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At least 343 records · Page 19Linked to original sources
PubMed1977

Epidemiologic characteristics of benign breast disease.

To see if the risk factors associated with fibroadenoma and cystic disease were similar to those reported for breast cancer, a retrospective study of benign breast tumor in a general population was conducted in Washington County, Maryland. The study population consisted of 320 white women 20 to 49 years of age who had had benign breast disease and 320 age-matched controls. More cystic disease cases than controls had the following characteristics, which had been reported to have been associated with breast cancer in other studies: higher socioeconomic status; fewer pregnancies; and a lack of association with lactation patterns. Nulliparity, late natural menopause and a maternal history of breast cancer were also more common among cystic cases than controls, although these differences could have occurred by chance. Cystic disease cases and controls did not differ with respect to other factors associated with breast cancer, such as early age at menarche, late age at first pregnancy, and negative history of artificial menopause. In contrast to cystic breast disease, fibroadenoma was not associated with most of the risk factors of breast cancer.

Adenofibroma↗
PubMed1987

Importance of cellular DNA content in pre-malignant breast disease and pre-invasive carcinoma of the female breast.

The risk of malignant change in pre-invasive breast disease such as proliferative atypia (PA) or the risk of invasive carcinoma arising from ductal carcinoma in situ (DCIS) remains uncertain in individual women because of the absence of any prognostic criteria. In order to clarify this, the cellular DNA content (ploidy) of 51 screen-detected lesions has been investigated. Cellular DNA measurements were made by static cytometry following Feulgen staining of disaggregated tissue sections and the resulting histograms classified as either diploid or aneuploid. Thirteen cases of PA and twelve of DCIS were compared with twenty-six biopsies showing DCIS with adjacent invasive carcinoma (DCIS + Ca). In the latter group, ploidy of the invasive carcinoma was compared with the associated DCIS in 16 cases. Aneuploid cells were found in approximately 30 per cent of PA and DCIS lesions but in 23 of 26 cases of DCIS + Ca. Of 16 assessable cases of co-existing DCIS and micro-invasive carcinoma both were aneuploid in 11, both diploid in 1, and in 4 cases the DCIS was aneuploid whereas the invasive carcinoma was diploid. These results suggest that aneuploidy may be of value in predicting the most biologically aggressive of these pre-invasive lesions.

Aged↗
PubMed2002

Establishing a molecular continuum in breast cancer DNA microarrays and benign breast disease.

Although the risk of breast cancer for women in the United States is approximately 1 in 9, identification of risk factors and translation of that knowledge into strategies for prevention have been inhibited by poor understanding of disease pathogenesis. A few benign breast proliferations are associated with higher risks of breast cancer, but definition of a preneoplastic morphologic continuum is lacking. If progression from a premalignant state to malignancy is accompanied by genetic changes, then identification in benign breast disease lesions (BBD) of alterations similar to those found in breast cancer should strengthen the perception of BBD as a premalignant condition. Current testing for hereditary breast cancer susceptibility presumes that only women with invasive breast or ovarian cancer are gene carriers. Therefore, neither in situ breast cancer nor atypical hyperplasias are considered clinically as evidence of a breast-ovarian syndrome, nor are these diagnoses used to predict carrier status within at-risk families. This reflects lack of evidence that breast cancer develops along a recognized morphologic continuum from precursor lesions. New mutation screening procedures such as DNA microarrays can provide sensitivity, specificity, and high throughput that circumvent limitations imposed on the scope of molecular marker analyses applied to archival resources. We have studied a BRCA1-mutant individual with loss of the wild type BRCA1 allele in benign breast proliferations. Both her benign and malignant lesions showed molecularly identical TP53 mutations, indicating that significant genetic alterations can occur in BBD and supporting the clonal evolution from BBD to malignancy.

BRCA1 Protein↗
PubMed1988

A quantitative analysis of the spatial relationships of grouped microcalcifications demonstrated on xeromammography in benign and malignant breast disease.

The mammograms of 444 patients who had a breast biopsy leading to a definitive histological diagnosis were reviewed. In 21 cases (4.7%) grouped microcalcifications were identified as the only mammographic abnormality. These groups of microcalcifications were analysed to determine whether there was any quantitative difference between benign and malignant lesions with respect to a shape parameter of the group, the spatial frequency of the particles and neighbour-to-neighbour relationships of the particles. This analysis did not reveal any significant difference between the spatial relationships of the grouped microcalcifications found in benign and malignant breast disease.

Biopsy↗
PubMed1987

Preliminary results using computerized telediaphanography for investigating breast disease.

An instrument (telediaphanograph) for examination of the female breast has been developed which is optically based and carries no risk to the patient. Malignant lesions, which are strongly light absorbing, can be visualized by dark shadows cast on the superior aspect of the breast. The discriminating ability of telediaphanography for carcinoma has been investigated in relation to 129 patients with suspected breast disease. The sensitivity was found to be 0.94 and the specificity 0.89.

Breast Diseases↗
PubMedDate not supplied

[Clinical manifestations in benign breast diseases. The surgeon's role in the evaluation of signs and diagnostic work-up].

From January 1988 through December 1995, 1022 patients having a breast disease have been operated on in our center. Of them 342 had a breast malignancies whereas 680 beared a benign breast disease. Benign breast pathology presents to the physician two main problems, they are: i) the need to rule out a breast cancer, which often may be simulated by special clinical presentation ii) the need to determine if eventually such a benign lesion can degenerate into a malignancy. We conclude according to our experience and following several authors that although a very careful diagnostic evaluation must be performed for every breast lesion, only few benign lesions arising with particular patterns can change into a breast cancer.

Breast Diseases↗
PubMedDate not supplied

[Benign breast diseases: the surgeon's role in its treatment].

INTRODUCTION: Surgery plays a key role in the diagnosis and treatment of breast diseases. Diagnostic answers and therapeutic solutions are offered thanks to surgery for both benign and malignant situations. PATIENTS AND METHODS: From January 1975 to August 1995 in our centre 1933 breast biopsy for benign breast diseases have been performed. In 98% of all cases the intervention has been performed under local anesthesia throughout the infiltration of 5 to 40 cc of Lidocaine or Mepivacaine. RESULTS: Mortality in our series was 0. Morbidity affected the 0.75% of all operated cases with hematomas or wound infections. DISCUSSION: Surgery becomes the solution in the diagnosis of breast diseases whenever previous diagnostic steps (Clinical examination+mammography+FNAB) or (Clinical examination+Ultrasonography+FNAB) or (Clinical examination+FNAB) fail to reveal a preoperative diagnosis. Of course surgery represents also the logical treatment of previously diagnosed lesions. The surgical excision of benign lesions must be meticulous due to the high recurrency rate that some of these lesions have (some histotype of fibrocystic disease or phyllodes tumors). Moreover surgery due to the benign nature of the lesions and to the fact that most part of the patients is represented by young women should always be as conservative and aesthetic as possible, by following anatomic lines and calibre sutures.

Adolescent↗
PubMed2002

Benign breast disease.

This article describes 25 years of clinical experience in the setting of a Breast Health Center devoted to benign and malignant disease of the breast. During this period, more than 100,000 patients have been evaluated and treated for a wide variety of breast problems. This experience has provided an extraordinary opportunity to evaluate the natural history of benign breast disease and the frequent observation that the relevant medical literature does not reflect the entire spectrum of these conditions or the appropriate treatment. Most textbooks on breast disease emphasize breast cancer and the late manifestations of benign breast disease that often require surgical treatment. More than 180,000 cases of breast cancer occur each year in the United States. The number of women with benign breast disease is far greater and can be counted in the millions. For these patients, the well-trained primary care physician can provide appropriate evaluation and treatment, including appropriate recommendations for referral. For most patients with breast symptomatology, the goal is relief of symptoms and resolution of the problem. To accomplish this requires a contemporary knowledgebase combined with adequate time spent with the patient.

Breast↗
PubMed1990

Steroid patterns of benign breast disease.

We briefly review some biochemical aspects of benign breast disease (BBD), mainly focusing on free and conjugate estrogen content of breast cyst fluid (BCF), also in relation to cyst type. Evidence is reported that high K(+)-type I-cysts clearly associate with low Cl- levels and accumulate significantly higher quantities of dehydroepiandrosterone sulfate (DHAS) and estrone-3-sulfate (E1S). In spite of the limited number of cases, both increasing DHAS and E1S levels correlate with the increment of K+ to Na+ ratio. A positive correlation was also found between DHAS and E1S. Using electrochemical detection (ECD) on-line to high performance liquid chromatography (HPLC) in the reverse phase mode, we also studied the free estrogen profile. We observed that in type I BCF there are significantly increased amounts of free estrone (E1). The E1S to E1 ratio was significantly different in the two cyst subpopulations; again, a positive correlation was found between free and sulfated E1 (r = 0.820, p less than 10(-6). This last, together with other experimental observations, allows us to hypothesize that in BCF a main pathway of steroids should be E1S----E1. Besides, high specific activity of sulfatase, as well as beta-glucuronidase enzymes, has been demonstrated for BBD. Preliminary information is also reported concerning the BCF pattern of free estrogens, including the highly polar ones, i.e., catecholestrogens (CCE) and the parent methoxy (MeO) conjugates, which represent, in BCF, a predominant portion of all free estrogens. Both CCE levels and ratios appear unevenly distributed in the two different cyst types. In addition, some BCFs show very high concentrations of 16 alpha-OH-E1. Further studies are needed to answer the main question: whether estrogen patterns could represent additive parameters to further categorize breast cystic disease (BCD) or whether they are of minor interest to determine patients' risk of developing breast cancer.

Adenofibroma↗