When smokers were contrasted with nonsmokers, however, the risk was 4.6 for dye manufacturing process workers who smoked, while for nonsmokers the risk was much less at 1.9.

Adult↗
PubMed2000

Affect and cognition in dreams: a critique of the cognitive role in adaptive dream functioning and support for associative models.

Dream affect and cognition are examined in a 4-month longitudinal study of depressed, recently divorced subjects. Several measures of cognition in dream reports were used to determine whether remitting subjects were more likely to utilize certain cognitive strategies than nonremitters. No differences were found in the cognition between those who were remitting and nonremitting subjects. Levels of cognition in dreaming were directly related to the emotional intensity of the dreams across all subjects. In subjects with higher depression scores (Beck Depression Inventory > 20), depression levels were inversely related to both dream affect and cognition. It is argued that cognition plays a secondary role in dream production. A modification of David Foulkes's model of dreaming is proposed, in which emotional intensity drives associative processes, which in turn require more elaborate cognitive devices to relate diverse activated mnemonic units.

Adaptation, Psychological↗
PubMed2003

Preterm birth a long distance from home and its significant social and financial stress.

The present paper reports a retrospective cohort of preterm infants admitted to our hospital who delivered outside the normal geographical catchment area of the mother's local level three neonatal nursery. Nineteen mothers had 21 preterm infants (23.1-34.9 weeks, 500-2330 g born) where 14 infants required ventilation (median 57 h, range 3-428). Eighteen survivors had a median length of stay of 41 days (range 3-91). Twelve of 19 mothers were interviewed: all described isolation, loneliness, poor social support and significant financial hardship related to getting their infants back to a local hospital or home. To avoid these problems, we recommend confining travel to within a short distance from home or local maternity unit after 22 weeks.

Catchment Area, Health↗
PubMed2005

Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease.

The distribution and tempo of neuronal loss in Parkinson's disease correlates poorly with the characteristic and more widely spread intracellular changes associated with the disease process (Lewy bodies and Lewy neurites). To determine early intracellular changes in regions where cell loss is most marked (dopaminergic A9 substantia nigra) versus regions with Lewy bodies but where cell loss is limited, we assessed 13 patients with definite Parkinson's disease at various disease stages in comparison with controls. Using immunohistochemistry for alpha-synuclein, we confirmed the concentration of this protein in the soma of normal A9 neurons and in Lewy body pathology in brainstem catecholamine neurons in Parkinson's disease. Analysis of the degree of cell loss in brainstem catecholamine cell groups revealed that only the A9 substantia nigra had consistent significant cell loss early in the disease course with greater A9 cell loss correlating with increasing disease duration. To assess the earliest intracellular changes differentiating neurons more likely to degenerate, pigmented A9 and A10 neurons with and without obvious pathology were targeted, cell size and pigment density measured, and intracellular changes in alpha-synuclein location and lipid components analysed at both the light and electron microscope levels. There were no changes observed in healthy A10 neurons in Parkinson's disease compared with controls. Pigmented A9 neurons in later stages of degeneration with obvious Lewy body formation had a significant reduction in intracellular pigment, as previously described. In contrast, A9 neurons of normal morphological appearance and no characteristic pathology in Parkinson's disease exhibited significantly increased pigment density associated with a concentration of alpha-synuclein to the lipid component of the pigment and a loss of associated cholesterol. These changes in vulnerable but apparently healthy A9 neurons occurred without any change in cell size or in the amount of intracellular pigment compared with controls. The increase in pigment density is consistent with previously reported increases associated with oxidation and iron loading, reactions known to precipitate alpha-synuclein. The selectivity of the changes observed in A9 nigral neurons suggests that these early intracellular changes predispose these neurons to more rapid cell loss in Parkinson's disease. The increased concentration of neuronal alpha-synuclein and pigment in normal A9 neurons may already predispose these neurons to precipitate alpha-synuclein around pigment-associated lipid under oxidative conditions. Overall, these changes may trigger a cascade of events leading to larger intracellular aggregates of alpha-synuclein and the dispersement of protective pigment to precipitate cell death in Parkinson's disease.

Aged↗
PubMed1986

The Inter-Regional, Epidemiological Study of Childhood Cancer (IRESCC): case-control study in children with germ cell tumours.

In 1980-1983 members of IRESCC interviewed parents of 555 children with newly diagnosed cancer on topics of possible aetiological significance. Identical questions were asked of the parents of 1100 control children chosen from hospital admissions and general practitioner lists. Medical information was confirmed whenever possible by cross-checking with NHS records. Data for the 41 children with germ cell tumours and their 82 controls are reported here. The cases had more major congenital malformations than controls, including one neural tube defect. More case than control mothers and fathers reported occupational exposure to chemicals. Nine close relatives of cases had multiple primary tumours, which were often benign or of low-grade malignancy, compared with 1 hospital control and 3 general practitioner control relatives. Cases and controls differed with respect to birth weight and paternal age. No case-control differences were shown for: birth rank, maternal age, chronic illnesses and smoking, mothers' reproductive histories and oral contraceptive usage. In index pregnancies there were no case-control differences for maternal illness, infections, alcohol intake and X-ray and ultrasound exposure. There was no difference between cases and controls for the frequency of twinning the families.

Adolescent↗
PubMed1993

Hairy cell leukaemia: descriptive epidemiology and a case-control study.

The descriptive epidemiology of hairy cell leukaemia is reported from a specialized register of haematological malignancies covering approximately one-third of England and Wales. The overall incidence of hairy cell leukaemia at 2.9 per million persons per year is similar to that recorded in America. There is a marked male preponderance (4.0 compared with 1.7 per million per year for females). A case-control study on hairy cell leukaemia was conducted in the Yorkshire and Trent Regional Health Authority areas. 50 cases and 95 controls were identified, and interviewed using a structured questionnaire. Previous results on the aetiology of hairy cell leukaemia were not supported by this study, with the exception of an association between hairy cell leukaemia and exposure to organic solvents, petrochemicals and related products.

Adult↗