Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “immunogenetics”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 325 records · Page 18Linked to original sources
PubMed1986

Multiple sclerosis in 3 gipsy and 2 partly gipsy subjects (a clinical and immunogenetic study).

Based on a clinical and immunogenetical study of three Gipsy and two partly Gipsy patients with multiple sclerosis (MS) it is concluded that clinically the MS of pure Gipsies resembles the Eastern form of MS and that of the partly Gipsy patients the Caucasian form of the disease. In respect of histocompatibility the association of the DR2 and B7 antigens with the disease has been confirmed. By taking into account the data on the frequency of the HLA antigens in the healthy Gipsy population the genetic factors determining MS are probably only indirectly related to the B and DR loci inside the complex HLA system.

Adult↗
PubMed1985

Immunogenetic studies of spontaneous abortion in mice. Preimmunization of females with allogeneic cells.

CBA females (H-2k) mated with DBA2 males (H-2d) exhibit a high rate of fetal resorption (30%) when compared with the CBA female BALB/c male, CBA female/CBA male, DBA2 female/CBA male, DBA2 female/DBA2 male combinations (6 to 8%). Preimmunization of CBA females with spleen cells from DBA2, BALB/c, or CBA males were performed in order to test their effects on CBA maternal tolerance of (CBA X DBA2)F1 fetuses. Only preimmunization with BALB/c male cells was effective in decreasing resorption; cells from BALB/c females had no effect. In order to further test 1) the role of non-MHC-encoded antigens present in the BALB/c male background, 2) the necessity of an additional H-2 difference, and 3) whether or not the phenomenon is H-2d restricted, preimmunizations were performed by using cells from congenic BALB/k (H-2k), BALB/b (H-2b), or BALB/c (H-2d). Only the latter treatment was efficient, which suggests that the paternal H-2d haplotype must be presented in synergy with some non-MHC-encoded antigens in the BALB/c male background. Immunogenetic studies with cells from nine recombinant inbred strains that reassorted DBA2 and BALB/c genomes showed that three of them behave like BALB/c and six like DBA2. This would suggest that the genetic determinism of this phenomenon is simple.

Abortion, Spontaneous↗
PubMed1979

An immunogenetic basis for the tissue involvement in Behçet's syndrome.

The multifocal involvement in Behçet's syndrome was grouped into a spectrum of four types, three of which appeared to have an immunogenetic basis. HLA-B5 was related to the ocular type of Behçet's syndrome (relative risk 7.3), HLA-B27 to the arthritic type (relative risk 12.1) and HLA-B12 to the muco-cutaneous type (relative risk 3.9). The concept that recurrent oral ulceration and Behçet's syndrome may belong to a disease spectrum is substantiated by the natural course of the disease. Furthermore, patients with recurrent oral ulcers share with the muco-cutaneous type of Behçet's syndrome a significantly increased frequency of HLA-B12 (relative risk 2.6). The HLA markers may also prove to be significant in the differential diagnosis and prognosis of a disease which may present under a confusing variety of clinical manifestations.

Adolescent↗
PubMed1976

Suppression of antibody responses in allogeneic mice by products of lymphoid tissue. II. Lack of antigenic specificity and immunogenetic requirements of allogeneic suppressive factor (ASF).

Mice were irradiated, infused with thymocytes and immunized with a variety of antigens, i.e., sheep or horse red blood cells (SRBC or HRBC), diphtheria toxoid (DT) or bovine gamma-globulin (BGG). The spleen cells (T.Spleen cells) were harvested 5 days later and cellfree extracts were prepared. The extracts contained an allogeneic suppressive factor (ASF) that was capable of inhibiting IgM antibody responses of allogeneic or semi-allogeneic unirradiated mice. ASF had to be injected within 24 hr of immunization to be effective and a single injection delayed, rather than abolished, the antibody response at the cellular level. However, daily injections of ASF resulted in persistent suppression of antibody response. ASF activity was antigen nonspecific, i.e., the antigen used to stimulate ASF production did not have to be the same as the antigen used to test for ASF activity. C3H T.Spleen extracts were even immunosuppressive when prepared by exposure to C3BF1 alloantigens only; such extracts suppressed antibody responses of C3BF1 and DBA/2 mice. C3H ASF was removed from extracts after incubation with C3BF1 spleen cells but not after incubation with C3H spleen cells. C3BF1 spleen cells which had been preincubated with C3H ASF were unable to generate antibody-forming cells upon transfer to irradiated C3BF1 host mice. This suggests that the ASF molecule may be or include receptors for alloantigens. The immunogenetic requirements for ASF activity were evaluated by injecting extracts from C3H, C57BL, C3BF and BALB/c T.Spleen cells into C3H, CBA, C57BL, BALB/c, DBA/2, A or C3H.A recipient mice. All extracts tested had ASF activity. However, all allogeneic recipients were not suppressed by the extract material. The suppressive activity of ASF seemed to require two (or more) antigenic differences between donors and recipients of extract material, an H-2K or I antigen difference and a second antigen difference, possibility Ig-1. In the limited numbers of strain combinations tested, T.Spleen extracts suppressed IgM antibody response only if exposed to H-2 and Ig-1 antigens, e.g., BALB/c (H-2d, Ig-1a) ASF suppressed A (H-2a, Ig-1e) but not C3H.A (H-2a, Ig-1a) or DBA/2 (H-2d, Ig-1c). Separate ASF molecules may react with separate antigens on the cell surface, i.e., with H-2 and gammaG2a. Alternatively, one ASF molecule may react with two structurally associated antigens. If the latter is correct, it is conceivable that the beta2-microglobulin which is non-covalently linked to the major component of H-2 molecules expresses allotypic antigens coded for by Ig-1 and beta2-microglobulin is one of the antigens recognized by ASF.

Animals↗
PubMed1982

Lipoprotein immunogenetics in primates. I. Two serum beta-lipoprotein allotypes (Lmb1 and Lmb11) in rhesus monkeys and the LP-B immunological relationship with other primates.

Immunogenetic investigations on two serum beta-lipoprotein allotypes of rhesus monkeys (Macaca mulatta) are reported. The allotypes, designated Lmb1 and Lmb11, are associated with the main lipoprotein family, LP-B or beta-lipoprotein, expressed on independent beta-molecules, and classify rhesus monkeys into three phenotypes: Lmb1, Lmb11, and Lmb1,11. Genetic and molecular studies indicate that the allotypes are encoded by two codominant autosomal allelic genes, Lmb1 and Lmb11. Anti-Lmb1 cross-reacts with the sera of two other macaque species, whereas anti-Lmb11 with sera of all Old World monkeys. Heteroimmune sera, antihuman apo-B and antirhesus LP-B, showed high but diversified degrees of cross reactivity with other primates.

Animals↗
PubMedDate not supplied

Beta-2 microglobulin--an immunogenetic marker of inflammatory and malignant origin.

Major contributions have been made in the last few years to the knowledge of the structure, fate and cellular origin of beta-2 microglobulin (B2M); but the question of its function still remains unclear. The concept of B2M being simply a marker of renal physiology seems less satisfactory when reference is made to its relationship to the immunogenetic system. Although assay of B2M cannot be considered as a specific diagnostic tool, it still may be regarded as a useful parameter in monitoring inflammatory, malignant, and auto-immune disease activity.

Beta-Globulins↗
PubMed1983

Response against single minor histocompatibility antigens. I. Functional and immunogenetic analysis of cloned cytolytic T cells.

A clonal approach was used to investigate the cellular basis of a T cell response to single minor histocompatibility antigens (miHA). This analysis was performed by functional and immunogenetic characterization of a large number of clones derived from short-term mixed leukocyte culture (MLC) populations generated against the miHA, H-1.3. Forty-nine clones isolated from such MLC were specifically cytolytic for H-1.3-bearing, H-2Db-compatible target cells. Thirty-seven of the 49 cytolytic clones were driven to proliferate when stimulated by spleen cells bearing the H-1.3 alloantigen in the absence of added T cell-derived growth factor(s) (GF). The remaining 12 clones proliferated only when GF was added. A strong positive correlation was observed between antigen-induced proliferation and the production of interleukin 2 (IL 2) activity. A similar correlation was observed when comparing the ability of both antigen and concanavalin A to induce IL 2 activity from the clones. These data suggest that i) antigen-driven or helper T cell-independent cytolytic T cells (HITc) are frequent components of an MLC response to a single miHA, and ii) the ability of HITc to undergo antigen-driven proliferation is related to their ability to produce antigen-induced GF.

Animals↗
PubMed1983

[AIDS and its association with human tumors and viruses. A viral and/or immunogenetic cause?].

This paper is an editorial review of the relationship between the AIDS, Kaposi sarcoma, adult-T-lymphoma, other neoplasias, HTLV, ATLV and other viruses, amyl-nitrite and immunosuppressive drugs and the possible immunogenetic mechanism related to the immunity suppressor branch due to Ia antigen allogenic reaction similar to that of graft versus host reaction which may also induce angiosarcomas.

Acquired Immunodeficiency Syndrome↗
PubMed1984

Immunogenetic differences in subpopulations of patients with IgA nephropathy (Berger's disease).

Gm and Km as well as HLA-A, HLA-B, and HLA-DR phenotype frequencies were examined in 64 well-defined IgA nephropathy patients. The patients were divided into subpopulations according to clinical symptoms, e.g. macrohematuria and chronic renal failure (CRF). In patients with CRF the frequency of the Gm1,3,17;5,13,21 phenotype tended to be increased (p = 0.016; pcorr = 0.08). The frequency of the HLA-DR phenotype with only one antigen (HLA-DR-) was increased in the whole population (p less than 0.001; pcorr less than 0.011), which appeared to be confined to the patients with macrohematuria (p less than 0.001; pcorr less than 0.01) and non-CRF (p less than 0.001; pcorr less than 0.011). Patients with the Gm1,3,17;5,13,21 phenotype developed a CRF significantly earlier (p = 0.009; pcorr = 0.045) than patients with other Gm phenotypes. These data suggest that clinically observed subpopulations of IgA nephropathy patients differ in immunogenetic background.

Actuarial Analysis↗
PubMed1983

[Immunogenetics and veterinary medicine].

Combining immunology and genetics has become a highly productive line of research in recent years, namely the study of the effects of genetic factors on immunological processes and differences in susceptibility to disease caused by these factors. The implications of this new field of research are discussed in the present paper. Particular attention is paid to one of the most exhaustively studied immunogenetic systems, the Major Histocompatibility Complex.

Animal Diseases↗
PubMed1983

Immunogenetic and immunologic aspects of gliosarcoma growth in rats.

Growth of the chemically induced, transplantable rat brain tumor gliosarcoma 9L (GS-9L) is under immunogenetic control. Both susceptible and resistant rats produce an immune response to the tumor, but the response is qualitatively different in the two groups. The intraperitoneal administration of gliosarcoma-9L cells in resistant KGH rats causes the production of cytotoxic lymphocytes and macrophages, and in susceptible F344 rats suppressor lymphocytes are produced. After gliosarcoma-9L cells were administered to (KGH x F344)F1 and backcross rats, tumor susceptibility or resistance and the nature of the immune response correlated well with the histocompatibility type, indicating the parallel genetic control of both traits. However, a second gene or gene complex, not linked to the major histocompatibility complex, may participate in the regulation of tumor growth.

Animals↗
PubMed1983

[Immunogenetics of intercapillary glomerulonephritis due to IgA deposits].

Idiopathic mesangial IgA nephritis (Berger's disease) and Schönlein-Henoch purpura mesangial IgA nephritis (SHP) have a common immunopathological pattern. There is a weak association with the MHC class I antigen, B35, which is a poor prognosis marker in Berger's disease and which predisposes to renal involvement in SHP. There is also an association with the MHC class II antigen, DR4, whose signification remains unclear. Many familial cases of Berger's disease have been reported in patients bearing the HLA-B35 antigen. We proposed that Berger's disease and SHP should be viewed as a unique entity according to their common immunogenetics and also common immunopathology.

Capillaries↗
PubMed1995

[Clinical and immunogenetic aspects of children with local and multiple forms of primary tuberculosis].

Immunogenetic examination of 146 preschool children with local and multiple tuberculous lesions and 148 controls found out the key role of unfavourable premorbid background (low-quality BCG vaccine, family contacts, associated diseases) in the disease onset. General trends in systemic immunity shifts are characterized. These depend on the age, inflammation phase, severity of clinical symptoms. Representation of antigens HLA DR2, DR5, Cw2, Cw4 indicates that a child has a 5-9 times greater risk to develop tuberculosis. These data should be allowed for in forming groups of higher risk among children.

Age Factors↗
PubMed1975

[Immunogenetic analysis of the localization of the Y-factor in the mouse genome. I. Study of interspecific F1 hybrids].

Immunogenetic analysis of Y-factor localization in mouse genome was carried out by means of skin grafts. The data obtained indicate to autosomal localization of Y-factor rather than Y-linked one. This leads to the conclusion that Y-factor is a sex-influenced factor, but not a sex-linked one. If the hypothesis about Y-factor localization in Y-chromosome is accepted, this gene will be identical in CGA and C57B1/6 strains and the variety of reactions, caused by T-antigen, will be determined by the genetical constitution of the male donors and the female recipients.

Animals↗
PubMed1994

Immunogenetic marrow donor search for 1012 patients: a retrospective analysis of strategies, outcome and costs.

To analyse strategies, outcome and costs of immunogenetic marrow donor search 1012 patients were enrolled in a retrospective single centre study covering the period from January 1990 to December 1992. An HLA-compatible donor was identified for 562 of the patients (55.4%). Core family donor search (CFDS) provided a donor for 39%, extended family donor search (EFDS) for 6.4% and unrelated marrow donor search (UMDS) for 10% of the patients. During the period analysed, UMDS success rate increased from 13.3% to 47.8%, while mean search length decreased from 7.2 to 4.8 months. The percentage of donors from German registries rose from 5% in 1990 to 50% in 1993. Search length was dependent on patient's HLA phenotype frequency, but even for patients with frequencies as low as < 1:3 000 000 a donor was found in 5 of 24 cases. The mean costs (DM) per donor identified by CFDS, EFDS and UMDS were 2921, 19 172 and 24 036, respectively. Thus, CFDS is the utmost effective type of search. In view of the clinical outcome of BMT, EFDS remains a meaningful strategy and should not be replaced by UMDS despite its increasing success rate.

Actuarial Analysis↗
PubMed1994

Incidence patterns of immunogenetic diseases in the North American Indians.

Epidemiologic studies have defined a number of disease susceptibility patterns based on host-environment interaction. The antithetical approach of studying disease resistance patterns has been utilized less frequently. This preliminary data report describes the incidence of certain immunogenetic diseases in North American Indians for "internal comparison" of tribal population groups residing in disparate geographic areas and for "external comparison" with incidence patterns of Caucasian populations residing in the same geographic areas. The preliminary nature of the data precludes any conclusionary statements.

Arthritis, Rheumatoid↗
PubMed1993

Immunogenetics of inflammatory myopathies.

The genes most commonly considered when investigating immunogenetic associations with autoimmune diseases, including inflammatory muscle disease (IMD), are those encoded in the major histocompatibility complex (MHC), the T-cell receptor (TCR) genes and the immunoglobulin genes. In caucasoids HLA DR3 is associated with adult polymyositis (PM) and juvenile dermatomyositis (JDM) and is probably increased in frequency in adult DM. In inclusion body myositis (IBM) DR3 and DR1 have been separately reported to be increased but few patients have been analysed. The DR3 in IMD is almost always present on the ancestral haplotype marked by HLA-B8, C4A*Q0 and DR3 and presumably accounts for the association with C4A*Q0 which has been reported in some subgroups of IMD. In other races the associations are less clear although DR6 may be increased in blacks with PM. In PM, DR3 is strongly associated with the presence of antibodies to histidyl tRNA synthetase (Jo-1). DR52 is even more strongly associated with the presence of this autoantibody and this association can be demonstrated in black and white patients. It is unlikely that DR3 is associated with autoantibodies to other aminoacyl-tRNA synthetases or signal recognition proteins although fewer cases have been reported and racial differences may exist. Antibodies to the Pm-Scl antigen are also associated with DR3 while autoantibodies to Mi-2 may be associated with DR53. In caucasoids DR4 was increased in D-penicillamine induced IMD but again there may be inter-racial differences. Amongst caucasoids with mixed connective tissue disease (MCTD) there is an increased frequency of DR4 and this allele is associated with the development of antibodies to ribonucleoprotein (RNP). In other races the data are minimal. Very few investigations of associations between TCR polymorphisms or immunoglobulin allotypes and IMD have been reported. The phenotype Gm 3;5 has been associated with PM in caucasoids and may interact with DR3 in predisposing to disease. The Gm phenotype 1,3;5,21 has been associated with MCTD and with the development of anti-RNP, with or without MCTD, in caucasoids. Multiple genetic factors are likely to determine the development of IMD and the particular combination of alleles at predisposing loci may differ between races and according to the inducing agent. Furthermore, the predisposing genetic factors may vary between subgroups of IMD.

Autoantibodies↗
PubMedDate not supplied

Immunogenetics of polymyalgia rheumatica.

The distribution of HLA-D region antigens was studied in 17 patients with well-documented polymyalgia rheumatica (PMR). HLA-D region antigens were defined by the oligonucleotide typing of polymerase chain reaction (PCR)-amplified genomic DNA. The results demonstrate that the prevalence of DR4 was significantly higher (p < 0.0002; RR = 8.10) in patients (70.6%) compared to normal controls (22.9%), and the frequency of DR1 and/or DR4 in patients (82.4%) was also higher (p < 0.0006; RR = 8.40) than that in normal healthy controls (35.7%). Of the subtypes of DR4,Dw13 was significantly higher (p < 0.002; RR = 9.30) in patients (29.4%) than in normal controls (4.3%). However, these data must still be confirmed by other investigators. The distribution of the remaining DR antigens and of the DQ and DP alleles in patients did not differ significantly from those in controls. The results suggest immunogenetic similarity between PMR and late onset rheumatoid arthritis in elderly populations.

Aged↗