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At least 343 records · Page 19Linked to original sources
PubMed1984

Protease-inhibitor deficiencies in a patient with Weber-Christian panniculitis.

The diagnosis of Weber-Christian disease was made by clinical and histopathologic findings in a 25-year-old woman who had recurrent nodules on the legs and arms. The patient's history also disclosed multiple episodes of swelling trauma. Histopathologic examination of the lesions showed a prominent vasculitis. Studies of serum complement and kallikrein levels and of the fibrinolysis-clotting system showed a decrease in the levels of C3, C4, and total hemolytic complement activity and deficiencies (less than 20% of the normal values) of alpha 1-antitrypsin (alpha 1-AT) and antichymotrypsin activity. Chemical analyses of the patient's alpha 1-AT indicated a PiZZ genotype. Intermediate values of both inhibitor levels were detected in six family members. It is assumed that protease-inhibitor deficiencies predispose the development of panniculitis and vasculitis on trauma.

Adult↗
PubMed1981

[Anniversary 1980 of the history of the Faculty of Medicine Wittenberg (II): education and research during Christian Vater's (1651-1732) and Abraham Vater's (1684-1751) duration of office].

Fixed jubilees from the history of the Faculty of Medicine of the University of Wittenberg gave rise to remember the work of some representative persons. We remind of the investigations of the hypophysis carried out by the professor in ordinary Konrad Viktor Schneider (1614-1680) who died 300 years age and of the clinical and theoretically significant achievements of Daniel Sennert (1572-1637). Christian Vater (1651-1732) and Abraham Vater (1684-1751) once more coin a profile of the medical science in the 18th century, whose details in teaching and research were to be illustrated in the present treatise.

Germany↗
PubMedDate not supplied

Factitial Weber-Christian disease: a case report.

A 28 yr old white woman with fevers, arthralgias, and panniculitis was found to have factitial Weber-Christian disease induced by repeated subcutaneous injections of paint. The characteristics of self-induced dermatoses, various agents used in their production, and the psychodynamics of patients with self-induced illnesses are discussed. It is important that this diagnostic possibility be considered in patients presenting with obscure constitutional, musculoskeletal, and cutaneous findings.

Adult↗
PubMed1995

[Carl Christian Wilhelm Juch (1772-1821). His biography and his scientific work].

This article introduces Carl Christian Wilhelm Juch, Pharmacist, Doctor and Chemist, who, now almost forgotten, was well known in his time for his numerous works and essays on Natural Science. Some new biographic findings are disclosed. Juch's work covers a series of writings on Natural Science, in which he put great emphasis on economic and technological themes. His translation of and commentary on the Pharmacopoea Borussica 1805 provided an important contribution to pharmacy. In 1801 Juch was appointed Professor of Medicine and Chemistry at the University of Altdorf. In his position as University Professor he went 1805 to the Munic Lyceum and in 1808 to the Augsburg Realinstitut in order to teach Chemistry, Natural History and Dietetics. In 1816/17 he retired due to poor health. Juch died in Augsburg in 1821 at the age of forty-eight.

Chemistry↗
PubMedDate not supplied

Glucocorticoid-unresponsive fever in a patient with Weber-Christian disease.

Weber-Christian disease, a disease of unknown aetiology, is characterised by relapsing febrile episodes and systemic panniculitis. Glucocorticoid therapy is often useful during acute phases of the disease. This report describes a patient in whom hyperpyrexia did not respond to high-dose glucocorticoid treatment, yet did respond to a non-steroidal anti-inflammatory drug (NSAID).

Adult↗
PubMed1993

[The Bartholinian era--anatomy at the time of Christian IV].

At the time of King Christian IV of Denmark and Norway the University of Copenhagen was one of the most famous universities in Europe because of the epoch making medical research carried out there. The author presents a dynasty of anatomists--the Bartholin family--who dominated medical teaching and science for a century.

Anatomy↗
PubMed1996

[We're moving closer and closer to the insane asylum...": Modern life and nervous system diseases by Johann CHristian Reil (1759-1813)].

Johann Christian Reil is usually portrayed as a pioneer in the realm of neuroanatomy and psychiatry, and as a pragmatic physician engaged in contemporary problems of social medicine and hygiene. In this article, the connection between these two fields of interest is focused: Reil's ideas on the relation between the "modern" way of life and the occurrence of diseases of the nervous system. The first part of the paper summarizes Reil's statements on the issue, as laid out e.g. in his "Ueber die Erkenntnis und Cur der Fieber" (1802), and in the "Rhapsodieen über die Anwendung der psychischen Curmethode auf Geisteszerrüttungen" (1803). The second part gives an outline of Reil's neurophysiological model of the interaction between the organ of the soul ("Seelenorgan") and the social environment. In the third part, Reil's conceptions of culture, civilisation, and history are investigated. For Reil, madness is not an alienation from reason, but from a postulated healthy state of nature which is located in the past. Modern life causes and steadily increases a contradiction between the needs of the body and those of the soul, resulting in a concomitant tension and irritability of the nerves. Modern culture is thus criticized for its potentially harmful effects on mental health. The balance between physical and mental activities, and the constitution of a decentralized state would be means to prevent the manifestation of the ensuing diseases.

Germany↗
PubMed1996

Recognizing Weber-Christian disease.

The eponym Weber-Christian Disease (WCD) defines a chronic disorder characterized by relapsing febrile episodes and panniculitis. Systemic manifestations due to visceral involvement may be present. WCD is associated with no identifiable cause, although chronic panniculitis may be due to definable underlying disorders. A variety of distinctive disease entities, such as systemic lupus erythematosus (SLE), pancreatic disease, alpha-I-antitrypsin disease, lymphoproliferative neoplasia, infections, or trauma are associated with chronic panniculitis. The accurate diagnosis of panniculitis requires an adequate deep skin biopsy showing inflammation of the subcutaneous layers. We describe a white woman with fever and recurrent episodes of painful nodules of the lower extremities, excisional biopsy of which confirmed panniculitis. The febrile episodes and skin lesions responded dramatically with the use of oral corticosteroids.

Adrenal Cortex Hormones↗
PubMed1977

[Arthropathy in the Weber-Christian disease].

It is reported on five cases of Weber-Christian's syndrome which were observed in our institute during the last years due to difficulties involving motion organs. In three of the cases short-term arthritis was found and in one of the cases erosion arthritis of rheumatoid type was found, too. As far as the last case is concerned detailed information on the system manifestation of the patient is given; the disease started in her young days with regular relapses and visceral manifestation. At the same time typical morphologic changes in the subcutaneous fatty tissue and in the liver as well as clinical findings of diabetes, pericarditis and focal myocarditis were observed which proved a general disorder of the lipid metabolism.

Adolescent↗
PubMed1997

[A 100 year old thesis. Amanuensis Hans Christian Geelmuyden].

Hans Christian Geelmuyden (1861-1945) was amanuensis (assistant professor) at the Institute of Physiology, University of Oslo from 1889 to 1931. In 1897 he was awarded the degree "Doctor of Medicine" for his thesis "Om aceton som stofvexelprodukt" (On acetone as a metabolic product). The Nobel laureate Feodor Lynen referred to this thesis, which was also published in German, stating that Geelmuyden was the first to establish that ketone bodies are formed from fatty acids. Geelmuyden also established that acetone is metabolized in rabbits and dogs. Geelmuyden was a prolific writer on fat metabolism and diabetes and wrote a series of extensive reviews on these topics in Ergebnisse der Physiologie. Geelmuyden was active in the treatment of diabetic patients.

Academic Dissertations as Topic↗