Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “BLASTOMYCOSIS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 343 records · Page 19Linked to original sources
PubMed1978

Atypical isolate of Cryptococcus neoformans cultured from sputum of a patient with pulmonary cancer and blastomycosis.

Cryptococcus neoformans was isolated repeatedly from a patient with epider-moid carcinoma and pulmonary blastomycosis. The isolate was atypical in that it had only a minute capsule, caused persistent infection but no perceptible disease in mice, and initially appeared not to assimilate trehalose. Only after an incubation of 2 to 3 weeks did utilization of this substrate become apparent.

Aged↗
PubMed1978

The radiological appearance of pulmonary blastomycosis.

A retrospective analysis of patients with pulmonary blastomycosis was made. Correlation of the mode of clinical presentation with the thoracic radiograph revealed a spectrum of clinical and radiological disease. The results substantiate the absence of specific clinico-radiological patterns, and amplify current concepts of clinical and radiological manifestations.

Adult↗
PubMedDate not supplied

Blastomycosis in a young African man presenting with a pleural effusion.

Blastomyces dermatitidis is a dimorphic fungus endemic to north-western Ontario, Manitoba and some parts of the United States. The fungus is also endemic to parts of Africa. Pulmonary and extrapulmonary findings of a 24-year-old African man who presented with weight loss, dry cough and chronic pneumonia not resolving with antibiotic treatment are presented. The unusual occurrence of pulmonary blastomycosis associated with skin lesions and a moderate pleural effusion is reported.

Adult↗
PubMed1977

Apparent diminution of the blastomycin skin test; follow-up of an epidemic of blastomycosis.

Eighteen persons involved in an epidemic of blastomycosis were followed for a period of 3 years. None of the symptomatic patients received antifungal therapy and all recovered spontaneously. During the period of follow-up observation all patients remained in excellent health, and none showed evidence of late exacerbation of the original illness. Two of the originally symptomatic patients continue to show stable pulmonary nodules on chest roentgenograms, whereas the previously abnormal chest roentgenograms in the other patients have become negative. Sixteen of these 18 patients showed a minimum of 5 mm of induration when tested with blastomycin skin test antigen. During the period of observation, the size of this induration tended to diminish.

Antigens, Fungal↗
PubMed1978

Miconazole treatment of relapsed pulmonary blastomycosis.

Two patients with second relapses of pulmonary blastomycosis after successful treatments with adequate doses of amphotericin B were retreated with miconazole. One patient had experienced an acute intrabronchial spread of disease to the contralateral lung before miconazole therapy. Marked clinical and roentgenographic improvement occurred with treatment, followed by mycologic relapse 1 month later. The other patient sustained a more indolent relapse of disease. A favorable response to treatment with miconazole was demonstrated by improvement in abnormalities noted on a chest roentgenogram and a [67]gallium-citrate scan.

Amphotericin B↗
PubMed1982

Disseminated blastomycosis in a pregnant woman: review of amphotericin B usage during pregnancy.

Disseminated blastomycosis was diagnosed in a 27-yr-old woman during her twenty-eighth week of pregnancy. Her skin lesions resolved promptly on treatment with amphotericin B. At full-term delivery when the mother had already received 1,536 mg of amphotericin B, the infant was normal and the placenta showed no evidence of blastomycotic infection. After administration of 16 mg of amphotericin B over 140 min, at delivery the concentrations of amphotericin B in serum of blood samples from the mother and the cord were 0.32 and 0.12 micrograms/ml, respectively. The published experience with systemic mycoses and amphotericin B treatment in pregnant women is reviewed. There is no evidence of teratogenesis or persistent toxic side effects in infants delivered from mothers treated with this drug during pregnancy.

Adult↗
PubMed1983

Pulmonary function studies in diffuse pulmonary North American blastomycosis.

Detailed pulmonary function studies were performed on 2 patients with diffuse pulmonary North American blastomycosis before and after therapy. Our studies showed a significant increase in lung restriction, stiffness, and small airways obstruction, which completely resolved with therapy. We conclude that adequate therapy, even in the presence of extensive disease, results in both clinical and physiologic recovery.

Blastomycosis↗
PubMed1987

Growth inhibition of Blastomyces dermatitidis in alveolar and peripheral macrophages from patients with blastomycosis.

Blastomyces dermatitidis evokes a pyogranulomatous disorder with organisms frequently found inside giant cells. Macrophages from bronchoalveolar lavage fluid and peripheral blood in monolayer cell cultures were challenged with live yeast organisms to examine phagocytosis and intracellular growth. A greater number of macrophages from patients recovering from blastomycosis had phagocytized Blastomyces compared with macrophages from healthy control donors. No differences were detected within the groups between alveolar and peripheral macrophages. Intracellular growth of the fungus was reduced in cultures of both cell types from patients compared with those from control subjects. Supernatants from specific Blastomyces antigen-stimulated lymphocyte cultures were collected, and treatment with the supernatant to control donors' macrophages resulted in increased phagocytosis and inhibition of intracellular growth. Antigen-induced lymphocyte stimulation as a correlate of cellular immunity is qualitatively related to alveolar or peripheral macrophage phagocytosis and growth inhibition of this fungus.

Blastomyces↗
PubMed1999

Disseminated blastomycosis in a rhesus monkey (Macaca mulatta).

An 8-year-old male rhesus monkey (Macaca mulatta) died following a 6-day illness consisting of progressive depression, anorexia, labored abdominal breathing, coughing, and tachypnea. Gross necropsy findings included severe multifocal (miliary) granulomatous pneumonia, granulomatous splenitis, and multifocal cerebral abscesses. Histologic examination revealed 10-15-microm broad-based budding organisms within pyogranulomatous inflammatory lesions in the lung, tracheobronchial lymph node, brain, spleen, and liver. The distribution of extrapulmonary lesions was intermediate between that described for dogs and that described for humans. These findings were consistent with blastomycosis, which is previously unreported in nonhuman primates.

Animals↗
PubMed1979

Acute miliary blastomycosis presenting as fluminating respiratory failure.

A patient with miliary blastomycosis had acute fulminating respiratory failure requiring prolonged external ventilatory support. Treatment consisted of antifungal chemotherapy with two drugs and administration of corticosteroids. Restrictive ventilatory impairment and exercise-induced hypoxemia persist at one year after completion of therapy.

Acute Disease↗
PubMed1990

Adult respiratory distress syndrome due to blastomycosis during pregnancy.

A 23-year-old healthy woman in her third trimester of pregnancy developed adult respiratory distress syndrome secondary to Blastomyces dermatitides. Pregnancy-related immunosuppression was believed to be responsible for the fungal infection. Following emergency delivery of the infant and a full course of amphotericin B therapy, the patient made an uneventful recovery. Although the fetal and maternal sides of the placenta demonstrated fungal spores, the child remained healthy. To our knowledge, this is the first report of blastomycosis-associated adult respiratory distress syndrome occurring during pregnancy.

Adult↗
PubMed2000

Disseminated blastomycosis in two California sea lions (Zalophus californianus).

Two captive California sea lions (Zalophus californianus) from different facilities were diagnosed with disseminated blastomycosis. The first, a 12-yr-old male, died after a 3-wk history of progressive anorexia and lethargy. Gross examination revealed acute jejunitis with focal perforation and associated peritonitis, along with severe purulent bronchopneumonia. The second, a 15-yr-old female, was euthanized after a 2-wk history of severe cutaneous ulceration and declining clinical condition. Gross examination revealed severe pyogranulomatous bronchopneumonia and ulcerative dermatitis. Histopathologic examination in both individuals revealed severe multifocal subacute to chronic pyogranulomatous pneumonia associated with massive numbers of fungal organisms morphologically compatible with Blastomyces sp. Fungal organisms were 8-20-microm-diameter broad-based budding yeasts with thick, refractile, double-contoured walls. The male sea lion had multifocal transmural Blastomyces-induced enteritis with subsequent rupture and peritonitis. The organism was also present in the liver, with minimal associated inflammation. The female had severe multifocal pyogranulomatous ulcerative dermatitis associated with large numbers of intralesional fungal organisms. Dissemination to the spleen had occurred in both animals. A serologic immunodiffusion test for Blastomyces dermatitidis was positive in the male. The presumptive primary pathogen in both cases was Blastomyces dermatitidis.

Animals↗
PubMed1994

Delayed treatment of pulmonary blastomycosis causing vertebral osteomyelitis, paraspinal abscess, and spinal cord compression.

A 36-year-old woman with gallbladder disease had an incidental finding of asymptomatic cavitary lung infection with Blastomyces dermatitidis. No treatment was given initially, and 2 months later she presented with vertebral osteomyelitis, paraspinal abscess, and spinal cord compression due to dissemination of the fungus. The patient recovered following surgical debridement and treatment with 1 g of amphotericin B, followed by itraconazole 400 mg QD for 6 months. In spite of previous reports of the self limiting nature of primary pulmonary blastomycosis in the normal host, antifungal therapy may be needed in cases that do not resolve spontaneously within a short period of time, or if transient immunosuppression may be anticipated as may occur following surgery or after acquisition of other infections.

Abscess↗
PubMedDate not supplied

Disseminated blastomycosis and acquired immunodeficiency syndrome: a case report and ultrastructural study.

A 42-year-old, African-American man presented with a 2-month history of weight loss and fever for 2 weeks. Presumptive diagnoses of human immunodeficiency virus infection (HIV) and acquired immunodeficiency syndrome were made on the basis of a CD4 lymphocyte count of 23 lymphocytes/mL. Chest x-ray revealed right paratracheal adenopathy and a miliary pattern. The etiology of the patient's pulmonary infection was not known, but tuberculosis was an important consideration. Over 5 days, the pulmonary infection progressed and was complicated by acute respiratory distress syndrome (ARDS), septic shock, and death, despite vigorous antibiotic and supportive therapy. Serologic tests for HIV infection were reported as positive after the patient's demise. The etiology of the patient's pulmonary infection, ARDS, and sepsis was not known until autopsy study revealed enumerable yeast-like cells of Blastomyces dermatitidis in the extensively consolidated lungs and in disseminated foci of infection in most other major organs. Diffuse alveolar damage was closely associated with the pulmonary blastomycosis. Electron microscopic study of the yeast-like cells of B. dermatitidis in the autopsy lung obtained and fixed 5 days after the patient's death revealed excellent preservation of viable organisms.

AIDS-Related Opportunistic Infections↗
PubMed2006

Human and canine pulmonary blastomycosis, North Carolina, 2001-2002.

We investigated a cluster of blastomycosis in 8 humans and 4 dogs in a rural North Carolina community. Delayed diagnosis, difficulty isolating Blastomyces dermatitidis in nature, and lack of a sensitive and specific test to assess exposure make outbreaks of this disease difficult to study.

Adolescent↗
PubMed1976

South American blastomycosis of the ureter.

A case of disseminated South American blastomycosis with unilateral involvement of the ureter and hydronephrosis is described; it is the third such case to be reported.

Blastomycosis↗