Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Cancer genetics”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 343 records · Page 19Linked to original sources
PubMed1998

Recent discoveries in cancer genetics of exocrine pancreatic neoplasia.

Within the past 4 years major advances in our understanding of pancreatic carcinogenesis have been made. The discovery of a high frequency of mutations in the tumor suppressor genes p16 and p53 together with an extraordinary high rate of K-ras mutations have shed light on how the disturbance of cell cycle control is a major hallmark in this tumor type. Furthermore, another very recently identified tumor suppressor gene, DPC4 (deleted in pancreatic carcinoma, locus 4), revealed that the TGFbeta-Smad signalling pathway is also likely to contribute to the development of this tumor type. It is now hoped that our improved knowledge of the molecular profile of pancreatic carcinoma will also translate into better diagnostic and therapeutic options to deal with this dismal disease.

Adenocarcinoma↗