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Color vision: a sensitive indicator of exposure to neurotoxins.

In the last 15 years an increasing number of studies have investigated color discrimination in workers exposed to various neurotoxins. Color vision was generally evaluated using the Lanthony D-15 desaturated panel (D-15 d), a test suited to identify mild acquired impairments, that can be easily performed at the workplace. In most studies, results were quantitatively expressed using the method of Bowman or that of Vingrys and King-Smith: the former is the most widely reported, while the latter gives information on the type of color defect. Applying D-15 d, or other color perception tests, impairment in color vision was observed among workers exposed to several solvents (styrene, perchloroethylene, toluene, n-hexane, and carbon disulfide), or to solvent mixtures, and also to metals like mercury. Chemical related color vision loss is a sub-clinical early effect, and in most studies proved dose-related. For styrene and perchloroethylene, and also for solvent mixtures, an impairment was observed at exposure levels lower than the current occupational limits, suggesting that these limits may be inadequate for a proper protection of visual function of workers.

Carbon Disulfide↗

The effect of glaucoma on central visual function.

Glaucoma has traditionally been thought to affect peripheral visual function in its early stages and to spare central visual function until late in the disease process. The basis for this assumption has been the reliance on Goldmann-type perimetry, a rather sensitive method for assessing the peripheral visual function, and on Snellen-type visual acuity measurements, a rather insensitive method of assessing central visual function. This belief has persisted despite frequent complaints from patients with glaucoma that their central vision is disturbed. Over the past two decades, several investigations of central visual functions and their anatomic substrate have challenged this assumption. Histologic studies of the nerve fiber layer in eyes with glaucoma suggest that the number of ganglion cells subserving macular function is decreased even in early stages of the disease. In addition, afferent pupillary defects (a gross measurement of macular nerve fiber function) may also be present in eyes with early glaucoma. Several studies have demonstrated that color perception (largely mediated by the fovea) is defective in glaucoma. Furthermore, defects in color perception may even precede the development of visual field abnormalities. Seventy-eight percent of patients with early glaucomatous visual field defects were found to have a defect in color perception when tested with a desaturated D-15 color panel that tests only the central 1.5 degrees. In addition, both chromatic and achromatic foveal perception channels are defective in eyes with glaucoma and even in some eyes of those with suspected glaucoma. Contrast sensitivity has become recognized as an important component of visual function. Partial loss of contrast sensitivity may cause a degradation in the quality of perception even though the Snellen visual acuity remains normal. Although contrast sensitivity is not entirely a macular function, it has been shown that as little as 3 degrees of disturbance of the macula (eg, with macular degeneration or with an artificial central scotoma) will reduce the contrast sensitivity, suggesting that this modality is indeed mediated to a significant extent by this portion of the retina. Spatial contrast sensitivity appears to be reduced in patients with glaucoma. However, because of overlap and lack of a sharp cutoff measurement, present testing procedures fail to allow a clear distinction between the glaucomatous and normal populations. Although reduced temporal contrast sensitivity has been demonstrated in glaucomatous eyes by others, I undertook a systematic investigation of this function in a large group of patients with glaucoma and with suspected glaucoma.(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗

Evolution of color vision loss induced by occupational exposure to chemicals.

The evolution of occupationally induced color vision loss was studied in workers exposed to various chemicals. Exposure was evaluated by biological monitoring or personal air samplers, and color vision using the Lanthony D-15 desaturated panel (D-15 d). The effect of short-term interruption of exposure was studied in 39 Styrene (St) exposed workers: at a first examination a dose-related color vision loss was disclosed; a re-test performed after one month's interruption of exposure did not show any improvement of the effect. The evolution during longer periods was studied in another group of 30 St workers. Exposure and color vision were evaluated, then a follow-up was done 12 months later: the exposure was unmodified or slightly decreased in 20 subjects, and D-15 d outcomes remained unchanged, while St levels had increased and color vision loss progressed in the other 10. Similar results were obtained in 33 PCE exposed dry-cleaners: no change in color perception was observed in 14 workers whose exposure decreased, while in the other 19 a rise in PCE levels was followed by a significant color vision worsening. In 21 Hg exposed workers whose mean urinary excretion of Hg was threefold the BEI proposed by ACGIH, a dose-related impairment in color perception was observed. 12 months after a marked reduction of exposure, an almost complete recovery of the impairment was observed. Our data show that an increase in exposure can induce a worsening in color vision loss. A short interruption in exposure did not reduce the effect. A more prolonged reduction of dose reversed color vision loss in Hg exposed workers, while in solvent-exposed individuals the progression deserves further evaluation. D-15 d proved a useful test for studies on the evolution of color perception in workers exposed to eye-toxic chemicals.

Color Perception↗

Localization of hemiachromatopsia.

Impaired color perception with relative preservation of form vision (achromatopsia) caused by cerebral lesions was first described over a century ago. However, for many years some researchers questioned the existence of an area of cerebral cortex apart from the primary visual cortex specialized in color processing. The development of sophisticated structural and functional neuroimaging techniques has allowed verification of the cortical structures important in color perception. We describe a case of a patient with impaired color perception in one hemifield of vision (hemiachromatopsia) and compare the localization of the lesion with previous cases described in the literature. These cases show that lesions of the ventromedial occipital cortex can impair color perception and leave form vision intact.

Aged↗

A model of color vision based on cortical reentry.

It is known that the perceived color of an object depends on the context in which it is viewed, its reflectance properties and the spectral distribution of the illuminating light. What is not known, however, is how the visual system functions so that color percepts depend upon the integration of local and contextual cues. While phenomenological theories of color vision exist, robust neurally based theories consistent with psychophysical observations are sparse. In the present study we develop such a theory and establish its self-consistency by computer simulations of cerebral cortical areas involved in color perception. The simulations test the hypothesis that long-range reciprocal connections within and between cortical areas mediate a dynamic process of reentry that integrates contextual cues into the color percept. When stimuli similar to those used in psychophysical testing of contextual influence were used, firing patterns consistent with psychophysical data on color constancy and color induction in humans were observed. Selective disruption of reciprocal inter- or intra-areal connections reduced the correspondence between the model's responses and the psychophysical data. The findings are consistent with the proposal that reentrant interactions within and between cortical areas provide a major basis for the context-sensitive aspects of color vision.

Animals↗

[The study of color vision in children].

The paper analyses results after investigation of color perception in 520 children (264 boys and 256 girls), aged 3-5 years, by means of two simple tests: a "Pflüger-Trident Test" (Velhagen) and a "Simplified Test of Color Vision" (Fletcher). It is proved that in children of under school age color perception is already developed enough and can be investigated for detecting disturbances in color vision.

Child, Preschool↗

Visual performance: Comparison of foldable intraocular lenses.

PURPOSE: To compare best distance visual acuity, color perception, and contrast sensitivity between eyes with an AcrySof Natural intraocular lens (IOL) (Alcon Laboratories Inc.) and fellow eye with an AcrySof IOL and to compare results in the IOL groups to those in normal, similarly aged patients with clear phakic eyes. SETTING: Sri Sankaradeva Nethralaya, Guwahati, India. METHODS: This prospective randomized parallel group single-center patient-masked examiner-masked study comprised 26 eyes of 13 healthy patients with bilateral age-related cataract. All patients had cataract surgery by phacoemulsification in both eyes; 1 eye received an AcrySof Natural IOL (SN60AT) and the fellow eye, an AcrySof (SA60AT) IOL. Final postoperative examination was performed at the end of 18 months. In addition to other findings, visual acuity, color perception, and contrast sensitivity were recorded. A group of normal, similarly aged phakic individuals with clear lenses was examined for contrast sensitivity. The records thus obtained were analyzed statistically. RESULTS: The AcrySof and AcrySof Natural IOL groups had a statistically significant improvement in visual acuity and color perception in comparison to preoperative status, and this was maintained until the last postoperative follow-up at 18 months. There was no statistically significant difference in the findings between the 2 IOL groups. The AcrySof and the AcrySof Natural IOL groups showed significant improvement in contrast sensitivity from the preoperative to the postoperative period (both P < .001). However, the AcrySof Natural IOL group was better than the AcrySof IOL group when each group was compared separately to similarly aged phakic individuals with clear lenses. CONCLUSIONS: Pseudophakia following AcrySof Natural SN60AT and AcrySof SA60AT IOL implantation led to equivalent visual acuity and color perception. But the contrast sensitivity in the AcrySof Natural group was better and near normal in reference to a healthy, age-matched control group.

Acrylic Resins↗

[Electroretinogram and electrooculogram in a family with Stargardt's disease].

PURPOSE: The aim of this study is to present the earliest functional changes in Stargardt disease in family with three affected and one unaffected children. PATIENTS AND METHODS: Four children: three girls (4, 7, 10, year old) and one boy (13 year old) and their parents (34 rear old mother and 36 year old father) were examined. Visual acuity (Snellen card), color perception (Ishihara's cards), electroretinography (flash full-field ERG--standard and chromatic) and electrooculography (EOG) were done. For ERG and EOG LKC equipment and UTAS E-2000 program was used. RESULTS: 13 year old boy has had visual acuity about 5/50 for about 3 years, nystagmus and no color perception. On his ocular fundus abnormal macular reflex (like beaten metal) was seen. Visual acuity about 5/12 was found in 7 year old girl during routine examination at school, but color perception and ocular fundus were normal. The others examined family members had visual acuity 5/5 without correction and no changes on ocular fundus. Color perception was normal in girls and mother. The father had red-green deficiency. Arden ratio in EOG was below normal (1.4) only in boy but dark trough and light peak amplitudes were lower than normal also in girls 4 and 7 year old and these two girls were also suspected of Stargardt's disease. ERG was nearly abolished in boy and markedly abnormal in his 7 year old sister. In father's ERG small reduction of cone function especially after chromatic stimulations was found. ERG was normal and similar in mother and 10 year old daughter. ERG was not done in the youngest girl. Two years later loss of visual acuity to 4/50 occurred in girl previously 7 and to 5/6 in the youngest sister. CONCLUSION: Detail analysis of EOG and ERG results may lead to diagnose retinal dystrophy in preclinical stadium.

Adolescent↗

The categorical perception of colors and facial expressions: the effect of verbal interference.

A series of five experiments examined the categorical perception previously found for color and facial expressions. Using a two-alternative forced-choice recognition memory paradigm, it was found that verbal interference selectively removed the defining feature of categorical perception. Under verbal interference, there was no longer the greater accuracy normally observed for cross-category judgments relative to within-category judgments. The advantage for cross-category comparisons in memory appeared to derive from verbal coding both at encoding and at storage. It thus appears that while both visual and verbal codes may be employed in the recognition memory for colors and facial expressions, subjects only made use of verbal coding when demonstrating categorical perception.

Adolescent↗

Perception of color and material properties in complex scenes.

How do human observers estimate the location, form, and color of objects? Accurate estimation is challenging because the light arriving at the eyes depends not only on object properties, but also on the spectra and spatial layout of the light sources (Nassau, 1983; Foley et al., 1990). How well the visual system separates illuminant and object properties to achieve a stable representation has traditionally been studied under the rubric of color and lightness constancy. Most previous work used very simple stimuli, typically a few diffusely illuminated surfaces arranged perpendicular to the line of sight. Over the past several years, however, there has been an evident increase of interest in expanding the conceptualization of this area to incorporate effects that emerge only for complex, typically three-dimensional, scenes. The current issue features papers that represent various manifestations of this interest. One line of research investigates how the three-dimensional layout of a scene affects the perception of lightness and color. Although the current work has long-standing antecedents (e.g. Mach, 1886/1959; Hochberg and Beck, 1954; Gilchrist, 1980), methodological advances in i) experimentation with real illuminated objects (e.g. Brainard et. al, 1987; Rutherford and Brainard, 2002; Ripamonti et al., 2004; Robilotto and Zaidi, 2004), ii) the use of sophisticated graphics simulations (e.g. Yang and Maloney, 1999; Fleming, Dror, & Adelson, 2003; Boyaci, Maloney, & Hersh, 2003; Delahunt and Brainard, 2004), iii) the design of hybrid systems that combine real objects with image-based graphics and video projection (Ling and Hurlbert, 2004), and iv) psychophysical procedures (Maloney and Yang, 2003; Obein, Knoblauch, & Vienot, 2004) have opened the door for systematic exploration of a wider range of phenomena. Recent papers include work on how well vision compensates for changes in surface orientation (Boyaci et al., 2003; Ripamonti et al., 2004), how effectively it discounts inter-reflections among nearby surfaces (Bloj, Kersten, & Hurlbert, 1999; Doerschner, Boyaci, & Maloney, 2004; Delahunt and Brainard, 2004), and how the visual system effectively estimates the spectral properties and spatial layout of the illuminant in three-dimensional scenes (Kraft & Brainard, 1999; Yang & Maloney, 1999; Boyaci, Maloney, & Hersh, 2003; Bloj et al., 2004; Boyaci, Doerschner, & Maloney, 2004; Khang and Zaidi, 2004). The second thread that leads to papers in the current issue is a focus on the functional utility of color and lightness perception -- the idea that these percepts inform us about the properties of objects rather than those of light spectra. This focus resulted in a renaissance of research in color constancy over the past two decades, with particular progress being made in the development of computational models that explore how, in principle, object surface properties can be estimated from image data. As with the experimental lines, early work focused on simple scene geometries (for reviews see Hurlbert, 1998; Maloney, 1999) but consideration has recently expanded to three-dimensional configurations (Adelson and Pentland, 1996; Yang and Maloney, 1999; Bell and Freeman, 2001; Dror, Willsky, & Adelson, 2004) Of particular interest has been the elaboration of purely computational formulations into parametric models of human performance (e.g. Brainard Brunt, & Speigle, 1997; Brainard Kraft, & Longere, 2003; Boyaci et al., 2003; Doerschner et al., 2004; Boyaci et al., 2004; Bloj et al., 2004), tests of how well the visual system exploits image information identified in computational studies (Yang and Maloney, 2001; Delahunt and Brainard, 2004; Smithson and Zaidi, 2004), investigations of how well the visual system recovers perceptual correlates of material properties other than diffuse surface reflectance, such as gloss and translucency (Lu, Koenderink, & Kappers, 2000; Fleming et al., 2003; Pont & Koenderink, 2003; Obein et al., 2004), as well as how geometric aspects of surface reflectance interact with the perception of shape (Fleming et al., 2003).

Color Perception↗

Dichromatic color language: "reds" and "greens" don't look alike but their colors do.

When protanopes or deuteranopes arrange the Farnsworth Dichotomous Test colors in order of similarity, they reveal their lack of red/green hue discriminations by alternating chips that the normal trichromat sees as reddish and greenish test colors. The dichromatic orderings follow a systematic variation in saturation of blue hues through neutral and into yellow hues as described by theory for each of the two types. Some dichromats who show the typical test behavior nevertheless use reddish and greenish hue terms appropriately when instructed to name the same test colors. Lightness cues are probably used by these dichromats in the naming task but ignored in the perceptual similarity task. Thus, unlike normal trichromats, who use similar names for perceptually similar colors, dichromats may use dissimilar names for perceptually similar colors. In this way they can achieve concordance with the normative language system despite its discordance with their impoverished color perceptions.

Color Perception↗

[The development of the skin-optical perception of color and images in blind schoolchildren on an "internal visual screen"].

In profound impairement of vision the function of colour and seen objects perception is absent, with the person being unable to orient himself in space. The uncovered sensory sensations of colour allowed their use in training the blind in recognizing the colour of paper, fabric, etc. Further study in those having become blind will, we believe, help in finding eligible people and relevant approaches toward educating the blind, which will make for development of the trainee's ability to recognize images on the "inner visual screen".

Blindness↗

[Quantitative criteria for the evaluation of congenital chromatic vision disorders].

The minimum angular size of a color stimulus required for its discrimination has been ascertained to be a quantitative criterion for evaluating the form and degree of congenital chromatic visual diseases. Unlike individuals with normal color perception who distinguish all basic and intermediate colors despite their saturation, anomalous trichromats discriminate more saturated colors with larger angular sizes of stimuli than those with normal color perception. Mild and moderate anomalous trichromats do not discriminate lowly saturated colors or for this they require the angular sizes tens of times greater those for normal trichromats. Persons with severe chromatic visual diseases (Type A) do not distinguish moderately saturated colors either. On recognizing the color of test objects, anomalous trichomats make the most mistakes in perceiving the green and yellow colors, the fewest mistakes in perceiving the red color. The minimum angular sizes required to distinguish colors, the percent of errors in their discrimination, and the range of vision of safety signs depend on the form and degree of congenital chromatic diseases. This makes it necessary to apply a differential approach to providing jobs that require rapid and accurate color discrimination in persons with the protanomalous forms of chromatic pathology.

Adaptation, Physiological↗

[Color vision in diabetics].

Color perception is often already altered even if the ocular, anatomic and functional exams maintain their results within the normal limits. This fact is more important in diabetes, where chromatic abnormalities exist at half of the subjects, even if they do not reveal any signs of diabetic retinopathy. The authors present some of the methods in clinical exam of color perception, the characters of dyschromatopsia and glycemic self control using the method of coloured bandelets, types of dyschromatopsia which may appear during the evolution of the diabetes, and also the predictive effect of dyschromatopsia for the appearance of diabetic retinopathy.

Color Perception↗

[Comparative study of the impact of diet versus pravastatin on color vision in Brodman area 19 detected by computerized chromatic analysis (CARDIOCOLOUR Study)].

INTRODUCTION AND OBJECTIVES: Hypercholesterolemia causes important neurodegenerative changes in the cerebral cortex, which are manifested by defects in the color perception by the neurons of Brodman area 19. Extensive interventional epidemiological data from both primary and secondary-prevention clinical trials indicate that cardiac ischemic events decrease when total cholesterol or LDL-C is reduced. Our goal was to elucidate the effects of diet compared with a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (pravastatin) on color perception using computerized chromatic analysis (CCA) and plasma cholesterol levels. PATIENTS AND METHODS: We studied 191 normotensive patients (133 men and 58 women) with pre-study plasma cholesterol levels in excess of 200 mg/dl. Seventy of these patients were treated with the American Heart Association Step II diet for six months. The remaining 121 were treated with pravastatin, 61 patients with 10 mg and 60 patients with 40 mg. They were examined by CCA after excluding any general or ophthalmological pathology. RESULTS: Chromatic vision recovered by 23% with diet, 38% with pravastatin 10 mg and 92% with pravastatin 40 mg. CONCLUSIONS: This study confirmed a strong association between therapeutic intervention with either diet or pravastatin and improved color vision.

Adult↗

Color stability of compomer after immersion in various media.

PURPOSE: The purpose of this study was to evaluate the effect of various media on the color stability of compomer and to compare these results to those of other materials that could be used in similar clinical circumstances. MATERIALS AND METHODS: In this test, six materials (shade A2) were used: four compomers (Dyract, Compoglass F, Xeno, F2000), one composite resin (Clearfil AP-X), and one resin-modified glass ionomer cement (Fuji II LC). There were four test solutions: one alcoholic (whiskey), two low pH soft drinks (Coca Cola, orange juice), and deionized water as a control. A plastic ring mold (9-mm diameter x 1-mm height) was used to prepare 120 disk specimens. For 60 days, the test specimens were immersed in the various media daily for 3 hours then transferred to the deionized water. Color was measured by CIE L* a* b* relative to CIE source against a white background, using a colorimeter. Color change (delta E*) was calculated as delta E* = [(delta L*)2 + (delta a*)2 + (delta b*)2]1/2. Color changes (delta E*) were recorded after 1, 7, 30, and 60 days. RESULTS: The results indicated that compomer and resin-modified glass ionomer were susceptible to discoloration in various solutions over an extended period of time. Composite resin showed minimal perceptible color change. Specimens immersed in whiskey showed a significantly high perceptible color change (p < .0001). Water caused no perceptible color changes.

Analysis of Variance↗