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Representation of the internal world in catatonic schizophrenia.

Catatonia, which until 1874 was called atonic melancholia, has remained a relative mystery despite many advances in the understanding of schizophrenia. Its typical symptoms are certainly distinctive: a motionless stupor, bizarre posturing, waxen flexibility, religious delusions, stereotyped movements, negativism, loss of will, confusion, and recurrent frenzy (Kahlbaum 1874). The processes which motivate this particular derailment of self and body have been sought in various organic etiologies, with little success. Arieti (1974) proposes several reasons for the paucity of case studies of the treatment of catatonic schizophrenia. First, catatonic schizophrenia has been declining in occurrence. Second, the symptoms themselves, such as mutism and excitement, make verbal therapy extremely difficult. Finally, catatonics often have no memory of their psychotic experiences. Psychotherapists have therefore had to rely on highly personal intuitions of their patients' crisis-in-being. Despite therapists' attention to nonverbal behavior, mutism and stupor are particularly effective hindrances to communication in psychotherapy. Psychotherapy is often not begun until the patient's symptoms ameliorate through chemotherapy and milieu support. The centrality of the verbal medium of communication in psychotherapy suggests that other approaches, using nonverbal media, may be indicated in the study of catatonia. This paper describes a treatment of a catatonic schizophrenic man which utilized movement and drama therapy. These methods were successful in evoking representations of the patient's inner life.

Adolescent↗

When being included is being excluded: a note on complement set focus and the inclusion relation.

Some negative quantifiers lead to pronominal reference patterns that are different from those obtained with positive quantifiers (Moxey & Sanford, 1993). This has been interpreted as meaning that the negatives give rise to a focus on the complement set (Moxey & Sanford, 1987); so, given few of the children enjoyed the trip, focus is on those who did not enjoy the trip. To date, this interpretation has depended on subjective judgments as to which set an anaphoric plural pronoun is referring to, allowing other interpretations of the data to be given by discourse semanticists. In two studies, we use the attachment patterns associated with the expression including, thereby circumventing the judgment problem. We show that a case like not many people enjoyed the race, including John leads to a representation in which John maps into the set of individuals who did not enjoy the race. We test and support the earlier claim that complement set focus is driven by denials associated with some negative quantifiers.

Attention↗

Ineffability of qualia: a straightforward naturalistic explanation.

In this paper I offer an explanation of the ineffability (linguistic inexpressibility) of sensory experiences. My explanation is put in terms of computational functionalism and standard externalist theories of representational content. As I will argue, many or most sensory experiences are representational states without constituent structure. This property determines both the representational function these states can serve and the information that can be extracted from them when they are processed. Sensory experiences can indicate the presence of certain external states of affairs but they cannot convey any more information about them than that. So, format- or code-conversion mechanisms that link different systems of representation (linguistic and perceptual) to each other will fail to extract any relevant information from sensory experiences that could be coded in language. They only way to establish specific roles for sensory experiences in communication and the organization of behavior is to attach to them, by associative links, words, or other behavioral responses. If a sensory experience has no linguistic label associated to it in a particular subject, then no linguistic description can token, or activate, that state in the subject. In other words, no linguistic description can cause a subject to undergo an unlabeled perceptual state. On the contrary, complex, or syntactically structured perceptual states can be built up, on the basis of descriptions, by mechanisms of constructive imagination (conceived here as one sort of format conversion). It is this difference between complex and unstructured representational states that gives us an understanding of the phenomenon we call the ineffability of qualia.

Color Vision Defects↗

PharaCon: a new framework for identifying bacteriophages via conditional representation learning.

MOTIVATION: Identifying bacteriophages (phages) within metagenomic sequences is essential for understanding microbial community dynamics. Transformer-based foundation models have been successfully employed to address various biological challenges. However, these models are typically pre-trained with self-supervised tasks that do not consider label variance in the pre-training data. This presents a challenge for phage identification as pre-training on mixed bacterial and phage data may lead to information bias due to the imbalance between bacterial and phage samples. RESULTS: To overcome this limitation, we proposed a novel conditional BERT framework that incorporates label classes as special tokens during pre-training. Specifically, our conditional BERT model attaches labels directly during tokenization, introducing label constraints into the model's input. Additionally, we introduced a new fine-tuning scheme that enables the conditional BERT to be effectively utilized for classification tasks. This framework allows the BERT model to acquire label-specific contextual representations from mixed sequence data during pre-training and applies the conditional BERT as a classifier during fine-tuning, and we named the fine-tuned model as PharaCon. We evaluated PharaCon against several existing methods on both simulated sequence datasets and real metagenomic contig datasets. The results demonstrate PharaCon's effectiveness and efficiency in phage identification, highlighting the advantages of incorporating label information during both pre-training and fine-tuning. AVAILABILITY AND IMPLEMENTATION: The source code and associated data can be accessed at https://github.com/Celestial-Bai/PharaCon.

Bacteriophages↗

The relationship of adult attachment constructs to object relational patterns of representing self and others.

This study examined the relation between attachment constructs assessed by self-report and object relations constructs assessed from narratives. Young adult participants (N = 65; median age 28) completed the Reciprocal Attachment Questionnaire (West, Sheldon, &Reiffer, 1987), provided a set of interpersonal narratives rated using the Social Cognition and Object Relations Scale (SCORS; Westen, Barends, Leigh, Mendel, &Silbert, 1994), and completed other relationship-related measures. Results suggest some conceptual convergence between internal working models and representations of self, others, and relationships; for example, individuals who perceive significant others as offering a secure base for emotional connection tend to have complex, well-differentiated representations of self and others. In addition, multiple dimensions of object relationships were found to be significantly associated with participants' relationship status (current involvement in a significant relationship) and their parents' marital status.

Adolescent↗

A model of fluid-biofilm interaction using a Burger material law.

A two-dimensional finite element model of the biofilm response to flow was developed. The numerical code sequentially coupled the fluid dynamics of turbulent, incompressible flow with the mechanical response of a single hemispherical biofilm cluster (approximately 100 microm) attached to the flow boundary. A non-linear Burger material law was used to represent the viscoelastic response of a representative microbial biofilm. This constitutive law was incorporated into the numerical model as a Prony series representation of the biofilm's relaxation modulus. Model simulations illuminated interesting details of this fluid-structure interaction. Simulations revealed that softer biofilms (characterized by lower elastic moduli) were highly susceptible to lift forces and consequently were subject to even greater drag forces found higher in the velocity field. A bimodal deformation path due to the two Burger relaxation times was also observed in several simulations. This suggested that interfacial biofilm may be most susceptible to hydrodynamically induced detachment during the initial relaxation time. This result may prove useful in developing removal strategies. Additionally, plots of lift versus drag suggested that the deformation paths taken by viscoelastic biofilms are largely insensitive to specific material coefficients. Softer biofilms merely seem to follow the same path (as a stiffer biofilm) at a faster rate. These relationships may be useful in estimating the hydrodynamic forces acting on an attached biofilm based on changes in scale and cataloged material properties.

Biofilms↗

Transference and countertransference in the analysis of a child with autistic nuclei.

The author stresses the importance of using the countertransference when working with autistic and borderline children, in whom severe disorders of cognitive and emotional development have not permitted the establishment of an internal three-dimensional space whereby emotions can be contained, meaning can be assigned to those emotions and symbols can be formed. She argues that the transference will arise gradually in response to the analyst's countertransference. Great importance is attached to the setting in both its material and psychic aspects, the stability of the former being essential because of the patient's two-dimensional mode of functioning, in which he lacks any representation of space and time. After a review of the theoretical background to the treatment of autistic children with particular reference to the work of Houzel and Tustin and a brief discussion of general aspects of the transference in the light of the views of Freud, Klein and Bion, the author turns to the clinical material proper, presenting vignettes from a number of sessions in the analysis of an autistic boy. These show how she utilises her own emotions, sensations and associations to gain information about the patient's state and, by assigning meaning to these manifestations and communicating it to him, to impart motion to his frozen internal world. The author reports that, after several years of analysis, the patient has introjected a stable object that will lead to healthier development and a sense of security.

Autistic Disorder↗

The role of the idealizing transference in the treatment of psychotic patients.

A segment of the psychotherapy with a schizophrenic woman and her psychological testing are presented in this paper. The authors focus on the role of the idealizing transference, and illustrate how its operation, along with the mechanisms of fusion, basic trust, and narcissistic alliance, facilitates the process of therapeutically transforming this patient's object representations. Changes in her hallucinations and delusions reflected this process. The idealizing transference may be more generally applicable in the treatment of individuals with schizophrenic psychosis than was previously thought. Its importance lies in catalyzing changes in patient object representations, object relations, and psychotic symptoms.

Adult↗

A quantile plot for simultaneous representation of clinical and statistical attributes of probing change: application to early identification of the downhill patient.

When multiple periodontal sites are observed in patients over time there is an intention to identify those sites where there is important change, typically loss of attachment or increase in probing depth. A change may be declared if it: (a) exceeds a threshold level, and/or (b) is determined to be statistically significant (e.g. regression slope different from zero), perhaps after (c) that significance level has been corrected for multiple testing. These criteria are not often considered when clinical or research decisions are made and there is no universal protocol for their evaluation. A quantile (uniform probability) plot, modified to incorporate additional information, is proposed as a graphical method for the display of changes at multiple sites within a mouth. This plot identifies, for each site, clinical changes beyond a threshold, site-wise statistical significance and statistical significance adjusted for multiple testing. These alternative criteria for attachment change are, thereby, made explicit, providing a detailed evaluative context. In addition, this methodology permits incorporation of an estimation procedure for the number of sites for which the null hypothesis of no change is false. This statistic can provide evidence of progressive disease even when no site has significant clinical or statistical change and even if the average change is zero. Use of the quantile plot was elucidated by application to simulated data, and to a clinical dataset using a BASIC program to automate the computational process. In the clinical example presented, the approach appeared more effective in detecting periodontal change than traditional clinical and statistical criteria. Pending technical refinement, this graphical approach may represent a new tool for the early identification of the downhill patient.

Adult↗

Projections from striate and extrastriate visual cortices of the cat to the reticular thalamic nucleus.

We have studied the pattern of connectivity of the visual cortical areas 17, 18, 19, 20a, 21a, posteromedial lateral (PMLS), and the posterolateral lateral (PLLS) suprasylvian areas with the reticular thalamic nucleus (RTN) of the cat ventral thalamus. Three cortical areas per hemisphere were injected iontophoretically with either 4% wheat germ agglutinin-horseradish peroxidase, 4% dextran-fluororuby, or 4% dextran-biotin. The visual field representations of the injection sites were determined by reference to previously published visuotopic maps of the cortex. The locations of labelled fibres, presumed terminals and cell bodies were determined with the aid of a camera lucida attachment and computer aided stereometry. In the ventral thalamus, the primary visual cortices (areas 17 and 18) project in a topographic manner to both the perigeniculate nucleus (PGN) and the RTN. By contrast, the "higher" visual cortical areas (areas 19, 21a, 20a, PMLS, and PLLS) project only to the RTN. Our experiments demonstrate the existence of a single, albeit coarse, visuotopic map within the RTN but do not support the notion of separate subregions within the RTN that can be related specifically to a particular visual cortical area. The putative single visuotopic map in the RTN appears to be organised in such a way that the vertical meridians are represented along the rostrocaudal axis of the RTN, whereas the horizontal meridians are mapped within the dorsoventral axis of the nucleus. The upper visual field is represented within regions of the RTN adjacent to the caudal part of the dorsal lateral geniculate nucleus (LGNd), whereas the lower visual field is represented in the parts of the RTN rostral to the LGNd. The map also shows a ventrodorsal shift along the rostrocaudal axis of the RTN such that in the rostral RTN the representation of vertical meridian is placed more ventrally than that in the caudal part of the nucleus.

Animals↗

The dream specimen in psychosomatic medicine in the light of clinical observations.

The author attempts to demonstrate a relationship between dreams and symptom formation in the psychosomatic patient. The egos of many patients predisposed to psychosomatic illness have shown a deformation of a defensive nature because of early impingement of the protective shield (a maternal function) which caused a precocious development of a false-self in Winnicott's sense. In a series of dreams the failure of one or more dream functions became evident. Such failures are often found in patients with psychosomatic symptoms and depend on the severity of illness and preillness factors such as personality, body image and type of object relationships. The dream functions identified were the traumatolytic, the wish-fulfilling, the symbolizing and the integrating ones. The author further speculates on the relationship between the physical symptom, the failure of a particular dream function, the physiological correlates of the manifest versus the latent content of the dream, the breakdown of the process of symbolization and the activation of an archaic body image representation.

Adult↗

[Metapsychological considerations on the model of attachment of J. Bowlby].

J. Bowlby's thought may be divided into two different aspects. The first one, which has had a fertile function in the history of psychoanalysis, emphasizes the influence of the real environment on the infant development and, furthermore, it shows that the infant attachment to the mother is based on a mutual instinctive behaviour, rather than on the oral drive. The second aspect concerns the construction of a new theory radically conflicting with metapsychology. Indeed, as Bowlby demonstrates, the latter is based on concepts (e.g. drive) incompatible with contemporary biology. Nevertheless, I think that these concepts have been misunderstood and that metapsychology is still unreplaceable, although it needs further developments. For instance, the possibility to base primitive (pre-object, pre-representational, pre-drive) relationship on metapsychology, preserving the economic viewpoint, may be examined carefully.

Anxiety, Separation↗

Self-envy and the concealment of inner resources.

Self-envy refers to envy of one's own inner resources. This term is an adjunct to the psychodynamic understanding of developmental self-arrest, defined as deliberate and defensive impairment of one's own abilities and accomplishments and the concealment of inner resources. The article suggests possible explanations for the formation of self-envy, emphasizing the formation of envious object representations and the construction of a part of the personality based on these introjections. The effects of self-envy on patient therapist relations are also described, focusing on two particular manifestations: attachment to the therapist as a defense against self-envy and attacking the therapeutic contract as one of the patient's assets. Excerpts from a case study are included.

Countertransference↗

An anatomy-based coordinate system for the description of the kinematic displacements in the human knee.

The effects and interaction of the anatomical displacements in the human knee are a prerequisite to an accurate assessment and communication of the kinematic data. For the kinematic information to be used to improve diagnosis and treatment, and for better prosthetic design and installation, there must be clear, concise, and universal definitions of the displacements. In general, the displacements are defined as three translations and three rotations. In this paper, anatomic landmarks on the femur and on the tibia are used to define the locations and orientations of the six displacement axes; i.e. three translational and three rotational displacement axes. The most commonly accepted kinematic representation of the knee joint, in the literature, is a special geometry three-cylindric open chain in which the axes of the cylindric joints are defined according to the rotational displacement axes. The sequentially adjacent joint axes are assumed to not only intersect but to intersect at right-angles. The open chain permits a total of six degrees of freedom between a Cartesian reference frame attached to the femur and a Cartesian reference frame attached to the tibia. In this paper, the three rotational axes are shown to be skewed and off-set from each other, therefore, a three-cylindric open chain with skewed joint axes is proposed to measure the six displacements between the two reference frames. The authors believe that the proposed open chain is the most general to date and provides a more realistic representation of the displacements in the knee. To illustrate the significance of the reference frames on the interpretation of measured data, the anterior/posterior drawer is plotted against per cent gait cycle for three existing open chains and the proposed open chain.

Biomechanical Phenomena↗

[A method of selective PCR-amplification of genomic DNA fragments (SAGF method)].

A method for separating into definite sets of a complex mixture of fragments obtained by DNA cleavage with IIS- or IIN-types of restriction endonucleases producing single-stranded termini of different sequences at the fragment ends has been developed. The method is based on the ligation of short double-stranded adapters with single-stranded termini complementary to the termini of a selected set of fragments followed by PCR-amplification with the primer which represents a strand of the adapters. Using endonucleases BcoKI and Bli7361 recognizing sequences CTCTTC and GGTCTC and producing three- and four-nucleotide 5'-termini, respectively, it has been shown that amplification of a set of fragments occurs only when the adapters are attached to DNA fragments with DNA-ligase. Several applications of the SAGF-method are suggested: for obtaining individual bands in DNA fingerprinting; for reducing the kinetic complexity of DNA in the representational difference analysis (RDA method) of complex genomes; for cataloguing DNA fragments, and for constructing physical genomic maps.

Animals↗

Representation of anatomical constraints in motor imagery: mental rotation of a body segment.

Classically, the mental rotation paradigm has shown that when subjects are asked to judge whether objects that differ in orientation are spatially congruent, reaction times increase with angular discrepancy, although some reports have shown that this is not always the case. Would similar results be obtained with realistic figures of body segments? In this work, the mental rotation of a hand attached to its forearm and arm in anatomically possible and impossible starting positions is compared with the mental rotation of a hammer. The main results show that reaction times increase monotonically with the angle of discrepancy for both stimuli and that the speed of rotation is higher for anatomically possible orientations in the case of the hand. Thus, mental rotation of body segments follows the same empirical rules as objects of another nature, and biomechanical constraints imposed to the motility of these segments can be considered as attributes of the mental representation.

Adult↗